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    Centrifugal force based microfluidic device, microfluidic system including the same, and method of determining home position of the microfluidic device
    4.
    发明授权
    Centrifugal force based microfluidic device, microfluidic system including the same, and method of determining home position of the microfluidic device 失效
    基于离心力的微流体装置，包括其的微流体系统和确定微流体装置的原位置的方法

    公开(公告)号：US07758810B2

    公开(公告)日：2010-07-20

    申请号：US11875973

    申请日：2007-10-22

    申请人： Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park ,  Jung-suk Yoo

    发明人： Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park ,  Jung-suk Yoo

    IPC分类号： G01N21/07 ,  G01B11/00

    CPC分类号： G01N35/00069 ,  B01L3/5027 ,  B01L2300/0654 ,  B01L2300/0803 ,  B01L2400/0409 ,  G01N35/0092 ,  G01N2035/00574

    摘要： Provided is a centrifugal force based microfluidic system including: a microfluidic device including a rotatable platform and an optical path formed to extend horizontally in a straight line from a circumference of the platform; a motor rotating so as to control the microfluidic device; a light emitting unit emitting light towards the microfluidic device; a light receiving unit detecting the light emitted from the light emitting unit; and a controller determining a home position to be the position of the microfluidic device at a point of time when the light emitted from the light emitting unit is detected by the light receiving unit, wherein the light emitted from the light emitting unit passes through the optical path to be incident on the light receiving unit only when the microfluidic device is located in a predetermined position.

    摘要翻译： 提供了一种基于离心力的微流体系统，包括：微流体装置，其包括可旋转平台和形成为从平台的圆周以直线水平延伸的光路; 旋转的马达以控制微流体装置; 向所述微流体装置发射光的发光单元; 光接收单元，检测从所述发光单元发射的光; 以及控制器，其在从所述光接收单元检测到从所述发光单元发射的光的时刻，将所述微流体装置的位置确定为所述位置，其中，从所述发光单元发射的光通过所述光 仅当微流体装置位于预定位置时入射在光接收单元上的路径。

    Centrifugal force-based microfluidic device for protein detection and microfluidic system including the same
    8.
    发明授权
    Centrifugal force-based microfluidic device for protein detection and microfluidic system including the same 有权
    用于蛋白质检测和微流体系统的基于离心力的微流体装置包括相同的

    公开(公告)号：US07951333B2

    公开(公告)日：2011-05-31

    申请号：US12851819

    申请日：2010-08-06

    申请人： Beom Seok Lee ,  Yoon Kyoung Cho ,  Jeong Gun Lee ,  Jong-myeon Park

    发明人： Beom Seok Lee ,  Yoon Kyoung Cho ,  Jeong Gun Lee ,  Jong-myeon Park

    IPC分类号： G01N9/30

    CPC分类号： B01L3/502738 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0442 ,  B01L2400/0633 ,  B01L2400/0677 ,  B01L2400/0688 ,  G01N33/54326 ,  G01N33/54366 ,  Y10T436/25375

    摘要： A centrifugal force-based microfluidic device for the detection of a target biomolecule and a microfluidic system including the same are provided. The device includes a body of revolution; a microfluidic structure disposed in the body of revolution including chambers, channels connecting the chambers, and valves disposed in the channels to control fluid flow, the microfluidic structures transmitting fluid using centrifugal force due to rotation of the body of revolution; and beads disposed in the microfluidic structures, the beads having capture probes on the surfaces thereof which are selectively bonded with target protein; and a detection probe disposed in the microfluidic structures and selectively bonded to the target protein, and which includes a material required to express an optical signal, wherein the microfluidic structure mixes the beads, biological samples, and the detection probe to react and washes and separates the beads after the reaction.

    摘要翻译： 提供了用于检测靶生物分子的离心力微流体装置和包括其的微流体系统。 该装置包括一个革命体; 设置在旋转体中的微流体结构，包括腔室，连接腔室的通道，以及设置在通道中的阀，以控制流体流动，微流体结构由于旋转体旋转而使用离心力传送流体; 和珠子，其设置在微流体结构中，珠粒在其表面上具有与靶蛋白质选择性结合的捕获探针; 以及设置在微流体结构中并选择性地结合到靶蛋白上并且包括表达光信号所需的材料的检测探针，其中微流体结构混合珠，生物样品和检测探针以反应和洗涤和分离 反应后的珠子。

    CENTRIFUGAL FORCE BASED MICROFLUIDIC DEVICE FOR DILUTION AND MICROFLUIDIC SYSTEM INCLUDING THE SAME
    9.
    发明申请
    CENTRIFUGAL FORCE BASED MICROFLUIDIC DEVICE FOR DILUTION AND MICROFLUIDIC SYSTEM INCLUDING THE SAME 失效
    基于离散力的微流体装置，包括它们的渗透和微流体系统

    公开(公告)号：US20080193336A1

    公开(公告)日：2008-08-14

    申请号：US12029480

    申请日：2008-02-12

    申请人： Yoon-kyoung CHO ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park ,  Young-sun Lee

    发明人： Yoon-kyoung CHO ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park ,  Young-sun Lee

    IPC分类号： B01L11/00

    CPC分类号： B01L3/502738 ,  B01L3/50273 ,  B01L3/502792 ,  B01L2200/0605 ,  B01L2200/0647 ,  B01L2200/16 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0677

    摘要： Provided are a centrifugal force based microfluidic device which can automatically perform a dilution operation and a microfluidic system including the same. The centrifugal force based microfluidic device for dilution includes a rotatable disk type platform, a mixing chamber disposed on the platform; a buffer solution storage disposed on a portion of the platform which is closer to a center of the platform than the mixing chamber, connected to the mixing chamber through a channel to supply a predetermined amount of buffer solution to the mixing chamber at least one time, and a plurality of diluted solution chambers which are disposed on a portion of the platform which is farther from the center of the platform than the mixing chamber, are each connected to the mixing chamber through flow paths extended from a middle exit corresponding to a predetermined water level, and sequentially receiving a solution which is serially diluted in the mixing chamber at least one time.

    摘要翻译： 提供了一种能够自动执行稀释操作的离心力微流体装置和包括其的微流体系统。 用于稀释的基于离心力的微流体装置包括可旋转盘式平台，设置在平台上的混合室; 缓冲溶液储存器，其设置在所述平台的比混合室更靠近所述平台的中心的部分上，所述缓冲溶液存储器经由通道至少一次向所述混合室提供预定量的缓冲溶液，所述通道连接到所述混合室， 并且多个稀释溶液室通过从对应于预定水的中间出口延伸的流路连接到平台的比混合室更远离平台中心的部分上的稀释溶液室 至少一次连续地接收在混合室中连续稀释的溶液。

    Method of concentrating and disrupting cells or viruses
    10.
    发明申请
    Method of concentrating and disrupting cells or viruses 审中-公开
    浓缩和破坏细胞或病毒的方法

    公开(公告)号：US20080090275A1

    公开(公告)日：2008-04-17

    申请号：US11783351

    申请日：2007-04-09

    申请人： Yoon-kyoung Cho ,  Jeong-gun Lee ,  Jong-myeon Park ,  Young-sun Lee ,  Hyo-yeon Lee

    发明人： Yoon-kyoung Cho ,  Jeong-gun Lee ,  Jong-myeon Park ,  Young-sun Lee ,  Hyo-yeon Lee

    IPC分类号： C12N13/00

    CPC分类号： C12N1/066 ,  C12M47/06 ,  C12N13/00 ,  G01N33/54326

    摘要： Provided is a method for concentrating and disrupting cells or viruses, the method employs magnetic particles which are capable of binding the cells or viruses to capture the cells or viruses and a laser to disrupt the cells or viruses. Since the same particles are used in target cell separation and cell lysis, there is no need to add additional particles in a laser lysis process, and thus integration of a target cell separation, concentration, purification, and nucleic acid extraction process is easy.

    摘要翻译： 提供了一种用于浓缩和破坏细胞或病毒的方法，该方法使用能够结合细胞或病毒以捕获细胞或病毒的磁性颗粒和激光以破坏细胞或病毒。 由于在靶细胞分离和细胞裂解中使用相同的颗粒，因此不需要在激光裂解过程中添加额外的颗粒，因此靶细胞分离，浓缩，纯化和核酸提取过程的整合是容易的。