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公开(公告)号：US07926514B2
公开(公告)日：2011-04-19
申请号：US11766806
申请日：2007-06-22
IPC分类号： F15C1/04
CPC分类号： F16K99/0019 , B01L3/502738 , B01L2300/0803 , B01L2300/1861 , B01L2400/0409 , B01L2400/0677 , F16K99/0001 , F16K99/0032 , F16K99/0034 , F16K99/004 , F16K2099/0084 , Y10T137/1827 , Y10T137/2196 , Y10T137/6606 , Y10T137/7755
摘要： Provided are a valve unit and a reaction apparatus having the valve unit. The valve unit includes a phase transition material, which melts and expands upon an application of the electromagnetic waves to the valve filler, and the valve filler is directed into the channel through the connection passage and closes the channel. The valve unit also includes heat generation particles, which are dispersed in the phase transition material and generate heat upon an application of electromagnetic wave energy.
摘要翻译： 提供具有阀单元的阀单元和反应装置。 阀单元包括相变材料，其在将电磁波施加到阀填充器时熔化和膨胀，并且阀填料通过连接通道引导到通道中并关闭通道。 阀单元还包括发散颗粒，其分散在相变材料中并且在施加电磁波能量时产生热量。
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公开(公告)号：US08499793B2
公开(公告)日：2013-08-06
申请号：US12979049
申请日：2010-12-27
IPC分类号： F15C1/04
CPC分类号： F16K99/0019 , B01L3/502738 , B01L2300/0803 , B01L2300/1861 , B01L2400/0409 , B01L2400/0677 , F16K99/0001 , F16K99/0032 , F16K99/0034 , F16K99/004 , F16K2099/0084 , Y10T137/1827 , Y10T137/2196 , Y10T137/6606 , Y10T137/7755
摘要： Provided are a valve unit and a reaction apparatus having the valve unit. The valve unit includes a phase transition material, which melts and expands upon an application of the electromagnetic waves to the valve filler, and the valve filler is directed into the channel through the connection passage and closes the channel. The valve unit also includes heat generation particles, which are dispersed in the phase transition material and generate heat upon an application of electromagnetic wave energy.
摘要翻译： 提供具有阀单元的阀单元和反应装置。 阀单元包括相变材料，其在将电磁波施加到阀填充器时熔化和膨胀，并且阀填料通过连接通道引导到通道中并关闭通道。 阀单元还包括发散颗粒，其分散在相变材料中并且在施加电磁波能量时产生热量。
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3.发明申请MAGNETIC MICROPARTICLE SEPARATION DEVICE AND MICROFLUIDIC SYSTEM INCLUDING THE SAME 审中-公开磁性微波分离装置和包括其的微流体系统公开(公告)号：US20080023388A1
公开(公告)日：2008-01-31
申请号：US11752321
申请日：2007-05-23
CPC分类号： G01N33/54326 , B01L3/502761 , B01L2200/0668 , B01L2300/0861 , B01L2400/043 , B01L2400/0487 , G01N35/0098
摘要： Provided are a magnetic microparticle separation device for separating and purifying target biomolecules and a microfluidic system using the device. The device includes a magnetic microparticle, a chamber to receive a buffer, a channel including an inlet, outlet and a connecting portion which is connected to and fluid communicates with the chamber, wherein a fluid sample containing the target biomolecules and magnetic microparticle flows through the channel and the magnetic microparticle which captures the target biomolecules are separated from the fluid sample.
摘要翻译： 提供了使用该装置分离和纯化目标生物分子和微流体系统的磁性微粒分离装置。 该装置包括磁性微粒，用于接纳缓冲器的腔室，包括入口，出口和连接部分的通道，其连接到腔室并与其流体连通，其中含有目标生物分子和磁性微粒的流体样品流过 捕获目标生物分子的磁性微粒与流体样品分离。
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公开(公告)号：US20080029158A1
公开(公告)日：2008-02-07
申请号：US11766806
申请日：2007-06-22
CPC分类号： F16K99/0019 , B01L3/502738 , B01L2300/0803 , B01L2300/1861 , B01L2400/0409 , B01L2400/0677 , F16K99/0001 , F16K99/0032 , F16K99/0034 , F16K99/004 , F16K2099/0084 , Y10T137/1827 , Y10T137/2196 , Y10T137/6606 , Y10T137/7755
摘要： Provided are a valve unit and a reaction apparatus having the valve unit. The valve unit includes a phase transition material, which melts and expands upon an application of the electromagnetic waves to the valve filler, and the valve filler is directed into the channel through the connection passage and closes the channel. The valve unit also includes heat generation particles, which are dispersed in the phase transition material and generate heat upon an application of electromagnetic wave energy.
摘要翻译： 提供具有阀单元的阀单元和反应装置。 阀单元包括相变材料，其在将电磁波施加到阀填充器时熔化和膨胀，并且阀填料通过连接通道引导到通道中并关闭通道。 阀单元还包括发散颗粒，其分散在相变材料中并且在施加电磁波能量时产生热量。
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公开(公告)号：US08057759B2
公开(公告)日：2011-11-15
申请号：US11835461
申请日：2007-08-08
申请人： Jeong-gun Lee , Yoon-kyoung Cho , Beom-seok Lee , Jong-myeon Park
发明人： Jeong-gun Lee , Yoon-kyoung Cho , Beom-seok Lee , Jong-myeon Park
CPC分类号： B01L3/502715 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L2200/14 , B01L2300/0806 , B01L2300/1861 , B01L2400/0409 , B01L2400/0677 , F16K99/0001 , F16K99/0032 , F16K2099/0084 , F16K2099/0086 , G01N35/00069 , Y10T436/11 , Y10T436/25375 , Y10T436/2575
摘要： Provided are an apparatus and a method of controlling a microfluidic system, and the microfluidic system. The apparatus of controlling the microfluidic system includes a central control block controlling an operation of the microfluidic system, a rotator control block controlling a rotator, a position control block controlling the position of a moving unit, the moving unit moving to a position of the microfluidic structure, and a radiation energy source control block controlling energy of a radiation energy source, the radiation energy source using an electromagnetic wave to scan over a position of the microfluidic structure. Such a configuration allows effective control of a miniaturized portable microfluidic system.
摘要翻译： 提供了一种控制微流体系统和微流体系统的装置和方法。 控制微流体系统的装置包括控制微流体系统的操作的中央控制块，控制旋转器的旋转体控制块，控制移动单元的位置的位置控制块，移动到微流体位置的移动单元 结构以及辐射能量源控制块，其控制辐射能源的能量，所述辐射能源使用电磁波扫描微流体结构的位置。 这种配置允许有效地控制微型便携式微流体系统。
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6.发明申请CENTRIFUGAL FORCE BASED MICROFLUIDIC DEVICE FOR DILUTION AND MICROFLUIDIC SYSTEM INCLUDING THE SAME 失效基于离散力的微流体装置，包括它们的渗透和微流体系统公开(公告)号：US20080193336A1
公开(公告)日：2008-08-14
申请号：US12029480
申请日：2008-02-12
IPC分类号： B01L11/00
CPC分类号： B01L3/502738 , B01L3/50273 , B01L3/502792 , B01L2200/0605 , B01L2200/0647 , B01L2200/16 , B01L2300/0806 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2300/1861 , B01L2400/0409 , B01L2400/0677
摘要： Provided are a centrifugal force based microfluidic device which can automatically perform a dilution operation and a microfluidic system including the same. The centrifugal force based microfluidic device for dilution includes a rotatable disk type platform, a mixing chamber disposed on the platform; a buffer solution storage disposed on a portion of the platform which is closer to a center of the platform than the mixing chamber, connected to the mixing chamber through a channel to supply a predetermined amount of buffer solution to the mixing chamber at least one time, and a plurality of diluted solution chambers which are disposed on a portion of the platform which is farther from the center of the platform than the mixing chamber, are each connected to the mixing chamber through flow paths extended from a middle exit corresponding to a predetermined water level, and sequentially receiving a solution which is serially diluted in the mixing chamber at least one time.
摘要翻译： 提供了一种能够自动执行稀释操作的离心力微流体装置和包括其的微流体系统。 用于稀释的基于离心力的微流体装置包括可旋转盘式平台，设置在平台上的混合室; 缓冲溶液储存器，其设置在所述平台的比混合室更靠近所述平台的中心的部分上，所述缓冲溶液存储器经由通道至少一次向所述混合室提供预定量的缓冲溶液，所述通道连接到所述混合室， 并且多个稀释溶液室通过从对应于预定水的中间出口延伸的流路连接到平台的比混合室更远离平台中心的部分上的稀释溶液室 至少一次连续地接收在混合室中连续稀释的溶液。
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公开(公告)号：US09726685B2
公开(公告)日：2017-08-08
申请号：US13269249
申请日：2011-10-07
申请人： Beom-seok Lee , Yoon-kyoung Cho , Jong-myeon Park , Jeong-gun Lee
发明人： Beom-seok Lee , Yoon-kyoung Cho , Jong-myeon Park , Jeong-gun Lee
CPC分类号： B01L3/502738 , B01L3/502723 , B01L3/502746 , B01L3/502753 , B01L2200/0684 , B01L2200/10 , B01L2300/0636 , B01L2300/0803 , B01L2300/0806 , B01L2300/0867 , B01L2300/087 , B01L2400/0409 , B01L2400/0677 , B01L2400/084 , B01L2400/086 , F16K99/0001 , F16K99/0019 , F16K99/0032 , F16K99/004 , F16K99/0061 , F16K2099/0084 , G01N35/00069
摘要： Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.
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8.发明授权Method of mixing at least two kinds of fluids in centrifugal micro-fluid treating substrate 有权在离心微流体处理基材中混合至少两种流体的方法公开(公告)号：US09180418B2
公开(公告)日：2015-11-10
申请号：US11751677
申请日：2007-05-22
申请人： Yoon-kyoung Cho , Jeong-gun Lee , Beom-seok Lee , Jong-myeon Park
发明人： Yoon-kyoung Cho , Jeong-gun Lee , Beom-seok Lee , Jong-myeon Park
CPC分类号： B01F13/0059 , B01F11/0002 , B01F11/0014 , B01F15/0201 , B01F15/0233
摘要： Provided is a method of mixing fluids including introducing at least two kinds of fluids to a chamber of a substrate including a microchannel structure; and alternately rotating the substrate clockwise and counter-clockwise until the at least two kinds of fluids are mixed, wherein the rotation is changed from one direction to the opposite direction before a vortex created in the mixing chamber by the one direction rotation disappears.
摘要翻译： 提供了一种混合流体的方法，包括将至少两种流体引入到包括微通道结构的基板的室中; 并且顺时针和逆时针地交替地旋转衬底，直到混合至少两种流体，其中在通过单向旋转在混合室中产生的涡流消失之前，旋转从一个方向改变到相反的方向。
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公开(公告)号：US20120028852A1
公开(公告)日：2012-02-02
申请号：US13269411
申请日：2011-10-07
申请人： Beom-seok LEE , Yoon-kyoung Cho , Jong-myeon Park , Jeong-gun Lee
发明人： Beom-seok LEE , Yoon-kyoung Cho , Jong-myeon Park , Jeong-gun Lee
IPC分类号： C40B60/12
CPC分类号： B01L3/502738 , B01L3/502723 , B01L3/502746 , B01L3/502753 , B01L2200/0684 , B01L2200/10 , B01L2300/0636 , B01L2300/0803 , B01L2300/0806 , B01L2300/0867 , B01L2300/087 , B01L2400/0409 , B01L2400/0677 , B01L2400/084 , B01L2400/086 , F16K99/0001 , F16K99/0019 , F16K99/0032 , F16K99/004 , F16K99/0061 , F16K2099/0084 , G01N35/00069
摘要： Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.
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10.发明授权Centrifugal force-based microfluidic device for protein detection and microfluidic system including the same 有权用于蛋白质检测和微流体系统的基于离心力的微流体装置包括相同的公开(公告)号：US07776267B2
公开(公告)日：2010-08-17
申请号：US11850129
申请日：2007-09-05
申请人： Beom-seok Lee , Yoon-kyoung Cho , Jeong-gun Lee , Jong-myeon Park
发明人： Beom-seok Lee , Yoon-kyoung Cho , Jeong-gun Lee , Jong-myeon Park
IPC分类号： G01N9/30
CPC分类号： G01N33/54326 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2200/0647 , B01L2300/0806 , B01L2300/0867 , B01L2300/1861 , B01L2400/0409 , B01L2400/0633 , B01L2400/0677 , B01L2400/0688 , G01N33/54366 , Y10T436/25375
摘要： A centrifugal force-based microfluidic device for the detection of a target biomolecule and a microfluidic system including the same are provided. The device includes a body of revolution; a microfluidic structure disposed in the body of revolution including chambers, channels connecting the chambers, and valves disposed in the channels to control fluid flow, the microfluidic structures transmitting fluid using centrifugal force due to rotation of the body of revolution; and beads disposed in the microfluidic structures, the beads having capture probes on the surfaces thereof which are selectively bonded with target protein; and a detection probe disposed in the microfluidic structures and selectively bonded to the target protein, and which includes a material required to express an optical signal, wherein the microfluidic structure mixes the beads, biological samples, and the detection probe to react and washes and separates the beads after the reaction.
摘要翻译： 提供了用于检测靶生物分子的离心力微流体装置和包括其的微流体系统。 该装置包括一个革命体; 设置在旋转体中的微流体结构，包括腔室，连接腔室的通道，以及设置在通道中的阀，以控制流体流动，微流体结构由于旋转体旋转而使用离心力传送流体; 和珠子，其设置在微流体结构中，珠粒在其表面上具有与靶蛋白质选择性结合的捕获探针; 以及设置在微流体结构中并选择性地结合到靶蛋白上并且包括表达光信号所需的材料的检测探针，其中微流体结构混合珠，生物样品和检测探针以反应和洗涤和分离 反应后的珠子。
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