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    Medicament dry powder inhaler dispensing device
    1.
    发明授权
    Medicament dry powder inhaler dispensing device 失效
    药物干粉吸入器分配装置

    公开(公告)号：US06752148B1

    公开(公告)日：2004-06-22

    申请号：US09623937

    申请日：2000-09-01

    申请人： Joseph T. McGinn ,  Suggy S. Chrai ,  Bogdan Brycki ,  Bawa Singh ,  Peter Coyle ,  Gary Santonastaso ,  Hoi Cheong Sun

    发明人： Joseph T. McGinn ,  Suggy S. Chrai ,  Bogdan Brycki ,  Bawa Singh ,  Peter Coyle ,  Gary Santonastaso ,  Hoi Cheong Sun

    IPC分类号： A61M1500

    CPC分类号： A61M15/0045 ,  A61M15/0043 ,  A61M15/0048 ,  A61M15/0051 ,  A61M15/0055

    摘要： An inhaler disc cartridge comprises a carrier disc with radially outwardly extending resilient fingers, each with a medicament powder dosage. A sealing disc and an indexing ring are bonded to the disc. A cam sequentially and manually deflects a selected finger causing it to snap against an anvil to release the dosage by momentum energy transfer. In other embodiments, a cassette includes a carrier substrate reel of deposited powder dosages with a dosage sealing tape. The substrate comprises a belt with a plurality of transversely extending triangular fingers, each finger tip with a dosage thereon. Each finger is snapped in sequence against an anvil while a clamp secures the belt as the fingers are deflected. The spring fingers are corrugated in one embodiment cooperating with an anvil having channels and a device for inducing agglomeration breakup air streams through the channels. Other embodiments are for impact deflection of a dosage carrying substrate in a cartridge or cassette against an anvil to release the dosages.

    摘要翻译： 一个吸入式盘盒包括一个具有径向向外延伸的弹性指状物的承载盘，每个都带有药物粉末剂量。 密封盘和分度环结合到盘上。 凸轮顺序地并且手动地偏转所选择的手指，使其与砧座卡扣以通过动量能量传递释放剂量。 在其他实施例中，盒包括具有剂量密封带的沉积的粉末剂量的载体衬底卷轴。 衬底包括具有多个横向延伸的三角形指状物的带，每个指尖具有其上的剂量。 每个手指按照砧座顺序扣合，同时当手指偏转时，夹具固定皮带。 在一个实施例中，弹簧指状物是波纹状的，与具有通道的砧座配合，以及用于通过通道引起团聚分解空气流的装置。 其他实施方案是用于将剂量携带衬底在药筒或药盒中抵抗砧座的冲击挠曲以释放剂量。

    Method of deposition a dry powder and dispensing device
    3.
    发明授权
    Method of deposition a dry powder and dispensing device 失效
    沉积干粉和分配装置的方法

    公开(公告)号：US6146685A

    公开(公告)日：2000-11-14

    申请号：US187092

    申请日：1998-11-05

    申请人： Suggy S. Chrai ,  Joseph Thomas McGinn ,  Bawa Singh

    发明人： Suggy S. Chrai ,  Joseph Thomas McGinn ,  Bawa Singh

    IPC分类号： A61J3/00 ,  A61J7/00 ,  A61K9/00 ,  A61M15/00 ,  A61M15/02 ,  B05D1/06 ,  B05D1/04

    CPC分类号： B05D1/06 ,  A61M11/001 ,  A61M15/0043 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0055 ,  A61K9/0075 ,  A61M15/02 ,  A61M2202/064

    摘要： A dry powder, for example, a medicament for an inhaler, comprises elongated particles with an aspect ratio sufficient to cause the particles to be bound to a preferably metal or non-metallic sheet material substrate at the particle tips by electrostatic deposition and for aligning a plurality of particles with their major axes aligned normal to the substrate and oriented tip-to-tip. Particles deposited form a low density, high relative void deposition to minimize attractive forces between the particles. This minimizes agglomeration and bonding forces to the substrate facilitating the release of a powdered medicament in an inhaler. Medicament dosages in a substrate pocket are covered by a sealing layer. An embodiment of a drug dosage inhaler substrate and inhaler is disclosed.

    摘要翻译： 干粉，例如用于吸入器的药物，包括细长的颗粒，其长宽比足以使得颗粒通过静电沉积而在颗粒尖端处与优选金属或非金属片材基材结合，并且用于对准 多个颗粒的主轴与衬底垂直对齐并且取向尖端到尖端。 沉积的颗粒形成低密度，高相对空隙沉积，以最小化颗粒之间的吸引力。 这最小化对基质的附聚和结合力，有助于在吸入器中释放粉末状药物。 衬底袋中的药物剂量被密封层覆盖。 公开了药物剂量吸入器基质和吸入器的实施方案。

    Dry powder dispensing device
    4.
    发明授权
    Dry powder dispensing device 失效
    干粉分配装置

    公开(公告)号：US06397840B1

    公开(公告)日：2002-06-04

    申请号：US09588090

    申请日：2000-06-06

    申请人： Suggy S. Chrai ,  Joseph Thomas McGinn ,  Bawa Singh

    发明人： Suggy S. Chrai ,  Joseph Thomas McGinn ,  Bawa Singh

    IPC分类号： A61M1502

    CPC分类号： B05D1/06 ,  A61K9/0075 ,  A61M11/001 ,  A61M15/0043 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0055 ,  A61M15/02 ,  A61M2202/064

    摘要： A dry powder, for example, a medicament for an inhaler, comprises elongated particles with an aspect ratio sufficient to cause the particles to be bound to a preferably metal or non-metallic sheet material substrate at the particle tips by electrostatic deposition and for aligning a plurality of particles with their major axes aligned normal to the, substrate and oriented tip-to-tip. Particles deposited form a low density, high relative void deposition to minimize attractive forces between the particles. This minimizes agglomeration and bonding forces to the substrate facilitating the release of a powdered medicament in an inhaler. Medicament dosages in a substrate pocket are covered by a sealing layer. An embodiment of a drug dosage inhaler substrate and inhaler is disclosed.

    摘要翻译： 干粉，例如用于吸入器的药物，包括细长的颗粒，其长宽比足以使得颗粒通过静电沉积在颗粒尖端处与优选的金属或非金属片材基材结合，并且用于使 多个颗粒的主轴与基板垂直对准并定向到尖端。 沉积的颗粒形成低密度，高相对空隙沉积，以最小化颗粒之间的吸引力。 这最小化对基质的附聚和结合力，有助于在吸入器中释放粉末状药物。 衬底袋中的药物剂量被密封层覆盖。 公开了药物剂量吸入器基质和吸入器的实施方案。

    Bead or particle manipulating chucks
    7.
    发明授权
    Bead or particle manipulating chucks 失效
    珠或粒子操纵卡盘

    公开(公告)号：US06295194B1

    公开(公告)日：2001-09-25

    申请号：US09393871

    申请日：1999-09-10

    申请人： Hoi Cheong Sun ,  Bawa Singh ,  Howard Christopher Rivenburg

    发明人： Hoi Cheong Sun ,  Bawa Singh ,  Howard Christopher Rivenburg

    IPC分类号： H02N1300

    CPC分类号： B82Y15/00 ,  B01J2219/00468 ,  B01J2219/005 ,  H02N1/004

    摘要： Provided is a method of moving a charged particle from a first position at which it is retained by a first electrode to a second position at which it is retained by a second electrode, the method comprising: applying a potential to the second electrode to attract the particle; and applying a potential to a guide electrode offset from the particle at the first position, wherein the applied potential is effective to reduce the attraction of the particle to the first position sufficiently to allow the potential applied at the second electrode to be effective to move the particle from the first position to the second position.

    摘要翻译： 提供了一种将带电粒子从第一位置移动到第一位置的方法，其中第二位置被第二电极保持在第二位置，该方法包括：向第二电极施加电位以吸引 粒子; 以及将电位施加到在所述第一位置处偏离所述粒子的引导电极，其中所施加的电位有效地减小所述粒子对所述第一位置的吸引力，以足以允许施加在所述第二电极处的电位有效地移动 颗粒从第一位置到第二位置。