公开(公告)号：US5424212A

公开(公告)日：1995-06-13

申请号：US197457

申请日：1994-02-16

申请人： Judith Pinsl-Ober ,  Herbert Buschek ,  Klaus Erler

发明人： Judith Pinsl-Ober ,  Herbert Buschek ,  Klaus Erler

IPC分类号： G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G01N21/13 ,  G01N33/48

CPC分类号： G01N35/00663 ,  G01N35/00712 ,  G01N35/025 ,  G01N2035/00435 ,  G01N2035/00534 ,  G01N2035/00564 ,  G01N2035/00673 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/1076 ,  G01N2035/1086 ,  Y10T436/11 ,  Y10T436/115831

摘要： Analysis system for the automatic analysis of body fluids for a plurality of different analytes (parameters). An analytical apparatus incorporates reaction vessels (8) which are transported on the apparatus to various handling stations (10 to 16). The system also includes liquid reagents, which are held in readiness on the apparatus in reagent vessels (9), their volume sufficing for a large number of analyses. In order to achieve a high degree of analytical accuracy with reduced probability of operating errors and without significant increasing of the overall system costs, a calibrator is stored ready for use in liquid form in a calibrator station (17) of the analytical apparatus, the calibration is initiated and carried out fully automatically (i.e. without human intervention) for the various parameters independently of one another. For the initiation of the calibration for a parameter, in at least one system-immanent calibration-influencing variable is determined and combined logically with a control value defined specifically for the respective parameter and the decision on the initiation of the calibration is taken automatically in accordance with the logic combination.

摘要翻译： 用于多种不同分析物（参数）的体液自动分析的分析系统。 分析装置包括在装置上运送到各种处理站（10至16）的反应容器（8）。 该系统还包括液体试剂，其在试剂容器（9）中的装置上保持准备，其容量足以进行大量分析。 为了实现高度的分析精度，降低了操作错误的可能性，并且没有显着提高整个系统成本，校准器被储存成准备在液体形式中用于分析仪器的校准器站（17），校准 对于各个参数彼此独立地启动和完全自动执行（即无需人为干预）。 为了启动参数的校准，在至少一个系统内在的校准影响变量中被确定并且与逻辑上与专门针对相应参数定义的控制值进行组合，并且根据校准自动地进行关于校准开始的决定 与逻辑组合。

公开(公告)号：US06274304B1

公开(公告)日：2001-08-14

申请号：US08195018

申请日：1994-02-14

申请人： Herbert Buschek ,  Michael Kuehnl ,  Roland Ihrig ,  Klaus Erler ,  Maria Cully

发明人： Herbert Buschek ,  Michael Kuehnl ,  Roland Ihrig ,  Klaus Erler ,  Maria Cully

IPC分类号： C12Q100

CPC分类号： B01L3/508 ,  B01L3/50825

摘要： There is provided a system for the preparation of liquids from at least one solid and at least one liquid phase. The system is composed of a vessel in which the solid or solids are located and a drying chamber which is connected to the vessel or can be connected to the vessel. The drying chamber is separated from the vessel interior by a separating means which is permeable to water vapour but is impermeable to liquids. The system is suitable for the production of liquids from moisture-sensitive solids. These solids can be stored in the vessel since the air humidity in the interior is lowered by the desiccant. The preparation of the liquid by addition of a liquid phase can be carried out in one and the same vessel since the desiccant is separated from the vessel interior.

摘要翻译： 提供了用于从至少一个固体和至少一个液相制备液体的系统。 该系统由固体或固体所在的容器和连接到容器上或可连接到容器的干燥室组成。 干燥室通过分离装置与容器内部分离，该分离装置可渗透水蒸汽，但不透液体。 该系统适用于从湿度敏感的固体生产液体。 这些固体可以储存在容器中，因为内部的空气湿度被干燥剂降低。 由于干燥剂与容器内部分离，所以通过添加液相来制备液体可以在同一个容器中进行。

公开(公告)号：US20150036125A1

公开(公告)日：2015-02-05

申请号：US13824413

申请日：2011-09-16

申请人： Aldo Bojarski ,  Klaus Erler ,  Katrin Kunzelmann ,  Andre Legner ,  Paul Smith ,  Tobby Strasseberger

发明人： Aldo Bojarski ,  Klaus Erler ,  Katrin Kunzelmann ,  Andre Legner ,  Paul Smith ,  Tobby Strasseberger

IPC分类号： G01N21/41

CPC分类号： G01N21/4133 ,  G01N21/41 ,  G01N2201/0221

摘要： The invention relates to sensors for monitoring a medium, comprising an electromagnetic radiation source and a detector of electromagnetic radiation, the medium being located in the ray path between the electromagnetic radiation source and the detector and the refraction varying when the medium varies. The sensors are characterized by their ease of production. To that end, the electromagnetic radiation source and detector are disposed in at least one housing. Furthermore, either at least one region or at least one component of the housing consists of material which is transparent to electromagnetic radiation, the medium being located in the region or at the component of the housing. At least one wall of the region is so disposed or designed that the radiation for refraction impinges on or emerges from the surface at an angle which is different from 90°. In addition, the detector is at least one photo diode, such that, when the medium varies, the radiation either does not impinge or impinges on the photo diode.

公开(公告)号：US09188528B2

公开(公告)日：2015-11-17

申请号：US13824413

申请日：2011-09-16

申请人： Aldo Bojarski ,  Klaus Erler ,  Katrin Künzelmann ,  Andre Legner ,  Paul Smith ,  Tobby Strassberger

发明人： Aldo Bojarski ,  Klaus Erler ,  Katrin Künzelmann ,  Andre Legner ,  Paul Smith ,  Tobby Strassberger

IPC分类号： G01N21/41

CPC分类号： G01N21/4133 ,  G01N21/41 ,  G01N2201/0221

摘要： The invention relates to sensors for monitoring a medium, comprising an electromagnetic radiation source and a detector of electromagnetic radiation, the medium being located in the ray path between the electromagnetic radiation source and the detector and the refraction varying when the medium varies. The sensors are characterized by their ease of production. To that end, the electromagnetic radiation source and detector are disposed in at least one housing. Furthermore, either at least one region or at least one component of the housing consists of material which is transparent to electromagnetic radiation, the medium being located in the region or at the component of the housing. At least one wall of the region is so disposed or designed that the radiation for refraction impinges on or emerges from the surface at an angle which is different from 90°. In addition, the detector is at least one photo diode, such that, when the medium varies, the radiation either does not impinge or impinges on the photo diode.

摘要翻译： 本发明涉及用于监测介质的传感器，其包括电磁辐射源和电磁辐射检测器，所述介质位于电磁辐射源和检测器之间的光线路径中，并且当介质变化时折射变化。 传感器的特点是易于生产。 为此，电磁辐射源和检测器设置在至少一个壳体中。 此外，壳体的至少一个区域或至少一个部件由对电磁辐射透明的材料组成，介质位于壳体的区域或部件中。 该区域的至少一个壁被如此设置或设计成使得用于折射的辐射以不同于90°的角度撞击或从表面出射。 此外，检测器是至少一个光电二极管，使得当介质发生变化时，辐射不会撞击或撞击光电二极管。

公开(公告)号：US5248593A

公开(公告)日：1993-09-28

申请号：US908535

申请日：1992-06-29

申请人： Christa Hubner-Parajsz ,  Hartmut Schetters ,  Helmut Lenz ,  Klaus Erler

发明人： Christa Hubner-Parajsz ,  Hartmut Schetters ,  Helmut Lenz ,  Klaus Erler

IPC分类号： C07K16/26

CPC分类号： C07K16/26

摘要： The present invention provides an immunological process for the determination of the luteinizing hormone (LH), wherein at least one monoclonal antibody is used which is directed against LH and cross-reacts with other glycoprotein hormones to an extent of less than 3%.The present invention also provides a reagent for the determination of the luteinizing hormone, wherein it contains at least one monoclonal antibody which is directed against LH and cross-reacts with other glycoprotein hormones to an extent of less than 3%.Furthermore, the present invention provides a monoclonal antibody against the luteinizing hormone and a process and a hybridoma cell line for producing it.

摘要翻译： 本发明提供了用于确定黄体生成激素（LH）的免疫学方法，其中使用至少一种针对LH的单克隆抗体和与其他糖蛋白激素交叉反应至少于3％的程度。 本发明还提供了用于测定黄体生成激素的试剂，其中它含有至少一种针对LH的单克隆抗体和与其他糖蛋白激素交叉反应至少于3％的程度。 此外，本发明提供了针对黄体生成激素的单克隆抗体及其制备方法和杂交瘤细胞系。

公开(公告)号：US20130271756A1

公开(公告)日：2013-10-17

申请号：US13824417

申请日：2011-09-16

申请人： Aldo Bojarski ,  Klaus Erler ,  Katrin Künzelmann ,  Andre Legner ,  Paul Smith ,  Tobby Strassberger

发明人： Aldo Bojarski ,  Klaus Erler ,  Katrin Künzelmann ,  Andre Legner ,  Paul Smith ,  Tobby Strassberger

IPC分类号： G01N21/27

CPC分类号： G01J3/2803 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/14 ,  G01N21/27 ,  G01N21/4133 ,  G01N2201/0221 ,  G01N2201/0627

摘要： The invention relates to sensors for monitoring a medium comprising at least one electromagnetic radiation source and a detector of electromagnetic radiation, the medium being located in the ray path between the electromagnetic radiation source and the detector. The sensors are characterized by their ease of production. To that end, the electromagnetic radiation source and detector are disposed in at least one housing. Furthermore, the housing comprises two flat wall regions which are arranged at a mutual angle and are transparent to the electromagnetic radiation, such that these wall regions and the medium located thereat form a prism which refracts the electromagnetic radiation. In addition, the detector is at least a one-dimensional sensor comprising photo diodes for the refracted electromagnetic radiation, a spectrum which varies when the medium varies being detectable.

摘要翻译： 本发明涉及用于监测包括至少一个电磁辐射源和电磁辐射检测器的介质的传感器，该介质位于电磁辐射源和检测器之间的射线路径中。 传感器的特点是易于生产。 为此，电磁辐射源和检测器设置在至少一个壳体中。 此外，壳体包括两个平面壁区域，它们以相互的角度布置并且对于电磁辐射是透明的，使得这些壁区域和位于其上的介质形成折射电磁辐射的棱镜。 另外，检测器是至少一个包含用于折射电磁辐射的光电二极管的一维传感器，当介质变化时可以检测到的光谱变化。

公开(公告)号：US4985204A

公开(公告)日：1991-01-15

申请号：US159253

申请日：1988-02-23

申请人： Sigmar Klose ,  Klaus Erler ,  Wolfgang Uhl ,  Manfred Baier

发明人： Sigmar Klose ,  Klaus Erler ,  Wolfgang Uhl ,  Manfred Baier

IPC分类号： B01L3/00 ,  G01N33/543

CPC分类号： B01L3/502 ,  G01N33/54366

摘要： The present invention provides a device for carrying out a heterogeneous reaction for the determination of a component of a sample liquid on a first capillary action carrier present in a measurement chamber, to which carrier adheres at least one non-soluble reagent, wherein at least one soluble reagent is present on a second capillary action carrier in a first pre-chamber, which carrier is in capillary contact with the capillary action carrier in the measurement chamber, which first pre-chamber is connected via a first capillary with a first application chamber to be filled from outside through a filling opening and the measurement chamber is also connected with a waste chamber by a capillary arrangement through which can only flow a liquid under a predetermined gravitational force into the measurement chamber.

摘要翻译： 本发明提供一种用于进行非均相反应的装置，用于确定存在于测量室中的第一毛细作用载体上的样品液体的组分，载体粘附至至少一种不溶性试剂，其中至少一种 可溶性试剂存在于第一预处理室中的第二毛细管作用载体上，该第一预处理室与测量室中的毛细管作用载体毛细接触，该第一预先室经由第一毛细管与第一施加室连接， 从外部通过填充开口填充，并且测量室还通过毛细管装置与废物室连接，通过该毛细管装置，只能将液体以预定重力流动到测量室中。

公开(公告)号：US4762783A

公开(公告)日：1988-08-09

申请号：US834316

申请日：1986-02-27

申请人： Christa Hubner-Parajsz ,  Hartmut Schetters ,  Helmut Lenz ,  Klaus Erler

发明人： Christa Hubner-Parajsz ,  Hartmut Schetters ,  Helmut Lenz ,  Klaus Erler

IPC分类号： G01N33/53 ,  C07K14/005 ,  C07K14/195 ,  C07K14/575 ,  C07K16/00 ,  C07K16/26 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577 ,  G01N33/532 ,  C12N15/00

CPC分类号： C07K16/26 ,  Y10S435/81 ,  Y10S435/948 ,  Y10S436/808 ,  Y10S436/815

摘要： The present invention provides an immunological process for the determination of the follicle-stimulating hormone (FSH), wherein there is used at least one monoclonal antibody which is directed specifically against FSH and cross-reacts with other glycoprotein hormones to an extent of less than 3%.The present invention also provides a reagent for the determination of the follicle-stimulating hormone, wherein it contains at least one monoclonal antibody which is directed against FSH and cross-reacts with other glycoprotein hormones to an extent of less than 3%.Furthermore, the present invention provides a monoclonal antibody against the follicle-stimulating hormone and a process and a hybridoma cell line for producing it.

摘要翻译： 本发明提供了用于确定促卵泡激素（FSH）的免疫学方法，其中使用至少一种单克隆抗体，其特异性针对FSH并与其他糖蛋白激素交叉反应至少于3 ％。 本发明还提供了一种用于确定促卵泡激素的试剂，其中它含有至少一种针对FSH的单克隆抗体并与其他糖蛋白激素交叉反应至少于3％的程度。 此外，本发明提供了针对促卵泡激素的单克隆抗体和用于制备它的方法和杂交瘤细胞系。