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    Antibacterial compositions with synergistic effect, drugs and remedies for digestive diseases containing the same, process for the production thereof and preparations associated therewith
    4.
    发明授权
    Antibacterial compositions with synergistic effect, drugs and remedies for digestive diseases containing the same, process for the production thereof and preparations associated therewith 失效
    具有协同效应的抗菌组合物，含有其的消化疾病的药物和补救剂，其生产方法和与其相关的制剂

    公开(公告)号：US06362169B1

    公开(公告)日：2002-03-26

    申请号：US09622712

    申请日：2000-08-22

    申请人： Kenji Fujii ,  Katsuji Yamashita ,  Kazunori Hosoe ,  Takayoshi Hidaka

    发明人： Kenji Fujii ,  Katsuji Yamashita ,  Kazunori Hosoe ,  Takayoshi Hidaka

    IPC分类号： A61K3170

    CPC分类号： A61K45/00 ,  A61K31/395 ,  A61K31/415 ,  A61K31/44 ,  A61K31/60 ,  A61K33/245 ,  A61K2300/00

    摘要： Antibacterial compositions comprising (1) a rifamycin derivative represented by the formula (I) or its physiologically acceptable salt, and (2) a proton pump inhibitor (a) or a bismuth preparation (b) wherein the components (1) and (2) are used in such amounts as producing a synergistic effect against Helicobacter pylori, drugs and remedies for digestive organ diseases which contain the antibacterial compositions, process for producing them, and pharmaceutical preparations related to the antibacterial compositions. The compositions can be administered to patients with digestive diseases caused by infection of Helicobacter pylori in a smaller dose and at a lower administration frequency as compared with conventional remedies.

    摘要翻译： 抗菌组合物，其包含（1）由式（I）表示的利福霉素衍生物或其生理学上可接受的盐，和（2）质子泵抑制剂（a）或铋制剂（b），其中组分（1）和（2） 用于产生对幽门螺杆菌的协同效应，含有抗菌组合物的消化器官疾病的药物和补救剂，其制备方法和与抗菌组合物相关的药物制剂。 与常规治疗相比，组合物可以以较小的剂量和较低的施用频率施用于由幽门螺杆菌感染引起的消化系统疾病的患者。

    Composition for transmucosal administration containing conenzyme Q as the active ingredient
    5.
    发明授权
    Composition for transmucosal administration containing conenzyme Q as the active ingredient 有权
    用于经粘膜给药的组合物，其含有辅酶Q作为活性成分

    公开(公告)号：US07754205B2

    公开(公告)日：2010-07-13

    申请号：US10476208

    申请日：2002-05-08

    申请人： Kenji Fujii ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

    发明人： Kenji Fujii ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

    IPC分类号： A61K38/43

    CPC分类号： A61K31/122 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0031 ,  A61K9/0048 ,  A61K9/02 ,  A61K31/047 ,  A61K31/09 ,  Y10S514/882 ,  A61K2300/00 ,  A23V2250/314

    摘要： The present invention relates to the supply of coenzyme Q which is highly useful in maintaining human health, and provides a method and preparations whereby coenzyme Q can be efficiently supplied to patients having difficulties in oral administration, aged having swallowing difficulties and patients with diseases caused by topical disorders. It is found that the coenzyme Q concentration in the blood or topical mucosae can be elevated by using a composition for transmucosal administration containing oxidized coenzyme Q and/or reduced coenzyme Q as the active ingredient, wherein the total content of the oxidized coenzyme Q and the reduced coenzyme Q amounts to 0.0001 to 99% by weight of the whole composition.

    摘要翻译： 本发明涉及能够维持人体健康的辅酶Q的供给，提供可以将辅酶Q有效地供给口服给药困难的患者，患有吞咽困难的老年患者以及由 局部疾病。 通过使用含有氧化型辅酶Q和/或还原型辅酶Q作为活性成分的经粘膜给药用组合物，可以提高血液或局部粘膜中的辅酶Q浓度，其中氧化型辅酶Q和 还原型辅酶Q占整个组合物的0.0001-99重量％。

    Fatigue reducing agent
    6.
    发明申请
    Fatigue reducing agent 有权

    公开(公告)号：US20060165672A1

    公开(公告)日：2006-07-27

    申请号：US10541020

    申请日：2004-01-19

    申请人： Kenji Fujii ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

    发明人： Kenji Fujii ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

    IPC分类号： A61K38/43 ,  A01N31/14

    CPC分类号： A61K31/09 ,  A61K31/122

    摘要： To maintain physical fitness and health of middle-aged and older persons living in the threshold of the aging society, the present invention provides a fatigue reducing agent which is highly effective for preventing and reducing fatigue, wherein the agent is made of a composition of substances that are very safe so that long-term administration is possible. A composition containing reduced coenzyme Q was found to be effective for preventing and reducing fatigue, including muscle fatigue. Since the fatigue reducing effect of the composition of the present invention is seen not only in young rats but also more pronounced in aged rats, the present invention can provide the fatigue reducing agent which is very useful, especially, for middle-aged and older persons as well as for young people.

    Compositions for lessening oxidative stress
    7.
    发明授权
    Compositions for lessening oxidative stress 有权
    用于减轻氧化应激的组合物

    公开(公告)号：US07015252B2

    公开(公告)日：2006-03-21

    申请号：US10492164

    申请日：2002-10-15

    申请人： Kenji Fujii ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

    发明人： Kenji Fujii ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

    IPC分类号： A61K31/12

    CPC分类号： A61K31/085 ,  A61K31/122

    摘要： The present invention provides an antioxidative composition with high safety, which is capable of lessening oxidative stress due to active oxygen species, free radicals, or the like in vivo, thereby preventing the occurrence or worsening of a disease. It was confirmed that by using a composition containing oxidized coenzyme Q and/or reduced coenzyme Q, the amount of urinary 8-hydroxydeoxyquanosine can be decreased in normal or diabetic animals. Also, in histopathological research of the spleens of diabetic rats, it was confirmed that spleen tissue denaturation caused by oxidative stress can be prevented. It was thus found that oxidative stress in vivo can be lessened. According to the present invention, oxidative stress in vivo can be lessened by using a composition containing coenzyme Q as an active ingredient.

    摘要翻译： 本发明提供了具有高安全性的抗氧化组合物，其能够在体内减少由活性氧，自由基等引起的氧化应激，从而防止疾病的发生或恶化。 确认通过使用含有氧化型辅酶Q和/或还原型辅酶Q的组合物，在正常或糖尿病动物中尿8-羟基脱氧奎诺糖的量可以降低。 此外，在糖尿病大鼠脾脏的组织病理学研究中，证实可以预防由氧化应激引起的脾脏组织变性。 因此发现体内的氧化应激可以减轻。 根据本发明，通过使用含有辅酶Q作为有效成分的组合物，可以减轻体内的氧化应激。

    Dermal compositions containing coenzyme q as the active ingredient
    8.
    发明申请
    Dermal compositions containing coenzyme q as the active ingredient 审中-公开
    含有辅酶q作为活性成分的皮肤组合物

    公开(公告)号：US20050070610A1

    公开(公告)日：2005-03-31

    申请号：US10275882

    申请日：2001-05-09

    申请人： Kenji Fujii ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

    发明人： Kenji Fujii ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

    IPC分类号： A61K8/34 ,  A61K8/35 ,  A61K8/86 ,  A61K9/00 ,  A61K9/06 ,  A61K9/107 ,  A61K31/05 ,  A61K31/075 ,  A61K31/12 ,  A61K31/122 ,  A61K47/10 ,  A61L15/44 ,  A61P17/00 ,  A61P17/02 ,  A61P17/04 ,  A61P17/06 ,  A61P17/08 ,  A61P37/08 ,  A61Q19/00 ,  A61Q19/10

    CPC分类号： A61Q19/00 ,  A61K8/347 ,  A61K8/355 ,  A61K8/86 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/05 ,  A61K31/122 ,  A61K47/10 ,  A61K2800/70 ,  A61L15/44 ,  A61L2300/216 ,  A61Q19/10

    摘要： The present invention provides a composition for dermal application which comprises, as an active ingredient, an oxidized coenzyme Q represented by the formula (1): in which n represents an integer of 1 to 12, and/or a reduced coenzyme Q represented by the formula (2): in which n represents an integer of 1 to 12, the total content of the oxidized coenzyme Q and reduced coenzyme Q being 0.01 to 99% by weight relative to the whole amount of the composition. The present invention also provides a therapeutic composition for skin diseases, a cosmetic composition, a skin health care composition and a bath salt composition, each comprising the above composition for dermal application. The present invention is further provides a method for the treatment of skin diseases which comprises applying, to a patient suffering from a skin disease, the above-mentioned therapeutic composition for skin diseases, or a method for the treatment of skin diseases which comprises applying, to a patient suffering from a skin disease, the above therapeutic agent for skin diseases other than the oxidized coenzyme Q represented by the formula (1) and other than the reduced coenzyme Q represented by the formula (2) in parallel with a therapeutic composition for skin diseases.

    摘要翻译： 本发明提供了一种用于真皮应用的组合物，其包含作为活性成分的由式（1）表示的氧化型辅酶Q：其中n表示1〜12的整数，和/或由下式表示的还原型辅酶Q 式（2）：其中n表示1〜12的整数，相对于组合物的总量，氧化型辅酶Q和还原型辅酶Q的总含量为0.01〜99重量％。 本发明还提供了一种皮肤病的治疗组合物，化妆品组合物，皮肤保健组合物和浴盐组合物，每种组合物包含上述用于真皮应用的组合物。 本发明还提供了一种治疗皮肤病的方法，其包括向患有皮肤病的患者应用上述皮肤病治疗组合物或皮肤病治疗方法， 对于患有皮肤病的患者，除了由式（1）表示的氧化型辅酶Q以外，除了式（2）所示的还原型辅酶Q以外，还可以使用与上述治疗组合物平行的上述皮肤病治疗剂， 皮肤病。

    Hydroxystyrene compounds having tyrosine kinase inhibiting activity
    10.
    发明授权
    Hydroxystyrene compounds having tyrosine kinase inhibiting activity 失效
    具有酪氨酸激酶抑制活性的羟基苯乙烯化合物

    公开(公告)号：US5202341A

    公开(公告)日：1993-04-13

    申请号：US735581

    申请日：1991-07-25

    申请人： Tadayoshi Shiraishi ,  Keiji Kameyama ,  Takeshi Domoto ,  Naohiro Imai ,  Yoshio Shimada ,  Yutaka Ariki ,  Kazunori Hosoe ,  Masaji Kawatsu ,  Ikuo Katsumi ,  Takayoshi Hidaka ,  Kiyoshi Watanabe

    发明人： Tadayoshi Shiraishi ,  Keiji Kameyama ,  Takeshi Domoto ,  Naohiro Imai ,  Yoshio Shimada ,  Yutaka Ariki ,  Kazunori Hosoe ,  Masaji Kawatsu ,  Ikuo Katsumi ,  Takayoshi Hidaka ,  Kiyoshi Watanabe

    IPC分类号： A61K31/26 ,  C07C255/34 ,  C07D207/38 ,  C07D209/34 ,  C07D231/36 ,  C07D277/20 ,  C07D277/36 ,  C07D277/54 ,  C07D279/16 ,  C07D307/58 ,  C07D417/12

    CPC分类号： C07D277/20 ,  C07C255/00 ,  C07C255/34 ,  C07D207/38 ,  C07D209/34 ,  C07D231/36 ,  C07D277/36 ,  C07D277/54 ,  C07D279/16 ,  C07D307/58 ,  C07D417/12

    摘要： A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O- (R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sup.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O-- (R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 -- (Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.4 are taken together to represent ##STR4## (n.sup.1, R.sup.6 : as defined above), or a salt thereof. The hydroxystyrene derivative or a salt thereof is a compound which is useful as an active ingredient of an antiallergic agent, a 5-lipoxygenase inhibiting agent, an antibacterial agent, a tyrosine kinase inhibiting agent, an ultraviolet absorber or a reverse transcriptase inhibiting agent, and also is useful as an intermediate for preparing various organic compounds.

    摘要翻译： 由式（I）表示的羟基苯乙烯衍生物：其中当R1和R2：苯基，苄基或苯乙基或R1：R5O-（R5：H，C1-C5烷基或苄基 基团）和R 2：苄基或PhSCH 2，R 3和R 4一起表示-CONH-CS-S-，或（X1：H，卤素，甲基，乙基，R7O-（ R7：甲基或乙基），硝基，氨基磺酰基或氨基，m1：1或2），吡啶基，呋喃基或噻吩基，n1：0〜3的整数）。 当R1和R2：苯基，苄基或苯乙基或R1：R5O-（R5：如上定义）和R2：苄基，R3：氰基和R4：氨基甲酰基，或R3和R4合在一起 表示-CO-Y-CH 2 CH 2 - （Y：O或-NH-）或，并且当R 1和R 2为C 1至C 3烷基时，R 3和R 4一起表示（n1，R6 ：如上所定义），或其盐。 羟基苯乙烯衍生物或其盐是可用作抗变应性剂的活性成分，5-脂氧合酶抑制剂，抗菌剂，酪氨酸激酶抑制剂，紫外线吸收剂或逆转录酶抑制剂的化合物，以及 也可用作制备各种有机化合物的中间体。