公开(公告)号：US5211829A

公开(公告)日：1993-05-18

申请号：US664604

申请日：1991-03-04

申请人： Kazumichi Imai ,  Masataka Koga ,  Takehiko Kitamori ,  Tsuguo Sawada ,  Jiaqi Wu

发明人： Kazumichi Imai ,  Masataka Koga ,  Takehiko Kitamori ,  Tsuguo Sawada ,  Jiaqi Wu

IPC分类号： G01N25/00 ,  G01N21/00 ,  G01N27/447 ,  G01N29/00 ,  G01N30/62 ,  G01N30/74 ,  G01N30/76 ,  G01N35/08

CPC分类号： G01N30/76 ,  G01N27/44717

摘要： The present invention is applied to an analyzer according to which a sample to be analyzed is moved through a capillary tube in liquid chromatography or capillary-zone electrophoretic method. The capillary tube has a separation zone and a detection zone. The capillary tube in the detection zone has a section in which it can vibrate and both ends of this section are fixed.Analytes of the sample introduced into the analyzer are separated from each other in the separation zone. When each of the separated analytes is led to the area irradiated with beam in the detection zone, the capillary tube in the detection zone vibrates. This vibration phenomenon is brought about by tension fluctuation of the capillary tube caused by intermittent irradiation of the detection zone with an excitation beam and absorption of the excitation beam by the analyte. Concentration of analytes in the sample can be measured by detecting amplitude of the vibration.

摘要翻译： 本发明应用于分析器，通过液相色谱法或毛细管区电泳方法将待分析样品移动通过毛细管。 毛细管具有分离区和检测区。 检测区域中的毛细管具有能够振动的部分，并且该部分的两端固定。 在分离区中引入分析仪的样品的分析物彼此分离。 当每个分离的分析物被引导到在检测区域中用光束照射的区域时，检测区域中的毛细管管振动。 这种振动现象是由于由激发束间歇地照射检测区域而引起的毛细管的张力波动和被分析物吸收激发光束引起的。 可以通过检测振动的幅度来测量样品中分析物的浓度。

公开(公告)号：US5136172A

公开(公告)日：1992-08-04

申请号：US567319

申请日：1990-08-14

申请人： Toshihiko Nakata ,  Yukio Kembo ,  Tsuguo Sawada ,  Takehiko Kitamori

发明人： Toshihiko Nakata ,  Yukio Kembo ,  Tsuguo Sawada ,  Takehiko Kitamori

IPC分类号： G01N21/17 ,  G01N21/88

CPC分类号： G01N21/88 ,  G01N21/1702 ,  G01N2021/1765

摘要： A method and apparatus are disclosed for detection of surface defects and internal defect information of a sample, such as a semiconductor device, using the photoacoustic effect. Operationally, an intensity-modulated laser beam is provided having a predetermined desired frequency. The intensity-modulated laser beam is focused on the sample thereby inducing said photoacoustic effect inside the sample which is detected in two-dimensional directions of the sample so as to compose a two-dimensional photoacoustic image of the excited sample. Surface and internal information of the sample is then extracted from the two-dimensional photoacoustic image and an inverse filtering factor is in turn computed on the basis of a thermal impulse response of the particular sample for compensating degradation of the resolution of the actual photoacoustic image obtained. Lastly, the computed inverse filtering factor is then applied to the detected photoacoustic image to arrive at an image having greatly improved resolution.

公开(公告)号：US4722602A

公开(公告)日：1988-02-02

申请号：US894665

申请日：1986-08-01

申请人： Takehiko Kitamori ,  Kazumichi Suzuki ,  Tsuguo Sawada

发明人： Takehiko Kitamori ,  Kazumichi Suzuki ,  Tsuguo Sawada

IPC分类号： G01N21/00 ,  G01N15/10 ,  G01N29/00 ,  G01N29/032 ,  G01N21/01

CPC分类号： G01N29/4454 ,  G01N15/10 ,  G01N29/032 ,  G01N21/1702 ,  G01N2291/02408 ,  G01N2291/02416 ,  G01N2291/02854

摘要： A medium including particles to be analyzed is contained in a cell through which excitation rays are passed. The excitation rays are focused and have a predetermined wave form. A period in time of the excitation rays is set substantially equal to and preferably longer than the attenuation time of an acoustic pulse which is generated when the excitation rays are absorbed in the particle and when the particle release heat. The acoustic pulse is used to analyze particle size and number of particles.

摘要翻译： 包含要分析的颗粒的介质被包含在通过激发光线的单元中。 激发光线被聚焦并具有预定的波形。 激发光线的时间段被设定为基本上等于并且优选地长于当激发光线在粒子中被吸收时以及当粒子释放热时产生的声脉冲的衰减时间。 声脉冲用于分析颗粒大小和颗粒数。

公开(公告)号：US4557137A

公开(公告)日：1985-12-10

申请号：US530061

申请日：1983-09-07

申请人： Takehiko Kitamori ,  Masaaki Fujii ,  Tsuguo Sawada

发明人： Takehiko Kitamori ,  Masaaki Fujii ,  Tsuguo Sawada

IPC分类号： G01N21/00 ,  G01N21/17 ,  G01N29/00

CPC分类号： G01N21/1702

摘要： A photoacoustic analyzer comprises an analyzing cell having a beam entrance window and including a cylindrical piezoelectric transducer element forming at least a part of the wall thereof, and a laser beam emitter emitting a laser beam directed toward and into the analyzing cell through the beam entrance window. In the photoacoustic analyzer, the ratio r/r.sub.o between the radius r of the inner side of the analyzing cell and the radius r.sub.o of the incident laser beam is selected to lie within the range of 1.ltoreq.r/r.sub.o .ltoreq.8.

摘要翻译： 光声分析仪包括具有光束入口窗口的分析单元，并且包括形成其壁的至少一部分的圆柱形压电换能器元件和激光束发射器，其通过光束入口窗口发射朝向分析单元的激光束 。 在光声分析仪中，选择分析单元的内侧的半径r与入射激光束的半径r之间的比r / ro在1 / r /ro≤8的范围内 。

公开(公告)号：US06184517B2

公开(公告)日：2001-02-06

申请号：US09061848

申请日：1998-04-18

申请人： Tsuguo Sawada ,  Takehiko Kitamori ,  Toshitsugu Ueda ,  Seiichi Naitou ,  Hisao Takahara ,  Yukihiko Takamatsu

发明人： Tsuguo Sawada ,  Takehiko Kitamori ,  Toshitsugu Ueda ,  Seiichi Naitou ,  Hisao Takahara ,  Yukihiko Takamatsu

IPC分类号： G01V800

CPC分类号： G01N15/0205 ,  G01N21/71

摘要： A particle analyzer system that reduces size and cost, wherein particles are introduced into a cell, then the particles are irradiate in the cell with a laser beam, then atomic emission of the particles generated by the irradiation of the laser beam is transmitted, then a spectrum is obtained of the photo emission so transmitted, and the spectrum of the photo emission is detected and the wavelength of the laser beam is, other than the wavelength of the emission of the particles, is used to provide a filter to block the intrusion of the wavelength of the laser beam in a stage proceeding the photo emission.

摘要翻译： 一种降低尺寸和成本的颗粒分析仪系统，其中将颗粒引入电池中，然后使用激光束将颗粒照射在电池中，然后传输由激光束照射产生的颗粒的原子发射，然后将 获得如此透射的光发射的光谱，并且检测光发射的光谱，并且除了颗粒的发射波长之外，激光束的波长被用于提供滤光器以阻止 在进行光发射的阶段中的激光束的波长。

公开(公告)号：US5122752A

公开(公告)日：1992-06-16

申请号：US575422

申请日：1990-08-30

申请人： Masataka Koga ,  Tsuyoshi Nishitarumizu ,  Tetsuya Matsui ,  Kenji Yokose ,  Masaharu Sakagami ,  Takehiko Kitamori

发明人： Masataka Koga ,  Tsuyoshi Nishitarumizu ,  Tetsuya Matsui ,  Kenji Yokose ,  Masaharu Sakagami ,  Takehiko Kitamori

IPC分类号： G01N21/62 ,  G01N15/06 ,  G01N15/10 ,  G01N27/02 ,  G01N27/62 ,  G01N27/64 ,  G01N33/18

CPC分类号： G01N15/0656 ,  G01N27/628 ,  G01N33/18

摘要： A method of and an apparatus for analyzing a granular material contained in a sample of a medium such as water produced by an ultra-pure water producing apparatus includes the steps of adding energy to granular materials contained in a sample which is mixed with the medium, wherein the energy is set to be lower than the breakdown threshold of the medium and to be higher than the breakdown threshold of the granular materials, detecting ions which are generated with the breakdown of the granular materials by using a pair of positive and negative electrodes; and analyzing characteristics of the granular materials based on the ions.

摘要翻译： 一种用于分析由超纯水生产设备产生的诸如水的介质样品中所含的颗粒状物质的方法和装置，包括以下步骤：向包含在与介质混合的样品中的颗粒材料加入能量， 其中所述能量被设定为低于所述介质的击穿阈值并且高于所述粒状材料的击穿阈值，检测通过使用一对正极和负极的所述粒状材料的击穿而产生的离子; 并基于离子分析粒状材料的特性。

公开(公告)号：US5164592A

公开(公告)日：1992-11-17

申请号：US581908

申请日：1990-09-13

申请人： Takehiko Kitamori ,  Masataka Koga ,  Tsuyoshi Nishitarumizu ,  Tetsuya Matsui ,  Kenji Yokose ,  Masaharu Sakagami

发明人： Takehiko Kitamori ,  Masataka Koga ,  Tsuyoshi Nishitarumizu ,  Tetsuya Matsui ,  Kenji Yokose ,  Masaharu Sakagami

IPC分类号： G01N27/62 ,  H01J49/04 ,  H01J49/10 ,  H01J49/16 ,  H01J49/26

CPC分类号： H01J49/164

摘要： The power density of a pulsed laser beam for irradiating a sample is adjusted to break down the sample into the form of a plasma. After the momentary breakdown of the sample into the form of a plasma, ions are generated having a high charge. Then, after a certain time elapses, the ions having a high charge recombine with the electrons in the plasma to provide monovalent or low valent ions. These low valent ions are taken out of the plasma and introduced to a mass spectrometric apparatus.

公开(公告)号：US20100247429A1

公开(公告)日：2010-09-30

申请号：US12734384

申请日：2008-10-30

申请人： Katsuhiko Ohsaki ,  Shigeki Yamazaki ,  Takehiko Kitamori ,  Masaharu Ueno ,  Kazuma Mawatari ,  Yoshikuni Kikutani

发明人： Katsuhiko Ohsaki ,  Shigeki Yamazaki ,  Takehiko Kitamori ,  Masaharu Ueno ,  Kazuma Mawatari ,  Yoshikuni Kikutani

IPC分类号： A61K51/00 ,  B01D3/00 ,  B01D1/00

CPC分类号： B01D1/0082 ,  B01D1/14 ,  B01D1/221 ,  B01J19/0093 ,  B01J2219/00837 ,  B01J2219/00873 ,  B01L3/5027 ,  B01L2200/0678 ,  B01L2300/161 ,  B01L2400/04 ,  B01L2400/0406 ,  B01L2400/0466

摘要： Provided is a microchip capable of integrating liquid evaporation as an operation on the microchip. In the microchip 10 having a gas flow path 13 inside, liquid is dispersed by capillary action and pooled in a pool portion 12 at a bottom of the gas flow path 13, and at least a part of the liquid pooled in the pool portion 12 is evaporated. As the capillary action is used, the liquid can be dispersed and pooled in the pool portion 12 at the bottom of the gas flow path 13 inside the microchip 10. Besides, the liquid pooled in the pool portion 12 remains in the pool portion by a surface tension even if gas is made to flow in the gas flow path 13 or the gas flow path is evacuated for evaporation. This enables highly efficient evaporation inside the microchip 10.

摘要翻译： 提供了能够将液体蒸发作为微芯片上的操作来集成的微芯片。 在内部具有气体流路13的微芯片10中，通过毛细管作用使液体分散，并且汇集在气体流路13的底部的池部12中，并且在池部12中收集的液体的至少一部分为 蒸发 当使用毛细管作用时，液体可以分散和汇集在微芯片10内的气体流动通道13底部的池部分12中。此外，汇集在池部分12中的液体通过一个 即使使气体在气体流路13中流动或者气体流路被抽真空以进行蒸发，表面张力也是如此。 这使得能够在微芯片10内部进行高效蒸发。

公开(公告)号：US20090035793A1

公开(公告)日：2009-02-05

申请号：US11988731

申请日：2006-08-31

申请人： Taito Nishino ,  Masaki Kitahara ,  Manabu Tokeshi ,  Takehiko Kitamori

发明人： Taito Nishino ,  Masaki Kitahara ,  Manabu Tokeshi ,  Takehiko Kitamori

IPC分类号： G01N33/53 ,  C12M1/00 ,  C12Q1/02

CPC分类号： B01L3/502761 ,  B01L3/5025 ,  B01L2200/0668 ,  B01L2300/0825 ,  B01L2400/0487 ,  C12M23/34

摘要： In a microchip which enables cell cultivation and accurate cell count measurement, fine particles affixed with cells are trapped within a passage by making the minimum width of a solution and fine particle inlet into a cell culture portion larger than the maximum diameter of the fine particles, and making the width of an outlet smaller than the maximum diameter of the fine particles.

摘要翻译： 在能够进行细胞培养和精确细胞计数测定的微芯片中，通过使溶液和细颗粒入口的最小宽度进入细胞培养部分的最小宽度大于微粒的最大直径，将细胞附着的细小颗粒捕获在通道内， 并使出口的宽度小于微粒的最大直径。

公开(公告)号：US07079315B2

公开(公告)日：2006-07-18

申请号：US11118320

申请日：2005-05-02

申请人： Takehiko Kitamori ,  Akihide Hibara ,  Manabu Tokeshi

发明人： Takehiko Kitamori ,  Akihide Hibara ,  Manabu Tokeshi

IPC分类号： G02B21/00

CPC分类号： G02B21/0008 ,  G02B6/13 ,  G02B21/02 ,  G02B2006/12102

摘要： A small and portable microscope for ultramicroanalysis has an excellent spatial resolution and fixed position analyzing ability. The microscope has at least a part of an excitation light source, a part of a probe light source and a part of a thermal lens microscope optical system arranged integrally in a device body. The device body also includes an analyzing cell and substrates supporting the analyzing cell.

摘要翻译： 用于超微量分析的小型便携式显微镜具有优异的空间分辨率和固定位置分析能力。 显微镜具有至少一部分激发光源，探针光源的一部分和一体地设置在器件主体中的热透镜显微镜光学系统的一部分。 该装置主体还包括分析单元和支撑分析单元的基板。