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17 条记录 (耗时 0.024 秒)

    Nanopore and carbon nanotube based DNA sequencer and a serial recognition sequencer
    1.
    发明授权
    Nanopore and carbon nanotube based DNA sequencer and a serial recognition sequencer 有权
    纳米孔和基于碳纳米管的DNA测序仪和序列识别测序仪

    公开(公告)号：US08628649B2

    公开(公告)日：2014-01-14

    申请号：US12920809

    申请日：2009-03-18

    申请人： Stuart Lindsay ,  Jin He ,  Peiming Zhang ,  Kevin Reinhart

    发明人： Stuart Lindsay ,  Jin He ,  Peiming Zhang ,  Kevin Reinhart

    IPC分类号： G01N27/327

    CPC分类号： C12Q1/6869 ,  B82Y15/00 ,  G01N33/48721 ,  C12Q2565/631

    摘要： The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.

    摘要翻译： 本发明涉及用于识别生物聚合物的系统，装置和方法，例如当DNA通过诸如碳纳米管纳米孔的收缩体时，DNA的链。 更具体地，本发明涉及这样的系统，装置和方法，其中生物聚合物的新易位部分在纳米管纳米孔和也可以是纳米管的第二电极之间形成临时电路。 此外，本发明涉及这样的系统，装置和方法，其中收缩部设置有功能化单元，其与生物聚合物的新易位部分一起形成临时电路，其可用于表征该部分的 生物聚合物。

    Nanopore and Carbon Nanotube Based DNA Sequencer
    2.
    发明申请
    Nanopore and Carbon Nanotube Based DNA Sequencer 有权
    纳米孔和碳纳米管的DNA测序仪

    公开(公告)号：US20110168562A1

    公开(公告)日：2011-07-14

    申请号：US12920817

    申请日：2009-03-18

    申请人： Colin Nuckolls ,  Jinyao Tang ,  Stuart Lindsay ,  Jin He ,  Peiming Zhang ,  Kevin Reinhart

    发明人： Colin Nuckolls ,  Jinyao Tang ,  Stuart Lindsay ,  Jin He ,  Peiming Zhang ,  Kevin Reinhart

    IPC分类号： G01N27/00 ,  B32B37/24 ,  C23F1/00 ,  B82Y99/00

    CPC分类号： G01N33/48721 ,  C12Q1/6869 ,  C12Q2565/631

    摘要： The present invention provides a device for analyzing the composition of a heteropolymer comprising a carbon nanotube through which the heteropolymer is driven by electrophoresis. The carbon nanotube also serves as one electrode in a reading circuit. One end of the carbon nanotube is held in close proximity to a second electrode, and each end of the carbon nanotube is functionalized with flexibly-tethered chemical-recognition moieties, such that one will bind one site on the emerging polymer, and the second will bind another site in close proximity, generating an electrical signal between the two electrodes when the circuit is completed by the process of chemical recognition.

    摘要翻译： 本发明提供一种用于分析包含碳纳米管的杂聚物的组成的装置，通过该电极驱动该杂聚物。 碳纳米管也用作读取电路中的一个电极。 碳纳米管的一端保持靠近第二电极，并且碳纳米管的每一端用柔性系带的化学识别部分功能化，使得将结合新出现的聚合物上的一个位点，而第二个 在另一个位置紧密接合，当通过化学识别过程完成电路时，在两个电极之间产生电信号。

    Nanopore and Carbon Nanotube Based DNA Sequencer and a Serial Recognition Sequencer
    3.
    发明申请
    Nanopore and Carbon Nanotube Based DNA Sequencer and a Serial Recognition Sequencer 有权
    基于纳米孔和碳纳米管的DNA测序仪和串行识别测序仪

    公开(公告)号：US20110120868A1

    公开(公告)日：2011-05-26

    申请号：US12920809

    申请日：2009-03-18

    申请人： Stuart Lindsay ,  Jin He ,  Peiming Zhang ,  Kevin Reinhart

    发明人： Stuart Lindsay ,  Jin He ,  Peiming Zhang ,  Kevin Reinhart

    IPC分类号： G01N27/447 ,  H05K3/06 ,  H05K3/02 ,  B82Y99/00

    CPC分类号： C12Q1/6869 ,  B82Y15/00 ,  G01N33/48721 ,  C12Q2565/631

    摘要： The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.

    摘要翻译： 本发明涉及用于识别生物聚合物的系统，装置和方法，例如当DNA通过诸如碳纳米管纳米孔的收缩体时，DNA的链。 更具体地，本发明涉及这样的系统，装置和方法，其中生物聚合物的新易位部分在纳米管纳米孔和也可以是纳米管的第二电极之间形成临时电路。 此外，本发明涉及这样的系统，装置和方法，其中收缩部设置有功能化单元，其与生物聚合物的新易位部分一起形成临时电路，其可用于表征该部分的 生物聚合物。

    Trans-base tunnel reader for sequencing
    4.
    发明授权
    Trans-base tunnel reader for sequencing 有权
    用于排序的Trans-base隧道读取器

    公开(公告)号：US08968540B2

    公开(公告)日：2015-03-03

    申请号：US13122104

    申请日：2009-10-06

    申请人： Kevin Reinhart ,  Stuart Lindsay ,  Peiming Zhang

    发明人： Kevin Reinhart ,  Stuart Lindsay ,  Peiming Zhang

    IPC分类号： G01N27/447 ,  G01N27/453 ,  G01N27/327 ,  C12Q1/68 ,  G01N33/487

    CPC分类号： C07D235/24 ,  C12Q1/6869 ,  G01N27/447 ,  G01N27/44791 ,  G01N33/48721 ,  C12Q2565/631

    摘要： A device for reading the sequence of a polymer, consisting of a first electrode and a second electrode, each electrode being functionalized with a reader molecule strongly bonded to the electrodes, but forming weak bonds with a molecule to be sequenced. In particular, the reader molecule is designed to form bonds with at least two points on the target molecule such that the target molecule is trapped between a first reader molecule on one electrode and a second reader molecule on the second electrode, with the overall size of the molecular complex being small enough to permit significant electric current to flow.

    摘要翻译： 一种用于读取由第一电极和第二电极组成的聚合物序列的装置，每个电极用强度键合到电极的读取器分子进行功能化，但与待测序的分子形成弱键。 特别地，阅读器分子被设计成与靶分子上的至少两个点形成键，使得靶分子被捕获在一个电极上的第一阅读器分子和第二电极上的第二读取器分子之间，其总体尺寸 分子复合物足够小以允许显着的电流流动。

    Nanopore and carbon nanotube based DNA sequencer
    5.
    发明授权
    Nanopore and carbon nanotube based DNA sequencer 有权
    纳米孔和基于碳纳米管的DNA测序仪

    公开(公告)号：US08961757B2

    公开(公告)日：2015-02-24

    申请号：US12920817

    申请日：2009-03-18

    申请人： Colin Nuckolls ,  Jinyao Tang ,  Stuart Lindsay ,  Jin He ,  Peiming Zhang ,  Kevin Reinhart

    发明人： Colin Nuckolls ,  Jinyao Tang ,  Stuart Lindsay ,  Jin He ,  Peiming Zhang ,  Kevin Reinhart

    IPC分类号： G01N27/327 ,  C12Q1/68 ,  G01N33/487

    CPC分类号： G01N33/48721 ,  C12Q1/6869 ,  C12Q2565/631

    摘要： The present invention provides a device for analyzing the composition of a heteropolymer comprising a carbon nanotube through which the heteropolymer is driven by electrophoresis. The carbon nanotube also serves as one electrode in a reading circuit. One end of the carbon nanotube is held in close proximity to a second electrode, and each end of the carbon nanotube is functionalized with flexibly-tethered chemical-recognition moieties, such that one will bind one site on the emerging polymer, and the second will bind another site in close proximity, generating an electrical signal between the two electrodes when the circuit is completed by the process of chemical recognition.

    摘要翻译： 本发明提供一种用于分析包含碳纳米管的杂聚物的组成的装置，通过该电极驱动该杂聚物。 碳纳米管也用作读取电路中的一个电极。 碳纳米管的一端保持靠近第二电极，并且碳纳米管的每一端用柔性系带的化学识别部分功能化，使得将结合新出现的聚合物上的一个位点，而第二个 在另一个位置紧密接合，当通过化学识别过程完成电路时，在两个电极之间产生电信号。

    Nanopore and Carbon Nanotube Based Dna Sequencer and A Serial Recognition Elements
    6.
    发明申请
    Nanopore and Carbon Nanotube Based Dna Sequencer and A Serial Recognition Elements 有权
    纳米孔和基于碳纳米管的Dna测序仪和串行识别元件

    公开(公告)号：US20130186757A1

    公开(公告)日：2013-07-25

    申请号：US13122104

    申请日：2009-10-06

    申请人： Kevin Reinhart ,  Stuart Lindsay ,  Peiming Zhang

    发明人： Kevin Reinhart ,  Stuart Lindsay ,  Peiming Zhang

    IPC分类号： G01N27/447

    CPC分类号： C07D235/24 ,  C12Q1/6869 ,  G01N27/447 ,  G01N27/44791 ,  G01N33/48721 ,  C12Q2565/631

    摘要： The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.

    摘要翻译： 本发明涉及用于识别生物聚合物的系统，装置和方法，例如当DNA通过诸如碳纳米管纳米孔的收缩体时，DNA的链。 更具体地，本发明涉及这样的系统，装置和方法，其中生物聚合物的新易位部分在纳米管纳米孔和也可以是纳米管的第二电极之间形成临时电路。 此外，本发明涉及这样的系统，装置和方法，其中收缩部设置有功能化单元，其与生物聚合物的新易位部分一起形成临时电路，其可用于表征该部分的 生物聚合物。

    CONTROLLED TUNNEL GAP DEVICE FOR SEQUENCING POLYMERS
    8.
    发明申请
    CONTROLLED TUNNEL GAP DEVICE FOR SEQUENCING POLYMERS 有权
    用于测序聚合物的控制隧道缝隙装置

    公开(公告)号：US20120288948A1

    公开(公告)日：2012-11-15

    申请号：US13395956

    申请日：2011-01-31

    申请人： Stuart Lindsay ,  Shuai Chang ,  Jin He ,  Peiming Zhang ,  Shuo Huang

    发明人： Stuart Lindsay ,  Shuai Chang ,  Jin He ,  Peiming Zhang ,  Shuo Huang

    IPC分类号： G01N27/00 ,  C25B7/00 ,  B82Y5/00

    CPC分类号： G01N33/48721 ,  C12Q1/6869 ,  G01N27/3275 ,  Y10T436/143333

    摘要： The invention includes compositions, devices, and methods for analyzing a polymer and/or polymer unit. The polymer may be a homo- or hetero-polymer such as DNA, RNA, a polysaccharide, or a peptide. The device includes electrodes that form a tunnel gap through which the polymer can pass. The electrodes are functionalized with a reagent attached thereto, and the reagent is capable of forming a transient bond to a polymer unit. When the transient bond forms between the reagent and the unit, a detectable signal is generated and used to analyze the polymer.

    摘要翻译： 本发明包括用于分析聚合物和/或聚合物单元的组合物，装置和方法。 聚合物可以是均聚物或异质聚合物，例如DNA，RNA，多糖或肽。 该装置包括形成隧道间隙的电极，聚合物可通过该间隙通过。 电极用附着于其上的试剂进行功能化，并且试剂能够形成与聚合物单元的暂时结合。 当试剂和单元之间形成瞬态键时，产生可检测的信号并用于分析聚合物。