APTAMER PROBE FOR LOCATING MOLECULES AND METHOD OF USE
    4.
    发明申请
    APTAMER PROBE FOR LOCATING MOLECULES AND METHOD OF USE 审中-公开
    用于定位分子的APTAMER探针和使用方法

    公开(公告)号:US20080223121A1

    公开(公告)日:2008-09-18

    申请号:US11948960

    申请日:2007-11-30

    IPC分类号: G01B5/28

    CPC分类号: G01Q60/42

    摘要: An atomic force microscope and a method for detecting interactions between a probe and at least one sensed agent on a scanned surface is provided. The microscope has a scanning probe with a tip that is sensitive to a property of said scanned surface; a nucleic acid aptamer tethered to the tip of the probe; and a device for simultaneously recording the displacement of said probe tip as a function of time, topographic images, and the spatial location of interactions between said probe and the at least one sensed agent on said surface.

    摘要翻译: 提供了一种原子力显微镜和用于检测探针与被扫描表面上的至少一个检测到的试剂之间的相互作用的方法。 显微镜具有扫描探针,其具有对所述扫描表面的特性敏感的尖端; 连接到探针末端的核酸适配子; 以及用于根据时间,地形图像以及所述探针和所述表面上的所述至少一个感测到的感测剂之间的相互作用的空间位置同时记录所述探针尖端的位移的装置。

    FACET-BASED FILTERING OF SOCIAL NETWORK UPDATE DATA
    7.
    发明申请
    FACET-BASED FILTERING OF SOCIAL NETWORK UPDATE DATA 有权
    基于FACET的社会网络更新数据的过滤

    公开(公告)号:US20120072432A1

    公开(公告)日:2012-03-22

    申请号:US13237844

    申请日:2011-09-20

    IPC分类号: G06F17/30 G06F15/16

    摘要: A network update interface is presented to a user on a network to display network updates from other users of a mutual social-networking site. The network updates shared by the other users are gathered in a stream and supplied to a facet-filtering system including a network update interface. The user controls the display of certain network update items according to facet-filter characteristics enabled in facet-filter selection panels in the network update interface. The facet-filter characteristics are used by a facet filter to select certain network updates for display to the user in the network update interface. Trending links to further articles with content corresponding to the facet-filter characteristics are displayed to the user according to greatest popularity among the other users. Links to the profiles of the users sharing the articles are also provided in the network update interface.

    摘要翻译: 向网络上的用户呈现网络更新界面以显示来自相互社交网站的其他用户的网络更新。 由其他用户共享的网络更新集中在一个流中,并提供给包括网络更新界面的构面过滤系统。 用户根据网络更新界面中的小平面过滤器选择面板中启用的特征滤波器特征来控制某些网络更新项目的显示。 小平面滤波器特征由小平面滤波器用于选择某些网络更新以在网络更新界面中向用户显示。 根据其他用户的最大的普及程度,向用户显示与具有相关特征的内容对应的其他文章的趋势链接。 在网络更新界面中还提供了共享文章用户的配置文件的链接。

    Multifunctional aptamer-nucleic acid nanostructures for tumor-targeted killing
    10.
    发明授权
    Multifunctional aptamer-nucleic acid nanostructures for tumor-targeted killing 有权
    用于肿瘤靶向杀伤的多功能适体 - 核酸纳米结构

    公开(公告)号:US08552167B2

    公开(公告)日:2013-10-08

    申请号:US13392735

    申请日:2010-10-07

    申请人: Yung Chang Hao Yan

    发明人: Yung Chang Hao Yan

    IPC分类号: C07H21/04 A61K48/00

    摘要: The present invention provides compositions comprising a ligand-nucleic acid nanostructure that promote tumor cell-specific killing and methods of using the compositions. Specially, the invention provides aptamer-nucleic acid nanostructures for treating tumors in a mammal. The methods of making the compositions are also provided.

    摘要翻译: 本发明提供了包含促进肿瘤细胞特异性杀伤的配体 - 核酸纳米结构的组合物和使用该组合物的方法。 特别地,本发明提供用于治疗哺乳动物肿瘤的适体 - 核酸纳米结构。 还提供了制备组合物的方法。