CELLULASE VARIANTS
    1.
    发明申请
    CELLULASE VARIANTS 有权
    纤维素酶变体

    公开(公告)号:US20090170747A1

    公开(公告)日:2009-07-02

    申请号:US12394202

    申请日:2009-02-27

    IPC分类号: C11D3/386 C12N9/42

    摘要: The present invention relates to a method for improving the properties of a cellulolytic enzyme by amino acid substitution, deletion or insertion, the method comprising the steps of:a. constructing a multiple alignment of at least two amino acid sequences known to have three-dimensional structures similar to endoglucanase V (EGV) from Humicola insolens known from Protein Data Bank entry 4ENG; b. constructing a homology-built three-dimensional structure of the cellulolytic enzyme based on the structure of the EGV; c. identifying amino acid residue positions present in a distance from the substrate binding cleft of not more than 5 Å; d. identifying surface-exposed amino acid residues of the enzyme; e. identifying all charged or potentially charged amino acid residue positions of the enzyme; f. choosing one or more positions wherein the amino acid residue is to be substituted, deleted or where an insertion is to be provided; and g. carrying out the substitution, deletion or insertion by using conventional protein engineering techniques. Also described are cellulase variants obtained by this method.

    摘要翻译: 本发明涉及通过氨基酸取代,缺失或插入改进纤维素分解酶的性质的方法,该方法包括以下步骤:a。 构建已知具有类似于蛋白质数据库条目4ENG中已知的Humicola insolens的内切葡聚糖酶V(EGV)的三维结构的至少两个氨基酸序列的多重比对; b。 基于EGV的结构构建纤维素分解酶的同源构建的三维结构; C。 鉴定存在于与所述基质结合裂缝一定距离的氨基酸残基位置不大于5埃; d。 鉴定酶的表面暴露的氨基酸残基; e。 鉴定酶的所有带电荷或潜在带电的氨基酸残基位置; F。 选择其中氨基酸残基被取代,缺失或提供插入的一个或多个位置; 和g。 通过使用常规蛋白质工程技术进行取代,缺失或插入。 还描述了通过该方法获得的纤维素酶变体。

    Medical System And A Method Of Controlling The System For Use By A Patient For Medical Self Treatment
    4.
    发明申请
    Medical System And A Method Of Controlling The System For Use By A Patient For Medical Self Treatment 审中-公开
    医疗系统和一种用于医疗自我治疗的病人使用系统的方法

    公开(公告)号:US20070293742A1

    公开(公告)日:2007-12-20

    申请号:US11846028

    申请日:2007-08-28

    IPC分类号: A61B5/00

    摘要: This invention relates to an system for self treatment. The system consists of several portable modules where one of the modules is designated as a master module. The master module controls, supervises and monitors all the mutual information and data exchange between itself and the rest of the modules. The modules can e.g. consist of a BGM, a doser and a storage container. The modules may be able to generate and store data which is transmitted to the master module if it is within range. If the master module is not within range, the data is kept locally in the module until the master module is available. The master module can send the data to an external unit like a computer or database for further processing. A physician or an expert care-team can access the data in the database and give guidance to the patient on the basis of these processed data. This processing could also be done automatically by utilization of an expert system.

    摘要翻译: 本发明涉及一种用于自我治疗的系统。 该系统由几个便携式模块组成,其中一个模块被指定为主模块。 主模块控制,监督和监视其本身与其余模块之间的所有互信息和数据交换。 模块可以例如 由BGM,加料器和储存容器组成。 如果模块在范围内,则可以生成并存储发送到主模块的数据。 如果主模块不在范围内,则数据将保留在模块本地,直到主模块可用。 主模块可以将数据发送到外部单元,如计算机或数据库进行进一步处理。 医生或专家护理团队可以访问数据库中的数据,并根据这些处理的数据对患者进行指导。 这种处理也可以通过利用专家系统自动完成。

    Device with time indicating means
    7.
    发明申请
    Device with time indicating means 有权
    具有时间指示装置的装置

    公开(公告)号:US20070030764A1

    公开(公告)日:2007-02-08

    申请号:US11544525

    申请日:2006-10-05

    IPC分类号: G04F10/00

    摘要: The invention relates to a timer device capable of performing one or more control actions in response to the time lapsed since a user initiated action took place. The timer device comprises contact means operatable between two conditions, timer means, and means for storing first and second time stamps. The device further comprises control means for setting a first time stamp in response to the contact means being operated between first and second conditions, setting a second time stamp in response to the contact means being operated between the second and first conditions, calculating the time elapsed between the two time stamps, comparing the elapsed time with a preset time value, and performing a control action if the elapsed time is greater than the preset time value.

    摘要翻译: 本发明涉及一种定时器装置,其能够响应于由于用户发起动作而发生的时间而执行一个或多个控制动作。 定时器装置包括可在两个状态之间操作的接触装置,定时器装置和用于存储第一和第二时间戳的装置。 该装置还包括控制装置,用于响应于在第一和第二条件之间操作的接触装置来设置第一时间戳,响应于在第二和第一条件之间操作的接触装置设置第二时间戳,计算经过的时间 在两个时间戳之间,将经过的时间与预设时间值进行比较,以及如果经过时间大于预设时间值,则执行控制动作。