Crystalline antifungal compounds
    2.
    发明授权
    Crystalline antifungal compounds 有权
    结晶抗真菌化合物

    公开(公告)号:US08258296B2

    公开(公告)日:2012-09-04

    申请号:US12970297

    申请日:2010-12-16

    IPC分类号: A61K31/517

    CPC分类号: C07D403/06

    摘要: The present subject matter relates to novel crystalline forms of (1R,2R)-7-chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one represented by Formula II: , pharmaceutical compositions containing these crystalline forms, methods of using these crystalline forms for treating and/or preventing various microbial and/or fungal infections or disorders, and processes for obtaining these crystalline forms. In particular, the present subject matter relates to the specific crystalline Forms I, II, III, IV V, and VI of (1R,2R)-7-chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one.

    摘要翻译: 本发明涉及(1R,2R)-7-氯-3- [2-(2,4-二氟苯基)-2-羟基-1-甲基-3-(1H-1,2' 4-三唑-1-基)丙基]喹唑啉-4(3H) - 酮,含有这些结晶形式的药物组合物,使用这些结晶形式用于治疗和/或预防各种微生物和/或真菌感染的方法 或紊乱,以及获得这些结晶形式的方法。 特别是本发明涉及(1R,2R)-7-氯-3- [2-(2,4-二氟苯基)-2- 羟基-1-甲基-3-(1H-1,2,4-三唑-1-基)丙基]喹唑啉-4(3H) - 酮。

    Crystalline antifungal compounds
    3.
    发明申请
    Crystalline antifungal compounds 有权
    结晶抗真菌化合物

    公开(公告)号:US20080076787A1

    公开(公告)日:2008-03-27

    申请号:US11882892

    申请日:2007-08-06

    CPC分类号: C07D403/06

    摘要: Novel crystalline forms of (1R,2R)-7-chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one, pharmaceutical compositions containing these crystalline forms, methods of using these crystalline forms for treating and/or preventing various microbial and/or fungal infections or disorders, and processes for obtaining these crystalline forms. In particular, the present subject matter relates to the specific crystalline Forms I, II, III, IV, V, and VI of (1R,2R)-7-chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one.

    摘要翻译: (1R,2R)-7-氯-3- [2-(2,4-二氟苯基)-2-羟基-1-甲基-3-(1H-1,2,4-三唑-1-基) 丙基]喹唑啉-4(3H) - 酮,含有这些结晶形式的药物组合物,使用这些结晶形式用于治疗和/或预防各种微生物和/或真菌感染或病症的方法,以及获得这些结晶形式的方法。 特别地,本主题涉及(1R,2R)-7-氯-3- [2-(2,4-二氟苯基)-2(2R,2R) (1H-1,2,4-三唑-1-基)丙基]喹唑啉-4(3H) - 酮。

    Crystalline antifungal compounds
    4.
    发明授权
    Crystalline antifungal compounds 有权
    结晶抗真菌化合物

    公开(公告)号:US07879867B2

    公开(公告)日:2011-02-01

    申请号:US11882892

    申请日:2007-08-06

    IPC分类号: A61K31/517

    CPC分类号: C07D403/06

    摘要: Novel crystalline forms of (1R,2R)-7-chloro-3-[2-(2,4-difluorophenyl)-2 -hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one, pharmaceutical compositions containing these crystalline forms, methods of using these crystalline forms for treating and/or preventing various microbial and/or fungal infections or disorders, and processes for obtaining these crystalline forms. In particular, the present subject matter relates to the specific crystalline Forms I, II, III, IV, V, and VI of (1R,2R)-7-chloro-3-[2 -(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin -4(3H)-one, represented by formula II:

    摘要翻译: (1R,2R)-7-氯-3- [2-(2,4-二氟苯基)-2-羟基-1-甲基-3-(1H-1,2,4-三唑-1-基) 丙基]喹唑啉-4(3H) - 酮,含有这些结晶形式的药物组合物,使用这些结晶形式用于治疗和/或预防各种微生物和/或真菌感染或病症的方法,以及获得这些结晶形式的方法。 特别是本发明涉及(1R,2R)-7-氯-3- [2-(2,4-二氟苯基)-2(2R,2R) - 羟基-1-甲基-3-(1H-1,2,4-三唑-1-基)丙基]喹唑啉-4(3H) - 酮,由式II表示:

    Transmission having a backup latch mechanism
    7.
    发明申请
    Transmission having a backup latch mechanism 失效
    传输具有备用锁定机构

    公开(公告)号:US20070137973A1

    公开(公告)日:2007-06-21

    申请号:US11311304

    申请日:2005-12-20

    IPC分类号: B60K23/02 F16D25/10

    摘要: A transmission for a work machine is disclosed. The transmission has a source of pressurized fluid, a low pressure reservoir, a plurality of hydraulically actuated clutches, a first plurality of valve mechanisms, and a second plurality of valve mechanisms. Each of the first plurality of valve mechanisms is associated with one of the plurality of hydraulically actuated clutches and configured to selectively fill and drain the associated one of the plurality of hydraulically actuated clutches. Each of the second plurality of valve mechanisms is associated with one of the plurality of hydraulically actuated clutches and configured to selectively fill and drain the associated one of the plurality of hydraulically actuated clutches. The transmission also includes a master latch mechanism in fluid communication with only the second plurality of valve mechanisms. The master latch mechanism is configured to selectively affect movement of the second plurality of valve mechanisms in response to an electrical power failure.

    摘要翻译: 公开了一种用于工作机械的变速器。 变速器具有加压流体源,低压储存器,多个液压驱动离合器,第一多个阀机构和第二多个阀机构。 第一多个阀机构中的每一个与多个液压驱动的离合器中的一个相关联,并且构造成选择性地填充和排出多个液压驱动的离合器中的相关联的一个。 第二多个阀机构中的每一个与多个液压驱动的离合器中的一个相关联,并且构造成选择性地填充和排出多个液压驱动的离合器中的相关联的一个。 传动装置还包括仅与第二多个阀机构流体连通的主闩锁机构。 主闩锁机构构造成响应于电力故障选择性地影响第二多个阀机构的运动。

    Rear power takeoff
    8.
    发明申请
    Rear power takeoff 审中-公开
    后方电力起飞

    公开(公告)号:US20060137484A1

    公开(公告)日:2006-06-29

    申请号:US11022630

    申请日:2004-12-28

    IPC分类号: F16H37/00 B60K17/28 B60K25/00

    摘要: A system for transferring power from a work machine engine to a pump assembly of the work machine includes a power transfer assembly configured to transfer power to the pump assembly independent of transmission gear ratio. The pump assembly is mounted to a rear portion of a transmission of the work machine.

    摘要翻译: 用于将功率从工作机械发动机传递到作业机械的泵组件的系统包括被配置成将发电功率独立于变速比传递给泵组件的动力传递组件。 泵组件安装到工作机械的变速器的后部。

    MULTI-SPEED TRANSMISSION
    9.
    发明申请
    MULTI-SPEED TRANSMISSION 有权
    多速传输

    公开(公告)号:US20130150201A1

    公开(公告)日:2013-06-13

    申请号:US13324002

    申请日:2011-12-13

    IPC分类号: F16H3/62 F16H3/44

    摘要: A multi-speed transmission may include an input member and an output member disposed in a housing. A first planetary gear set, a second planetary gear set, a third planetary gear set, and a fourth planetary gear set may be disposed within the housing, each planetary gear set including a sun gear, a planet carrier, and a ring gear. Six control elements may be operably coupled to each of the planetary gear sets and selectively engagable to create a set of different gear ratios between the input member and the output member. The set of different gear ratios may include at least ten forward gear ratios and at least one reverse gear ratio.

    摘要翻译: 多速变速器可以包括设置在壳体中的输入构件和输出构件。 第一行星齿轮组,第二行星齿轮组,第三行星齿轮组和第四行星齿轮组可以设置在壳体内,每个行星齿轮组包括太阳齿轮,行星架和齿圈。 六个控制元件可以可操作地联接到每个行星齿轮组并且选择性地可接合以在输入构件和输出构件之间产生一组不同的齿轮比。 不同齿轮比的组可以包括至少十个前进档和至少一个倒档。