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公开(公告)号：US06224683B1
公开(公告)日：2001-05-01
申请号：US09402415
申请日：1999-10-04
IPC分类号： C07B6300
CPC分类号： C13B20/14 , B01D15/185 , B01D2215/023 , B01J39/26 , C13B20/144
摘要： In demineralization of a beet sugar solution before boiling as the starting solution with a simulated moving bed chromatographic separator comprising a plurality of packed column units packed with a strongly acidic cation exchange resin in a salt form having an average grain size of 300 to 500 &mgr;m and a uniformity coefficient of at most 1.2 as chromatographic packing (separating packing), and each provided with a starting solution feed inlet, an eluent water feed inlet, a withdrawal outlet for a fraction of a component having a strong affinity for chromatographic packing (“strong-affinity component”), and a withdrawal outlet for a fraction of a component having a weak affinity for chromatographic packing (“weak-affinity component”); use is made of circulating pumps, the number of which is at least half of the number of the packed column units, and the beet sugar solution before boiling is demineralized under the following conditions: starting solution feed rate/eluent water feed rate volume ratio=1/2.5 to 1/3.5, strong-affinity component fraction withdrawal rate/weak-affinity component fraction withdrawal rate volume ratio=0.5/1 to 1.2/1, and circulating flow rate=25 to 80 vol. % /hr. based on chromatographic packing in a slowest flow velocity zone in the circulation system, whereby a sucrose fraction having a high sucrose concentration is obtained using a small amount of eluent water with a large throughput.
摘要翻译： 在用沸腾前的甜菜糖溶液作为起始溶液进行脱矿化，其中模拟移动床层析分离器包含多个填充柱单元，其填充有平均粒径为300-500μm的盐形式的强酸性阳离子交换树脂，和 均匀系数最多为1.2，色谱填料（分离填料），每个均具有起始溶液进料口，洗脱水进料口，对色谱填料具有很强亲和力的成分部分的萃取出口（“强 - 亲和性组分“）和用于色谱填充弱亲和性的组分的一部分的提取出口（”弱亲和组分“）; 使用循环泵，其数量至少是填充柱单元数量的一半，煮沸前的甜菜糖溶液在以下条件下脱矿质：起始溶液进料速率/洗脱液进料速率体积比= 1 / 2.5〜1 / 3.5，强亲和成分馏分提取率/弱亲和成分馏分体积比= 0.5 / 1〜1.2 / 1，循环流量= 25〜80体积％。 ％/小时。 基于循环系统中最慢流速区域中的色谱填充，由此使用少量具有大生产量的洗脱水获得具有高蔗糖浓度的蔗糖级分。
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公开(公告)号：US06331250B1
公开(公告)日：2001-12-18
申请号：US09308560
申请日：1999-05-20
申请人： Kikuzo Kaneko , Takayuki Masuda , Fumihiko Matsuda , Kohei Sato , Kouji Tanikawa
发明人： Kikuzo Kaneko , Takayuki Masuda , Fumihiko Matsuda , Kohei Sato , Kouji Tanikawa
IPC分类号： B01D1508
CPC分类号： B01D15/1828 , B01D15/361 , B01D2215/023
摘要： At least 2 different packings differing in the resolution of components contained in a starting fluid material such as a starting solution material and desired to be separated are used in a coexistent state to adjust the resolution of the components. The starting fluid material is flowed through the resultant packing bed to effect chromatographic separation, whereby high-purity fractions enriched with respective components can be obtained at high recoveries with a small amount of desorbent such as eluent. In a chromatographic separator, at least 2 packings comprising a first packing high in the resolution of a component having a medium affinity (affinity for packing) and a weak-affinity component and a second packing high in the resolution of a strong-affinity component and the medium-affinity component in a coexistent state are used as chromatographic packing in contact with a fluid containing the medium-affinity component to adjust the resolution of every two of at least 3 components, whereby at least 3 fractions can be obtained.
摘要翻译： 在起始溶液材料（例如起始溶液材料）中包含的期望分离的组分的分辨率不同的至少2种不同的填料以共存状态使用以调节组分的分辨率。 起始流体材料流过所得填料床以进行色谱分离，由此可以用少量解吸剂如洗脱液以高回收率获得富含各组分的高纯度馏分。 在色谱分离器中，包含至少2个包装，其具有高分辨率的具有中等亲和性（对包装的亲和性）和弱亲和性成分的成分的高度分离的第一包装，以及高亲和性成分分辨率的第二包装， 共存状态的中等亲和性成分用作与含有中等亲和力成分的流体接触的色谱填料，以调节至少3种成分中的每两种的分辨率，由此可以获得至少3个级分。
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公开(公告)号：US6099654A
公开(公告)日：2000-08-08
申请号：US367690
申请日：1999-08-19
申请人： Kikuzo Kaneko , Takayuki Masuda , Fumihiko Matsuda , Kohei Sato , Kouji Tanikawa
发明人： Kikuzo Kaneko , Takayuki Masuda , Fumihiko Matsuda , Kohei Sato , Kouji Tanikawa
IPC分类号： B01D15/08 , C07C227/28 , C07C227/40 , C07C227/42 , C07C229/02 , C07C229/12 , G01N30/46 , G01N30/88 , C07B63/00
CPC分类号： C07C227/42 , C07C227/28
摘要： A starting solution material in the form of waste produced in the course of separation and recovery of sucrose from sugar beet extract or sugar beet molasses with a 2-component separation simulated moving bed chromatographic separator (using a strongly acidic cation exchange resin in a salt form as chromatographic packing) or its concentrate is used to separate therefrom a crude betaine fraction with a 2-component separation simulated moving bed chromatographic separator using as chromatographic packing a strongly acidic cation exchange resin in an ionic form equilibrated with that of the starting solution material. The crude betaine fraction or its concentrate is used to separate therefrom a betaine fraction with a 2-component separation simulated moving bed chromatographic separator using as chromatographic packing a strongly acidic cation exchange resin having at least 10% (based on the ion exchange capacity) of the ionic form thereof changed to the Ca form. The betaine fraction may be concentrated and subjected to crystallization, whereby high-purity betaine can be obtained.
摘要翻译： PCT No.PCT / JP98 / 05843 Sec。 371日期1999年8月19日 102（e）1999年8月19日PCT 1998年12月24日PCT PCT。 出版物WO99 / 33784 日期1999年7月8日在使用2-组分分离模拟移动床色谱分离器（使用强酸性阳离子交换器）从甜菜提取物或甜菜糖蜜分离和回收蔗糖过程中产生的废物形式的起始溶液材料 树脂为盐形式作为色谱填充）或其浓缩物用于将粗制甜菜碱部分与2-组分分离模拟移动床层析分离器分离，使用与酸性阳离子交换树脂平衡的离子形式的强酸性阳离子交换树脂 起始溶液材料。 使用粗制甜菜碱级分或其浓缩物将其与2-组分分离模拟移动床层析分离器的甜菜碱级分分离，使用色谱填料将具有至少10％（基于离子交换容量）的强酸性阳离子交换树脂 其离子形式变为Ca形式。 可以将甜菜碱级分浓缩并进行结晶，由此可以获得高纯度的甜菜碱。
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公开(公告)号：US06409922B1
公开(公告)日：2002-06-25
申请号：US09367522
申请日：1999-08-16
申请人： Kikuzo Kaneko , Takayuki Masuda , Fumihiko Matsuda , Kohei Sato , Kouji Tanikawa
发明人： Kikuzo Kaneko , Takayuki Masuda , Fumihiko Matsuda , Kohei Sato , Kouji Tanikawa
IPC分类号： B01D1508
CPC分类号： G01N30/466 , B01D15/1828 , B01D15/1842 , B01D15/361 , B01D53/02 , B01D53/025 , B01D2215/023 , C07H3/02 , C07H3/04 , C07H3/06 , C13B20/14 , C13B20/144 , C13B20/148 , C13B35/06 , C13K3/00 , C13K13/005 , G01N30/02 , B01D15/36
摘要： In chromatographic separation in a plurality of steps with a chromatographic separator packed with an ion exchanger used as at least part of chromatographic packing, at least part of the ionic form of at least part of the ion exchanger is changed to an ionic form fit for separation of components to be separated in each step to effect chromatographic separation, whereby a starting fluid material containing at least 3 components can be efficiently separated into at least 3 fractions. A preferred example of the chromatographic separator comprising a group of packing bed units linked in endless series to form a circulation flow path is provided with a shutoff valve at a position of the circulation flow path; starting fluid material feed means, desorbent feed means and 2-fraction withdrawal means for all the packing bed units; and a single-fraction withdrawal means connected to the circulation flow path on the upstream side of the shutoff valve and without any packing bed unit therebetween.
摘要翻译： 在使用填充有至少部分色谱填料的离子交换剂的色谱分离器的多个步骤中的色谱分离中，至少部分离子交换剂的至少部分离子形式被改变为适于分离的离子形式 在每个步骤中要分离的组分进行色谱分离，由此含有至少3种组分的起始流体材料可以有效地分离成至少3个级分。 包括以循环串联连接形成循环流路的一组填料床单元的色谱分离器的优选实例在循环流动路径的位置处设置有截止阀; 起始流体材料进料装置，解吸剂进料装置和用于所有填料床装置的2-馏分萃取装置; 以及连接到截流阀的上游侧的循环流路并且没有任何填料床单元的单馏分抽出装置。
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公开(公告)号：US06328895B1
公开(公告)日：2001-12-11
申请号：US09463688
申请日：2000-01-28
申请人： Takayuki Masuda , Kikuzo Kaneko , Kohei Sato , Fumihiko Matsuda
发明人： Takayuki Masuda , Kikuzo Kaneko , Kohei Sato , Fumihiko Matsuda
IPC分类号： B01Q1508
CPC分类号： B01D15/1828 , B01D2215/023
摘要： In separation of 3 components A, B and C having a C>B>A relation in respect of affinity for packing with a chromatographic separator comprising a circulation system formed by linking packing bed units 1 to 4 in endless series, the following Operations → → → → are performed in Step (1) as Stage 1, and the following Operations → → are repeatedly performed 3 times in subsequent Stages 2 to 4 in Step (2), provided that the fluid feed and withdrawal positions are respectively displaced one by one in the downstream direction of the circulation system every time after completion of each stage; : shutting off the circulation system, and withdrawing the whole of a component B fraction on the upstream side of the shutoff position while feeding a starting fluid material f to a packing bed unit on the downstream side of the shutoff position and feeding eluent D to the circulation system; : withdrawing part of a component A fraction while feeding eluent D to the circulation system; : withdrawing part of a component C fraction while feeding eluent D to the circulation system; and : circulating the internal fluid through the system with neither fluid feed to nor fluid withdrawal from the circulation system.
摘要翻译： 在分离具有C> B> A关系的3种组分A，B和C的关系中，包括通过连续填充床单元1至4连续形成的循环系统的色谱分离器的包装亲和力，以下操作<2 > - > <4> - > <1> - > <4> - > <3>在步骤（1）中作为阶段1执行，并且以下操作<2> - > <4> - > <3> 在步骤（2）中的后续阶段2至4中重复执行3次，条件是在每个阶段完成之后，流体进给和取出位置在循环系统的下游方向上分别逐个移位; 关闭循环系统，并且在关闭位置的上游侧取出部件B馏分的全部，同时将起始流体物料f供给到关闭位置的下游侧的填充床单元，并将洗脱液D供给循环 系统; <2>：将洗脱液D供给到循环中，抽出部分A组分 取出部分C部分，同时将洗脱液D送入循环系统; 和<4>：使内部流体通过系统循环，既没有流体供给也没有流体从循环系统中排出。
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6.发明授权
公开(公告)号：US5223143A
公开(公告)日：1993-06-29
申请号：US897795
申请日：1992-06-12
申请人： Takayuki Masuda , Tohru Sonobe , Kikuzo Kaneko , Fumihiko Matsuda
发明人： Takayuki Masuda , Tohru Sonobe , Kikuzo Kaneko , Fumihiko Matsuda
IPC分类号： B01D15/00 , B01D15/04 , B01D15/08 , B01D15/18 , C07H1/06 , G01N30/44 , G01N30/46 , G01N30/58 , G01N30/88
CPC分类号： C07H1/06 , B01D15/1828 , B01D2215/023 , G01N2030/445 , G01N2030/8813 , G01N30/461 , G01N30/468 , G01N30/58
摘要： There is provided a process for efficient chromatographic separation of a plurality of components from a fluid feed containing the same, which process comprises repeating a cycle comprising the step (1) of substantially shutting off the internal fluid circulation at a position of endless, or continuous, circulatory system and withdrawing a fraction enriched with a component having a strong affinity for an adsorbent upstream of the shut-off position while feeding the fluid feed downstream of the shut-off position, and the step (2) of withdrawing a plurality of fractions enriched with the remaining components while feeding a fluid desorbent and circulating the internal fluid.
摘要翻译： 提供了一种用于从含有该组分的流体进料高效色谱分离多个组分的方法，该方法包括重复一个循环，该循环包括步骤（1），其在无端或连续的位置基本上切断内部流体循环 循环系统，并且在向所述关闭位置的下游供给所述流体进料的同时，将在所述关闭位置上游的吸附剂的吸附剂富集的部分富集的部分富集，并且所述步骤（2）取出多个馏分 富含剩余的组分，同时供给流体解吸剂并循环内部流体。
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公开(公告)号：US5198120A
公开(公告)日：1993-03-30
申请号：US629702
申请日：1990-12-18
CPC分类号： C13B20/12 , B01D15/1828 , C13K1/04 , B01D2215/023
摘要： A process for chromatographic fractional separation of a ternary or more fluid feed into at least three fractions according to a simulated moving bed procedure in a system wherein the simulated moving bed packed with an adsorbent is provided with a circulatory channel having a shutoff position where the circulation of the system can be shut off, comprises step (1) of feeding fresh fluid feed into the system on the downstream side of the shutoff position while withdrawing a fraction(s) of a component(s) having a medium affinity for the adsorbent from an adsorption zone(s) located upstream of the shutoff position, which step (1) is repeated alternately with step (2) of separately withdrawing fractions of components fractionated into respective adsorption zones remaining after the step (1) by feeding a fluid desorbent into the system with sequentially shifting the position of feeding the fluid desorbent and the positions of withdrawing enriched fractions, corresponding to the migration of the respective adsorption zones in the downstream direction of circulation, while allowing the circulation of the system and feeding no fresh fluid feed into the system. Step (2) may, if desired, be followed by step (3) of further feeding the desorbent into each of the adsorption zones and separately withdrawing the fractions out of the system while allowing the fluid circulation of the system.
摘要翻译： 根据系统中的模拟移动床程序，将三元或更多流体进料层析分离成至少三个馏分的方法，其中填充有吸附剂的模拟移动床设置有具有截止位置的循环通道，其中循环 可以关闭系统的步骤（1），其中，在将关闭位置的下游侧的新鲜流体进料供给到系统中，同时从吸附剂中分离具有介质亲和性的组分的一部分 位于关闭位置上游的吸附区域，与步骤（2）交替地重复步骤（1）的步骤（1），其通过将流体解吸剂进料分离到分离到步骤（1）之后残留的各个吸附区域中的组分馏分 该系统依次移动供给流体解吸器的位置和排出富集部分的位置，对应于其的迁移 在循环的下游方向上的各个吸附区域，同时允许系统的循环并且不将新鲜的流体进料输送到系统中。 如果需要，步骤（2）可以在步骤（3）之后进一步将解吸剂进料到每个吸附区中，并且在允许系统的流体循环的同时单独地将馏分抽出系统。
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公开(公告)号：US6031796A
公开(公告)日：2000-02-29
申请号：US21689
申请日：1998-02-10
申请人： Misao Fukuda , Takayuki Masuda , Keishi Ueno , Akira Mashimo
发明人： Misao Fukuda , Takayuki Masuda , Keishi Ueno , Akira Mashimo
CPC分类号： G11B7/0037 , G11B20/10 , G11B27/3027 , G11B20/1217 , G11B2020/1476 , G11B2220/20 , G11B2220/2545 , G11B7/00745
摘要： An optical disk apparatus for performing recording and reproduction of information on an optical disk is disclosed. The optical disk has a sector format which consists of a sector mark area in which a sector mark is recorded and an address area in which a plurality of VFO segments and ID segments are alternately provided. The apparatus comprises a sector mark detector, a read gate controller, a PLL controller and an address information detector. The sector mark detector detects the sector mark. The read gate controller controls a read gate to be opened and closed. The read gate enables readout of information from the VFO segment when it is opened. The PLL controller initiates synchronization of a signal read from the VFO segment with a PLL in response to the opening of the read gate. The address information detector detects an address identifier recorded in the ID segment. If the address information detector cannot detect the address identifier, the read gate controller closes the read gate and opens the read gate at a timing corresponding to the VFO segment located immediately after the ID segment in which the address identifier cannot be detected.
摘要翻译： 公开了一种用于在光盘上执行信息的记录和再现的光盘装置。 光盘具有由记录有扇区标记的扇区标记区域和交替设置多个VFO段和ID段的地址区域构成的扇区格式。 该装置包括扇区标记检测器，读门控制器，PLL控制器和地址信息检测器。 扇区标记检测器检测扇区标记。 读门控制器控制读门被打开和关闭。 读门可以在VFO段打开时读取信息。 响应于读门的打开，PLL控制器启动从VFO段读取的信号与PLL的同步。 地址信息检测器检测记录在ID段中的地址标识符。 如果地址信息检测器不能检测到地址标识符，则读门控制器关闭读门，并在与不能检测到地址标识符的ID段紧邻的VFO段对应的定时打开读门。
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公开(公告)号：US6113475A
公开(公告)日：2000-09-05
申请号：US408851
申请日：1999-09-30
摘要： A method of cleaning a container and an apparatus therefor for cleaning a surface layer of the container by blasting fine particles of sodium bicarbonate with pressurized air into the container. The apparatus provdes a ball joint construction and a nozzle angle control mechanism for swing a nozzle body at an angle within a range of 50 degrees.
摘要翻译： 一种清洁容器及其装置的方法，用于通过用加压空气将细小的碳酸氢钠喷射到容器中来清洁容器的表面层。 该装置提供球形接头结构和喷嘴角度控制机构，用于使喷嘴体在50度的范围内摆动。
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公开(公告)号：US5391299A
公开(公告)日：1995-02-21
申请号：US193865
申请日：1994-02-09
申请人： Takayuki Masuda , Kuniaki Kawano , Isamu Miyawaki
发明人： Takayuki Masuda , Kuniaki Kawano , Isamu Miyawaki
摘要： The present invention provides a process for production of starch sugars, wherein starch is subjected to liquefaction and saccharification to prepare a mixture containing 10-50% by weight, based on the total solid content, of glucose and 30-50% by weight, also based on the total solid content, of maltose and the mixture is concentrated so as to have a total solid content of 40-70% by weight; and the resulting mixture is subjected to component separation using a chromatographic separator of simulated moving bed type capable of fractionating the mixture into at least three fractions, to produce a glucose fraction with a glucose purity of at least 97% by weight, a maltose fraction with a maltose purity of at least 80% by weight and a high-purity oligosaccharide fraction at a high efficiency in one operation. In the process, no strict control is required for the enzymatic reactions taking place in the liquefaction and saccharification of starch, and all the fractions obtained by the chromatographic fractionation can be made into marketable products.
摘要翻译： 本发明提供一种生产淀粉糖的方法，其中将淀粉进行液化和糖化以制备基于总固体含量为10-50重量％的葡萄糖和30-50重量％的混合物，还 基于总固体含量，将麦芽糖和该混合物浓缩，使总固体含量为40-70重量％; 并将所得混合物进行成分分离，使用能够将混合物分馏成至少三个级分的模拟移动床型的色谱分离器，以产生葡萄糖纯度为至少97重量％的葡萄糖馏分，具有至少97重量％的麦芽糖馏分 麦芽糖纯度至少为80重量％，高纯度寡糖部分在一次操作中效率高。 在此过程中，不需要对淀粉液化和糖化过程中发生的酶反应进行严格的控制，通过色谱分离得到的所有级分均可制成市售产品。
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