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    Apparatus and methods for performing electrochemical reactions
    1.
    发明授权
    Apparatus and methods for performing electrochemical reactions 有权

    公开(公告)号：US11567029B2

    公开(公告)日：2023-01-31

    申请号：US14162612

    申请日：2014-01-23

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： John Nobile ,  George T. Roth ,  Todd Rearick ,  Jonathan M. Schultz ,  Jonathan Rothberg ,  David Marran

    IPC: G01N27/30 ,  G01N27/414 ,  B01L3/00

    Abstract: The invention is directed to apparatus and methods for delivering multiple reagents to, and monitoring, a plurality of analytical reactions carried out on a large-scale array of electronic sensors under minimal noise conditions. In one aspect, the invention provides method of improving signal-to-noise ratios of output signals from the electronic sensors sensing analytes or reaction byproducts by subtracting an average of output signals measured from neighboring sensors where analyte or reaction byproducts are absent. In other aspects, the invention provides an array of electronic sensors integrated with a microwell array for confining analytes and/or particles for analytical reactions and a method for identifying microwells containing analytes and/or particles by passing a sensor-active reagent over the array and correlating sensor response times to the presence or absence of analytes or particles. Such detection of analyte- or particle-containing microwells may be used as a step in additional noise reduction methods.

    Temperature control of chemical detection system
    4.
    发明授权
    Temperature control of chemical detection system 有权

    公开(公告)号：US10578578B2

    公开(公告)日：2020-03-03

    申请号：US15351253

    申请日：2016-11-14

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd Rearick ,  Jeremy Jordan ,  John Nobile ,  William Mileski ,  Chun Heen Ho

    IPC: G01N33/48 ,  G01N27/414 ,  G01N31/20 ,  G05D23/19 ,  B01L3/00

    Abstract: An apparatus for detecting chemical reactions may be provided. The apparatus may comprise a chemical detection device. The chemical detection device may include a chemical sensor, which may be mounted on the chemical detection device. The apparatus may further comprise a valve block. The valve block may fluidly couple a plurality of reagent containers to the chemical detection device. The apparatus may further comprise a heat exchanger and a controller. The controller may control a fluid connection between the valve block and the chemical detection device. The controller may be also configured to adjust a temperature of a selected reagent from the plurality of reagent containers via the heat exchanger. The temperature of the selected reagent may be adjusted prior to the reagent entering the chemical detection device.

    TEMPERATURE CONTROL OF CHEMICAL DETECTION SYSTEM
    8.
    发明申请
    TEMPERATURE CONTROL OF CHEMICAL DETECTION SYSTEM 审中-公开
    化学检测系统温度控制

    公开(公告)号：US20170059516A1

    公开(公告)日：2017-03-02

    申请号：US15351253

    申请日：2016-11-14

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd REARICK ,  Jeremy Jordan ,  John Nobile ,  William Mileski ,  Chun Heen Ho

    IPC: G01N27/414 ,  B01L3/00

    CPC classification number: G01N27/4145 ,  B01L3/502 ,  B01L3/52 ,  B01L7/00 ,  B01L2200/0605 ,  B01L2200/147 ,  B01L2200/16 ,  B01L2300/0627 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2300/1894 ,  B01L2400/0487 ,  B01L2400/0622 ,  G01N27/414 ,  G01N31/20 ,  G05D23/19 ,  G05D23/1931

    Abstract: An apparatus for detecting chemical reactions may be provided. The apparatus may comprise a chemical detection device. The chemical detection device may include a chemical sensor, which may be mounted on the chemical detection device. The apparatus may further comprise a valve block. The valve block may fluidly couple a plurality of reagent containers to the chemical detection device. The apparatus may further comprise a heat exchanger and a controller. The controller may control a fluid connection between the valve block and the chemical detection device. The controller may be also configured to adjust a temperature of a selected reagent from the plurality of reagent containers via the heat exchanger. The temperature of the selected reagent may be adjusted prior to the reagent entering the chemical detection device.

    Abstract translation: 可以提供用于检测化学反应的装置。 该装置可以包括化学检测装置。 化学检测装置可以包括可安装在化学检测装置上的化学传感器。 该装置还可以包括阀块。 阀块可以将多个试剂容器流体耦合到化学检测装置。 该装置还可以包括热交换器和控制器。 控制器可以控制阀块和化学检测装置之间的流体连接。 控制器还可以被配置为经由热交换器从多个试剂容器调节所选择的试剂的温度。 可以在试剂进入化学检测装置之前调整所选择的试剂的温度。

    SYSTEM AND METHODS FOR MAKING AND PROCESSING EMULSIONS
    10.
    发明申请
    SYSTEM AND METHODS FOR MAKING AND PROCESSING EMULSIONS 有权
    制备和处理乳液的系统和方法

    公开(公告)号：US20150224457A1

    公开(公告)日：2015-08-13

    申请号：US14696642

    申请日：2015-04-27

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jonathan SCHULTZ ,  John Nobile ,  Brian Reed ,  Prasanna Krishnan Thwar ,  Todd Roswech

    IPC: B01F5/06

    CPC classification number: B01F5/0602 ,  B01F3/0807 ,  B01F5/0485 ,  B01F13/0059 ,  B01F2215/0037 ,  B01L3/502784 ,  B04B5/0414 ,  B04B7/02

    Abstract: An automated on-touch template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, an emulsion PCR (ePCR) thermocycling plate and subsystem, and a continuous centrifugation emulsion breaking and templated bead collection subsystem. The emulsion generation subsystem provides uniformity in the preparation of an inverse emulsion and may be used to create large or small volume inverse emulsions rapidly and reproducibly. An emulsion-generating device is provided that can supply a continuous stream of an inverse emulsion to a thermocycling subsystem, in automated fashion. The ePCR subsystem can continuously thermocycle an inverse emulsion passed therethrough and includes static temperature zones and a consumable thermocycling plate. The continuous centrifugation subsystem can continuously break a thermally cycled inverse emulsion and collect template beads formed in the aqueous microreactor droplets of the inverse emulsion.

    Abstract translation: 提供了一种自动化的在线模板珠粒制备系统，包括膜基乳液生成子系统，乳液PCR（ePCR）热循环板和子系统，以及连续离心乳液破乳和模板珠收集子系统。 乳液生成子系统在制备反相乳液时提供均匀性，并可用于快速且可再现地产生大体积或小体积的反相乳液。 提供一种乳液生成装置，其能够以自动方式向逆循环子系统提供连续的反相乳液流。 ePCR子系统可以连续热循环通过的反相乳液，并包括静态温度区和可消耗的热循环板。 连续离心子系统可以连续地破坏热循环的反相乳液并收集形成在反相乳液的微量微反应器液滴中的模板珠粒。

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