专利检索 ap:("Len F. Lee" OR "Thomas D. Penning" OR "Steven W. Kramer") AND inv:"Steven W. Kramer" 第 1 页

1.

发明授权
3,4-substituted pyrazoles for the treatment of inflammation 失效
标题翻译：用于治疗炎症的3,4-取代的吡唑

公开(公告)号：US5756530A

公开(公告)日：1998-05-26

申请号：US721787

申请日：1996-09-25

申请人： Len F. Lee , Thomas D. Penning , Steven W. Kramer

发明人： Len F. Lee , Thomas D. Penning , Steven W. Kramer

IPC分类号： A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/47 , A61K31/505 , A61P19/02 , A61P25/04 , A61P29/00 , C07D231/12 , C07D401/04 , C07D401/14 , C07D403/04 , C07D231/14

CPC分类号： C07D231/12

摘要： A class of pyrazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ##STR1## wherein R.sup.1 is selected from hydrido, alkyl, alkenyl, aralkyl, alkynyl, cyanoalkyl, carboxyalkyl, aminocarbonylalkyl, arylaminocarbonylalkyl, heterocyclicalkyl, and alkoxycarbonylalkyl; wherein R.sup.3 is aryl substituted at a substitutable position with halo; wherein R.sup.4 is selected from hydrido and haloalkyl; and wherein R.sup.5 is selected from alkyl and amino; or a pharmaceutically-acceptable salt or prodrug thereof.

摘要翻译： 描述了一类吡唑基化合物用于治疗炎症和炎症相关疾病。特别感兴趣的化合物由式II定义：其中R 1选自氢，烷基，烯基，芳烷基，炔基，氰基烷基，羧基烷基，氨基羰基烷基，芳基氨基羰基烷基，杂环烷基和烷氧基羰基烷基; 其中R3是在可取代的位置被卤素取代的芳基; 其中R 4选自氢和卤代烷基; 并且其中R 5选自烷基和氨基; 或其药学上可接受的盐或前药。

2.

发明授权
Substituted pyrazoles for the treatment of inflammation 失效
标题翻译：用于治疗炎症的取代的吡唑

公开(公告)号：US5580985A

公开(公告)日：1996-12-03

申请号：US535688

申请日：1995-09-28

申请人： Len F. Lee , Thomas D. Penning , Steven W. Kramer

发明人： Len F. Lee , Thomas D. Penning , Steven W. Kramer

IPC分类号： A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/47 , A61K31/505 , A61P19/02 , A61P25/04 , A61P29/00 , C07D231/12 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06

CPC分类号： C07D231/12

摘要： A class of pyrazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ##STR1## wherein R.sup.1 is selected from hydrido, alkyl, alkenyl, aralkyl, alkynyl, cyanoalkyl, carboxyalkyl, aminocarbonylalkyl, arylaminocarbonylalkyl, heterocyciicalkyl, and alkoxycarbonylalkyl; wherein R.sup.3 is aryl substituted at a substitutable position with halo; wherein R.sup.4 is selected from hydrido and haloalkyl; and wherein R.sup.5 is selected from alkyl and amino; or a pharmaceutically-acceptable salt or prodrug thereof.

摘要翻译： 描述了一类吡唑基化合物用于治疗炎症和炎症相关疾病。特别感兴趣的化合物由式II定义：其中R 1选自氢，烷基，烯基，芳烷基，炔基，氰基烷基，羧基烷基，氨基羰基烷基，芳基氨基羰基烷基，杂环烷基和烷氧基羰基烷基; 其中R3是在可取代的位置被卤素取代的芳基; 其中R 4选自氢和卤代烷基; 并且其中R 5选自烷基和氨基; 或其药学上可接受的盐或前药。

3.

发明授权
3,4-substituted pyrazoles for the treatment of inflammation 失效
标题翻译：用于治疗炎症的3,4-取代的吡唑

公开(公告)号：US5486534A

公开(公告)日：1996-01-23

申请号：US278297

申请日：1994-07-21

申请人： Len F. Lee , Thomas D. Penning , Steven W. Kramer

发明人： Len F. Lee , Thomas D. Penning , Steven W. Kramer

IPC分类号： A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/47 , A61K31/505 , A61P19/02 , A61P25/04 , A61P29/00 , C07D231/12 , C07D401/04 , C07D401/14 , C07D403/04

CPC分类号： C07D231/12

摘要： A class of pyrazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ##STR1## wherein R.sup.1 is selected from hydrido, alkyl, alkenyl, aralkyl, alkynyl, cyanoalkyl, carboxyalkyl, aminocarbonylalkyl, arylaminocarbonylalkyl, heterocyclicalkyl, and alkoxycarbonylalkyl; wherein R.sup.3 is aryl substituted at a substitutable position with halo; wherein R.sup.4 is selected from hydrido and haloalkyl; and wherein R.sup.5 is selected from alkyl and amino; or a pharmaceutically-acceptable salt or prodrug thereof.

摘要翻译： 描述了一类吡唑基化合物用于治疗炎症和炎症相关疾病。特别感兴趣的化合物由式II定义：其中R 1选自氢，烷基，烯基，芳烷基，炔基，氰基烷基，羧基烷基，氨基羰基烷基，芳基氨基羰基烷基，杂环烷基和烷氧基羰基烷基; 其中R3是在可取代的位置被卤素取代的芳基; 其中R 4选自氢和卤代烷基; 并且其中R 5选自烷基和氨基; 或其药学上可接受的盐或前药。

4.

发明授权
Imino pyrrolidine derivatives useful as nitric oxide synthase inhibitors 失效
标题翻译：可用作一氧化氮合酶抑制剂的亚氨基吡咯烷衍生物

公开(公告)号：US06448286B1

公开(公告)日：2002-09-10

申请号：US09123720

申请日：1998-07-28

申请人： Donald W. Hansen, Jr. , Mark G. Currie , E. Ann Hallinan , Kam F. Fok , Timothy J. Hagen , Arija A. Bergmanis , Steven W. Kramer , Len F. Lee , Suzanne Metz , William M. Moore , Karen B. Peterson , Barnett S. Pitzele , Dale P. Spangler , R. Keith Webber , Mihaly V. Toth , Mahima Trivedi , Foe S. Tjoeng

发明人： Donald W. Hansen, Jr. , Mark G. Currie , E. Ann Hallinan , Kam F. Fok , Timothy J. Hagen , Arija A. Bergmanis , Steven W. Kramer , Len F. Lee , Suzanne Metz , William M. Moore , Karen B. Peterson , Barnett S. Pitzele , Dale P. Spangler , R. Keith Webber , Mihaly V. Toth , Mahima Trivedi , Foe S. Tjoeng

IPC分类号： A61K3154

CPC分类号： C07D213/06 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/505 , A61K31/535 , A61K31/54 , A61K31/55 , C07D207/22 , C07D209/44 , C07D211/72 , C07D211/74 , C07D215/38 , C07D217/22 , C07D221/22 , C07D221/24 , C07D223/12 , C07D225/02 , C07D233/46 , C07D239/12 , C07D239/14 , C07D263/28 , C07D265/08 , C07D277/18 , C07D279/06 , C07D405/06

摘要： The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.

摘要翻译： 本发明公开了含有用作一氧化氮合酶抑制剂的脒基衍生物的有用的药物组合物。

5.

发明授权
Imidino piperidine derivatives useful as nitric oxide synthase inhibitors 失效
标题翻译：可用作一氧化氮合酶抑制剂的咪嘧啶哌啶衍生物

公开(公告)号：US6071906A

公开(公告)日：2000-06-06

申请号：US123822

申请日：1998-07-28

申请人： Donald W. Hansen, Jr. , Mark G. Currie , E. Ann Hallinan , Kam F. Fok , Timothy J. Hagen , Arija A. Bergmanis , Steven W. Kramer , Len F. Lee , Suzanne Metz , William M. Moore , Karen B. Peterson , Barnett S. Pitzele , Dale P. Spangler , R. Keith Webber , Mihaly V. Toth , Mahima Trivedi , Foe S. Tjoeng

发明人： Donald W. Hansen, Jr. , Mark G. Currie , E. Ann Hallinan , Kam F. Fok , Timothy J. Hagen , Arija A. Bergmanis , Steven W. Kramer , Len F. Lee , Suzanne Metz , William M. Moore , Karen B. Peterson , Barnett S. Pitzele , Dale P. Spangler , R. Keith Webber , Mihaly V. Toth , Mahima Trivedi , Foe S. Tjoeng

IPC分类号： C07D207/32 , A61K31/12 , A61K31/15 , A61K31/16 , A61K31/215 , A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/4025 , A61K31/403 , A61K31/4035 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/4458 , A61K31/4468 , A61K31/451 , A61K31/47 , A61K31/505 , A61K31/535 , A61K31/54 , A61K31/55 , A61P3/08 , A61P9/00 , A61P9/08 , A61P9/10 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/00 , A61P43/00 , C07C251/44 , C07D207/22 , C07D207/263 , C07D207/273 , C07D207/28 , C07D209/44 , C07D209/46 , C07D211/72 , C07D211/74 , C07D211/76 , C07D213/16 , C07D215/38 , C07D217/22 , C07D221/22 , C07D221/24 , C07D223/12 , C07D223/16 , C07D225/02 , C07D233/46 , C07D239/12 , C07D239/14 , C07D263/28 , C07D265/08 , C07D277/18 , C07D279/06 , C07D405/06 , C07D471/08 , C07D498/04 , C07D513/04 , C07D239/02 , C07D279/04 , C07D413/02

CPC分类号： C07D213/06 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/505 , A61K31/535 , A61K31/54 , A61K31/55 , C07D207/22 , C07D209/44 , C07D211/72 , C07D211/74 , C07D215/38 , C07D217/22 , C07D221/22 , C07D221/24 , C07D223/12 , C07D225/02 , C07D233/46 , C07D239/12 , C07D239/14 , C07D263/28 , C07D265/08 , C07D277/18 , C07D279/06 , C07D405/06

摘要： The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.

摘要翻译： 本发明公开了含有用作一氧化氮合酶抑制剂的脒基衍生物的有用的药物组合物。

6.

发明授权
Substituted thiazoles for the treatment of inflammation 失效
标题翻译：用于治疗炎症的取代的噻唑

公开(公告)号：US5668161A

公开(公告)日：1997-09-16

申请号：US679462

申请日：1996-07-09

申请人： John J. Talley , Jeffery S. Carter , Paul W. Collins , Steven W. Kramer , Thomas D. Penning , Donald J. Rogier, Jr. , Roland S. Rogers

发明人： John J. Talley , Jeffery S. Carter , Paul W. Collins , Steven W. Kramer , Thomas D. Penning , Donald J. Rogier, Jr. , Roland S. Rogers

IPC分类号： C07D277/24 , A61K31/425 , A61K31/426 , A61K31/44 , A61P3/00 , A61P29/00 , C07D277/20 , C07D277/26 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/34 , C07D277/40 , C07D277/42 , C07D277/50 , C07D277/52 , C07D277/56 , C07D417/04 , C07D417/12

CPC分类号： C07D417/04 , C07D277/26 , C07D277/30 , C07D277/42 , C07D277/56 , C07D417/12

摘要： A class of substituted thiazolyl compounds is described for use in treating inflammation disorders. Compounds are defined by Formula II ##STR1## wherein R.sup.1 is selected from hydrido, alkyl, haloalkyl, cyanoalkyl, alkylamino, aralkyl, arylamino, heteroarylsulfonylalkyl, heteroarylsulfonylhaloalkyl, aralkylamino, aryloxyalkyl, alkoxycarbonyl, aryl optionally substituted at a substitutable position with one or more radicals selected from halo and alkoxy, and heterocyclic optionally substituted at a substitutable position with one or more radicals selected from halo and alkyl; wherein R.sup.4 is selected from alkyl and amino; and wherein R.sup.5 is selected from aryl and heteroaryl; wherein R.sup.5 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkyl and alkoxy; provided R.sup.5 is not phenyl at position 4 when R.sup.1 is .alpha.,.alpha.-bis(trifluoromethyl)methanol and R.sup.4 is methyl; or a pharmaceutically-acceptable salt thereof.

摘要翻译： 描述了一类用于治疗炎症的取代的噻唑基化合物。化合物由式II其中R 1选自氢，烷基，卤代烷基，氰基烷基，烷基氨基，芳烷基，芳基氨基，杂芳基磺酰基烷基，杂芳基磺酰基卤代烷基，芳烷基氨基，芳氧基烷基，烷氧基羰基，任选地在可取代的位置被取代的芳基与一个或多个选自卤素和烷氧基的基团和任选地在可取代的位置被一个或多个选自卤素和烷基的基团取代的杂环; 其中R 4选自烷基和氨基; 并且其中R 5选自芳基和杂芳基; 其中R 5任选在可取代的位置被一个或多个选自卤素，烷基和烷氧基的基团取代; 条件是当R 1为α时，R 5不在第4位为苯基，α-双（三氟甲基）甲醇，且R 4为甲基; 或其药学上可接受的盐。