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    Microfluidic chip with enhanced tip for stable electrospray ionization
    2.
    发明授权
    Microfluidic chip with enhanced tip for stable electrospray ionization 失效
    具有增强尖端的微流控芯片，用于稳定的电喷雾电离

    公开(公告)号：US07105812B2

    公开(公告)日：2006-09-12

    申请号：US10871498

    申请日：2004-06-18

    申请人： Mingqi Zhao ,  Iuliu Blaga ,  Luc Bousse ,  John Stults ,  Jing Ni

    发明人： Mingqi Zhao ,  Iuliu Blaga ,  Luc Bousse ,  John Stults ,  Jing Ni

    IPC分类号： H01J49/04 ,  B01D59/44

    CPC分类号： H01J49/167 ,  B01L3/0268 ,  B01L3/502715 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/027 ,  B81B1/008 ,  B81B2201/058 ,  G01N27/44717 ,  H01J49/0018

    摘要： A microfluidic chip formed with multiple fluid channels terminating at a tapered electrospray ionization tip for mass spectrometric analysis. The fluid channels may be formed onto a channel plate that are in fluid communication with corresponding reservoirs. The electrospray tip can be formed along a defined distal portion of the channel plate that can include a single or multiple tapered surfaces. The fluid channels may terminate at an open-tip region of the electrospray tip. A covering plate may substantially enclose most portions of the fluid channels formed on the channel plate except for the open-tip region. Another aspect of the invention provides methods for conducting mass spectrometric analysis of multiple samples flowing through individual fluid channels in a single microfluidic chip that is formed with a tapered electrospray tip having an open-tip region.

    摘要翻译： 微流体芯片形成有多个流体通道，终止于锥形电喷雾离子化尖端，用于质谱分析。 流体通道可以形成在与相应的储存器流体连通的通道板上。 电喷雾尖端可以沿着通道板的限定的远侧部分形成，其可以包括单个或多个锥形表面。 流体通道可以终止于电喷雾尖端的开口尖端区域。 覆盖板可以基本上封闭形成在通道板上的除了开口尖端区域之外的流体通道的大部分。 本发明的另一方面提供了在单个微流体芯片中流过单个流体通道的多个样品进行质谱分析的方法，所述单个微流体芯片由具有开口尖端区域的锥形电喷雾尖端形成。

    Microfluidic devices and methods with integrated electrical contact
    3.
    发明申请
    Microfluidic devices and methods with integrated electrical contact 审中-公开
    微流控器件和集成电接触方法

    公开(公告)号：US20060022130A1

    公开(公告)日：2006-02-02

    申请号：US10903248

    申请日：2004-07-29

    申请人： Luc Bousse ,  Mingqi Zhao ,  Jing Ni

    发明人： Luc Bousse ,  Mingqi Zhao ,  Jing Ni

    IPC分类号： H01J49/00

    CPC分类号： H01J49/165 ,  B01L3/0268 ,  B01L3/5027 ,  H01J49/0018

    摘要： Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include a substrate having at least one microchannel, a cover arranged on a surface of the microchannel, and at least one electrical potential source. Some embodiments include a microchannel widened at an outlet. Other embodiments position the electrical potential source along a surface of the cover. Still other embodiments include a well in which an electrode and a membrane are disposed. The various embodiments provide stable electrospray ionization of substances from a microfluidic device to a mass spectrometer.

    摘要翻译： 微流体装置向质谱仪提供物质。 微流体装置包括具有至少一个微通道的衬底，布置在微通道表面上的盖和至少一个电势源。 一些实施例包括在出口处加宽的微通道。 其他实施例将电势源沿着盖的表面定位。 其他实施例包括其中设置电极和膜的阱。 各种实施方案提供物质从微流体装置到质谱仪的稳定的电喷雾电离。

    Microfluidic devices and methods
    4.
    发明申请
    Microfluidic devices and methods 审中-公开
    微流体装置和方法

    公开(公告)号：US20050000569A1

    公开(公告)日：2005-01-06

    申请号：US10794572

    申请日：2004-03-04

    申请人： Luc Bousse ,  Mingqi Zhao ,  John Stults ,  Jing Ni ,  Jonathan Heller ,  Uthara Srinivasan

    发明人： Luc Bousse ,  Mingqi Zhao ,  John Stults ,  Jing Ni ,  Jonathan Heller ,  Uthara Srinivasan

    IPC分类号： F15C1/04 ,  F16L58/04 ,  G01N20060101 ,  H01J49/04 ,  H01J49/16

    CPC分类号： H01J49/0018 ,  H01J49/165 ,  Y10T137/0402 ,  Y10T137/2082 ,  Y10T137/2191 ,  Y10T137/2224 ,  Y10T137/7036 ,  Y10T436/2575

    摘要： Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include first and second surfaces, at least one microchannel formed by the surfaces, and an outlet at an edge of the surfaces. Some embodiments also include a tip surface with one or more surface features for helping guide substances from the outlet of the device toward a mass spectrometer. In some embodiments, the surface feature(s) includes a groove, which may be hydrophilic along all or part of its length. Hydrophilic surfaces and/or hydrophobic surfaces may also help guide substances out of the outlet and/or toward the mass spectrometer. In some embodiments, the outlet and/or the tip surface is recessed back from an adjacent portion of the edge. A source of electrical potential can help move substances through the microchannel, separate substances and/or provide electrospray ionization.

    摘要翻译： 微流体装置向质谱仪提供物质。 微流体装置包括第一和第二表面，由表面形成的至少一个微通道和表面边缘处的出口。 一些实施例还包括具有一个或多个表面特征的尖端表面，用于帮助将物质从装置的出口引向质谱仪。 在一些实施例中，表面特征包括凹槽，其可以沿其长度的全部或部分亲水。 亲水表面和/或疏水表面还可以帮助将物质引出出口和/或朝向质谱仪。 在一些实施例中，出口和/或尖端表面从边缘的相邻部分向后凹陷。 电势源可以帮助物质通过微通道，分离物质和/或提供电喷雾电离。

    ELECTROSPRAY APPARATUS WITH AN INTEGRATED ELECTRODE
    5.
    发明申请
    ELECTROSPRAY APPARATUS WITH AN INTEGRATED ELECTRODE 审中-公开
    具有集成电极的电绝缘装置

    公开(公告)号：US20080235948A1

    公开(公告)日：2008-10-02

    申请号：US12056109

    申请日：2008-03-26

    申请人： Luc Bousse ,  Mingqi Zhao

    发明人： Luc Bousse ,  Mingqi Zhao

    IPC分类号： B23P17/00

    CPC分类号： H01J49/167 ,  B05B5/025 ,  B05B5/0533 ,  H01J49/0018 ,  Y10T29/494

    摘要： The invention provides related apparatus and methods of making an integrated electrospray tip by depositing ionic and/or electronic conductor materials onto a planar substrate. The invention also features methods of forming an electrospray apparatus comprising coupling a first planar substrate to the surface of a second planar substrate, wherein a surface on at least one of the substrates includes one or more microfluidic channels and/or reservoirs which are at least partially or totally enclosed therebetween. The conductive regions of the apparatus do not intersect the microfluidic channels within other portions of the apparatus provided preferably. The invention further provides related apparatus and methods for manufacturing and using microfluidic devices with integrated electrodes for electrospray ionization. The electrospray apparatus in some embodiments may include an electronic conductor electrode or an ionic conductor electrode formed from a microfluidic channel containing a conductive material selected from a variety of solutions and gels.

    摘要翻译： 本发明提供了通过将离子和/或电子导体材料沉积到平面衬底上来制造集成电喷雾尖端的相关装置和方法。 本发明还具有形成电喷射装置的方法，其包括将第一平面基底耦合到第二平面基底的表面，其中至少一个基底上的表面包括一个或多个微流体通道和/或至少部分地 或完全封闭在其间。 设备的导电区域优选地不与装置的其它部分内的微流体通道相交。 本发明还提供了用于制造和使用具有用于电喷雾电离的集成电极的微流体装置的相关装置和方法。 在一些实施例中，电喷雾装置可以包括由包含选自多种溶液和凝胶的导电材料的微流体通道形成的电子导体电极或离子导体电极。

    Electrospray apparatus with an integrated electrode
    6.
    发明申请
    Electrospray apparatus with an integrated electrode 审中-公开
    具有集成电极的电喷设备

    公开(公告)号：US20060060769A1

    公开(公告)日：2006-03-23

    申请号：US11031963

    申请日：2005-01-06

    申请人： Luc Bousse ,  Mingqi Zhao

    发明人： Luc Bousse ,  Mingqi Zhao

    IPC分类号： B01D59/44

    CPC分类号： H01J49/167 ,  B05B5/025 ,  B05B5/0533 ,  H01J49/0018 ,  Y10T29/494

    摘要： The invention provides related apparatus and methods of making an integrated electrospray tip by depositing ionic and/or electronic conductor materials onto a planar substrate. The invention also features methods of forming an electrospray apparatus comprising coupling a first planar substrate to the surface of a second planar substrate, wherein a surface on at least one of the substrates includes one or more microfluidic channels and/or reservoirs which are at least partially or totally enclosed therebetween. The conductive regions of the apparatus do not intersect the microfluidic channels within other portions of the apparatus provided preferably. The invention further provides related apparatus and methods for manufacturing and using microfluidic devices with integrated electrodes for electrospray ionization. The electrospray apparatus in some embodiments may include an electronic conductor electrode or an ionic conductor electrode formed from a microfluidic channel containing a conductive material selected from a variety of solutions and gels.

    摘要翻译： 本发明提供了通过将离子和/或电子导体材料沉积到平面衬底上来制造集成电喷雾尖端的相关装置和方法。 本发明还具有形成电喷射装置的方法，其包括将第一平面基底耦合到第二平面基底的表面，其中至少一个基底上的表面包括一个或多个微流体通道和/或至少部分地 或完全封闭在其间。 设备的导电区域优选地不与装置的其它部分内的微流体通道相交。 本发明还提供了用于制造和使用具有用于电喷雾电离的集成电极的微流体装置的相关装置和方法。 在一些实施例中，电喷雾装置可以包括由包含选自多种溶液和凝胶的导电材料的微流体通道形成的电子导体电极或离子导体电极。

    Electrospray apparatus with an integrated electrode
    7.
    发明授权
    Electrospray apparatus with an integrated electrode 失效
    具有集成电极的电喷设备

    公开(公告)号：US07391020B2

    公开(公告)日：2008-06-24

    申请号：US11556671

    申请日：2006-11-03

    申请人： Luc Bousse ,  Mingqi Zhao

    发明人： Luc Bousse ,  Mingqi Zhao

    IPC分类号： H01J49/04 ,  B01D59/44

    CPC分类号： H01J49/167 ,  B05B5/025 ,  B05B5/0533 ,  H01J49/0018 ,  Y10T29/494

    摘要： The invention provides related apparatus and methods of making an integrated electrospray tip by depositing ionic and/or electronic conductor materials onto a planar substrate. The invention also features methods of forming an electrospray apparatus comprising coupling a first planar substrate to the surface of a second planar substrate, wherein a surface on at least one of the substrates includes one or more microfluidic channels and/or reservoirs which are at least partially or totally enclosed therebetween. The conductive regions of the apparatus do not intersect the microfluidic channels within other portions of the apparatus provided preferably. The invention further provides related apparatus and methods for manufacturing and using microfluidic devices with integrated electrodes for electrospray ionization. The electrospray apparatus in some embodiments may include an electronic conductor electrode or an ionic conductor electrode formed from a microfluidic channel containing a conductive material selected from a variety of solutions and gels.

    摘要翻译： 本发明提供了通过将离子和/或电子导体材料沉积到平面衬底上来制造集成电喷雾尖端的相关装置和方法。 本发明还具有形成电喷射装置的方法，包括将第一平面基底耦合到第二平面基底的表面，其中至少一个基底上的表面包括一个或多个微流体通道和/或至少部分地 或完全封闭在其间。 设备的导电区域优选地不与装置的其它部分内的微流体通道相交。 本发明还提供了用于制造和使用具有用于电喷雾电离的集成电极的微流体装置的相关装置和方法。 在一些实施例中，电喷雾装置可以包括由包含选自多种溶液和凝胶的导电材料的微流体通道形成的电子导体电极或离子导体电极。

    Microfluidic chip with enhanced tip for stable electrospray ionization
    8.
    发明申请
    Microfluidic chip with enhanced tip for stable electrospray ionization 失效
    具有增强尖端的微流控芯片，用于稳定的电喷雾电离

    公开(公告)号：US20050047969A1

    公开(公告)日：2005-03-03

    申请号：US10871498

    申请日：2004-06-18

    申请人： Mingqi Zhao ,  Iuliu Blaga ,  Luc Bousse ,  John Stults

    发明人： Mingqi Zhao ,  Iuliu Blaga ,  Luc Bousse ,  John Stults

    IPC分类号： H03H19/00 ,  B01L3/00 ,  B01L3/02 ,  B81B1/00 ,  G01D5/20 ,  G01N20060101 ,  G01N27/447 ,  H01J49/04

    CPC分类号： H01J49/167 ,  B01L3/0268 ,  B01L3/502715 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/027 ,  B81B1/008 ,  B81B2201/058 ,  G01N27/44717 ,  H01J49/0018

    摘要： A microfluidic chip formed with multiple fluid channels terminating at a tapered electrospray ionization tip for mass spectrometric analysis. The fluid channels may be formed onto a channel plate that are in fluid communication with corresponding reservoirs. The electrospray tip can be formed along a defined distal portion of the channel plate that can include a single or multiple tapered surfaces. The fluid channels may terminate at an open-tip region of the electrospray tip. A covering plate may substantially enclose most portions of the fluid channels formed on the channel plate except for the open-tip region. Another aspect of the invention provides methods for conducting mass spectrometric analysis of multiple samples flowing through individual fluid channels in a single microfluidic chip that is formed with a tapered electrospray tip having an open-tip region.

    摘要翻译： 微流体芯片形成有多个流体通道，终止于锥形电喷雾离子化尖端，用于质谱分析。 流体通道可以形成在与相应的储存器流体连通的通道板上。 电喷雾尖端可以沿着通道板的限定的远侧部分形成，其可以包括单个或多个锥形表面。 流体通道可以终止于电喷雾尖端的开口尖端区域。 覆盖板可以基本上封闭形成在通道板上的除了开口尖端区域之外的流体通道的大部分。 本发明的另一方面提供了在单个微流体芯片中流过单个流体通道的多个样品进行质谱分析的方法，所述单个微流体芯片由具有开口尖端区域的锥形电喷雾尖端形成。

    Electrospray Apparatus with an Integrated Electrode
    9.
    发明申请
    Electrospray Apparatus with an Integrated Electrode 失效
    具有集成电极的电喷雾装置

    公开(公告)号：US20070057179A1

    公开(公告)日：2007-03-15

    申请号：US11556671

    申请日：2006-11-03

    申请人： Luc Bousse ,  Mingqi Zhao

    发明人： Luc Bousse ,  Mingqi Zhao

    IPC分类号： H01J49/00

    CPC分类号： H01J49/167 ,  B05B5/025 ,  B05B5/0533 ,  H01J49/0018 ,  Y10T29/494

    摘要： The invention provides related apparatus and methods of making an integrated electrospray tip by depositing ionic and/or electronic conductor materials onto a planar substrate. The invention also features methods of forming an electrospray apparatus comprising coupling a first planar substrate to the surface of a second planar substrate, wherein a surface on at least one of the substrates includes one or more microfluidic channels and/or reservoirs which are at least partially or totally enclosed therebetween. The conductive regions of the apparatus do not intersect the microfluidic channels within other portions of the apparatus provided preferably. The invention further provides related apparatus and methods for manufacturing and using microfluidic devices with integrated electrodes for electrospray ionization. The electrospray apparatus in some embodiments may include an electronic conductor electrode or an ionic conductor electrode formed from a microfluidic channel containing a conductive material selected from a variety of solutions and gels.

    摘要翻译： 本发明提供了通过将离子和/或电子导体材料沉积到平面衬底上来制造集成电喷雾尖端的相关装置和方法。 本发明还具有形成电喷射装置的方法，包括将第一平面基底耦合到第二平面基底的表面，其中至少一个基底上的表面包括一个或多个微流体通道和/或至少部分地 或完全封闭在其间。 设备的导电区域优选地不与装置的其它部分内的微流体通道相交。 本发明还提供了用于制造和使用具有用于电喷雾电离的集成电极的微流体装置的相关装置和方法。 在一些实施例中，电喷雾装置可以包括由包含选自多种溶液和凝胶的导电材料的微流体通道形成的电子导体电极或离子导体电极。