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    Microfluidic chip with enhanced tip for stable electrospray ionization
    1.
    发明授权
    Microfluidic chip with enhanced tip for stable electrospray ionization 失效
    具有增强尖端的微流控芯片，用于稳定的电喷雾电离

    公开(公告)号：US07105812B2

    公开(公告)日：2006-09-12

    申请号：US10871498

    申请日：2004-06-18

    申请人： Mingqi Zhao ,  Iuliu Blaga ,  Luc Bousse ,  John Stults ,  Jing Ni

    发明人： Mingqi Zhao ,  Iuliu Blaga ,  Luc Bousse ,  John Stults ,  Jing Ni

    IPC分类号： H01J49/04 ,  B01D59/44

    CPC分类号： H01J49/167 ,  B01L3/0268 ,  B01L3/502715 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/027 ,  B81B1/008 ,  B81B2201/058 ,  G01N27/44717 ,  H01J49/0018

    摘要： A microfluidic chip formed with multiple fluid channels terminating at a tapered electrospray ionization tip for mass spectrometric analysis. The fluid channels may be formed onto a channel plate that are in fluid communication with corresponding reservoirs. The electrospray tip can be formed along a defined distal portion of the channel plate that can include a single or multiple tapered surfaces. The fluid channels may terminate at an open-tip region of the electrospray tip. A covering plate may substantially enclose most portions of the fluid channels formed on the channel plate except for the open-tip region. Another aspect of the invention provides methods for conducting mass spectrometric analysis of multiple samples flowing through individual fluid channels in a single microfluidic chip that is formed with a tapered electrospray tip having an open-tip region.

    摘要翻译： 微流体芯片形成有多个流体通道，终止于锥形电喷雾离子化尖端，用于质谱分析。 流体通道可以形成在与相应的储存器流体连通的通道板上。 电喷雾尖端可以沿着通道板的限定的远侧部分形成，其可以包括单个或多个锥形表面。 流体通道可以终止于电喷雾尖端的开口尖端区域。 覆盖板可以基本上封闭形成在通道板上的除了开口尖端区域之外的流体通道的大部分。 本发明的另一方面提供了在单个微流体芯片中流过单个流体通道的多个样品进行质谱分析的方法，所述单个微流体芯片由具有开口尖端区域的锥形电喷雾尖端形成。

    Microfluidic chip with enhanced tip for stable electrospray ionization
    2.
    发明申请
    Microfluidic chip with enhanced tip for stable electrospray ionization 失效
    具有增强尖端的微流控芯片，用于稳定的电喷雾电离

    公开(公告)号：US20050047969A1

    公开(公告)日：2005-03-03

    申请号：US10871498

    申请日：2004-06-18

    申请人： Mingqi Zhao ,  Iuliu Blaga ,  Luc Bousse ,  John Stults

    发明人： Mingqi Zhao ,  Iuliu Blaga ,  Luc Bousse ,  John Stults

    IPC分类号： H03H19/00 ,  B01L3/00 ,  B01L3/02 ,  B81B1/00 ,  G01D5/20 ,  G01N20060101 ,  G01N27/447 ,  H01J49/04

    CPC分类号： H01J49/167 ,  B01L3/0268 ,  B01L3/502715 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/027 ,  B81B1/008 ,  B81B2201/058 ,  G01N27/44717 ,  H01J49/0018

    摘要： A microfluidic chip formed with multiple fluid channels terminating at a tapered electrospray ionization tip for mass spectrometric analysis. The fluid channels may be formed onto a channel plate that are in fluid communication with corresponding reservoirs. The electrospray tip can be formed along a defined distal portion of the channel plate that can include a single or multiple tapered surfaces. The fluid channels may terminate at an open-tip region of the electrospray tip. A covering plate may substantially enclose most portions of the fluid channels formed on the channel plate except for the open-tip region. Another aspect of the invention provides methods for conducting mass spectrometric analysis of multiple samples flowing through individual fluid channels in a single microfluidic chip that is formed with a tapered electrospray tip having an open-tip region.

    摘要翻译： 微流体芯片形成有多个流体通道，终止于锥形电喷雾离子化尖端，用于质谱分析。 流体通道可以形成在与相应的储存器流体连通的通道板上。 电喷雾尖端可以沿着通道板的限定的远侧部分形成，其可以包括单个或多个锥形表面。 流体通道可以终止于电喷雾尖端的开口尖端区域。 覆盖板可以基本上封闭形成在通道板上的除了开口尖端区域之外的流体通道的大部分。 本发明的另一方面提供了在单个微流体芯片中流过单个流体通道的多个样品进行质谱分析的方法，所述单个微流体芯片由具有开口尖端区域的锥形电喷雾尖端形成。