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    Anticonvulsant and central nervous system-depressing bis(fluorophenyl)alkylamides and their uses
    1.
    发明授权
    Anticonvulsant and central nervous system-depressing bis(fluorophenyl)alkylamides and their uses 失效
    抗惊厥和中枢神经系统抑制双（氟苯基）烷基酰胺及其用途

    公开(公告)号：US06617358B1

    公开(公告)日：2003-09-09

    申请号：US09587179

    申请日：2000-06-02

    申请人： Manuel F. Balandrin ,  Bradford C. VanWagenen ,  Linda D. Artman ,  Alan L. Mueller ,  Daryl Smith ,  Scott T. Moe

    发明人： Manuel F. Balandrin ,  Bradford C. VanWagenen ,  Linda D. Artman ,  Alan L. Mueller ,  Daryl Smith ,  Scott T. Moe

    IPC分类号： A61K31165

    CPC分类号： A61K31/16 ,  A61K31/165 ,  A61K31/192 ,  C07C233/11 ,  C07C233/22

    摘要： Bis(Fluorophenyl)alkylamides have been chemically synthesized which possess beneficial pharmacological properties (e.g., anticonvulsant activity) useful for the treatment of neurological diseases or disorders, such as, for example, epilepsy, convulsions, and seizure disorders. The preferred compounds of the invention also cause little sedation and have high therapeutic and protective indices in animal models of epilepsy. These compounds further possess long pharmacological half-lives, which, in practical clinical therapeutic application, should translate into once-a-day dosing, of great benefit to patients suffering from these diseases and/or disorders. These compounds may also be of further clinical utility in the treatment of other diseases and disorders of the central and peripheral nervous systems, or diseases or disorders affected by them, including, but not limited to, spasticity, skeletal muscle spasms and pain, restless leg syndrome, anxiety and stress, and bipolar disorder.

    摘要翻译： 已经化学合成了双（氟苯基）烷基酰胺，其具有可用于治疗神经疾病或病症（例如癫痫，抽搐和癫痫发作）的有益的药理学性质（例如抗惊厥活性）。 本发明优选的化合物在癫痫的动物模型中也引起很少的镇静作用并具有较高的治疗和保护指标。 这些化合物还具有长的药理学半衰期，其在实际临床治疗应用中应该转化为每天一次给药，对患有这些疾病和/或病症的患者是非常有益的。 这些化合物还可用于治疗中枢和周围神经系统的其他疾病和病症，或受其影响的疾病或病症，包括但不限于痉挛性，骨骼肌痉挛和疼痛，不宁腿 综合征，焦虑和压力和双相情感障碍。