公开(公告)号：US20110166352A1

公开(公告)日：2011-07-07

申请号：US13046138

申请日：2011-03-11

申请人： Margaret M. Gleeson ,  Soojin Kim ,  Donald C. Kientzler ,  San Kiang

发明人： Margaret M. Gleeson ,  Soojin Kim ,  Donald C. Kientzler ,  San Kiang

IPC分类号： C07D401/12

CPC分类号： A61J3/02 ,  B01D9/0009 ,  B01D9/005 ,  B01D9/0054 ,  B01D9/0063 ,  B01D9/0081 ,  B01J2/06 ,  C07D215/227

摘要： A process is provided for making sterile aripiprazole having an average particle size less than 100 microns but preferably greater than 25 microns employing an impinging jet crystallization procedure. The resulting bulk aripiprazole of desired particle size may be used to form a sterile freeze-dried aripiprazole formulation, which upon constitution with water and intramuscular injection releases aripiprazole over a period of at least about one week and up to about eight weeks.

摘要翻译： 提供了一种制备平均粒径小于100微米但优选大于25微米的无菌阿立哌唑的方法，其采用冲击射流结晶方法。 所得粒度的阿立哌唑可用于形成无菌冷冻干燥的阿立哌唑制剂，其在用水和肌内注射后，在至少约一周至多达八周的时间内释放阿立哌唑。

公开(公告)号：US20050152981A1

公开(公告)日：2005-07-14

申请号：US10968481

申请日：2004-10-19

申请人： Margaret Gleeson ,  Soojin Kim ,  Donald Kientzler ,  San Kiang

发明人： Margaret Gleeson ,  Soojin Kim ,  Donald Kientzler ,  San Kiang

IPC分类号： B01D9/00 ,  C07D215/22 ,  C07D215/227 ,  A61K9/14

CPC分类号： A61J3/02 ,  B01D9/0009 ,  B01D9/005 ,  B01D9/0054 ,  B01D9/0063 ,  B01D9/0081 ,  B01J2/06 ,  C07D215/227

摘要： A process is provided for making sterile aripiprazole having an average particle size less than 100 microns but preferably greater than 25 microns employing an impinging jet crystallization procedure. The resulting bulk aripiprazole of desired particle size may be used to form a sterile freeze-dried aripiprazole formulation, which upon constitution with water and intramuscular injection releases aripiprazole over a period of at least about one week and up to about eight weeks.

摘要翻译： 提供了一种制备平均粒径小于100微米但优选大于25微米的无菌阿立哌唑的方法，其采用冲击射流结晶方法。 所得粒度的阿立哌唑可用于形成无菌冷冻干燥的阿立哌唑制剂，其在用水和肌内注射后，在至少约一周至多达八周的时间内释放阿立哌唑。

公开(公告)号：US20180211830A1

公开(公告)日：2018-07-26

申请号：US15841946

申请日：2017-12-14

申请人： Hoyoung Kim ,  Hyo-Sun Lee ,  Soojin Kim ,  Keonyoung Kim ,  Jinhye Bae ,  Hoon Han ,  Tae Soo Kwon ,  Jung Hun Lim

发明人： Hoyoung Kim ,  Hyo-Sun Lee ,  Soojin Kim ,  Keonyoung Kim ,  Jinhye Bae ,  Hoon Han ,  Tae Soo Kwon ,  Jung Hun Lim

IPC分类号： H01L21/02 ,  C11D7/26 ,  C11D7/08 ,  C11D7/32 ,  C11D11/00 ,  H01L21/683 ,  H01L23/00

CPC分类号： H01L21/02068 ,  C11D7/08 ,  C11D7/261 ,  C11D7/264 ,  C11D7/266 ,  C11D7/3209 ,  C11D7/3218 ,  C11D11/0047 ,  H01L21/02057 ,  H01L21/304 ,  H01L21/30604 ,  H01L21/30625 ,  H01L21/6835 ,  H01L24/05 ,  H01L24/06 ,  H01L24/11 ,  H01L24/13 ,  H01L24/16 ,  H01L24/17 ,  H01L24/81 ,  H01L2221/68327 ,  H01L2221/68381 ,  H01L2224/03002 ,  H01L2224/0401 ,  H01L2224/0557 ,  H01L2224/05624 ,  H01L2224/05647 ,  H01L2224/06181 ,  H01L2224/1181 ,  H01L2224/13111 ,  H01L2224/13139 ,  H01L2224/13147 ,  H01L2224/16145 ,  H01L2224/16227 ,  H01L2224/17181 ,  H01L2224/81193 ,  H01L2224/81815 ,  H01L2224/94 ,  H01L2225/06513 ,  H01L2225/06517 ,  H01L2225/06541 ,  H01L2225/06565 ,  H01L2924/10252 ,  H01L2924/10253 ,  H01L2924/15311 ,  H01L2924/3512 ,  H01L2924/37001 ,  H01L2224/11 ,  H01L2224/03

摘要： Embodiments of the inventive concepts provide a method of manufacturing a semiconductor device and a cleaning composition for an adhesive layer. The method includes preparing a semiconductor substrate to which an adhesive layer adheres, removing the adhesive layer from the semiconductor substrate, and applying a cleaning composition to the semiconductor substrate to remove a residue of the adhesive layer. The cleaning composition includes a solvent including a ketone compound and having a content that is equal to or greater than 40 wt % and less than 90 wt %, quaternary ammonium salt, and primary amine.

公开(公告)号：US20120108594A1

公开(公告)日：2012-05-03

申请号：US13293204

申请日：2011-11-10

申请人： Soojin Kim ,  Mary F. Malley ,  Zhongping Shi

发明人： Soojin Kim ,  Mary F. Malley ,  Zhongping Shi

IPC分类号： A61K31/53 ,  A61P29/00 ,  A61P11/06 ,  A61P11/00 ,  A61P19/02 ,  A61P1/00 ,  A61P19/10 ,  A61P17/06 ,  A61P37/06 ,  A61P9/10 ,  C07D487/04 ,  A61P3/10

CPC分类号： C07D487/04

摘要： Processes are provided for selectively preparing novel stable crystalline salt forms, selectively and consistently, namely, preparing Form N-1 of the methanesulfonic acid salt, and Form N-1 and Form N-4 of the hydrochloric acid salt of the p38 kinase inhibitor 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide. The processes preferably employ solvent systems including formic acid/acetone and formic acid/methylethyl ketone which produce crystals having suitable flow properties and desired particle size, and solvents such as N,N-dimethylformamide and N,N-dimethylacetamide may be employed as well.Novel Form N-1 crystals of the Form N-1 and Form N-4 crystals of the hydrochloride salt and Form N-1 crystals of the methanesulfonic acid salt of the above free base, pharmaceutical compositions containing such novel forms and a method of treating p38 kinase associated conditions, including rheumatoid arthritis are also provided.

摘要翻译： 提供了选择性和一致地选择性制备新的稳定结晶盐形式的方法，即制备甲磺酸盐的N-1型，和p38激酶抑制剂4的盐酸盐的N-1和N-4型 - [[5 - [（环丙基氨基）羰基] -2-甲基苯基]氨基] -5-甲基-N-丙基吡咯并[2,1-f] [1,2,4]三嗪-6-甲酰胺。 该方法优选使用包含甲酸/丙酮和甲酸/甲基乙基酮的溶剂体系，其产生具有合适流动性和所需粒径的晶体，并且也可以使用溶剂如N，N-二甲基甲酰胺和N，N-二甲基乙酰胺。 上述游离碱的甲磺酸盐的盐酸盐形式的N-1型和N-4型结晶的新型N-1晶体和形式N-1晶体，含有这种新形式的药物组合物和治疗方法 还提供p38激酶相关病症，包括类风湿性关节炎。

公开(公告)号：US20090041716A1

公开(公告)日：2009-02-12

申请号：US12175104

申请日：2008-07-17

申请人： Soojin Kim ,  Qi Gao ,  Fukang Yang

发明人： Soojin Kim ,  Qi Gao ,  Fukang Yang

IPC分类号： A61K38/20 ,  C07D403/14 ,  A61K31/4178 ,  A61K31/7105 ,  A61P31/12 ,  A61K38/21 ,  A61K31/708

CPC分类号： C07D403/04

摘要： The present disclosure generally relates to a crystalline form of methyl ((1S)-1-(((2S)-2-(5-(4′-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1 H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt. The present disclosure also generally relates to a pharmaceutical composition comprising a crystalline form, as well of methods of using a crystalline form in the treatment of Hepatitis C and methods for obtaining such crystalline form.

摘要翻译： 本发明一般涉及（（1S）-1 - （（1S）-2-（5-（4' - （2 - （（2S）-1 - （（2S） （（甲氧基羰基）氨基）-3-甲基丁酰基）-2-吡咯烷基）-1H-咪唑-5-基）-4-联苯基）-1H-咪唑-2-基）-1-吡咯烷基）羰基）-2- 甲基丙基）氨基甲酸酯二盐酸盐。 本公开还通常涉及包含结晶形式的药物组合物，以及在治疗丙型肝炎中使用结晶形式的方法以及获得这种结晶形式的方法。

公开(公告)号：US20050256202A1

公开(公告)日：2005-11-17

申请号：US11119558

申请日：2005-05-02

申请人： Soojin Kim ,  Bruce Lotz ,  Mary Malley ,  Jack Gougoutas ,  Martha Davidovich ,  Sushil Srivastava

发明人： Soojin Kim ,  Bruce Lotz ,  Mary Malley ,  Jack Gougoutas ,  Martha Davidovich ,  Sushil Srivastava

IPC分类号： A61K31/16 ,  C07C231/02 ,  C07C243/26 ,  C07D213/42

CPC分类号： C07D213/42

摘要： A process is provided for preparing the HIV protease inhibitor atazanavir bisulfate wherein a solution of atazanavir free base is reacted with concentrated sulfuric acid in an amount to react with less than about 15% by weight of the free base, seeds of Form A crystals of atazanavir bisulfate are added to the reaction mixture, and as crystals of the bisulfate form, additional concentrated sulfuric acid is added in multiple stages at increasing rates according to a cubic equation, to effect formation of Form A crystals of atazanavir bisulfate. A process is also provided for preparing atazanavir bisulfate as Pattern C material. A novel form of atazanavir bisulfate is also provided which is Form E3 which is a highly crystalline triethanolate solvate of the bisulfate salt from ethanol.

摘要翻译： 提供了一种制备HIV蛋白酶抑制剂阿扎那韦硫酸氢盐的方法，其中阿扎那韦游离碱的溶液与浓硫酸反应的量与小于约15重量％的游离碱反应，阿扎那韦的A型晶体种子 将硫酸氢盐加入到反应混合物中，并且以硫酸氢盐形式的结晶，按照立方式以增加的速率以多个阶段多次加入另外的浓硫酸，以实现阿扎那韦硫酸氢盐的形式A晶体的形成。 还提供了制备作为图案C材料的阿扎那韦硫酸氢盐的方法。 还提供了一种新型形式的阿扎那韦硫酸氢盐，其为E3型，其是来自乙醇的硫酸氢盐的高度结晶的三乙醇盐溶剂合物。

公开(公告)号：US08511115B2

公开(公告)日：2013-08-20

申请号：US12846171

申请日：2010-07-29

申请人： Dongyoon Kim ,  Soojin Kim ,  Youngbae Park ,  Dongmin Kim ,  Sunggi Hwang ,  Seogkyu Park ,  Jongdeuk Bae ,  Seongno Yoon ,  Younggon Kim

发明人： Dongyoon Kim ,  Soojin Kim ,  Youngbae Park ,  Dongmin Kim ,  Sunggi Hwang ,  Seogkyu Park ,  Jongdeuk Bae ,  Seongno Yoon ,  Younggon Kim

IPC分类号： D06F39/14 ,  D06F21/08 ,  E05D1/00 ,  E05D11/10 ,  E05F1/08

CPC分类号： D06F39/14 ,  Y10T16/2771 ,  Y10T16/525 ,  Y10T16/53845 ,  Y10T16/54021

摘要： A washing machine which includes a lid assembly opening/closing a laundry entrance hole, wherein the lid assembly includes a lid frame and a lid inner coupled to an inside of the lid frame and having a hinge unit, is provided. The lid assembly may be easily assembled and maintain a secure coupling, thereby allowing for a reliable and stable washing machine. Further, the lid assembly may be easily opened or closed by the hinge unit, and this increases convenience.

摘要翻译： 一种洗衣机，其包括打开/关闭衣物入口孔的盖组件，其中所述盖组件包括盖框架和连接到所述盖框架的内部并具有铰链单元的盖子。 盖组件可以容易地组装并保持牢固的联接，从而允许可靠和稳定的洗衣机。 此外，盖组件可以通过铰链单元容易地打开或关闭，这增加了方便性。

公开(公告)号：US20130059866A1

公开(公告)日：2013-03-07

申请号：US13402996

申请日：2012-02-23

申请人： Horst Dollinger ,  Rogelio Perez Frutos ,  Soojin Kim ,  Jason Alan Mulder ,  Peter Nickolaus ,  Nitinchandra D. Patel ,  Pascale Pouzet ,  Chris Hugh Senanayake ,  Thomas Gabriel Tampone ,  Xudong Wei ,  Ulrike Werthmann ,  Bing-Shiou Yang

发明人： Horst Dollinger ,  Rogelio Perez Frutos ,  Soojin Kim ,  Jason Alan Mulder ,  Peter Nickolaus ,  Nitinchandra D. Patel ,  Pascale Pouzet ,  Chris Hugh Senanayake ,  Thomas Gabriel Tampone ,  Xudong Wei ,  Ulrike Werthmann ,  Bing-Shiou Yang

IPC分类号： A61K31/519 ,  A61P11/00 ,  A61P1/00 ,  A61P19/02 ,  A61P17/00 ,  A61P27/02 ,  A61P25/00 ,  A61P11/06 ,  A61P1/04 ,  A61P25/28 ,  A61P25/18 ,  A61P25/16 ,  A61P25/04 ,  C07C213/02 ,  C07D401/04 ,  C07D495/04

CPC分类号： C07D495/04 ,  A61K31/519 ,  A61K45/06 ,  C07B2200/13 ,  C07C213/00 ,  C07D401/04 ,  C07C215/42

摘要： The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is Cl and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.

公开(公告)号：US08026008B2

公开(公告)日：2011-09-27

申请号：US12723119

申请日：2010-03-12

申请人： Soojin Kim ,  Hong-Kyu Park ,  Sung kyun Chang ,  Jeong-Ju Cho ,  Hochun Lee

发明人： Soojin Kim ,  Hong-Kyu Park ,  Sung kyun Chang ,  Jeong-Ju Cho ,  Hochun Lee

IPC分类号： H01M4/48

CPC分类号： H01M10/0525 ,  H01M4/131 ,  H01M4/364 ,  H01M4/366 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M10/0567

摘要： Disclosed herein is a lithium secondary cell including 20 to 100 wt. % of lithium transition metal oxide represented by a formula of Li1+zNibMncMe1−(b+c)O2, relative to a total amount of a cathode active material, as well as an electrolyte consisting of a lithium salt and a non-aqueous solvent, wherein a first additive to form a protective film (that is, a solid electrolyte interface film: SEI film) over a surface of an anode active material and a second additive to form another SEI film over the surface of the anode active material while inactivating impurities contained in the cathode active material are included in the electrolyte.

摘要翻译： 本文公开了一种锂二次电池，其包含20至100重量％ 由Li1 + zNibMncMe1（b + c）O2表示的锂过渡金属氧化物的相对于阴极活性物质的总量以及由锂盐和非水溶剂组成的电解质的％ 其中在阳极活性材料的表面上形成保护膜（即，固体电解质界面膜：SEI膜）的第一添加剂和第二添加剂，以在阳极活性材料的表面上形成另一SEI膜，同时使杂质失活 包含在阴极活性材料中的电解质包含在电解质中。

公开(公告)号：US20110183216A1

公开(公告)日：2011-07-28

申请号：US12672789

申请日：2008-08-08

申请人： Soojin Kim ,  Jeong-ju Cho

发明人： Soojin Kim ,  Jeong-ju Cho

IPC分类号： H01M10/056 ,  H01M10/02

CPC分类号： H01M10/0567 ,  H01M10/052 ,  H01M2300/0025

摘要： Disclosed is a non-aqueous electrolyte including an electrolyte salt and an electrolyte solvent, the non-aqueous electrolyte further including a compound containing both a carboxy group and a (meth)acrylic group, and a secondary battery including the non-aqueous electrolyte. The use of the compound containing both the carboxy group and the (meth)acrylic group as a component for an electrolyte significantly reduces the increase of battery thickness at high temperature storage.

摘要翻译： 公开了包含电解质盐和电解质溶剂的非水电解质，所述非水电解质还包含含有羧基和（甲基）丙烯酸基的化合物，以及包含所述非水电解质的二次电池。 含有羧基和（甲基）丙烯酸基团的化合物作为电解质的组分的使用显着地降低了高温储存时电池厚度的增加。