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1.
公开(公告)号:US5653939A
公开(公告)日:1997-08-05
申请号:US511649
申请日:1995-08-07
申请人: Mark A. Hollis , Daniel J. Ehrlich , R. Allen Murphy , Bernard B. Kosicki , Dennis D. Rathman , Chang-Lee Chen , Richard H. Mathews , Barry E. Burke , Mitch D. Eggers , Michael E. Hogan , Rajender Singh Varma
发明人: Mark A. Hollis , Daniel J. Ehrlich , R. Allen Murphy , Bernard B. Kosicki , Dennis D. Rathman , Chang-Lee Chen , Richard H. Mathews , Barry E. Burke , Mitch D. Eggers , Michael E. Hogan , Rajender Singh Varma
IPC分类号: G01N21/64 , B01J19/00 , C12M1/00 , C12M1/34 , C12N11/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N5/02 , G01N21/25 , G01N21/27 , G01N21/78 , G01N22/00 , G01N27/00 , G01N27/02 , G01N27/22 , G01N27/27 , G01N27/327 , G01N29/00 , G01N29/12 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/566 , G01N37/00 , G01N15/06 , C07K1/00
CPC分类号: G01N33/5438 , B01J19/0046 , B01J19/0093 , B82Y30/00 , C12Q1/6825 , C12Q1/6832 , C12Q1/6837 , C12Q1/6874 , G01N21/253 , G01N21/6454 , G01N27/221 , G01N27/226 , G01N33/54373 , B01J2219/00317 , B01J2219/00511 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B01J2219/00713 , B01J2219/00722 , B01J2219/00828 , B01J2219/00853 , C40B40/06 , C40B60/14 , Y10S436/806 , Y10S436/807
摘要: A method and apparatus are disclosed for identifying molecular structures within a sample substance using a monolithic array of test sites formed on a substrate upon which the sample substance is applied. Each test site includes probes formed therein to bond with a predetermined target molecular structure or structures. A signal is applied to the test sites and certain electrical, mechanical and/or optical properties of the test sites are detected to determine which probes have bonded to an associated target molecular structure.
摘要翻译: 公开了一种用于使用形成在其上施加样品物质的基底上的测试部位的整体阵列来鉴定样品物质内的分子结构的方法和装置。 每个测试部位包括形成在其中的探针,以与预定的靶分子结构结合。 将信号施加到测试位点,并检测测试位点的某些电,机械和/或光学性质,以确定哪些探针已经结合到相关的靶分子结构。
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2.
公开(公告)号:US5846708A
公开(公告)日:1998-12-08
申请号:US872582
申请日:1992-04-23
申请人: Mark A. Hollis , Daniel J. Ehrlich , R. Allen Murphy , Bernard B. Kosicki , Dennis D. Rathman , Richard H. Mathews , Barry E. Burke , Mitch D. Eggers , Michael E. Hogan , Rajender Singh Varma
发明人: Mark A. Hollis , Daniel J. Ehrlich , R. Allen Murphy , Bernard B. Kosicki , Dennis D. Rathman , Richard H. Mathews , Barry E. Burke , Mitch D. Eggers , Michael E. Hogan , Rajender Singh Varma
IPC分类号: G01N21/64 , B01J19/00 , C12M1/00 , C12M1/34 , C12N11/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N5/02 , G01N21/25 , G01N21/27 , G01N21/78 , G01N22/00 , G01N27/00 , G01N27/02 , G01N27/22 , G01N27/27 , G01N27/327 , G01N29/00 , G01N29/12 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/566 , G01N37/00 , G01N27/26
CPC分类号: G01N33/5438 , B01J19/0046 , B01J19/0093 , B82Y30/00 , C12Q1/6825 , C12Q1/6832 , C12Q1/6837 , C12Q1/6874 , G01N21/253 , G01N21/6454 , G01N27/221 , G01N27/226 , G01N33/54373 , B01J2219/00317 , B01J2219/00511 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B01J2219/00713 , B01J2219/00722 , B01J2219/00828 , B01J2219/00853 , C40B40/06 , C40B60/14 , Y10S436/806 , Y10S436/807
摘要: A method and apparatus are disclosed for identifying molecular structures within a sample substance using a monolithic array of test sites formed on a substrate upon which the sample substance is applied. Each test site includes probes formed therein to bond with a predetermined target molecular structure or structures. A signal is applied to the test sites and certain electrical, mechanical and/or optical properties of the test sites are detected to determine which probes have bonded to an associated target molecular structure.
摘要翻译: 公开了一种用于使用形成在其上施加样品物质的基底上的测试部位的整体阵列来鉴定样品物质内的分子结构的方法和装置。 每个测试部位包括形成在其中的探针,以与预定的靶分子结构结合。 将信号施加到测试位点,并检测测试位点的某些电,机械和/或光学性质,以确定哪些探针已经结合到相关的靶分子结构。
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