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公开(公告)号:US20120135404A1
公开(公告)日:2012-05-31
申请号:US13267276
申请日:2011-10-06
申请人: Eric. D. Schwoebel , James D. Harper , Martha S. Petrovick , Frances E. Nargi , Todd H. Rider , Kristine E. Hogan , Richard H. Mathews , Joseph Lacirignola , Mark Hennessy , Trina R. Vian , Rose M. Joseph , Raymond S. Uttaro , Shaun Berry , Bernadette Johnson , Mark A. Hollis
发明人: Eric. D. Schwoebel , James D. Harper , Martha S. Petrovick , Frances E. Nargi , Todd H. Rider , Kristine E. Hogan , Richard H. Mathews , Joseph Lacirignola , Mark Hennessy , Trina R. Vian , Rose M. Joseph , Raymond S. Uttaro , Shaun Berry , Bernadette Johnson , Mark A. Hollis
CPC分类号: G01N33/5304 , C12M1/3461 , C12M1/3476 , C12Q1/6825 , G01N21/6428 , G01N21/6454 , G01N33/582 , C12Q2565/619 , C12Q2563/131
摘要: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.
摘要翻译: 本文描述的本发明提供了用于检测可溶性抗原的方法。 特别地,该方法提供了可溶性蛋白质和化学物质的检测。 此外,本发明提供了检测样品中核酸序列的方法。 还描述了包含Fc受体和发射体分子的发射体细胞,用于检测样品中的靶颗粒,其中待检测的靶颗粒被一种或多种抗体结合。 还提供了一种用于检测多个样品中的目标颗粒的光电传感器装置。
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公开(公告)号:US4234883A
公开(公告)日:1980-11-18
申请号:US509708
申请日:1974-09-26
CPC分类号: H04B1/1036 , H04L7/0083
摘要: Time-correlation apparatus for collecting correlation data when the noise level is low and inhibiting the collection of correlation data when the noise level is high without losing valid correlation data which has already been obtained. An incoming signal is checked for data pulses during each correlation measurement pulse of a synchronizing signal. The correlation measurement pulses are counted by a first counter, and the coincidences of data pulses and correlation measurement pulses are counted by a second counter. A noise monitor samples the incoming signals 100 times during each of a continuous series of noise analysis periods and counts the number of times the signal (assumed to be noise) exceeds a predetermined threshold. A high noise signal is generated if the threshold is exceeded 30 or more times, and a low noise signal if it is exceeded less than 30 times. A low noise signal at the end of a noise analysis period causes the counts in the first and second counters to be loaded into first and second buffers, respectively. A high noise signal at the end of a noise analysis period causes the counts in the first and second buffers to be loaded into the first and second counters, respectively, in place of the counts therein. Thus, if there is a low noise level during a noise analysis period, correlation data is collected. If there is a high noise level during a noise analysis period, correlation data collected during that period is dumped but previously collected data is retained. When the count of correlation measurement pulses in the first counter reaches 100, the count of coincidences in the second counter is read out as a measure of the degree of correlation between the incoming signal and the synchronizing signal.
摘要翻译: 时间相关装置,用于当噪声电平低时收集相关数据,并且当噪声电平较高时禁止收集相关数据,而不会丢失已经获得的有效相关数据。 在同步信号的每个相关测量脉冲期间检查输入信号的数据脉冲。 相关测量脉冲由第一计数器计数,数据脉冲和相关测量脉冲的重合由第二计数器计数。 噪声监测器在连续的一系列噪声分析周期期间对输入信号进行100次采样,并对信号(假设为噪声)超过预定阈值的次数进行计数。 如果阈值超过30次以上,则产生高噪声信号,如果超过30次,则产生低噪声信号。 在噪声分析周期结束时的低噪声信号使得第一和第二计数器中的计数分别被加载到第一和第二缓冲器中。 在噪声分析周期结束时的高噪声信号使得第一和第二缓冲器中的计数分别被加载到第一和第二计数器中,代替其中的计数。 因此,如果在噪声分析期间存在低噪声电平,则收集相关数据。 如果在噪声分析期间存在高噪声电平,则在该期间收集的相关数据被转储,但是先前收集的数据被保留。 当第一计数器中的相关测量脉冲的计数达到100时,读出第二计数器中的重合计数作为输入信号和同步信号之间的相关程度的量度。
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公开(公告)号:US20100041031A1
公开(公告)日:2010-02-18
申请号:US12217471
申请日:2008-07-03
申请人: Eric D. Schwoebel , James D. Harper , Martha S. Petrovick , Frances E. Nargi , Todd H. Rider , Kristine E. Hogan , Richard H. Mathews , Joseph Lacirignola , Mark Hennessy , Trina R. Vian , Rose M. Joseph , Raymond S. Uttaro , Shaun Berry , Bernadette Johnson , Mark A. Hollis
发明人: Eric D. Schwoebel , James D. Harper , Martha S. Petrovick , Frances E. Nargi , Todd H. Rider , Kristine E. Hogan , Richard H. Mathews , Joseph Lacirignola , Mark Hennessy , Trina R. Vian , Rose M. Joseph , Raymond S. Uttaro , Shaun Berry , Bernadette Johnson , Mark A. Hollis
IPC分类号: C12Q1/68 , G01N33/566 , G01N21/00 , C12M1/34
CPC分类号: G01N33/5304 , C12M1/3461 , C12M1/3476 , C12Q1/6825 , G01N21/6428 , G01N21/6454 , G01N33/582 , C12Q2565/619 , C12Q2563/131
摘要: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.
摘要翻译: 本文描述的本发明提供了用于检测可溶性抗原的方法。 特别地,该方法提供了可溶性蛋白质和化学物质的检测。 此外,本发明提供了检测样品中核酸序列的方法。 还描述了包含Fc受体和发射体分子的发射体细胞,用于检测样品中的靶颗粒,其中待检测的靶颗粒被一种或多种抗体结合。 还提供了一种用于检测多个样品中的目标颗粒的光电传感器装置。
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公开(公告)号:US06961968B2
公开(公告)日:2005-11-08
申请号:US10808592
申请日:2004-03-25
CPC分类号: A47D11/005 , A47D5/00 , A47D9/00
摘要: A bassinet and changing table assembly includes a frame, a changing table mounted to the frame, and a bassinet releasably mounted to the changing table and/or the frame so that the bassinet is positioned over the changing table. Hence, the diaper changing activity is separated from the child sleeping area.
摘要翻译: 摇篮和换台组件包括框架,安装到框架的更换台以及可释放地安装到变更台和/或框架上的摇篮,使得摇篮位于变台上。 因此,尿布更换活动与儿童睡眠区域分离。
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公开(公告)号:US08067184B2
公开(公告)日:2011-11-29
申请号:US12217471
申请日:2008-07-03
申请人: Eric D. Schwoebel , James D. Harper , Martha S. Petrovick , Frances E. Nargi , Todd H. Rider , Kristine E. Hogan , Richard H. Mathews , Joseph Lacirignola , Mark Hennessy , Trina R. Vian , Rose M. Joseph , Raymond S. Uttaro , Shaun Berry , Bernadette Johnson , Mark A. Hollis
发明人: Eric D. Schwoebel , James D. Harper , Martha S. Petrovick , Frances E. Nargi , Todd H. Rider , Kristine E. Hogan , Richard H. Mathews , Joseph Lacirignola , Mark Hennessy , Trina R. Vian , Rose M. Joseph , Raymond S. Uttaro , Shaun Berry , Bernadette Johnson , Mark A. Hollis
CPC分类号: G01N33/5304 , C12M1/3461 , C12M1/3476 , C12Q1/6825 , G01N21/6428 , G01N21/6454 , G01N33/582 , C12Q2565/619 , C12Q2563/131
摘要: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.
摘要翻译: 本文描述的本发明提供了用于检测可溶性抗原的方法。 特别地,该方法提供了可溶性蛋白质和化学物质的检测。 此外,本发明提供了检测样品中核酸序列的方法。 还描述了包含Fc受体和发射体分子的发射体细胞,用于检测样品中的靶颗粒,其中待检测的靶颗粒被一种或多种抗体结合。 还提供了一种用于检测多个样品中的目标颗粒的光电传感器装置。
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公开(公告)号:US07422860B2
公开(公告)日:2008-09-09
申请号:US11001583
申请日:2004-12-01
申请人: Eric D. Schwoebel , James D. Harper , Martha S. Petrovick , Frances E. Nargi , Todd H. Rider , Kristine E. Hogan , Richard H. Mathews , Joseph Lacirignola , Mark Hennessy , Trina R. Vian , Rose M. Joseph , Raymond S. Uttaro , Shaun Berry , Bernadette Johnson , Mark A. Hollis
发明人: Eric D. Schwoebel , James D. Harper , Martha S. Petrovick , Frances E. Nargi , Todd H. Rider , Kristine E. Hogan , Richard H. Mathews , Joseph Lacirignola , Mark Hennessy , Trina R. Vian , Rose M. Joseph , Raymond S. Uttaro , Shaun Berry , Bernadette Johnson , Mark A. Hollis
IPC分类号: G01N33/53
CPC分类号: G01N33/5304 , C12M1/3461 , C12M1/3476 , C12Q1/6825 , G01N21/6428 , G01N21/6454 , G01N33/582 , C12Q2565/619 , C12Q2563/131
摘要: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.
摘要翻译: 本文描述的本发明提供了用于检测可溶性抗原的方法。 特别地,该方法提供了可溶性蛋白质和化学物质的检测。 此外,本发明提供了检测样品中核酸序列的方法。 还描述了包含Fc受体和发射体分子的发射体细胞,用于检测样品中的靶颗粒,其中待检测的靶颗粒被一种或多种抗体结合。 还提供了一种用于检测多个样品中的目标颗粒的光电传感器装置。
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7.
公开(公告)号:US5846708A
公开(公告)日:1998-12-08
申请号:US872582
申请日:1992-04-23
申请人: Mark A. Hollis , Daniel J. Ehrlich , R. Allen Murphy , Bernard B. Kosicki , Dennis D. Rathman , Richard H. Mathews , Barry E. Burke , Mitch D. Eggers , Michael E. Hogan , Rajender Singh Varma
发明人: Mark A. Hollis , Daniel J. Ehrlich , R. Allen Murphy , Bernard B. Kosicki , Dennis D. Rathman , Richard H. Mathews , Barry E. Burke , Mitch D. Eggers , Michael E. Hogan , Rajender Singh Varma
IPC分类号: G01N21/64 , B01J19/00 , C12M1/00 , C12M1/34 , C12N11/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N5/02 , G01N21/25 , G01N21/27 , G01N21/78 , G01N22/00 , G01N27/00 , G01N27/02 , G01N27/22 , G01N27/27 , G01N27/327 , G01N29/00 , G01N29/12 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/566 , G01N37/00 , G01N27/26
CPC分类号: G01N33/5438 , B01J19/0046 , B01J19/0093 , B82Y30/00 , C12Q1/6825 , C12Q1/6832 , C12Q1/6837 , C12Q1/6874 , G01N21/253 , G01N21/6454 , G01N27/221 , G01N27/226 , G01N33/54373 , B01J2219/00317 , B01J2219/00511 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B01J2219/00713 , B01J2219/00722 , B01J2219/00828 , B01J2219/00853 , C40B40/06 , C40B60/14 , Y10S436/806 , Y10S436/807
摘要: A method and apparatus are disclosed for identifying molecular structures within a sample substance using a monolithic array of test sites formed on a substrate upon which the sample substance is applied. Each test site includes probes formed therein to bond with a predetermined target molecular structure or structures. A signal is applied to the test sites and certain electrical, mechanical and/or optical properties of the test sites are detected to determine which probes have bonded to an associated target molecular structure.
摘要翻译: 公开了一种用于使用形成在其上施加样品物质的基底上的测试部位的整体阵列来鉴定样品物质内的分子结构的方法和装置。 每个测试部位包括形成在其中的探针,以与预定的靶分子结构结合。 将信号施加到测试位点,并检测测试位点的某些电,机械和/或光学性质,以确定哪些探针已经结合到相关的靶分子结构。
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8.
公开(公告)号:US5653939A
公开(公告)日:1997-08-05
申请号:US511649
申请日:1995-08-07
申请人: Mark A. Hollis , Daniel J. Ehrlich , R. Allen Murphy , Bernard B. Kosicki , Dennis D. Rathman , Chang-Lee Chen , Richard H. Mathews , Barry E. Burke , Mitch D. Eggers , Michael E. Hogan , Rajender Singh Varma
发明人: Mark A. Hollis , Daniel J. Ehrlich , R. Allen Murphy , Bernard B. Kosicki , Dennis D. Rathman , Chang-Lee Chen , Richard H. Mathews , Barry E. Burke , Mitch D. Eggers , Michael E. Hogan , Rajender Singh Varma
IPC分类号: G01N21/64 , B01J19/00 , C12M1/00 , C12M1/34 , C12N11/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N5/02 , G01N21/25 , G01N21/27 , G01N21/78 , G01N22/00 , G01N27/00 , G01N27/02 , G01N27/22 , G01N27/27 , G01N27/327 , G01N29/00 , G01N29/12 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/566 , G01N37/00 , G01N15/06 , C07K1/00
CPC分类号: G01N33/5438 , B01J19/0046 , B01J19/0093 , B82Y30/00 , C12Q1/6825 , C12Q1/6832 , C12Q1/6837 , C12Q1/6874 , G01N21/253 , G01N21/6454 , G01N27/221 , G01N27/226 , G01N33/54373 , B01J2219/00317 , B01J2219/00511 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B01J2219/00713 , B01J2219/00722 , B01J2219/00828 , B01J2219/00853 , C40B40/06 , C40B60/14 , Y10S436/806 , Y10S436/807
摘要: A method and apparatus are disclosed for identifying molecular structures within a sample substance using a monolithic array of test sites formed on a substrate upon which the sample substance is applied. Each test site includes probes formed therein to bond with a predetermined target molecular structure or structures. A signal is applied to the test sites and certain electrical, mechanical and/or optical properties of the test sites are detected to determine which probes have bonded to an associated target molecular structure.
摘要翻译: 公开了一种用于使用形成在其上施加样品物质的基底上的测试部位的整体阵列来鉴定样品物质内的分子结构的方法和装置。 每个测试部位包括形成在其中的探针,以与预定的靶分子结构结合。 将信号施加到测试位点,并检测测试位点的某些电,机械和/或光学性质,以确定哪些探针已经结合到相关的靶分子结构。
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公开(公告)号:US08835127B2
公开(公告)日:2014-09-16
申请号:US13267276
申请日:2011-10-06
申请人: Eric D. Schwoebel , James D. Harper , Martha S. Petrovick , Frances E. Nargi , Todd H. Rider , Kristine E. Hogan , Richard H. Mathews , Joseph Lacirignola , Mark Hennessy , Trina R. Vian , Rose M. Joseph , Raymond S. Uttaro , Shaun Berry , Bernadette Johnson , Mark A. Hollis
发明人: Eric D. Schwoebel , James D. Harper , Martha S. Petrovick , Frances E. Nargi , Todd H. Rider , Kristine E. Hogan , Richard H. Mathews , Joseph Lacirignola , Mark Hennessy , Trina R. Vian , Rose M. Joseph , Raymond S. Uttaro , Shaun Berry , Bernadette Johnson , Mark A. Hollis
CPC分类号: G01N33/5304 , C12M1/3461 , C12M1/3476 , C12Q1/6825 , G01N21/6428 , G01N21/6454 , G01N33/582 , C12Q2565/619 , C12Q2563/131
摘要: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.
摘要翻译: 本文描述的本发明提供了用于检测可溶性抗原的方法。 特别地,该方法提供了可溶性蛋白质和化学物质的检测。 此外,本发明提供了检测样品中核酸序列的方法。 还描述了包含Fc受体和发射体分子的发射体细胞,用于检测样品中的靶颗粒,其中待检测的靶颗粒被一种或多种抗体结合。 还提供了一种用于检测多个样品中的目标颗粒的光电传感器装置。
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公开(公告)号:US20080166705A1
公开(公告)日:2008-07-10
申请号:US11001583
申请日:2004-12-01
申请人: Eric D. Schwoebel , James D. Harper , Martha S. Petrovick , Frances E. Nargi , Todd H. Rider , Kristine E. Hogan , Richard H. Mathews , Joseph Lacirignola , Mark Hennessy , Trina R. Vian , Rose M. Joseph , Raymond S. Uttaro , Shaun Berry , Bernadette Johnson , Mark A. Hollis
发明人: Eric D. Schwoebel , James D. Harper , Martha S. Petrovick , Frances E. Nargi , Todd H. Rider , Kristine E. Hogan , Richard H. Mathews , Joseph Lacirignola , Mark Hennessy , Trina R. Vian , Rose M. Joseph , Raymond S. Uttaro , Shaun Berry , Bernadette Johnson , Mark A. Hollis
CPC分类号: G01N33/5304 , C12M1/3461 , C12M1/3476 , C12Q1/6825 , G01N21/6428 , G01N21/6454 , G01N33/582 , C12Q2565/619 , C12Q2563/131
摘要: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.
摘要翻译: 本文描述的本发明提供了用于检测可溶性抗原的方法。 特别地,该方法提供了可溶性蛋白质和化学物质的检测。 此外,本发明提供了检测样品中核酸序列的方法。 还描述了包含Fc受体和发射体分子的发射体细胞,用于检测样品中的靶颗粒,其中待检测的靶颗粒被一种或多种抗体结合。 还提供了一种用于检测多个样品中的目标颗粒的光电传感器装置。
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