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    Methods and Apparatus to Increase Secretion of Endogenous Naturetic Hormones
    2.
    发明申请
    Methods and Apparatus to Increase Secretion of Endogenous Naturetic Hormones 有权
    增加内源性自然激素分泌的方法和装置

    公开(公告)号：US20120215272A1

    公开(公告)日：2012-08-23

    申请号：US13426068

    申请日：2012-03-21

    申请人： Howard Levin ,  Mark Gelfand

    发明人： Howard Levin ,  Mark Gelfand

    IPC分类号： A61N1/362

    CPC分类号： A61M25/10181 ,  A61M25/10 ,  A61M25/1018 ,  A61M29/00 ,  A61M2025/102 ,  A61N1/36117 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/37235

    摘要： A method and apparatus for treatment of heart failure by increasing secretion of endogenous naturetic hormones ANP and BNP such as by stimulation of the heart atria. Heart pacing is done at an atrial contraction rate that is increased and can be higher than the ventricular contraction rate. Pacing may include mechanical distension of the right atrial appendage. An implantable device is used to periodically cyclically stretch the walls of the appendage with an implanted balloon.

    摘要翻译： 通过增加内源性激素ANP和BNP的分泌来治疗心力衰竭的方法和装置，例如通过刺激心脏心房。 心脏起搏是以增加的心房收缩速率完成的，可以高于心室收缩率。 起搏可能包括右心耳的机械扩张。 使用可植入装置周期性地用植入的气球循环地拉伸附肢的壁。

    METHODS AND APPARATUS TO STIMULATE HEART ATRIA
    3.
    发明申请
    METHODS AND APPARATUS TO STIMULATE HEART ATRIA 有权
    刺激心脏病的方法和装置

    公开(公告)号：US20110172731A1

    公开(公告)日：2011-07-14

    申请号：US12987498

    申请日：2011-01-10

    申请人： Howard Levin ,  Mark Gelfand

    发明人： Howard Levin ,  Mark Gelfand

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3627 ,  A61B5/0452 ,  A61N1/3624 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/37235

    摘要： A method and apparatus for treatment of hypertension and heart failure by increasing vagal tone and secretion of endogenous atrial hormones by excitory pacing of the heart atria. Atrial pacing is done during the ventricular refractory period resulting in atrial contraction against closed AV valves, and atrial contraction rate that is higher than the ventricular contraction rate. Pacing results in the increased atrial wall stress. An implantable device is used to monitor ECG and pace the atria in a nonphysiologic manner.

    摘要翻译： 一种通过增加迷走神经张力和通过心脏心房的兴奋性起搏分泌内源性心房激素来治疗高血压和心力衰竭的方法和装置。 心房起搏在心室不应期内完成，导致闭合性AV瓣膜的心房收缩，心房收缩率高于心室收缩率。 起搏导致心房壁压力增加。 可植入装置用于监测心电图并以非生理学方式对心房进行加速。

    METHOD AND APPARATUS FOR PERIPHERAL VEIN FLUID REMOVAL IN HEART FAILURE
    4.
    发明申请
    METHOD AND APPARATUS FOR PERIPHERAL VEIN FLUID REMOVAL IN HEART FAILURE 有权
    心脏缺血中外周血液去除的方法和装置

    公开(公告)号：US20080097273A1

    公开(公告)日：2008-04-24

    申请号：US11960145

    申请日：2007-12-19

    申请人： Howard Levin ,  Mark Gelfand ,  John O'Mahony ,  Hans-Dietrich Polaschegg

    发明人： Howard Levin ,  Mark Gelfand ,  John O'Mahony ,  Hans-Dietrich Polaschegg

    IPC分类号： A61M1/34 ,  A61M1/10

    CPC分类号： A61M1/341 ,  A61M1/1692 ,  A61M1/34 ,  A61M1/361 ,  A61M1/3612 ,  A61M2205/3393 ,  A61M2205/50 ,  A61M2205/7563

    摘要： A fluid removal apparatus comprising a blood removal catheter for insertion into a peripheral vein or artery and having a size 16 standard gage needle or less; a filter having a blood inlet port coupled to the blood removal catheter, a blood outlet port, an excess fluid removal port, and a blood flow passage with porous membrane which passes fluids to the fluid removal port and retains solutes of 60,000 Daltons or greater, and a blood return catheter for inserting into a peripheral vein or artery and having a size of 16 standard gage needle or less.

    摘要翻译： 一种流体去除装置，包括用于插入到外周静脉或动脉中并具有尺寸16标准规格针或更小的止血导管; 过滤器，其具有联接到除血导管的血液入口端口，血液出口端口，多余的流体移除端口以及具有多孔膜的血流通道，其将流体传递到流体移除端口并保持60,000道尔顿或更大的溶质， 以及用于插入外周静脉或动脉并具有16个标准规格针或更小尺寸的血液回流导管。

    Biodegradable pericardia constraint system and method
    5.
    发明申请
    Biodegradable pericardia constraint system and method 审中-公开
    可生物降解的心包约束系统及方法

    公开(公告)号：US20060135912A1

    公开(公告)日：2006-06-22

    申请号：US11282694

    申请日：2005-11-21

    申请人： Ary Chernomorsky ,  Mark Gelfand ,  Howard Levin

    发明人： Ary Chernomorsky ,  Mark Gelfand ,  Howard Levin

    IPC分类号： A61M1/00

    CPC分类号： A61M25/0084 ,  A61B17/00491 ,  A61B2017/00247 ,  A61B2018/00392

    摘要： A system has been developed for injecting a biodegradable pericardial constraint including: a biodegradable viscoelastic substance (BES); an external injection container for the BES; a cannula having a distal section adapted to be inserted into a pericardial sac of a mammalian heart and a proximal section connectable to the external injection container; wherein BES from the injection container is injected into the pericardial sac through the cannula.

    摘要翻译： 已经开发了用于注射可生物降解的心包约束的系统，包括：生物可降解粘弹性物质（BES）; 用于BES的外部注射容器; 套管，其具有适于插入哺乳动物心脏的心包囊中的远端部分和可连接到外部注射容器的近端部分; 其中来自注射容器的BES通过套管被注射到心包囊中。

    Kidney protection method
    6.
    发明申请
    Kidney protection method 审中-公开
    肾脏保护方法

    公开(公告)号：US20120259309A1

    公开(公告)日：2012-10-11

    申请号：US13507234

    申请日：2012-06-14

    申请人： Mark Gelfand ,  Howard Levin

    发明人： Mark Gelfand ,  Howard Levin

    IPC分类号： A61M5/142 ,  A61M5/14

    CPC分类号： A61M5/142 ,  A61B5/201 ,  A61B5/208 ,  A61B5/4839 ,  A61M5/007 ,  A61M5/16895 ,  A61M5/1723 ,  A61M5/365 ,  A61M2205/18 ,  A61M2205/3355 ,  A61M2205/3393 ,  G01G17/04

    摘要： A method of driving a toxin through a patient's kidneys, the method includes administering a diuretic to the patient to induce increased urine flow and collecting urine expelled by the patient. The amount of urine expelled by the patient is determined based on the collected urine. The patient is infused with fluid from a fluid source. Diuresis is induced by automatically adjusting the amount of fluid infused into the patient from the fluid source based on the determined amount of urine expelled by the patient to at least balance the amount of urine expelled by the patient with the amount of fluid infused into the patient to drive the toxin out of the patient's kidneys.

    摘要翻译： 一种通过患者的肾脏驱动毒素的方法，所述方法包括向患者施用利尿剂以诱导增加的尿流量并收集患者排出的尿液。 基于收集的尿确定患者排出的尿量。 患者从流体源注入流体。 基于由患者排出的尿液的确定量至少平衡患者排出的尿量与注入患者的液体量而自动调节从流体源输入到患者体内的液体的量引起的利尿 将毒素从病人的肾脏驱赶出去。

    Goal-directed fluid therapy
    7.
    发明申请
    Goal-directed fluid therapy 审中-公开
    目标导向流体治疗

    公开(公告)号：US20120259308A1

    公开(公告)日：2012-10-11

    申请号：US13507233

    申请日：2012-06-14

    申请人： Mark Gelfand ,  Howard Levin

    发明人： Mark Gelfand ,  Howard Levin

    IPC分类号： A61M5/142 ,  A61M5/14

    CPC分类号： A61M5/142 ,  A61B5/201 ,  A61B5/208 ,  A61B5/4839 ,  A61M5/007 ,  A61M5/16895 ,  A61M5/1723 ,  A61M5/365 ,  A61M2205/18 ,  A61M2205/3355 ,  A61M2205/3393 ,  G01G17/04

    摘要： A method includes setting a hydration goal and administering a diuretic to the patient to induce increased urine flow and collecting urine expelled by the patient. The amount of urine expelled by the patient is determined based on the collected urine. The patient is infused with fluid from a fluid source. The amount of fluid infused into the patient is determined. Diuresis is induced by automatically and continuously adjusting the amount of fluid infused into the patient from the fluid source to meet the hydration goal based on the set hydration goal, the determined amount of urine expelled by the patient and the fluid infused.

    摘要翻译： 一种方法包括设定水化目标并向患者施用利尿剂以诱导增加的尿液流动并收集由患者排出的尿液。 基于收集的尿确定患者排出的尿量。 患者从流体源注入流体。 确定输入患者体内的液体量。 通过基于设定的水化目标，由患者排出的尿液和输注的液体自动和连续地调节从流体源输入到患者体内的液体量以达到水化目标而诱发利尿。

    STIMULATION OF CORONARY ARTERY BARORECEPTORS
    9.
    发明申请
    STIMULATION OF CORONARY ARTERY BARORECEPTORS 审中-公开
    冠状动脉旁路器刺激

    公开(公告)号：US20080132966A1

    公开(公告)日：2008-06-05

    申请号：US11950911

    申请日：2007-12-05

    申请人： Howard Levin ,  Mark Gelfand

    发明人： Howard Levin ,  Mark Gelfand

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36117

    摘要： A method and apparatus for treatment of hypertension by electric stimulation of coronary artery baroreceptors wherein stimulation electrodes are implanted in the left coronary artery, periarterialy or in an adjacent coronary vein. Stimulation is non excitatory and does not cause heart contractions. Stimulation can be applied during the ventricular refractory period resulting in baroreceptor activation and subsequent reduction of blood pressure. An implantable device monitors ECG and applies to a field of stimulation of baroreceptors.

    摘要翻译： 一种用于通过电刺激冠状动脉压力感受器治疗高血压的方法和装置，其中将刺激电极植入左冠状动脉，横动脉周围或相邻冠状静脉。 刺激是非兴奋性的，不会引起心脏收缩。 刺激可以在心室不应期中施用，导致压力感受器激活和随后的血压降低。 可植入装置监测ECG并适用于压力感受器的刺激领域。

    SYSTEM AND METHOD FOR TREATMENT OF HEADACHES
    10.
    发明申请
    SYSTEM AND METHOD FOR TREATMENT OF HEADACHES 审中-公开
    用于治疗头部的系统和方法

    公开(公告)号：US20080027505A1

    公开(公告)日：2008-01-31

    申请号：US11828731

    申请日：2007-07-26

    申请人： Howard Levin ,  Mark Gelfand

    发明人： Howard Levin ,  Mark Gelfand

    IPC分类号： A61N1/34

    CPC分类号： A61N1/36071

    摘要： A method and apparatus for treatment of cervicogenic headaches by transvascular application of stimulation energy to nerves in the neck and head. A catheter equipped with electrodes is inserted into a vertebral or occipital vein in proximity to peripheral nerves that conduct pain signals. An external to the body or implanted generator is used to apply stimulation energy to the targeted nerves.

    摘要翻译： 一种治疗颈部头痛的方法和装置，其通过对颈部和头部的神经的刺激能量进行血管内应用。 配备有电极的导管插入到导致疼痛信号的周围神经附近的椎骨或枕叶静脉中。 使用身体或植入式发生器外部将刺激能量施加到目标神经。