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    Methods and systems for in situ tissue marking and orientation stabilization
    1.
    发明申请
    Methods and systems for in situ tissue marking and orientation stabilization 审中-公开
    用于原位组织标记和取向稳定的方法和系统

    公开(公告)号：US20070198010A1

    公开(公告)日：2007-08-23

    申请号：US11737382

    申请日：2007-04-19

    申请人： Roberta LEE ,  James Vetter ,  Ary Chernomorsky

    发明人： Roberta LEE ,  James Vetter ,  Ary Chernomorsky

    IPC分类号： A61B18/00 ,  A61B10/00

    CPC分类号： A61B10/0266 ,  A61B18/148 ,  A61B2018/00333 ,  A61B2018/00601 ,  A61B2018/141 ,  A61B2018/1475 ,  A61B2090/3908 ,  A61B2090/3937 ,  A61B2090/395

    摘要： A method of marking an orientation of a cut specimen of tissue prior to excision thereof from a body includes steps of disposing a tissue-marking probe in the body adjacent the cut specimen, the tissue-marking probe including a tissue-marking tool configured to selectively mark the cut specimen. A surface of the cut specimen is then marked with the tissue-marking tool such that the orientation of the cut specimen within the body is discernable after the cut specimen is excised from the body. The tissue-marking tool may be configured to selectively bow out of and back into a window defined near a distal tip of the probe and the marking step may include a step of selectively bowing the tissue-marking tool out of the window and following the surface of the cut specimen while rotating the probe. The tissue-marking tool may include an RF cutting tool and the marking step may include a step of coagulating or cauterizing a selected portion of the surface of the cut specimen with the RF cutting tool. Alternatively, the marking step may include a step of delivering dye onto selected portions of the surface of the cut specimen.

    摘要翻译： 在从身体切除之前标记组织切割样本的取向的方法包括以下步骤：将组织标记探针设置在与切割的样本相邻的身体中，组织标记探针包括组织标记工具，其被配置为选择性地 标记切割标本。 然后用组织标记工具标记切割的样品的表面，使得在切割的样品从身体切除之后，切割的样品在体内的取向是可辨别的。 组织标记工具可以被配置为选择性地弯曲到限定在探针的远侧末端附近的窗口中，并且标记步骤可以包括将组织标记工具选择性地弯曲出窗户并且跟随表面的步骤 同时旋转探头。 组织标记工具可以包括RF切割工具，并且标记步骤可以包括用RF切割工具凝固或烧灼切割样品表面的选定部分的步骤。 或者，标记步骤可以包括将染料递送到切割样品的表面的选定部分上的步骤。

    Post-biopsy cavity treatmetn implants and methods
    2.
    发明申请
    Post-biopsy cavity treatmetn implants and methods 审中-公开
    活检后治疗植入物和方法

    公开(公告)号：US20050020899A1

    公开(公告)日：2005-01-27

    申请号：US10627960

    申请日：2003-07-25

    申请人： Ary Chernomorsky ,  James Vetter ,  Simon Chernomorsky

    发明人： Ary Chernomorsky ,  James Vetter ,  Simon Chernomorsky

    IPC分类号： A61B19/00 ,  A61K49/04 ,  A61B5/05

    CPC分类号： A61M31/005 ,  A61B17/0057 ,  A61B90/39 ,  A61B2017/00654 ,  A61B2090/3908 ,  A61B2090/3987 ,  A61K49/04 ,  A61L31/146 ,  A61L31/18

    摘要： An embodiment of a post-biopsy cavity treatment implant includes a first portion including a first porous matrix defining a first controlled pore architecture or crosslinking density, and a second portion coupled to the first portion. The second portion includes a second porous matrix that defines a second controlled pore architecture or a second crosslinking density that is different from the first controlled pore architecture or the first crosslinking density, causing the second portion to swell in a different manner than the first portion when the implant is placed in an aqueous environment.

    摘要翻译： 活检后腔腔治疗植入物的实施方案包括第一部分，其包括限定第一受控孔结构或交联密度的第一多孔基质，以及耦合到第一部分的第二部分。 第二部分包括限定第二受控孔结构的第二多孔基质或不同于第一受控孔结构或第一交联密度的第二交联密度，导致第二部分以与第一部分不同的方式膨胀， 将植入物置于含水环境中。

    DRUG DELIVERY SYSTEMS
    4.
    发明申请
    DRUG DELIVERY SYSTEMS 审中-公开
    药物递送系统

    公开(公告)号：US20100185146A1

    公开(公告)日：2010-07-22

    申请号：US12580162

    申请日：2009-10-15

    申请人： Kamal RAMZIPOOR ,  Ary CHERNOMORSKY

    发明人： Kamal RAMZIPOOR ,  Ary CHERNOMORSKY

    IPC分类号： A61M25/10

    CPC分类号： A61M25/10 ,  A61M2025/105

    摘要： Drug delivery systems which are configured to retain and then distribute one or more drugs upon an actuating surface and/or balloon for delivery to a tissue region are described herein. The drug delivery system may comprise in one variation a volume of one or more drugs held in a reservoir, e.g., a silo, which may be located proximally of the expandable actuating surface and/or balloon. The one or more drugs may be separated from one another by valves or immiscible fluid barriers for distribution upon the surface, which may be varied in pore distribution, have a coating or covering for facilitating drug distribution, etc.

    摘要翻译： 这里描述了被配置为保持并随后将一种或多种药物分配在致动表面和/或球囊上以递送至组织区域的药物递送系统。 药物递送系统可以在一个变体中包括一个或多个药物的体积，其保持在储存器例如筒仓中，储存器可位于可膨胀致动表面和/或气囊的近侧。 一种或多种药物可以通过阀或不混溶的流体屏障彼此分离，用于分布在表面上，其可以在孔分布中变化，具有用于促进药物分布的涂层或覆盖物等。

    POST-BIOPSY CAVITY TREATMENT IMPLANTS AND METHODS
    5.
    发明申请
    POST-BIOPSY CAVITY TREATMENT IMPLANTS AND METHODS 审中-公开
    后生物处理植入物和方法

    公开(公告)号：US20090149746A1

    公开(公告)日：2009-06-11

    申请号：US12273754

    申请日：2008-11-19

    申请人： Ary CHERNOMORSKY ,  John Soo Hoo ,  James W. Vetter

    发明人： Ary CHERNOMORSKY ,  John Soo Hoo ,  James W. Vetter

    IPC分类号： A61M25/00 ,  A61B6/00

    CPC分类号： A61B90/39 ,  A61B2017/00004 ,  A61B2017/00495 ,  A61B2090/3908 ,  A61B2090/3987

    摘要： A method of forming a soft tissue biopsy cavity marker may include steps of providing a radio-opaque element and a bio-compatible and bio-degradable polymer such as alginate and delivering the provided radio-opaque element and the provided polymer to a biopsy site, such as a breast biopsy site. A gelling initiator that includes divalent cations such as NaCl2 may then be provided and delivered to the biopsy site, causing the previously delivered polymer to gel and to form a soft tissue biopsy marker in situ (within the biopsy site).

    摘要翻译： 形成软组织活检腔标记物的方法可以包括提供不透辐射元件和生物相容性和生物可降解聚合物如藻酸盐的步骤，并将提供的不透射线的元件和所提供的聚合物递送到活检部位， 如乳房活检部位。 然后可以提供包括二价阳离子如NaCl2的胶凝引发剂，并将其递送至活检部位，使先前递送的聚合物凝胶化并在原位（活检部位内）形成软组织活检标记物。

    Post-biopsy cavity treatment implants and methods
    7.
    发明申请
    Post-biopsy cavity treatment implants and methods 失效
    活检后腔内治疗植入物和方法

    公开(公告)号：US20080114329A1

    公开(公告)日：2008-05-15

    申请号：US12018170

    申请日：2008-01-22

    申请人： Ary CHERNOMORSKY ,  James Vetter ,  Simon Chernomorsky

    发明人： Ary CHERNOMORSKY ,  James Vetter ,  Simon Chernomorsky

    IPC分类号： A61M31/00

    CPC分类号： A61L31/146 ,  A61B17/0057 ,  A61B90/39 ,  A61B2017/00654 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3987 ,  A61K49/04 ,  A61L31/18

    摘要： A method of treating a cavity created by a percutaneous excisional procedure carried out through an incision includes steps of providing a post-procedure cavity implant, the post-procedure cavity implant including: a radiopaque element; a core portion coupled to the radiopaque element, the core portion including a first porous matrix defining a first controlled pore architecture, and a shell portion coupled to the core portion, the shell portion including a second porous matrix defining a second controlled pore architecture that is different from the first controlled pore architecture; implanting the post-procedure cavity implant into the cavity, and closing the incision.

    摘要翻译： 一种治疗由通过切口进行的经皮切除手术产生的腔的方法包括提供后程腔腔植入物的步骤，所述后程腔腔植入物包括：不透射线的元件; 芯部分，其连接到所述不透射线元件，所述芯部分包括限定第一受控孔结构的第一多孔基体和耦合到所述芯部分的壳部分，所述壳部分包括限定第二受控孔结构的第二多孔基体， 不同于第一受控孔结构; 将后程腔腔植入物植入腔中，并闭合切口。

    Methods and devices for cutting and collecting soft tissue
    8.
    发明申请
    Methods and devices for cutting and collecting soft tissue 失效
    切割和收集软组织的方法和装置

    公开(公告)号：US20070203513A1

    公开(公告)日：2007-08-30

    申请号：US11742391

    申请日：2007-04-30

    申请人： James VETTER ,  Ary Chernomorsky ,  Mark Clifford ,  Dan Brounstein ,  Scott Anderson

    发明人： James VETTER ,  Ary Chernomorsky ,  Mark Clifford ,  Dan Brounstein ,  Scott Anderson

    IPC分类号： A61B17/32

    CPC分类号： A61B10/0266 ,  A61B2017/00287 ,  A61B2017/008 ,  A61B2018/1407

    摘要： A method of cutting breast tissue for removal may include a step of providing a tissue cutting device having an elongate cutting element, the cutting element being movable between a bowed position and a retracted position, the cutting element having a radially outer side and a radially inner side. The tissue cutting device may be introduced into a breast and the elongate cutting element may be moved to the bowed position. A power source may be coupled to the elongate cutting element; and the cutting element may be rotated after the moving step so that the cutting element cuts the breast tissue. The radially outer side of the cutting element may have a larger surface area for transmitting energy to cut the tissue than the radially inner side.

    摘要翻译： 切割乳房组织以便去除的方法可以包括提供具有细长切割元件的组织切割装置的步骤，所述切割元件可在弓形位置和缩回位置之间移动，所述切割元件具有径向外侧和径向内部 侧。 组织切割装置可以被引入到乳房中，并且细长切割元件可以移动到弓形位置。 电源可以耦合到细长切割元件; 并且切割元件可以在移动步骤之后旋转，使得切割元件切割乳房组织。 切割元件的径向外侧可以具有比径向内侧更大的用于传递切割组织的能量的表面积。

    Biodegradable pericardia constraint system and method
    9.
    发明申请
    Biodegradable pericardia constraint system and method 审中-公开
    可生物降解的心包约束系统及方法

    公开(公告)号：US20060135912A1

    公开(公告)日：2006-06-22

    申请号：US11282694

    申请日：2005-11-21

    申请人： Ary Chernomorsky ,  Mark Gelfand ,  Howard Levin

    发明人： Ary Chernomorsky ,  Mark Gelfand ,  Howard Levin

    IPC分类号： A61M1/00

    CPC分类号： A61M25/0084 ,  A61B17/00491 ,  A61B2017/00247 ,  A61B2018/00392

    摘要： A system has been developed for injecting a biodegradable pericardial constraint including: a biodegradable viscoelastic substance (BES); an external injection container for the BES; a cannula having a distal section adapted to be inserted into a pericardial sac of a mammalian heart and a proximal section connectable to the external injection container; wherein BES from the injection container is injected into the pericardial sac through the cannula.

    摘要翻译： 已经开发了用于注射可生物降解的心包约束的系统，包括：生物可降解粘弹性物质（BES）; 用于BES的外部注射容器; 套管，其具有适于插入哺乳动物心脏的心包囊中的远端部分和可连接到外部注射容器的近端部分; 其中来自注射容器的BES通过套管被注射到心包囊中。