-
公开(公告)号：US20110124560A1
公开(公告)日：2011-05-26
申请号：US12663635
申请日：2008-06-06
Applicant: Mark I. Greene , Bin Li
Inventor： Mark I. Greene , Bin Li
CPC classification number: G01N33/6872 , G01N2500/00
Abstract: Methods of identifying immune response modulators are disclosed. Some methods comprise identifying chemical candidates that modulate oligomerization of FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Some methods comprise identifying chemical candidates that modulate the hetero-oligomerization of FOXP1 with FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Some methods comprise identifying chemical candidates that modulate interaction of IL-2 promoter with FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Method of treating individuals who have or are suspected of having autoimmune disease, inflammatory disease, cell, tissue or organ transplantation, or coronary artery disease, and methods of treating individuals who have or are suspected of having infectious disease, cancer, or who are immunocompromised or undergoing vaccination are disclosed.
Abstract translation: 公开了鉴定免疫应答调节剂的方法。 一些方法包括鉴定调节FOXP3和/或其包含Z-LeuZip结构域的片段的寡聚化的化学候选物。 一些方法包括鉴定用FOXP3调节FOXP1的异源寡聚化的化学候选物和/或其包含Z-LeuZip结构域的片段。 一些方法包括鉴定调节IL-2启动子与FOXP3和/或其包含Zinc-LeuZip结构域的片段的相互作用的化学候选物。 治疗患有或怀疑患有自身免疫性疾病，炎症性疾病，细胞，组织或器官移植或冠状动脉疾病的个体的方法，以及治疗患有或怀疑患有感染性疾病，癌症或免疫受损的个体的方法 或接受疫苗接种。
-
公开(公告)号：US08846308B2
公开(公告)日：2014-09-30
申请号：US12663635
申请日：2008-06-06
Applicant: Mark I. Greene , Bin Li
Inventor： Mark I. Greene , Bin Li
CPC classification number: G01N33/6872 , G01N2500/00
Abstract: Methods of identifying immune response modulators are disclosed. Some methods comprise identifying chemical candidates that modulate oligomerization of FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Some methods comprise identifying chemical candidates that modulate the hetero-oligomerization of FOXP1 with FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Some methods comprise identifying chemical candidates that modulate interaction of IL-2 promoter with FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Method of treating individuals who have or are suspected of having autoimmune disease, inflammatory disease, cell, tissue or organ transplantation, or coronary artery disease, and methods of treating individuals who have or are suspected of having infectious disease, cancer, or who are immunocompromised or undergoing vaccination are disclosed.
Abstract translation: 公开了鉴定免疫应答调节剂的方法。 一些方法包括鉴定调节FOXP3和/或其包含Z-LeuZip结构域的片段的寡聚化的化学候选物。 一些方法包括鉴定用FOXP3调节FOXP1的异源寡聚化的化学候选物和/或其包含Z-LeuZip结构域的片段。 一些方法包括鉴定调节IL-2启动子与FOXP3和/或其包含Zinc-LeuZip结构域的片段的相互作用的化学候选物。 治疗患有或怀疑患有自身免疫疾病，炎性疾病，细胞，组织或器官移植或冠状动脉疾病的个体的方法，以及治疗患有或怀疑患有感染性疾病，癌症或免疫受损的个体的方法 或接受疫苗接种。
-
3.发明授权Method for detecting molecules expressing a selected epitope via fluorescent dyes 有权通过荧光染料检测表达选定表位的分子的方法公开(公告)号：US07524628B2
公开(公告)日：2009-04-28
申请号：US09977716
申请日：2001-10-15
Applicant: Mark I. Greene , Hong Tao Zhang , Bin Li , Qindu Liu , Ramchandran Murali
Inventor： Mark I. Greene , Hong Tao Zhang , Bin Li , Qindu Liu , Ramchandran Murali
CPC classification number: C07K5/1013 , C07K5/1019 , C07K7/06 , C07K16/32 , C07K2319/32 , G01N33/532 , G01N33/58 , G01N33/6857 , G01N33/6878 , G01N2500/04
Abstract: Methods, systems and kits are provided for detecting molecules expressing a selected epitope in a sample through use of an epitope detector containing a single chain Fv for the selected epitope or a constrained epitope specific CDR, CDR mimetic or engineered CDR structure attached to an oligonucleotide.
Abstract translation: 提供方法，系统和试剂盒，用于通过使用含有选定表位的单链Fv或与寡核苷酸连接的约束表位特异性CDR，CDR模拟或工程化CDR结构的表位检测器来检测在样品中表达选定表位的分子。
-
4.发明申请Methods For Immuno-Detection Of Epitopes On Molecules And For Detection Of Interactions Of Molecules Via Fluorescent Dyes 审中-公开免疫检测分子表位的方法和通过荧光染料检测分子的相互作用公开(公告)号：US20090227468A1
公开(公告)日：2009-09-10
申请号：US12409857
申请日：2009-03-24
Applicant: Mark I. Greene , Hong Tao Zhang , Bin Li , Qindu Liu , Ramchandran Murali
Inventor： Mark I. Greene , Hong Tao Zhang , Bin Li , Qindu Liu , Ramchandran Murali
CPC classification number: C07K5/1013 , C07K5/1019 , C07K7/06 , C07K16/32 , C07K2319/32 , G01N33/532 , G01N33/58 , G01N33/6857 , G01N33/6878 , G01N2500/04
Abstract: Methods, systems and kits are provided for detecting molecules expressing a selected epitope in a sample through use of an epitope detector containing a single chain Fv for the selected epitope or a constrained epitope specific CDR, CDR mimetic or engineered CDR structure attached to an oligonucleotide.
Abstract translation: 提供了方法，系统和试剂盒，用于通过使用含有选定表位的单链Fv或与寡核苷酸连接的约束表位特异性CDR，CDR模拟或工程化CDR结构的表位检测器来检测在样品中表达选定表位的分子。
-
公开(公告)号：USD1026346S1
公开(公告)日：2024-05-07
申请号：US29863779
申请日：2022-12-22
Applicant: Bin Li
Designer： Bin Li
Abstract: FIG. 1 is a front, right and top perspective view of a pet feeder, showing my new design;
FIG. 2 is a rear, left and bottom perspective view thereof;
FIG. 3 is a front view thereof;
FIG. 4 is a rear view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a right side view thereof;
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.-
Patent Agency Ranking
公开(公告)号：US20220326999A1
公开(公告)日：2022-10-13
申请号：US17853564
申请日：2022-06-29
Applicant: Drew Penney , Bin Li , Tsung-Yuan Tai , Anna Drewek-Ossowicka , Rameshkumar Illikkal , Andrew J. Herdrich , Jaroslaw Sydir
Inventor： Drew Penney , Bin Li , Tsung-Yuan Tai , Anna Drewek-Ossowicka , Rameshkumar Illikkal , Andrew J. Herdrich , Jaroslaw Sydir
IPC: G06F9/50
Abstract: Apparatuses, methods, and systems for dynamic resource allocation based on quality-of-service prediction are disclosed. In embodiments, an apparatus includes quality-of-service prediction circuitry and a resource controller. The quality-of-service prediction circuitry is to make quality-of-service predictions using a model based at least in part on at least one performance counter measurements and at least one quality-of-service measurement. The resource controller is to allocate one or more shared resources based on the quality-of-service predictions and architectural performance counter measurements.
-
公开(公告)号：US20220125226A1
公开(公告)日：2022-04-28
申请号：US17083218
申请日：2020-10-28
Applicant: Bin Li
Inventor： Bin Li
Abstract: This utility model released one kind of multifunctional flexibly transformable cup, comprising one internally cut-through transformable cup and a nested bottom plug that is sealed and clamped with the transformable cup body. The above-mentioned transformable cup is comprised of a foldable enclosure and pin that are successively cut-through and flexibly and tightly connected. The aforesaid seal clamp for embedded bottom plug is located at the junction between the foldable enclosure and pin. When the multifunctional flexibly transformable cup of the utility model is in use, the folding enclosure body can be overturned freely, and the whole body is made of food-grade flexible silica gel material, which is safe and reliable and not easy to be broken. It can also be used as the wine cup, bottle stopper and the bottleneck inserted into the wine bottle that can be directly used for drainage of fluid, with complete functions.
-
公开(公告)号：US10924743B2
公开(公告)日：2021-02-16
申请号：US15549261
申请日：2015-02-06
Applicant: Microsoft Technology Licensing, LLC , Bin Li , Jizheng Xu
Inventor： Bin Li , Jizheng Xu
IPC: H04N19/132 , H04N19/119 , H04N19/52 , H04N19/172 , H04N19/147 , H04N19/127 , H04N19/176 , H04N19/61 , H04N19/70
Abstract: Various innovations in media encoding are presented herein. In particular, the innovations can reduce the computational complexity of encoding by selectively skipping certain evaluation stages during encoding. For example, based on analysis of decisions made earlier in encoding or based on analysis of media to be encoded, an encoder can selectively skip evaluation of certain coding tools (such as residual coding or rate-distortion-optimized quantization), skip evaluation of certain values for parameters or settings (such as candidate unit sizes or transform sizes, or candidate partition patterns for motion compensation), and/or skip evaluation of certain coding modes (such as frequency transform skip mode) that are not expected to improve rate-distortion performance during encoding.
-
公开(公告)号：US20180302640A1
公开(公告)日：2018-10-18
申请号：US15767992
申请日：2015-11-06
Applicant: Bin LI , Jizheng XU , Microsoft Technology Licensing, LLC
Inventor： Bin Li , Jizheng Xu
IPC: H04N19/513 , H04N19/58 , H04N19/105 , H04N19/117 , H04N19/142 , H04N19/146 , H04N19/17 , H04N19/179 , H04N19/46 , H04N19/82
Abstract: Innovations in flexible reference picture management are described. For example, a video encoder and video decoder use a global reference picture set (“GRPS”) of reference pictures that remain in memory, and hence are available for use in video encoding/decoding, longer than conventional reference pictures. In particular, reference pictures of the GRPS remain available across random access boundaries. Or, as another example, a video encoder and video decoder clip a reference picture so that useful regions of the reference picture are retained in memory, while unhelpful or redundant regions of the reference picture are discarded. Reference picture clipping can reduce the amount of memory needed to store reference pictures or improve the utilization of available memory by providing better options for motion compensation. Or, as still another example, a video encoder and video decoder filter a reference picture to remove random noise (e.g., capture noise due to camera imperfections during capture).
-
公开(公告)号：US09540637B2
公开(公告)日：2017-01-10
申请号：US13877203
申请日：2011-09-29
Applicant: Bin Li , Zhoutao Chen , Tanya Biorac , Melvin Shiwade Wei
Inventor： Bin Li , Zhoutao Chen , Tanya Biorac , Melvin Shiwade Wei
CPC classification number: C12Q1/6876 , C12N9/1252 , C12N9/20 , C12N15/1093 , C12N15/64 , C12Q1/6806 , C12Q1/6832 , C12Y207/07007 , C12Y301/01003 , C12Q2521/131 , C12Q2525/191 , C12Q2527/107 , C12Q2537/163 , C12Q2563/179
Abstract: Provided herein are compositions, systems, methods, and kits for joining together the ends of one or more polynucleotides using at least one pair of blocking oligonucleotide adaptors. Blocking oligonucleotide adaptors can be used to reduce the formation of adaptor dimers or trimers (or higher-order concatemers) which can improve the yield of desirable polynucleotide-adaptor products in any recombinant nucleic acid workflow. Blocking oligonucleotide adaptors can comprise a double-stranded oligonucleotide adaptor (duplex) having an overhang cohesive portion that anneals with a blocking oligonucleotide which can be a separate single-stranded oligonucleotide. A blocking oligonucleotide, when annealed to an overhang portion, can prevent undesirable hybridization of the overhang portion to another nucleic acid, such as the overhang portion from another blocking oligonucleotide adaptor or a polynucleotide of interest.
Abstract translation: 本文提供了使用至少一对封闭寡核苷酸衔接子将一个或多个多核苷酸的末端连接在一起的组合物，系统，方法和试剂盒。 阻断寡核苷酸衔接子可用于减少适配器二聚体或三聚体（或更高级并行物）的形成，其可以改善任何重组核酸工作流程中期望的多核苷酸 - 衔接子产物的产量。 阻断寡核苷酸衔接子可以包含具有悬伸粘性部分的双链寡核苷酸衔接子（双链体），其与可以是单独的单链寡核苷酸的封闭寡核苷酸退火。 当与突出部分退火时，封闭寡核苷酸可以防止突出部分与另一种核酸（例如来自另一种封闭寡核苷酸衔接子或感兴趣的多核苷酸的突出部分）的不期望的杂交。
-
-
-
-
-
-
-
-
-
Search Results
518
records
(took 0.032 seconds)
