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1.发明申请Methods For Immuno-Detection Of Epitopes On Molecules And For Detection Of Interactions Of Molecules Via Fluorescent Dyes 审中-公开免疫检测分子表位的方法和通过荧光染料检测分子的相互作用公开(公告)号：US20090227468A1
公开(公告)日：2009-09-10
申请号：US12409857
申请日：2009-03-24
Applicant: Mark I. Greene , Hong Tao Zhang , Bin Li , Qindu Liu , Ramchandran Murali
Inventor： Mark I. Greene , Hong Tao Zhang , Bin Li , Qindu Liu , Ramchandran Murali
CPC classification number: C07K5/1013 , C07K5/1019 , C07K7/06 , C07K16/32 , C07K2319/32 , G01N33/532 , G01N33/58 , G01N33/6857 , G01N33/6878 , G01N2500/04
Abstract: Methods, systems and kits are provided for detecting molecules expressing a selected epitope in a sample through use of an epitope detector containing a single chain Fv for the selected epitope or a constrained epitope specific CDR, CDR mimetic or engineered CDR structure attached to an oligonucleotide.
Abstract translation: 提供了方法，系统和试剂盒，用于通过使用含有选定表位的单链Fv或与寡核苷酸连接的约束表位特异性CDR，CDR模拟或工程化CDR结构的表位检测器来检测在样品中表达选定表位的分子。
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公开(公告)号：US08846308B2
公开(公告)日：2014-09-30
申请号：US12663635
申请日：2008-06-06
Applicant: Mark I. Greene , Bin Li
Inventor： Mark I. Greene , Bin Li
CPC classification number: G01N33/6872 , G01N2500/00
Abstract: Methods of identifying immune response modulators are disclosed. Some methods comprise identifying chemical candidates that modulate oligomerization of FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Some methods comprise identifying chemical candidates that modulate the hetero-oligomerization of FOXP1 with FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Some methods comprise identifying chemical candidates that modulate interaction of IL-2 promoter with FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Method of treating individuals who have or are suspected of having autoimmune disease, inflammatory disease, cell, tissue or organ transplantation, or coronary artery disease, and methods of treating individuals who have or are suspected of having infectious disease, cancer, or who are immunocompromised or undergoing vaccination are disclosed.
Abstract translation: 公开了鉴定免疫应答调节剂的方法。 一些方法包括鉴定调节FOXP3和/或其包含Z-LeuZip结构域的片段的寡聚化的化学候选物。 一些方法包括鉴定用FOXP3调节FOXP1的异源寡聚化的化学候选物和/或其包含Z-LeuZip结构域的片段。 一些方法包括鉴定调节IL-2启动子与FOXP3和/或其包含Zinc-LeuZip结构域的片段的相互作用的化学候选物。 治疗患有或怀疑患有自身免疫疾病，炎性疾病，细胞，组织或器官移植或冠状动脉疾病的个体的方法，以及治疗患有或怀疑患有感染性疾病，癌症或免疫受损的个体的方法 或接受疫苗接种。
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3.发明授权Method for detecting molecules expressing a selected epitope via fluorescent dyes 有权通过荧光染料检测表达选定表位的分子的方法公开(公告)号：US07524628B2
公开(公告)日：2009-04-28
申请号：US09977716
申请日：2001-10-15
Applicant: Mark I. Greene , Hong Tao Zhang , Bin Li , Qindu Liu , Ramchandran Murali
Inventor： Mark I. Greene , Hong Tao Zhang , Bin Li , Qindu Liu , Ramchandran Murali
CPC classification number: C07K5/1013 , C07K5/1019 , C07K7/06 , C07K16/32 , C07K2319/32 , G01N33/532 , G01N33/58 , G01N33/6857 , G01N33/6878 , G01N2500/04
Abstract: Methods, systems and kits are provided for detecting molecules expressing a selected epitope in a sample through use of an epitope detector containing a single chain Fv for the selected epitope or a constrained epitope specific CDR, CDR mimetic or engineered CDR structure attached to an oligonucleotide.
Abstract translation: 提供方法，系统和试剂盒，用于通过使用含有选定表位的单链Fv或与寡核苷酸连接的约束表位特异性CDR，CDR模拟或工程化CDR结构的表位检测器来检测在样品中表达选定表位的分子。
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公开(公告)号：US20110124560A1
公开(公告)日：2011-05-26
申请号：US12663635
申请日：2008-06-06
Applicant: Mark I. Greene , Bin Li
Inventor： Mark I. Greene , Bin Li
CPC classification number: G01N33/6872 , G01N2500/00
Abstract: Methods of identifying immune response modulators are disclosed. Some methods comprise identifying chemical candidates that modulate oligomerization of FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Some methods comprise identifying chemical candidates that modulate the hetero-oligomerization of FOXP1 with FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Some methods comprise identifying chemical candidates that modulate interaction of IL-2 promoter with FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Method of treating individuals who have or are suspected of having autoimmune disease, inflammatory disease, cell, tissue or organ transplantation, or coronary artery disease, and methods of treating individuals who have or are suspected of having infectious disease, cancer, or who are immunocompromised or undergoing vaccination are disclosed.
Abstract translation: 公开了鉴定免疫应答调节剂的方法。 一些方法包括鉴定调节FOXP3和/或其包含Z-LeuZip结构域的片段的寡聚化的化学候选物。 一些方法包括鉴定用FOXP3调节FOXP1的异源寡聚化的化学候选物和/或其包含Z-LeuZip结构域的片段。 一些方法包括鉴定调节IL-2启动子与FOXP3和/或其包含Zinc-LeuZip结构域的片段的相互作用的化学候选物。 治疗患有或怀疑患有自身免疫性疾病，炎症性疾病，细胞，组织或器官移植或冠状动脉疾病的个体的方法，以及治疗患有或怀疑患有感染性疾病，癌症或免疫受损的个体的方法 或接受疫苗接种。
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5.发明授权公开(公告)号：US08993634B2
公开(公告)日：2015-03-31
申请号：US13700906
申请日：2011-05-26
Applicant: Mark I. Greene , Ramachandran Murali , Hongtao Zhang
Inventor： Mark I. Greene , Ramachandran Murali , Hongtao Zhang
IPC: A61K31/17 , A61K31/15 , A61K31/165 , A61K45/06
CPC classification number: A61K31/15 , A61K31/165 , A61K31/17 , A61K45/06 , A61K2300/00
Abstract: This application describes pharmaceutical compositions, kits, and methods for inhibiting cell proliferative disorders, especially those disorders characterized by overactivity and/or inappropriate activity of a receptor tyrosine kinase, including Her2 related cancers, and methods for imaging an Her-2 expressing tumor.
Abstract translation: 本申请描述了用于抑制细胞增殖性疾病的药物组合物，试剂盒和方法，特别是特征在于包括Her2相关癌症的受体酪氨酸激酶（包括Her2相关癌症）的过度活跃和/或不适当活性特征的那些疾病，以及用于成像Her-2表达肿瘤的方法。
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Patent Agency Ranking
公开(公告)号：US20140309246A1
公开(公告)日：2014-10-16
申请号：US14005066
申请日：2012-03-16
Applicant: Mark I. Greene , Hongtao Zhang , Alan Berezov , Zheng Cai
Inventor： Mark I. Greene , Hongtao Zhang , Alan Berezov , Zheng Cai
IPC: C07D417/12 , A61K31/517
CPC classification number: C07D417/12 , A61K31/497 , A61K31/517 , C07D239/94 , C07D285/125
Abstract: This invention is in the fields of cancer therapy. More particularly it concerns compounds which are useful agents for inhibiting cell proliferative disorders, especially those disorders characterized by over activity and/or inappropriate activity of a EGFR, including EGFR-related cancers, and methods for treating these disorders.
Abstract translation: 本发明涉及癌症治疗领域。 更具体地说，涉及用于抑制细胞增殖性疾病的有用试剂的化合物，特别是EGFR，包括EGFR相关癌症的过度活性和/或不适当活性特征的那些疾病，以及用于治疗这些疾病的方法。
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公开(公告)号：US08445644B2
公开(公告)日：2013-05-21
申请号：US12787594
申请日：2010-05-26
Applicant: Mark I. Greene , Ramachandran Murali , Hongtao Zhang , Mark Richter , Alan Berezov , Qingdu Liu , Jinqiu Chen
Inventor： Mark I. Greene , Ramachandran Murali , Hongtao Zhang , Mark Richter , Alan Berezov , Qingdu Liu , Jinqiu Chen
IPC: C07K16/00
CPC classification number: C07K14/71 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K47/48238 , A61K47/4833 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/62 , A61K47/646 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K51/10 , C07K7/06 , C07K7/08 , C07K14/7151 , C07K14/82
Abstract: Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed.
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公开(公告)号：US20120245081A1
公开(公告)日：2012-09-27
申请号：US13210117
申请日：2011-08-15
Applicant: Mark I. Greene , Ramachandran Murali , Akihiro Hasegawa
Inventor： Mark I. Greene , Ramachandran Murali , Akihiro Hasegawa
IPC: A61K38/08 , A61P31/18 , A61P27/02 , A61P1/16 , A61P13/12 , A61P29/00 , A61P37/06 , A61P19/02 , A61K38/12
CPC classification number: C07K14/70578 , A61K38/00
Abstract: Exocyclic peptide mimetics that disable Fas were developed. A three dimensional model of the Fas receptor-ligand complex was constructed and structurally predicted regions of the receptor that were relevant to binding ligand were used to create constrained peptide mimetics. Exocyclic anti-Fas peptide mimetics were identified that block Fas receptor-ligand interactions, and modulate Fas biological activity both in vitro and in vivo. The mimetics are useful, e.g., for treating Fas-related pathologies.
Abstract translation: 开发了禁用Fas的外来肽模拟物。 构建了Fas受体 - 配体复合物的三维模型，并且结构上预测与结合配体相关的受体区域用于产生约束肽模拟物。 鉴定了外环抗Fas肽模拟物阻断Fas受体 - 配体相互作用，并在体外和体内调节Fas生物活性。 模拟物可用于例如治疗Fas相关病理学。
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公开(公告)号：US20120014965A1
公开(公告)日：2012-01-19
申请号：US13080313
申请日：2011-04-05
Applicant: Mark I. Greene , Donald M. O'Rourke , Ramachandran Murali , Byeong Woo Park
Inventor： Mark I. Greene , Donald M. O'Rourke , Ramachandran Murali , Byeong Woo Park
IPC: A61K38/02 , A61K31/711 , A61P35/00 , A61K39/395
CPC classification number: C07K16/32 , A61K38/1709 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/507 , A61K2039/572 , A61N5/10 , C07K14/71 , C07K2317/24 , C07K2317/73 , A61K2300/00
Abstract: Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.
Abstract translation: 公开了治疗患有erbB蛋白介导的肿瘤的个体的方法。 公开了预防个体中erbB蛋白介导的肿瘤的方法。 所述方法包括向个体施用编码与erbB蛋白二聚化并且缺乏酪氨酸激酶活性的蛋白质的核酸分子。 公开了包含这种核酸分子（包括药物组合物）的组合物。
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10.发明申请CAVITY INDUCED ALLOSTERIC MODIFICATION OF INTERMOLECULAR INTERACTIONS AND METHODS OF IDENTIFYING COMPOUNDS THAT EFFECT THE SAME 有权腔内诱导的分子间相互作用的修饰和识别影响其的化合物的方法公开(公告)号：US20110312920A1
公开(公告)日：2011-12-22
申请号：US13194832
申请日：2011-07-29
Applicant: Ramachandran Murali , Mark I. Greene
Inventor： Ramachandran Murali , Mark I. Greene
IPC: A61K31/655 , A61K31/17 , A61P29/00 , A61P25/00 , A61P3/10 , A61P1/16 , A61P19/02 , A61P17/00 , A61P17/06 , A61P9/00 , A61P7/06 , A61P11/06 , A61K31/40 , A61P37/06
CPC classification number: A61K31/655 , A61K8/42 , A61K31/17 , A61K31/40 , G01N33/573 , G01N33/68 , G01N2500/02
Abstract: Method of identifying compounds that modulate intermolecular interactions between a target protein and a modifier are disclosed. Pharmaceutical composition comprising compounds that inhibit intermolecular interactions between a target protein and a modifier are disclosed. Methods of treating individual suffering from inflammatory conditions, undesirable immune responses, immunological conditions and bacterial infections are disclosed.
Abstract translation: 公开了鉴定调节靶蛋白和修饰剂之间的分子间相互作用的化合物的方法。 公开了包含抑制靶蛋白和修饰剂之间的分子间相互作用的化合物的药物组合物。 公开了治疗患有炎性病症，不良免疫应答，免疫学条件和细菌感染的个体的方法。
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