利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

12 条记录 (耗时 0.031 秒)

    Reaction-based selection for expression of and concentration of catalytic moieties
    1.
    发明授权
    Reaction-based selection for expression of and concentration of catalytic moieties 失效
    用于催化部分的表达和浓缩的基于反应的选择

    公开(公告)号：US06177270B1

    公开(公告)日：2001-01-23

    申请号：US09235353

    申请日：1999-01-21

    申请人： Mark T. Martin ,  Rodger G. Smith ,  Michael J. Darsley ,  David M. Simpson ,  Gary F. Blackburn

    发明人： Mark T. Martin ,  Rodger G. Smith ,  Michael J. Darsley ,  David M. Simpson ,  Gary F. Blackburn

    IPC分类号： C12N700

    CPC分类号： C40B40/02 ,  C12N15/1037 ,  C12Q1/02 ,  C12Q1/6811 ,  C12Q1/70 ,  G01N33/56983

    摘要： Disclosed and claimed are methods for selecting a recombinant virus, phage or cell expressing a catalytic antibody or catalytic portion thereof, or for selecting catalytic activity by a moiety. The method employs reaction-based selection for catalytic activity. The method can also be used to concentrate (increase the proportion of catalytic to non-catalytic moieties) a sample containing a catalytic moiety or viruses, phages or cells expressing a catalytic moiety. The selection or concentrating can be by employing a mechanism-based inhibitor, catalysis-accelerated movement, surface binding, changes in enthalpic component of binding as a function of temperature, or changes in binding by competition, or combinations thereof. The invention also comprehends a method for producing a recombinant virus or a cell-line expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof; and, this method can include infecting a suitable host with viruses which are screened for the expression. In addition, recombinant viruses and cell-lines so expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof are also disclosed and claimed.

    摘要翻译： 公开并要求的是选择重组病毒，表达催化抗体或其催化部分的噬菌体或细胞，或用于通过部分选择催化活性的方法。 该方法采用基于反应的催化活性选择。 该方法还可用于浓缩（增加非催化部分的催化剂比例）含有催化部分或表达催化部分的病毒，噬菌体或细胞的样品。 选择或浓缩可以通过采用基于机理的抑制剂，催化加速运动，表面结合，作为温度的函数的结合焓分量的变化，或通过竞争的结合变化，或其组合。 本发明还包括生产重组病毒或表达催化部分如催化抗体或其催化部分的细胞系的方法; 并且该方法可以包括用筛选表达的病毒感染合适的宿主。 此外，还公开和要求保护了重组病毒和表达催化部分如催化抗体或其催化部分的细胞系。

    Reaction-based selection for expression of and concentration of catalytic moieties
    2.
    发明授权
    Reaction-based selection for expression of and concentration of catalytic moieties 失效
    用于催化部分的表达和浓缩的基于反应的选择

    公开(公告)号：US5631137A

    公开(公告)日：1997-05-20

    申请号：US377495

    申请日：1995-01-24

    申请人： Mark T. Martin ,  Rodger G. Smith ,  Michael J. Darsley ,  David M. Simpson ,  Gary F. Blackburn

    发明人： Mark T. Martin ,  Rodger G. Smith ,  Michael J. Darsley ,  David M. Simpson ,  Gary F. Blackburn

    IPC分类号： G01N33/53 ,  B01J20/281 ,  C12N5/10 ,  C12N7/02 ,  C12N15/10 ,  C12Q1/02 ,  C12Q1/68 ,  C12Q1/70 ,  C40B40/02 ,  G01N30/88 ,  G01N33/569 ,  C12Q1/25 ,  C12N9/00

    CPC分类号： C40B40/02 ,  C12N15/1037 ,  C12Q1/02 ,  C12Q1/6811 ,  C12Q1/70 ,  G01N33/56983

    摘要： Disclosed and claimed are methods for selecting a recombinant virus, phage or cell expressing a catalytic antibody or catalytic portion thereof, or for selecting catalytic activity by a moiety. The method employs reaction-based selection for catalytic activity. The method can also be used to concentrate (increase the proportion of catalytic to non-catalytic moieties) a sample containing a catalytic moiety or viruses, phages or cells expressing a catalytic moiety. The selection or concentrating can be by employing a mechanism-based inhibitor, catalysis-accelerated movement, surface binding, changes in enthalpic component of binding as a function of temperature, or changes in binding by competition, or combinations thereof. The invention also comprehends a method for producing a recombinant virus or a cell-line expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof; and, this method can include infecting a suitable host with viruses which are screened for the expression. In addition, recombinant viruses and cell-lines so expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof are also disclosed and claimed.

    摘要翻译： 公开并要求的是选择重组病毒，表达催化抗体或其催化部分的噬菌体或细胞，或用于通过部分选择催化活性的方法。 该方法采用基于反应的催化活性选择。 该方法还可用于浓缩（增加非催化部分的催化剂比例）含有催化部分或表达催化部分的病毒，噬菌体或细胞的样品。 选择或浓缩可以通过采用基于机理的抑制剂，催化加速运动，表面结合，作为温度的函数的结合焓分量的变化，或通过竞争的结合变化，或其组合。 本发明还包括生产重组病毒或表达催化部分如催化抗体或其催化部分的细胞系的方法; 并且该方法可以包括用筛选表达的病毒感染合适的宿主。 此外，还公开和要求保护了重组病毒和表达催化部分如催化抗体或其催化部分的细胞系。

    Reaction-based selection for expression of and concentration of catalytic moieties
    3.
    发明授权
    Reaction-based selection for expression of and concentration of catalytic moieties 失效
    用于催化部分的表达和浓缩的基于反应的选择

    公开(公告)号：US6121007A

    公开(公告)日：2000-09-19

    申请号：US747654

    申请日：1996-11-13

    申请人： Mark T. Martin ,  Rodger G. Smith ,  Michael J. Darsley ,  David M. Simpson ,  Gary F. Blackburn

    发明人： Mark T. Martin ,  Rodger G. Smith ,  Michael J. Darsley ,  David M. Simpson ,  Gary F. Blackburn

    IPC分类号： G01N33/53 ,  B01J20/281 ,  C12N5/10 ,  C12N7/02 ,  C12N15/10 ,  C12Q1/02 ,  C12Q1/68 ,  C12Q1/70 ,  C40B40/02 ,  G01N30/88 ,  G01N33/569 ,  C12Q1/25

    CPC分类号： C40B40/02 ,  C12N15/1037 ,  C12Q1/02 ,  C12Q1/6811 ,  C12Q1/70 ,  G01N33/56983

    摘要： Disclosed and claimed are methods for selecting a recombinant virus, phage or cell expressing a catalytic antibody or catalytic portion thereof, or for selecting catalytic activity by a moiety. The method employs reaction-based selection for catalytic activity. The method can also be used to concentrate (increase the proportion of catalytic to non-catalytic moieties) a sample containing a catalytic moiety or viruses, phages or cells expressing a catalytic moiety. The selection or concentrating can be by employing a mechanism-based inhibitor, catalysis-accelerated movement, surface binding, changes in enthalpic component of binding as a function of temperature, or changes in binding by competition, or combinations thereof. The invention also comprehends a method for producing a recombinant virus or a cell-line expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof; and, this method can include infecting a suitable host with viruses which are screened for the expression. In addition, recombinant viruses and cell-lines so expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof are also disclosed and claimed.

    摘要翻译： 公开并要求的是选择重组病毒，表达催化抗体或其催化部分的噬菌体或细胞，或用于通过部分选择催化活性的方法。 该方法采用基于反应的催化活性选择。 该方法还可用于浓缩（增加非催化部分的催化剂比例）含有催化部分或表达催化部分的病毒，噬菌体或细胞的样品。 选择或浓缩可以通过采用基于机理的抑制剂，催化加速运动，表面结合，作为温度的函数的结合焓分量的变化，或通过竞争的结合变化，或其组合。 本发明还包括生产重组病毒或表达催化部分如催化抗体或其催化部分的细胞系的方法; 并且该方法可以包括用筛选表达的病毒感染合适的宿主。 此外，还公开和要求保护了重组病毒和表达催化部分如催化抗体或其催化部分的细胞系。

    Lipid-A analogs: monosaccharide and dissaccharide compounds for inhibiting binding of lipid A receptors to lipid A receptors
    7.
    发明授权
    Lipid-A analogs: monosaccharide and dissaccharide compounds for inhibiting binding of lipid A receptors to lipid A receptors 失效
    脂质-A类似物：用于抑制脂质A受体与脂质A受体结合的单糖和非糖化合物

    公开(公告)号：US5593969A

    公开(公告)日：1997-01-14

    申请号：US123590

    申请日：1993-09-17

    申请人： Balreddy Kamireddy ,  Michael J. Darsley ,  David M. Simpson ,  Richard J. Massey

    发明人： Balreddy Kamireddy ,  Michael J. Darsley ,  David M. Simpson ,  Richard J. Massey

    IPC分类号： A61K38/00 ,  C07H13/06 ,  C07H15/04 ,  C07K16/12 ,  A61K31/70 ,  C07H3/02 ,  C07H3/04

    CPC分类号： C07H13/06 ,  C07H15/04 ,  C07K16/1203 ,  A61K38/00

    摘要： A compound of the formula: ##STR1## wherein: each of R.sub.1, R.sub.1 ', R.sub.2 and R.sub.2 ' independent of each other is a substituted or unsubstituted, branched or linear C.sub.1-12 alkyl, alkene or alkyne group, R.sub.3 is OH, OCH.sub.3, CH.sub.2 COOH or ##STR2## wherein each of R.sub.2" and R.sub.2 '41 independent of each other is a substituted or unsubstituted, branched or linear C.sub.1-12 alkyl, alkene or alkyne group and:A=NH.sub.2, X=P(OH), Y=Z=C, B=OCH.sub.3, orA=OH, X=P(OH), X=Z=C, B (if present)=OCH.sub.3, orA=OCO(CH.sub.2).sub.n NH.sub.2, X=P(OH), Y=Z=C, B=OCH.sub.3,wherein n=1-10, orA=OH, X=P(OH), Y=Z=C, B=O(CH.sub.2).sub.n CO.sub.2 H, wherein n=1-10, orA=OH, X=P(OH), Y=Z=C, B=(CH.sub.2).sub.n CO.sub.2 H, wherein n=1-10, orA=NH.sub.2, X=Z=C, Y=P(OH), B=OCH.sub.3, orA=OH, X=Z=C, Y=P(OH), B (if present)=OCH.sub.3, orA=OCO(CH.sub.2).sub.n NH.sub.2, X=Z=C, Y=P(OH), B=OCH.sub.3, wherein n=1-10, orA=OH, X=Z=C, Y=P(OH), B=O(CH.sub.2).sub.n CO.sub.2 H, wherein n=1-10, orA=OH, X=Z=C, Y=P(OH), B=(CH.sub.2).sub.n CO.sub.2 H, wherein n=1-11, orA=NH.sub.2, X=Y=C, Z=P(OH), B=OCH.sub.3, orA=OH, X=Y=C, Z=P(OH), B (if present)=OCH.sub.3, orA=OCO(CH.sub.2).sub.n NH.sub.2, X=Y=C, Z=P(OH), B=OCH.sub.3, wherein n=1-10, orA=OH, X=Y=C, Z=P(OH), B=O(CH.sub.2).sub.n CO.sub.2 H, wherein n=1-10, orA=OH, X=Y=C, Z=P (OH), B=(CH.sub.2).sub.n CO.sub.2 H and n=1-11 is disclosed. The compounds may be use to inhibit binding of Lipid A to Lipid A receptors.

    摘要翻译： 下式的化合物：其中：R 1，R 1'，R 2和R 2'彼此独立地为取代或未取代的支链或直链C 1-12烷基，烯烃或炔基，R 3为 OH，OCH 3，CH 2 COOH或者其中每个R 2“和R 21'彼此独立地是取代或未取代的支链或直链C 1-12烷基，烯烃或炔基，并且：A = NH 2，X = P （OH），Y = Z = C，B = OCH 3或A = OH，X = P（OH），X = Z = C，B（如果存在）= OCH 3或A = OCO（CH 2）n NH 2，X = P（OH），Y = Z = C，B = OCH 3，其中n = 1-10，或A = OH，X = P（OH），Y = Z = C，B = O（CH 2）n CO 2 H，其中 n = 1-10，或A = OH，X = P（OH），Y = Z = C，B =（CH2）nCO2H，其中n = 1-10，或A = NH2，X = Z = C，Y = P（OH），B = OCH3或A = OH，X = Z = C，Y = P（OH），B（如果存在）= OCH 3或A = OCO（CH 2）n NH 2，X = Z = C ，Y = P（OH），B = OCH 3，其中n = 1-10，或A = OH，X = Z = C，Y = P（OH），B = O（CH 2）n CO 2 H，其中n = 10或A = OH，X = Z = C，Y = P（OH），B =（CH2）nCO2H，其中n = 1-11或A = NH2，X = Y = C，Z = P ），B = OCH 3或A = OH，X = Y = C，Z = P（OH），B（如果存在）= OCH 3或A = OCO（CH 2）n NH 2，X = Y = C，Z = P （OH），B = OCH 3， 其中n = 1-10，或A = OH，X = Y = C，Z = P（OH），B = O（CH 2）n CO 2 H，其中n = 1-10，或A = OH，X = Y = C ，Z = P（OH），B =（CH2）nCO2H和n = 1-11。 该化合物可用于抑制脂质A与脂质A受体的结合。

    Spacecraft platforms
    9.
    发明授权
    Spacecraft platforms 失效
    航天器平台

    公开(公告)号：US6016999A

    公开(公告)日：2000-01-25

    申请号：US109385

    申请日：1998-07-02

    申请人： David M. Simpson ,  Joseph Daniel McCaughey ,  Charles David Hall

    发明人： David M. Simpson ,  Joseph Daniel McCaughey ,  Charles David Hall

    IPC分类号： B64G1/10 ,  B64G1/22 ,  B64G1/66 ,  B64G1/00

    CPC分类号： B64G1/222 ,  B64G1/1007 ,  B64G1/1021 ,  B64G1/66 ,  B64G2001/1035

    摘要： A spacecraft platform essentially having two or more panels hinged at the base and contained for launch in a fairing. The panels are hinged and latched in an open deployment and bear, for example, a SAR antenna or an interferometer. The rear faces of the panels are provided with stiffening ribs, webs and struts and carry elements of the payload module and service module which are normally separate structures on a conventional satellite.

    摘要翻译： 一个航天器平台基本上具有两个或多个铰接在基座上的面板，用于在整流罩中发射。 面板铰接并锁定在开放的部署中，并承载例如SAR天线或干涉仪。 面板的后表面设置有加强筋，腹板和支柱以及有效载荷模块和服务模块的承载元件，这些模块和服务模块通常是常规卫星上分离的结构。

    Compounds and methods for the selective treatment of cancer and bacterial infections
    10.
    发明授权
    Compounds and methods for the selective treatment of cancer and bacterial infections 失效
    用于选择性治疗癌症和细菌感染的化合物和方法

    公开(公告)号：US06218519B1

    公开(公告)日：2001-04-17

    申请号：US08635243

    申请日：1996-04-12

    申请人： John H. Kenten ,  David M. Simpson

    发明人： John H. Kenten ,  David M. Simpson

    IPC分类号： C07H1524

    CPC分类号： C07H15/252

    摘要： The present invention relates to compounds containing an anthracyclinone group such as doxorubicin, daunorubicin or a derivative thereof. The compounds of the invention also contain ester, glycoside or glucuronide structures which are hydrolyzed by the corresponding esterase, glycosidase or glucuronidase. These compounds possess potent cytotoxic activity which is developed after the hydrolysis of the ester or glycoside group of the compound and are effective in the inhibition of tumor cells and bacterial growth after activation.

    摘要翻译： 本发明涉及含有蒽环类基团的化合物，例如多柔比星，柔红霉素或其衍生物。 本发明的化合物还含有由相应的酯酶，糖苷酶或葡糖苷酸酶水解的酯，糖苷或葡糖苷酸结构。 这些化合物具有强效的细胞毒活性，其在化合物的酯或糖苷基团水解后发展，并且在活化后有效抑制肿瘤细胞和细菌生长。