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1.发明申请Method of modifying the genome of gram-positive bacteria by means of a novel conditionally negative dominant marker gene 审中-公开通过新型条件阴性显性标记基因修饰革兰氏阳性细菌基因组的方法公开(公告)号：US20100240131A1
公开(公告)日：2010-09-23
申请号：US11476404
申请日：2006-06-28
CPC分类号： C12N9/1055 , C12N15/77
摘要： The invention relates to a novel method for modifying the genome of Gram-positive bacteria, to these bacteria and to novel vectors. The invention particularly relates to a method for modifying corynebacteria or brevibacteria with the aid of a novel marker gene which has a conditionally negatively dominant action in the bacteria.
摘要翻译： 本发明涉及一种用于修饰革兰氏阳性菌，这些细菌和新颖载体的基因组的新方法。 本发明特别涉及一种借助于在细菌中具有有条件负向主导作用的新型标记基因来修饰棒状杆菌或短纤维细菌的方法。
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公开(公告)号：US20090029356A1
公开(公告)日：2009-01-29
申请号：US11699982
申请日：2007-01-29
CPC分类号： C07K14/34 , C07H21/02 , C07H21/04 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/222 , C12P13/225 , C12P13/227 , C12P13/24
摘要： Isolated nucleic acid molecules, designated MCP nucleic acid molecules, which encode novel MCP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCP proteins, mutated MCP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCP genes in this organism.
摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型MCP蛋白质的分离的核酸分子，命名为MCP核酸分子。 本发明还提供反义核酸分子，含有MCP核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供了分离的MCP蛋白，突变的MCP蛋白，融合蛋白，抗原肽和用于根据该生物体中MCP基因的遗传工程改进从谷氨酸棒球菌生产所需化合物的方法。
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3.发明申请Corynebacterium glutamicum genes encoding proteins involved in genetic stability, gene expression, and protein secretion and folding 审中-公开编码参与遗传稳定性，基因表达和蛋白质分泌和折叠的蛋白质的谷氨酸棒杆菌基因公开(公告)号：US20080096211A1
公开(公告)日：2008-04-24
申请号：US11890181
申请日：2007-08-03
IPC分类号： C12P21/04 , C07K14/00 , C12N1/20 , C12N15/00 , C12N15/11 , C12P13/04 , C12P13/06 , C12P13/08 , C12P7/64 , G01N33/53 , C12Q1/68 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/22 , C12P19/20 , C12P19/38
CPC分类号： C12P13/04 , G01N33/56911 , G01N2333/34 , G01N2500/00
摘要： Isolated nucleic acid molecules, designated SES nucleic acid molecules, which encode novel SES proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SES nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SES proteins, mutated SES proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SES genes in this organism.
摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型SES蛋白的分离的核酸分子，命名为SES核酸分子。 本发明还提供反义核酸分子，含有SES核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供了基于该生物体中SES基因的遗传工程的分离的SES蛋白，突变的SES蛋白，融合蛋白，抗原肽和用于从谷氨酸棒球菌生产所需化合物的方法。
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4.发明申请Corynebacterium glutamicum genes encoding proteins involved in genetic stability, gene expression, and protein secretion and folding 审中-公开编码参与遗传稳定性，基因表达和蛋白质分泌和折叠的蛋白质的谷氨酸棒杆菌基因公开(公告)号：US20070161091A1
公开(公告)日：2007-07-12
申请号：US11041504
申请日：2005-01-21
CPC分类号： C07K14/34 , C12N9/0069 , C12P13/04
摘要： Isolated nucleic acid molecules, designated SES nucleic acid molecules, which encode novel SES proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SES nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SES proteins, mutated SES proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SES genes in this organism.
摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型SES蛋白的分离的核酸分子，命名为SES核酸分子。 本发明还提供反义核酸分子，含有SES核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供了基于该生物体中SES基因的遗传工程的分离的SES蛋白，突变的SES蛋白，融合蛋白，抗原肽和用于从谷氨酸棒球菌生产所需化合物的方法。
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5.发明申请公开(公告)号：US20070015251A1
公开(公告)日：2007-01-18
申请号：US11505698
申请日：2006-08-17
IPC分类号： C07H21/04 , C12P21/06 , C12P19/62 , C12P19/28 , C12P13/04 , C12P13/24 , C12P13/22 , C12P13/20 , C12P13/14 , C12P13/18 , C12P13/16 , C12P13/12
CPC分类号： C12N9/1205 , C07K14/34 , C12N9/00 , C12N9/1223 , C12P1/04 , C12P13/04 , C12R1/15 , C12Y207/01069
摘要： Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated PTS proteins, mutated PTS proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of PTS genes in this organism.
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6.发明申请Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport 审中-公开编码参与膜合成和膜转运的蛋白质的谷氨酸棒杆菌基因公开(公告)号：US20050244935A1
公开(公告)日：2005-11-03
申请号：US11082389
申请日：2005-03-16
CPC分类号： C07K14/34
摘要： Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCT proteins, mutated MCT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCT genes in this organism.
摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型MCT蛋白质的分离的核酸分子，命名为MCT核酸分子。 本发明还提供反义核酸分子，含有MCT核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供了分离的MCT蛋白，突变的MCT蛋白，融合蛋白，抗原肽和基于该生物体中MCT基因的遗传工程改进从谷氨酸棒球菌生产所需化合物的方法。
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7.发明申请公开(公告)号：US20050009152A1
公开(公告)日：2005-01-13
申请号：US10494541
申请日：2002-10-31
申请人： Oskar Zelder , Markus Pompejus , Hartwig Schroder , Burkhard Kroger , Corinna Klopprogge , Gregor Haberhauer
发明人： Oskar Zelder , Markus Pompejus , Hartwig Schroder , Burkhard Kroger , Corinna Klopprogge , Gregor Haberhauer
CPC分类号： C12N9/00 , C07K14/34 , C12N9/0006 , C12P13/08
摘要： The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.
摘要翻译： 本发明涉及新颖的核酸分子，其用于构建遗传改良微生物的用途以及借助所述遗传改良的微生物制备精细化学品，特别是氨基酸的方法。
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公开(公告)号：US20080131942A1
公开(公告)日：2008-06-05
申请号：US11055717
申请日：2005-02-11
IPC分类号： C12P13/14 , C12N15/74 , C12P13/08 , C12P13/04 , C12P1/04 , C12P25/00 , C12P13/02 , C12N15/00
CPC分类号： C12N9/1007 , C12N15/77
摘要： The invention relates to a process for producing corynebacteria comprising one or more modified genomic sequences, where a vector is used which does not replicate in corynebacteria and whose nucleic acid is not recognized by corynebacteria as foreign.
摘要翻译： 本发明涉及一种生产棒状杆菌的方法，其包含一个或多个修饰基因组序列，其中使用不在棒状杆菌中复制且其核酸不被外源性棒状杆菌识别的载体。
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9.发明申请Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport 审中-公开编码参与膜合成和膜转运的蛋白质的谷氨酸棒杆菌基因公开(公告)号：US20070111230A1
公开(公告)日：2007-05-17
申请号：US11507094
申请日：2006-08-18
IPC分类号： C12Q1/68 , G01N33/554 , C07H21/04 , C12N15/74 , G01N33/569 , C07K14/195
CPC分类号： C12Q1/689 , C07K14/34 , C12N9/00 , C12N9/18 , G01N33/56911
摘要： Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCT proteins, mutated MCT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCT genes in this organism.
摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型MCT蛋白质的分离的核酸分子，命名为MCT核酸分子。 本发明还提供反义核酸分子，含有MCT核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供了分离的MCT蛋白，突变的MCT蛋白，融合蛋白，抗原肽和基于该生物体中MCT基因的遗传工程改进从谷氨酸棒球菌生产所需化合物的方法。
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公开(公告)号：US20070077576A1
公开(公告)日：2007-04-05
申请号：US11508673
申请日：2006-08-22
申请人： Markus Pompejus , Burkhard Kroger , Hartwig Schroder , Oskar Zelder , Gregor Haberhauer , Heung-Shick Lee , Hyung-Joon Kim
发明人： Markus Pompejus , Burkhard Kroger , Hartwig Schroder , Oskar Zelder , Gregor Haberhauer , Heung-Shick Lee , Hyung-Joon Kim
CPC分类号： C12P13/04 , C07K14/34 , C07K2319/00 , C12N9/00 , C12N9/18 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/222 , C12P13/225 , C12P13/227 , C12P13/24
摘要： Isolated nucleic acid molecules, designated SRT nucleic acid molecules, which encode novel SRT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SRT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SRT proteins, mutated SRT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SRT genes in this organism.
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