公开(公告)号：US20130263296A1

公开(公告)日：2013-10-03

申请号：US13881777

申请日：2011-10-28

申请人： Martin Gilbert Pomper ,  Hyo-eun Bhang ,  Paul Fisher

发明人： Martin Gilbert Pomper ,  Hyo-eun Bhang ,  Paul Fisher

IPC分类号： A61K49/00 ,  C12N15/85 ,  A61K49/04 ,  A61K38/20 ,  A61K51/04

CPC分类号： A61K49/0002 ,  A61K38/20 ,  A61K49/0013 ,  A61K49/0045 ,  A61K49/04 ,  A61K51/0491 ,  A61K51/0495 ,  C12N15/85 ,  C12N2710/10043 ,  C12Q1/6886 ,  C12Q1/6897 ,  G01N33/574

摘要： Genetic constructs comprising reporter genes operably linked to cancer specific or cancer selective promoters (such as the progression elevated gene-3 (PEG-3) promoter) are provided, as are methods for their use in cancer imaging, cancer treatment, and combined imaging and treatment protocols. Transgenic animals in which a reporter gene is linked to a cancer specific or cancer selective promoter, and which may be further genetically engineered, bred or selected to have a predisposition to develop cancer, are also provided.

摘要翻译： 提供了包含与癌症特异性或癌症选择性启动子（例如升高的基因-3（PEG-3）启动子）可操作连接的报告基因的遗传构建体，以及它们用于癌症成像，癌症治疗和组合成像和 治疗方案。 报告基因与癌症特异性或癌症选择性启动子连接并且可进一步基因工程改造，繁殖或选择以具有发展癌症倾向的转基因动物也被提供。

公开(公告)号：US09106175B2

公开(公告)日：2015-08-11

申请号：US13192867

申请日：2011-07-28

申请人： Paul Fisher ,  Christian E. Ross ,  Mohammad S. Islam

发明人： Paul Fisher ,  Christian E. Ross ,  Mohammad S. Islam

IPC分类号： H02P29/02

CPC分类号： H02P29/021 ,  B62D5/0481 ,  B62D15/021 ,  B62D15/0235 ,  H02P29/0241

摘要： A diagnostic system and method for an electric power steering system are provided. The diagnostic system includes a first microprocessor that determines a first relative position value indicating the relative rotational position of the rotatable shaft at the first time based on the signals from first and second position sensors. A second microprocessor determines a second relative position value indicating the relative rotational position of the rotatable shaft at the first time based on the signals from third and fourth position sensors. The first microprocessor determines whether the first relative position value is an acceptable value based on a difference between the first relative position value and the second relative position value.

摘要翻译： 提供了一种用于电动助力转向系统的诊断系统和方法。 诊断系统包括第一微处理器，其基于来自第一位置传感器和第二位置传感器的信号，确定第一相对位置值，该第一相对位置值指示可旋转轴在第一时间的相对旋转位置。 第二微处理器基于来自第三位置传感器和第四位置传感器的信号确定第一相对位置值，该第二相对位置值指示可旋转轴在第一时间的相对旋转位置。 第一微处理器基于第一相对位置值和第二相对位置值之间的差来确定第一相对位置值是否为可接受值。

公开(公告)号：US20140220347A1

公开(公告)日：2014-08-07

申请号：US14238788

申请日：2012-08-14

申请人： Max Dehtiar ,  Paul Fisher ,  Matthew A. Gave ,  William Herron ,  Takakazu Hino ,  Byung K. Hwang ,  Jennifer Larimer ,  Jeong Yong Lee ,  Joel P. McDonald ,  Mark Schrauben ,  Raymond Tabler

发明人： Max Dehtiar ,  Paul Fisher ,  Matthew A. Gave ,  William Herron ,  Takakazu Hino ,  Byung K. Hwang ,  Jennifer Larimer ,  Jeong Yong Lee ,  Joel P. McDonald ,  Mark Schrauben ,  Raymond Tabler

IPC分类号： H01M4/38 ,  C01B33/027

CPC分类号： H01M4/386 ,  C01B33/027 ,  H01M4/134 ,  H01M4/1395 ,  Y10T428/2982

摘要： An electrode composition comprises a silicon powder comprising non-crystalline and crystalline silicon, where the crystalline silicon is present in the silicon powder at a concentration of no more than about 20 wt. %. An electrode for an electrochemical cell comprises an electrochemically active material comprising non-crystalline silicon and crystalline silicon, where the non-crystalline silicon and the crystalline silicon are present prior to cycling of the electrode. A method of controlling the crystallinity of a silicon powder includes heating a reactor to a temperature of no more than 650° C. and flowing a feed gas comprising silane and a carrier gas into the reactor while maintaining an internal reactor pressure of about 2 atm or less. The silane decomposes to form a silicon powder having a controlled crystallinity and comprising non-crystalline silicon.

摘要翻译： 电极组合物包括含有非结晶和晶体硅的硅粉末，其中结晶硅以不大于约20wt。％的浓度存在于硅粉末中。 ％。 用于电化学电池的电极包括包含非晶硅和晶体硅的电化学活性材料，其中非晶硅和晶体硅在电极循环之前存在。 控制硅粉末的结晶度的方法包括将反应器加热到不高于650℃的温度，并将包含硅烷和载气的进料气体流入反应器，同时保持内部反应器压力为约2atm，或 减。 硅烷分解形成具有可控结晶度并包含非晶硅的硅粉末。

公开(公告)号：US08623301B1

公开(公告)日：2014-01-07

申请号：US12420457

申请日：2009-04-08

申请人： Mark Deininger ,  Mikhail Pozvonkov ,  Paul Fisher ,  Leonid V. Budaragin ,  D. Morgan Spears

发明人： Mark Deininger ,  Mikhail Pozvonkov ,  Paul Fisher ,  Leonid V. Budaragin ,  D. Morgan Spears

IPC分类号： C01F17/00 ,  H01M8/10

CPC分类号： C25B9/08 ,  C25B1/10 ,  C25B1/46 ,  C25B13/04 ,  G01N27/40 ,  G01N27/406 ,  G01N27/4073 ,  H01M8/0232 ,  H01M8/1246 ,  H01M8/1253 ,  H01M8/126 ,  H01M2008/1293 ,  H01M2300/0077 ,  H01M2300/0094 ,  Y02E60/366 ,  Y02E60/525 ,  Y02P70/56

摘要： The present invention provides solid oxide fuel cells, solid oxide electrolyzer cells, solid oxide sensors, components of any of the foregoing, and methods of making and using the same. In some embodiments, a solid oxide fuel cell comprises an air electrode (or cathode), a fuel electrode (or anode), an electrolyte interposed between the air electrode and the fuel electrode, and at least one electrode-electrolyte transition layer. Other embodiments provide novel methods of producing nano-scale films and/or surface modifications comprising one or more metal oxides to form ultra-thin (yet fully-dense) electrolyte layers and electrode coatings. Such layers and coatings may provide greater ionic conductivity and increased operating efficiency, which may lead to lower manufacturing costs, less-expensive materials, lower operating temperatures, smaller-sized fuel cells, electrolyzer cells, and sensors, and a greater number of applications.

摘要翻译： 本发明提供固体氧化物燃料电池，固体氧化物电解槽电池，固体氧化物传感器，任何前述的组分，以及制造和使用它们的方法。 在一些实施例中，固体氧化物燃料电池包括空气电极（或阴极），燃料电极（或阳极），介于空气电极和燃料电极之间的电解质，以及至少一个电极 - 电解质过渡层。 其它实施方案提供了生产包含一种或多种金属氧化物以形成超薄（但完全致密的）电解质层和电极涂层的纳米级膜和/或表面改性的新方法。 这样的层和涂层可以提供更大的离子传导性和提高的操作效率，这可能导致较低的制造成本，较便宜的材料，较低的操作温度，较小尺寸的燃料电池，电解池单元和传感器以及更多的应用。

公开(公告)号：US20060292157A1

公开(公告)日：2006-12-28

申请号：US11292571

申请日：2005-12-02

申请人： Paul Fisher ,  Pankaj Gupta

发明人： Paul Fisher ,  Pankaj Gupta

IPC分类号： A61K39/395 ,  A61K38/17 ,  A61K48/00 ,  C07K16/30 ,  C07K14/82 ,  C07H21/04

CPC分类号： G01N33/5011 ,  A61K38/00 ,  A61K45/06 ,  A61K48/005 ,  C07K14/47 ,  C07K14/52 ,  C07K14/54 ,  C07K16/244 ,  C12N15/86 ,  C12N2710/10343

摘要： The invention relates to the mda-7 gene, its encoded protein and fragments of the protein. Several of these fragments of the MDA-7 protein exhibit antiproliferative activity and/or inhibited the activity of intact MDA-7. Accordingly, the invention provides, among other things, for methods and compositions that may be used in the treatment of disorders of cell proliferation, including cancer.

摘要翻译： 本发明涉及mda-7基因，其编码的蛋白质和蛋白质的片段。 MDA-7蛋白的这些片段中的几个表现出抗增殖活性和/或抑制完整MDA-7的活性。 因此，本发明尤其提供了可用于治疗细胞增殖障碍（包括癌症）的方法和组合物。

公开(公告)号：US20060283169A1

公开(公告)日：2006-12-21

申请号：US11427515

申请日：2006-06-29

申请人： Krishnan Narayanan ,  Paul Fisher

发明人： Krishnan Narayanan ,  Paul Fisher

IPC分类号： F02C9/00

CPC分类号： F04D27/0284 ,  F04D27/0207

摘要： Many variables in processes such as those using turbocompressors and turbines must be limited or constrained. Limit control loops are provided for the purpose of limiting these variables. By using a combination of closed loop and open loop limit control schemes, excursions into unfavorable operation can be more effectively avoided. Transition between open loop and closed loop may be enhanced by testing the direction and magnitude of the rate at which the limit variable is changing. If the rate of change indicates recovery is imminent, control is passed back to the closed loop limit control function.

摘要翻译： 诸如使用涡轮压缩机和涡轮机的过程中的许多变量必须受到限制或约束。 提供限制控制回路用于限制这些变量。 通过使用闭环和开环限制控制方案的组合，可以更有效地避免对不利操作的偏移。 开环和闭环之间的转换可以通过测试极限变量正在改变的速率的方向和幅度来增强。 如果变化率指示恢复即将到来，则控制被传回回路限制控制功能。

公开(公告)号：US20060180535A1

公开(公告)日：2006-08-17

申请号：US11056202

申请日：2005-02-11

申请人： DeQuan Yu ,  Paul Fisher

发明人： DeQuan Yu ,  Paul Fisher

IPC分类号： B01D29/00

CPC分类号： B01D35/0273 ,  F02M37/50

摘要： An in-tank fuel supply unit self cleans the mesh filter of the primary fuel pump, thereby permitting smaller mesh sizes to decrease pump wear and increase the life of the pump. Generally, the in-tank fuel supply unit includes a reservoir, an auxiliary fuel pump, a primary fuel pump and a filter. Fuel exiting the auxiliary fuel pump outlet is directed towards the filter to wash debris from the filter. Preferably a swirling flow is generated within the reservoir, or the system in run in an overflow condition to assist in the self cleaning of the fuel filter.

摘要翻译： 内燃机燃料供应单元自洁清洁主燃料泵的网状过滤器，从而允许更小的筛网尺寸以减少泵磨损并增加泵的寿命。 通常，舱内燃料供应单元包括储存器，辅助燃料泵，主燃料泵和过滤器。 离开辅助燃料泵出口的燃料被引向过滤器以从过滤器洗涤碎屑。 优选地，在储存器内或在溢流状态下运行的系统中产生旋流，以有助于燃料过滤器的自清洁。

公开(公告)号：US20060165514A1

公开(公告)日：2006-07-27

申请号：US11041485

申请日：2005-01-24

申请人： DeQuan Yu ,  Stephen Kempfer ,  Paul Fisher ,  Harold Castle

发明人： DeQuan Yu ,  Stephen Kempfer ,  Paul Fisher ,  Harold Castle

IPC分类号： F04D5/00

CPC分类号： F04D5/002 ,  F02M37/048 ,  F02M37/106 ,  F02M2037/228 ,  F04D5/007 ,  F05B2250/503

摘要： A fuel pump includes a housing, and a motor. A single sided impeller has first and second impeller flow channels each including a plurality of vanes. The impeller defines a flow passageway extending therethrough. A cover is attached to the housing and has a cover surface that defines first and second cover flow channels. The cover flow channels receive fuel from inlets formed in the cover. The first and second cover flow channels are aligned with the first and second impeller flow channels and receive fuel through the inlets and deliver fuel to outlets. A body is positioned within the housing and defines an impeller chamber to receive the impeller, and a first outlet passageway fluidically connected to the first cover flow channel and impeller flow channel. A second outlet passageway formed within the cover is fluidically connected to the second cover flow channel and impeller flow channel.

摘要翻译： 燃料泵包括壳体和电动机。 单面叶轮具有每个包括多个叶片的第一和第二叶轮流动通道。 叶轮限定了通过其延伸的流动通道。 盖子附接到壳体并且具有限定第一和第二覆盖流动通道的盖表面。 盖子流动通道从形成在盖子上的入口接收燃料。 第一和第二盖流动通道与第一和第二叶轮流动通道对准，并通过入口接收燃料并将燃料输送到出口。 主体定位在壳体内并且限定叶轮室以容纳叶轮，以及第一出口通道，其流体连接到第一盖流动通道和叶轮流动通道。 形成在盖内的第二出口通道流体连接到第二盖流动通道和叶轮流动通道。

公开(公告)号：US20060154262A1

公开(公告)日：2006-07-13

申请号：US11032766

申请日：2005-01-11

申请人： Paul Fisher ,  Habib Boukerche

发明人： Paul Fisher ,  Habib Boukerche

IPC分类号： C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  A61K48/00

CPC分类号： C07K14/4748 ,  C12Q1/6886 ,  C12Q2600/118

摘要： The present invention relates to the discovery, identification and characterization of an eight genes that are differentially expressed as a consequence of metastatic progression in human melanoma cells. Six of the identified metastasis elevated genes (MEG genes), encode for known proteins (MEG-1 through MEG-6). However, two of the identified genes, referred to herein as MEG-7 and MEG-8, represent novel genes. The present invention relates to methods for inhibiting the metastatic potential of cancer cells through inhibition of the MEG genes/gene products, as well as diagnostic methods for determining the metastatic potential of cells. The invention further relates to novel MEG-7 and MEG-8 nucleotides, host cell expression systems, MEG-7 and MEG-8 proteins, fusion proteins, and antibodies to the MEG-7 and MEG-8. The present invention also relates to the discovery that inhibition of the mda-9 gene (also referred to as syntenin), a gene found to be upregulated in metastatic cancer cells, results in a decrease in the invasive and migratory properties of such cells. Thus, the present invention relates also to methods and compositions for inhibiting mda-9/syntenin activity.

摘要翻译： 本发明涉及在人黑素瘤细胞中差异表达为转移进展的结果的8个基因的发现，鉴定和表征。 确定的转移基因（MEG基因）中的六个，编码已知蛋白质（MEG-1至MEG-6）。 然而，在本文中称为MEG-7和MEG-8的两个鉴定的基因代表新的基因。 本发明涉及通过抑制MEG基因/基因产物来抑制癌细胞的转移潜力的方法以及用于确定细胞转移潜能的诊断方法。 本发明还涉及新的MEG-7和MEG-8核苷酸，宿主细胞表达系统，MEG-7和MEG-8蛋白，融合蛋白和针对MEG-7和MEG-8的抗体。 本发明还涉及发现在转移性癌细胞中被发现上调的基因的mda-9基因（也称为syntenin）的抑制导致这些细胞的侵入性和迁移性质的降低。 因此，本发明还涉及抑制mda-9 / syntenin活性的方法和组合物。

公开(公告)号：US20060127980A1

公开(公告)日：2006-06-15

申请号：US11197226

申请日：2005-08-04

申请人： Paul Fisher ,  Zhao-zhong Su

发明人： Paul Fisher ,  Zhao-zhong Su

IPC分类号： A61K38/17 ,  C07K14/705 ,  C07H21/04 ,  C12N5/08 ,  C12P21/06

CPC分类号： C07K14/705

摘要： The nucleic acid sequence of the human Excitatory Amino Acid Transporter-2 Gene (hEAAT2) promoter, a nucleic acid sequence that hybridizes to the hEAAT2 promoter nucleic acid sequence under stringent hybridization conditions, and a nucleic acid sequence that is functionally equivalent to the hEAAT2 promoter sequence are provided, as are vectors containing these nucleic acid sequences. In addition, methods for the use of these nucleic acids to achieve tissue- or cell-specific gene expression are provided, as are methods for the use of these hEAAT2 promoter nucleic acids to identify agents that can modulate glutamate transport or the activity of the glutamate promoter. Such agents may be useful in the prevention, palliation or treatment of neurodegenerative and/or cerebrovascular diseases.

摘要翻译： 人激动性氨基酸转运蛋白-2基因（hEAAT2）启动子的核酸序列，在严格杂交条件下与hEAAT2启动子核酸序列杂交的核酸序列以及在功能上等同于hEAAT2启动子的核酸序列 提供了序列，以及含有这些核酸序列的载体。 此外，提供了使用这些核酸实现组织或细胞特异性基因表达的方法，以及使用这些hEAAT2启动子核酸鉴定可调节谷氨酸转运或谷氨酸活性的试剂的方法 启动子。 这样的药剂可用于预防，缓解或治疗神经变性和/或脑血管疾病。