摘要:
A novel method for removal of protective group(s) from an amino acid or peptide having thiol group(s) protected with p-methoxybenzyl, 1-adamantyl or t-butyl group by treating the protected amino acid or peptide with the mercuric salt of acetic acid or halogenoacetic acid, the removal being effected selectively and very smoothly in a good yield under extremely mild conditions without giving any undesirable influence upon other functional or protective group(s).
摘要:
A guanidino group in an amino acid or a peptide can be protected with a specific group, i.e. pentamethylbenzensulfonyl, 2,4,6-trimethoxybenzenesulfonyl, 4-methoxy-2,3,5,6-tetramethylbenzenesulfonyl, 4-methoxy-2,6-dimethylbenzenesulfonyl or 4-methoxy-2,3,6-trimethylbenzenesulfonyl, and said group may easily be removed without affecting the amino acid or the peptide to be derived from the protected amino acid or peptide. Thus, the present invention is useful in the synthesis of peptides containing the guanidino group.
摘要:
Novel nonapeptides of the formula:pGlu-X-Lys-Ser-Gln-Y-Z-Ser-Asn-OHwherein X is Ala or (D)-Ala; Y and Z are the same or different and each is the residue of a D-amino acid containing 3 to 9 carbon atoms, or Gly; and at least one of X, Y and Z is the residue of D-amino acid, have immunoregulator activity and are of value as medicines.
摘要:
A novel peptide of the formula: ##STR1## wherein A is hydrogen, alkyl, aralkyl, alkoxyalkyl, hydroxyalkyl or alkoxy; R is ##STR2## X is --S-- or --(CH.sub.2).sub.n -- where n is 1 or 2 has a weaker TRH releasing activity than TRH and a stronger anaesthesia-antagonistic activity, spontaneous movement-stimulant activity or dopamine-potentiating activity than TRH.
摘要:
A novel dipeptide, L-aspartyl-aminomalonic acid methyl 2-methylcyclohexyl diester and its physiologically acceptable salts which are useful as a sweetener, and production thereof and sweetening compositions containing the dipeptide or its salt.
摘要:
The invention provides chemically modified lymphokines comprising a lymphokine moiety and at least one polyethylene glycol moiety of the formula: R.paren open-st.O--CH.sub.2 CH.sub.2 .paren close-st..sub.n wherein R is a protective group for the terminal oxygen and n is at least one, bonded directly to at least one primary amino group of the lymphokine moiety, and a method of producing the same.The chemically modified lymphokines according to the invention can be produced by reacting a lymphokine with an aldehyde of the formula R.paren open-st.O--CH.sub.2 CH.sub.2 .paren close-st..sub.n-1 O--CH.sub.2 CHO wherein R and n are as defined above, in the presence of a reducing agent.The chemically modified lymphokines according to the invention are useful as drugs, among others.
摘要:
A guanidino group in an amino acid or a peptide can be protected with a specific group, i.e. pentamethylbenzenesulfonyl, 2,4,6-trimethoxybenzenesulfonyl, 4-methoxy-2,3,5,6-tetramethylbenzenesulfonyl, 4-methoxy-2,6-dimethylbenzenesulfonyl or 4-methoxy-2,3,6-trimethylbenzenesulfonyl, and said group may easily be removed without affecting the amino acid or the peptide to be derived from the protected amino acid or peptide. Thus, the present invention is useful in the synthesis of peptides containing the guanidino group.
摘要:
According to one embodiment, a pressure sensor includes a base, and a first sensor unit. The first sensor unit includes a first transducer thin film, a first strain sensing device and a second strain sensing device. The first strain sensing device includes a first magnetic layer, a second magnetic layer, and a first intermediate layer provided between the first and the second magnetic layers. The second strain sensing device is provided apart from the first strain sensing device on the first membrane surface and provided at a location different from a location of the barycenter, the second strain sensing device including a third magnetic layer, a fourth magnetic layer, and a second intermediate layer provided between the third and the fourth magnetic layers, the first and the second intermediate layers being nonmagnetic. The first and the second strain sensing devices, and the barycenter are in a straight line.
摘要:
According to one embodiment, a pulse wave velocity measuring device includes a first sensor, a second sensor, a base body and a calculation unit. The first sensor is configured to sense a pulse wave propagating through an interior of a vessel. The second sensor is separated from the first sensor and is configured to sense the pulse wave. The base body is configured to hold the first sensor and the second sensor and regulate a distance between the first sensor and the second sensor. The calculation unit is configured to derive a difference between a time of the sensing of the pulse wave by the first sensor and a time of the sensing of the pulse wave by the second sensor.
摘要:
Provided is a cursor display method of displaying a cursor, indicating a focus point while being manipulatable to move, in a two-dimensional image in which sets of laser point cloud data distributed on a three-dimensional coordinate system are shown on the basis of a predetermined view point position. The cursor display method includes: performing arithmetic on a position on the three-dimensional coordinate system which corresponds to the focus point in the two-dimensional image; defining a predetermined plane graphic region, including the corresponding position and being orthogonal to a view point position direction, on the three-dimensional coordinate system on the basis of the corresponding position; dividing a view region, originating from the view point position passing through the plane graphic region, into segments on the basis of the plane graphic region; and performing non-display processing on sets of laser point cloud data placed in any one of the divided segments.