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公开(公告)号：US07745190B2
公开(公告)日：2010-06-29
申请号：US12067769
申请日：2006-09-08
CPC分类号： C12N9/22
摘要： A novel endoribonuclease activity exhibiting polypeptide; a nucleic acid coding for the polypeptide; a recombinant DNA comprising the nucleic acid; a transformant obtained by transformation using the recombinant DNA; a process for producing the polypeptide, characterized by including the steps of culturing the transformant and collecting the polypeptide from the culture; a process for producing single-strand RNA fragments, characterized by including the step of causing the polypeptide to act on a single-strand RNA; and a method of fragmenting a single-strand RNA.
摘要翻译： 展示多肽的新型内切核糖核酸酶活性; 编码该多肽的核酸; 包含该核酸的重组DNA; 通过使用重组DNA转化获得的转化体; 其特征在于包括培养转化体并从培养物中收集多肽的步骤; 一种产生单链RNA片段的方法，其特征在于包括使多肽作用在单链RNA上的步骤; 以及分裂单链RNA的方法。
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公开(公告)号：US07989184B2
公开(公告)日：2011-08-02
申请号：US11997071
申请日：2006-07-04
IPC分类号： C12P19/34
CPC分类号： C12N9/22
摘要： A polypeptide having a novel endoribonuclease activity; a nucleic acid encoding the polypeptide; recombinant DNA having the nucleic acid therein; a transformant transformed with the recombinant DNA; a process for producing the polypeptide comprising the steps of cultivating the transformant and collecting the polypeptide from the culture; a process for producing a digest of single-stranded RNA comprising the step of reacting the polypeptide with the single-stranded RNA; and a method for the digestion of single-stranded RNA.
摘要翻译： 具有新型内切核糖核酸酶活性的多肽; 编码该多肽的核酸; 其中具有核酸的重组DNA; 用重组DNA转化的转化体; 一种生产多肽的方法，包括培养转化体并从培养物中收集多肽的步骤; 一种生产单链RNA消化物的方法，包括使多肽与单链RNA反应的步骤; 以及消化单链RNA的方法。
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公开(公告)号：US20090047709A1
公开(公告)日：2009-02-19
申请号：US12067769
申请日：2006-09-08
CPC分类号： C12N9/22
摘要： A novel endoribonuclease activity exhibiting polypeptide; a nucleic acid coding for the polypeptide; a recombinant DNA comprising the nucleic acid; a transformant obtained by transformation using the recombinant DNA; a process for producing the polypeptide, characterized by including the steps of culturing the transformant and collecting the polypeptide from the culture; a process for producing single-strand RNA fragments, characterized by including the step of causing the polypeptide to act on a single-strand RNA; and a method of fragmenting a single-strand RNA.
摘要翻译： 展示多肽的新型内切核糖核酸酶活性; 编码该多肽的核酸; 包含该核酸的重组DNA; 通过使用重组DNA转化获得的转化体; 其特征在于包括培养转化体并从培养物中收集多肽的步骤; 一种产生单链RNA片段的方法，其特征在于包括使多肽作用在单链RNA上的步骤; 以及分裂单链RNA的方法。
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公开(公告)号：US08017356B2
公开(公告)日：2011-09-13
申请号：US11997119
申请日：2006-07-04
CPC分类号： C12N9/22
摘要： A polypeptide having a endoribonuclease activity; a nucleic acid encoding the polypeptide; recombinant DNA having the nucleic acid therein; a transformant transformed with the recombinant DNA; a process for producing the polypeptide comprising the steps of cultivating the transformant and collecting the polypeptide from the culture; a process for producing a digest of single-stranded RNA comprising the step of reacting the polypeptide with the single-stranded RNA; and a method for the digestion of single-stranded RNA.
摘要翻译： 具有内切核糖核酸酶活性的多肽; 编码该多肽的核酸; 其中具有核酸的重组DNA; 用重组DNA转化的转化体; 一种生产多肽的方法，包括培养转化体并从培养物中收集多肽的步骤; 一种生产单链RNA消化的方法，包括使多肽与单链RNA反应的步骤; 以及消化单链RNA的方法。
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公开(公告)号：US20100330616A1
公开(公告)日：2010-12-30
申请号：US11997071
申请日：2006-07-04
CPC分类号： C12N9/22
摘要： A polypeptide having a novel endoribonuclease activity; a nucleic acid encoding the polypeptide; recombinant DNA having the nucleic acid therein; a transformant transformed with the recombinant DNA; a process for producing the polypeptide comprising the steps of cultivating the transformant and collecting the polypeptide from the culture; a process for producing a digest of single-stranded RNA comprising the step of reacting the polypeptide with the single-stranded RNA; and a method for the digestion of single-stranded RNA.
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公开(公告)号：US20100093026A1
公开(公告)日：2010-04-15
申请号：US11997119
申请日：2006-07-04
CPC分类号： C12N9/22
摘要： A polypeptide having a novel endoribonuclease activity; a nucleic acid encoding the polypeptide; recombinant DNA having the nucleic acid therein; a transformant transformed with the recombinant DNA; a process for producing the polypeptide comprising the steps of cultivating the transformant and collecting the polypeptide from the culture; a process for producing a digest of single-stranded RNA comprising the step of reacting the polypeptide with the single-stranded RNA; and a method for the digestion of single-stranded RNA.
摘要翻译： 具有新型内切核糖核酸酶活性的多肽; 编码该多肽的核酸; 其中具有核酸的重组DNA; 用重组DNA转化的转化体; 一种生产多肽的方法，包括培养转化体并从培养物中收集多肽的步骤; 一种生产单链RNA消化的方法，包括使多肽与单链RNA反应的步骤; 以及消化单链RNA的方法。
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公开(公告)号：US5102988A
公开(公告)日：1992-04-07
申请号：US362983
申请日：1989-06-08
IPC分类号： C12P21/02 , A61K8/00 , A61K8/64 , A61K8/72 , A61K8/99 , A61K38/00 , A61K38/16 , A61P17/00 , A61P27/02 , A61P35/00 , A61P43/00 , A61Q11/00 , A61Q19/00 , C07K1/22 , C07K14/78 , C12N1/21 , C12N15/00 , C12N15/09 , C12R1/19 , C12R1/91
摘要： A polypeptide having the cell-spreading activity of human fibronectin. Methods of preparing the polypeptide are described.
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公开(公告)号：US20110105582A1
公开(公告)日：2011-05-05
申请号：US10574904
申请日：2004-10-07
IPC分类号： A61K31/7088 , C07H21/04 , C07H21/02 , C12N15/63 , C12N5/02
CPC分类号： C12N15/1138 , A61K31/7088
摘要： To provide a means of controlling the function of Flt3. A composition for inhibiting the function of human Flt3, a method of inducing apoptosis by using the composition, and a kit for the method.
摘要翻译： 提供控制Flt3功能的方法。 用于抑制人Flt3功能的组合物，通过使用该组合物诱导细胞凋亡的方法，以及该方法的试剂盒。
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公开(公告)号：US08138159B2
公开(公告)日：2012-03-20
申请号：US10574904
申请日：2004-10-07
CPC分类号： C12N15/1138 , A61K31/7088
摘要： To provide a means of controlling the function of Flt3. A composition for inhibiting the function of human Flt3, a method of inducing apoptosis by using the composition, and a kit for the method.
摘要翻译： 提供控制Flt3功能的方法。 用于抑制人Flt3功能的组合物，通过使用该组合物诱导细胞凋亡的方法，以及该方法的试剂盒。
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公开(公告)号：US06897042B2
公开(公告)日：2005-05-24
申请号：US10268229
申请日：2002-10-10
IPC分类号： C07K14/245 , C12N9/24 , C12N15/00 , C12N15/63 , C12N15/67 , C12N15/70 , C12N15/72 , C12P21/06 , C07H17/00
CPC分类号： C12N15/72 , C07K14/245 , C12N9/2471 , C12N15/00 , C12N15/635 , C12N15/67 , C12N15/70 , C12Y302/01023
摘要： A vector which is characterized in containing each of the following elements: (1) a promoter which shows its action in the host to be used; (2) regulatory region for regulating the action of the promoter of (1); and (3) a region which codes for the 5′-untranslated region derived from cold-shock protein gene mRNA or a region which codes for the region where substitution, deletion, insertion or addition of at least one base is applied to the said untranslated region.
摘要翻译： 一种载体，其特征在于含有以下元素：（1）在宿主中显示其作用的启动子; （2）调节（1）启动子作用的调节区; 和（3）编码来自冷休克蛋白基因mRNA的5'非翻译区的区域或编码至少一个碱基的取代，缺失，插入或添加的区域的区域，该区域应用于所述非翻译区 地区。
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