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公开(公告)号：US4118336A
公开(公告)日：1978-10-03
申请号：US750588
申请日：1976-12-15
申请人： Masataka Morishita , Yasuo Yokokawa , Tokio Nishikawa , Masahiro Mishiro , Shigeyasu Ohashi , Mitsuru Fukushima , Yoshihito Inaba , Tetsuo Matsuda
发明人： Masataka Morishita , Yasuo Yokokawa , Tokio Nishikawa , Masahiro Mishiro , Shigeyasu Ohashi , Mitsuru Fukushima , Yoshihito Inaba , Tetsuo Matsuda
CPC分类号： B01J20/28026 , B01J13/06 , B01J20/28004 , B01J20/2805 , B01J20/28078 , Y10T428/2989
摘要： A novel cellulose microcapsule having adsorbing capacity, consisting of outer semipermeable barrier layer of cellulose and adsorbent powders dispersed within inner cellulose gel matrix, is prepared by ester hydrolysis of a precursor microcapsule consisting of cellulose ester derivative and adsorbent powders. It is excellent in resistance to chemicals such as acids, alkalis or organic solvents and is useful for various purposes.
摘要翻译： 通过由纤维素酯衍生物和吸附剂粉末组成的前体微胶囊的酯水解制备具有吸附能力的新型纤维素微胶囊，其由纤维素的外部半透膜阻隔层和分散在内部纤维素凝胶基质内的吸附剂粉末组成。 它对耐酸性，碱性或有机溶剂的耐化学性是优异的，可用于各种目的。
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2.发明授权Process for producing cellulose microcapsules, and resulting cellulose microcapsules 失效生产纤维素微胶囊的方法和所得的纤维素微胶囊
公开(公告)号：US4123381A
公开(公告)日：1978-10-31
申请号：US766729
申请日：1977-02-08
申请人： Masataka Morishita , Mitsuru Fukushima , Tutomu Sasagawa , Yoshihito Inaba , Yasuo Yokokawa , Satoshi Araragi , Narumi Yoshida , Hachiro Uchiyama
发明人： Masataka Morishita , Mitsuru Fukushima , Tutomu Sasagawa , Yoshihito Inaba , Yasuo Yokokawa , Satoshi Araragi , Narumi Yoshida , Hachiro Uchiyama
CPC分类号： B01J20/28026 , B01J13/043 , B01J13/08 , B01J20/28004 , B01J20/2805 , B01J20/28078 , Y10T428/2989
摘要： A cellulose microcapsule having absorbing capacity, consisting of outer semipermeable barrier layer of cellulose and absorbent powders dispersed within inner cellulose gel matrix is prepared by dispersing adsorbent powders in a solution of cellulose dissolved in a solvent which is not adversely affected by the adsorbing capacity of adsorbent powders and capable of dissolving cellulose, then forming the dispersion into droplets and finally precipitating cellulose on the droplets. It is excellent in resistance to chemicals such as acids, alkalis or organic solvents and is useful for various purposes.
摘要翻译： 具有吸收能力的纤维素微胶囊由纤维素的外部半透性阻隔层和分散在内部纤维素凝胶基质内的吸收性粉末组成，通过将吸附剂粉末分散在溶解在溶剂中的纤维素溶液中而不受吸附剂的吸附能力的不利影响 粉末并能够溶解纤维素，然后将分散体形成液滴并最终在纤维素上沉淀纤维素。 它对耐酸性，碱性或有机溶剂的耐化学性是优异的，可用于各种目的。
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公开(公告)号：US3960757A
公开(公告)日：1976-06-01
申请号：US375027
申请日：1973-06-29
申请人： Masataka Morishita , Yoshihito Inaba , Mitsuru Fukushima , Yoshinori Hattori , Sadami Kobari , Tetsuo Matsuda
发明人： Masataka Morishita , Yoshihito Inaba , Mitsuru Fukushima , Yoshinori Hattori , Sadami Kobari , Tetsuo Matsuda
CPC分类号： A61K9/1694 , B01J13/125 , Y10T428/2989
摘要： Encapsulated medicaments are prepared by dissolving a wall material for capsules in at least one organic solvent poorly miscible with water which has a boiling point of less than 100.degree.C., a vapor pressure higher than that of water and a dielectric constant of less than about 10, dissolving or dispersing in the resulting solution a medicament which is insoluble or slightly soluble in water, dispersing the resulting solution or dispersion to the form of fine drops in a liquid vehicle comprising an aqueous solution of a hydrophilic colloid or surface active agent, and then removing the organic solvent by evaporation.
摘要翻译： 通过将胶囊的壁材料溶解在至少一种与水不易混合的有机溶剂中制备封闭的药物，所述有机溶剂的沸点低于100℃，蒸汽压高于水的蒸气压，介电常数小于约 10，在所得溶液中溶解或分散不溶于或微溶于水的药物，将所得溶液或分散体在包含亲水胶体或表面活性剂的水溶液的液体载体中分散成细滴形式，以及 然后通过蒸发除去有机溶剂。
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公开(公告)号：US3953360A
公开(公告)日：1976-04-27
申请号：US452530
申请日：1974-03-19
IPC分类号： C12P19/50 , A23L5/20 , A23L5/40 , A23L13/00 , A23L17/10 , A23L23/10 , B01D15/00 , B01D53/44 , B01D53/81 , B01J13/02 , B01J20/28 , B01J20/281 , B01J20/32 , C01B31/08 , C07B31/00 , C07B63/00 , C07C67/00 , C07H15/234 , C07K1/16 , C07K14/76 , C07K16/00 , C12N9/00 , C12P1/00 , G01N30/88 , B01J31/06
CPC分类号： B01J20/28026 , A23L5/273 , B01J20/20 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/28004 , B01J20/28078 , B01J20/3092 , B01J20/3204 , B01J20/327 , B01J20/3272 , B01J20/3276 , B01J20/3297 , C01B31/084 , B01J2220/46 , B01J2220/4812 , B01J2220/58
摘要： Selective adsorbing particles are prepared by dispersing activated charcoal in a hydrophilic solvent solution of a polymer capable of forming a semi-permeable film in a coagulating medium and then adding the dispersion dropwise into a coagulating bath. The selective adsorbing particles have adsorption capacity substantially the same as that of untreated activated charcoal. Separation of organic compounds is performed by a method wherein a solution containing a mixture of adsorptive organic compounds and non-adsorptive compounds is contacted with the selective adsorbing particles. The method is suitable for separation or purification of various organic compounds such as antibiotics, dyestuffs, nucleic acids, preteins or enzymes.
摘要翻译： 通过将活性炭分散在凝固介质中能够形成半透膜的聚合物的亲水溶剂溶液中，然后将分散液滴加到凝固浴中来制备选择性吸附颗粒。 选择性吸附颗粒具有与未处理活性炭基本相同的吸附能力。 通过使含有吸附性有机化合物和非吸附性化合物的混合物的溶液与选择性吸附粒子接触的方法进行有机化合物的分离。 该方法适用于各种有机化合物如抗生素，染料，核酸，前体蛋白或酶的分离或纯化。
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公开(公告)号：US4135943A
公开(公告)日：1979-01-23
申请号：US673522
申请日：1976-04-05
CPC分类号： B01J20/28026 , B01J20/28004 , B01J20/28019 , C08L1/28 , C08L5/02 , C12N9/00
摘要： Selective adsorbents are prepared by dispersing powdery adsorbents in a composition for forming a crosslinked high molecular weight polymer, then dispersing in fine droplets the dispersion in a vehicle and performing crosslinking reaction to form a crosslinked polymer. The fine powders of adsorbents are enclosed within the crosslinked polymer and dispersed in three-dimensional spaces. Hydroxyl group containing polymeric substance and crosslinking agent or a monomer mixture of ethylenically unsaturated monomer and crosslinking monomer is used in said composition. The selective adsorbents can be useful in separation or purification of various organic compounds.
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公开(公告)号：US3951859A
公开(公告)日：1976-04-20
申请号：US429677
申请日：1973-12-28
CPC分类号： B01J20/28026 , B01J20/28004 , B01J20/28047 , B01J20/28078
摘要： A novel molecular sieving particle containing adsorbent powders dispersed in matrix of micro-porous polymer gels is prepared by dispersing adsorbent powders into a polymeric material solution dissolved in a solvent, then emulsifying the thus prepared dispersion into a vehicle having a boiling point higher than that of the solvent and finally removing the solvent by evaporation. This molecular sieving particle has excellent molecular sieving effect as well as excellent adsorption capacity, and applicable in various applications.
摘要翻译： 通过将吸附剂粉末分散在溶解在溶剂中的聚合物材料溶液中，然后将如此制备的分散体乳化成沸点高于微孔聚合物凝胶的沸点的载体，制备含有分散在微孔聚合物凝胶基质中的吸附剂粉末的新型分子筛颗粒 溶剂，最后通过蒸发除去溶剂。 该分子筛颗粒具有优异的分子筛分效果以及优异的吸附能力，适用于各种应用。
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公开(公告)号：US3943063A
公开(公告)日：1976-03-09
申请号：US320180
申请日：1973-01-02
申请人： Masataka Morishita , Yoshihito Inaba , Mitsuru Fukushima , Sadami Kobari , Akiho Nagata , Jinnosuke Abe
发明人： Masataka Morishita , Yoshihito Inaba , Mitsuru Fukushima , Sadami Kobari , Akiho Nagata , Jinnosuke Abe
IPC分类号： C09J7/00 , A01N25/28 , A23L1/00 , A23L3/00 , A61K9/16 , A61K9/50 , B01J13/08 , B01J13/12 , C05G3/00 , C09B67/08 , C11B9/00 , C12N11/04 , B01J13/02
CPC分类号： B01J13/08 , A61K9/1694 , A61K9/50 , A61K9/5089 , B01J13/12 , C12N11/04 , Y10T428/2984 , Y10T428/2987 , Y10T428/2989
摘要： Microcapsules are made by (a.) dispersing or dissolving a core substance in a film-forming polymer solution, (b.) emulsifying in fine droplets the resulting dispersion or solution in a vehicle which is poorly miscible with the solvent of the polymer solution and which doesn't dissolve said polymer to prepare an emulsion, and (c.) adding to the emulsion a non-solvent for the polymer wherein the non-solvent is miscible with the solvent, poorly miscible with the vehicle, and does not dissolve the polymer, whereby the solvent is removed by being absorbed by non-solvent emulsion droplets to precipitate the polymer film around the core substance.
摘要翻译： 微胶囊通过（a。）将核心物质分散或溶解在成膜聚合物溶液中制成，（b。）将细小的液滴乳化成所得到的分散体或溶液在与聚合物溶液的溶剂不易混溶的载体中， 其不溶解所述聚合物以制备乳液，和（c）向所述乳液中加入用于所述聚合物的非溶剂，其中所述非溶剂与所述溶剂混溶，与所述载体不易混溶，并且不溶解 聚合物，由此通过被非溶剂乳液液滴吸收除去溶剂以使聚合物膜围绕核心物质沉淀。
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公开(公告)号：US3960662A
公开(公告)日：1976-06-01
申请号：US543639
申请日：1975-01-23
申请人： Tetsuo Matsuda , Tsutomu Yamaguchi , Tadashiro Fujii , Kunio Matsumoto , Masataka Morishita , Mitsuru Fukushima , Yuzo Shibuya
发明人： Tetsuo Matsuda , Tsutomu Yamaguchi , Tadashiro Fujii , Kunio Matsumoto , Masataka Morishita , Mitsuru Fukushima , Yuzo Shibuya
IPC分类号： C07D501/18 , C12P35/02 , C12D13/06
CPC分类号： C12P35/02 , Y10S435/822 , Y10S435/874
摘要： 7-Amino-cephem compounds are produced from 7-substituted-cephem compounds by the enzymatic action of microorganisms Comamonas sp. SY-77-1 FERM-P 2410 or Pseudomonas ovalis ATCC 950.
摘要翻译： 7-氨基头孢烯化合物由7-取代的头孢烯化合物通过微生物Comamonas sp的酶促作用产生。 SY-77-1 FERM-P 2410或椭圆形假单胞菌ATCC 950。
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公开(公告)号：US5292767A
公开(公告)日：1994-03-08
申请号：US19202
申请日：1993-02-18
申请人： Shiro Mita , Yoichi Kawashima , Nobuharu Kato , Hiroshi Suhara , Koji Yoneda , Masataka Morishita
发明人： Shiro Mita , Yoichi Kawashima , Nobuharu Kato , Hiroshi Suhara , Koji Yoneda , Masataka Morishita
IPC分类号： A61K31/38 , A61K31/381 , A61P37/00 , A61P37/04 , C07D333/38 , C07D409/06 , C07D409/12 , C07D409/14 , C07D495/08 , A01N43/08 , C07D233/54
CPC分类号： C07D409/12 , C07D333/38 , C07D495/08 , Y02P20/55
摘要： A compound of the formula [I] and pharmaceutically acceptable salts thereof; and a synthetic intermediate represented by the formula [II] and pharmaceutically acceptable salts thereof, ##STR1## wherein R 1 is hydrogen or lower alkyl;R 2 is hydrogen or a protective group of thiol;R 3 is hydroxy, a remainder of ester group or a remainder of amido group;A is straight or branched lower alkylene, andthe sulfur atom in the side chain may be directly join with --CO-- to conform a thiolactone ring.The compounds of this invention have excellent thymulin-like activities and are expected to be useful for treatment of various immune disorders such as immunodeficiency and autoimmune diseases.
摘要翻译： 式（I）的化合物及其药学上可接受的盐; 和式（II）表示的合成中间体及其药学上可接受的盐，（*化学结构*）（I）（*化学结构*）（II）其中R 1为氢或低级烷基; R 2是氢或硫醇的保护基; R 3是羟基，剩余的酯基或酰氨基的剩余部分; A是直链或支链的低级亚烷基，并且侧链中的硫原子可以直接与-CO-连接，以使硫内酯环符合。 本发明的化合物具有优异的胸腺素样活性，并且预期可用于治疗各种免疫疾病如免疫缺陷和自身免疫性疾病。
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公开(公告)号：US4873087A
公开(公告)日：1989-10-10
申请号：US355887
申请日：1982-03-08
CPC分类号： A61K9/02 , A61K47/183 , A61K47/42 , Y10S514/946 , Y10S514/947 , Y10S514/966 , Y10S514/967
摘要： A preparation containing an absorption promoter selected from N-acyl amino acid derivatives or N-acyl peptide derivatives represented by the formula: R-CO-A (R is an aliphatic hydrocarbon group, an aromatic hydrocarbon group or an aryl-substituted lower hydrocarbon group which may optionally be substituted, and A is an amino acid residue or a peptide residue), preferably in the presence of a salt at a concentation exhibiting higher osmotic pressure than isotonic sodium chloride solution, and a medicine is found to promote absorption of the medicine through a gastrointestinal organ such as the colon and rectum, and through the vagina.
摘要翻译： 含有选自N-酰基氨基酸衍生物或由下式表示的N-酰基肽衍生物的吸收促进剂的制剂：R-CO-A（R为脂族烃基，芳族烃基或芳基取代的低级烃基 其可以任选被取代，A是氨基酸残基或肽残基），优选在与等渗氯化钠溶液相比表现出较高渗透压浓度的盐存在下，发现药物促进药物的吸收 通过胃肠器官如结肠和直肠，并通过阴道。
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