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公开(公告)号：US08940872B2
公开(公告)日：2015-01-27
申请号：US12667624
申请日：2008-07-07
CPC分类号： C07K16/18 , G01N33/6875
摘要： The present invention provides an antibody that specifically binds to an abnormal TDP-43 protein aggregate, an agent comprising the antibody for detecting a TDP-43 proteinopathy lesion, and a method for detecting or diagnosing a TDP-43 proteinopathy lesion by using the antibody.
摘要翻译： 本发明提供特异性结合异常TDP-43蛋白质聚集体的抗体，包含用于检测TDP-43蛋白病变病变的抗体的试剂，以及使用该抗体检测或诊断TDP-43蛋白病变病变的方法。
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公开(公告)号：US20110287453A1
公开(公告)日：2011-11-24
申请号：US12667624
申请日：2008-07-07
CPC分类号： C07K16/18 , G01N33/6875
摘要： The present invention provides an antibody that specifically binds to an abnormal TDP-43 protein aggregate, an agent comprising the antibody for detecting a TDP-43 proteinopathy lesion, and a method for detecting or diagnosing a TDP-43 proteinopathy lesion by using the antibody.
摘要翻译： 本发明提供特异性结合异常TDP-43蛋白质聚集体的抗体，包含用于检测TDP-43蛋白病变病变的抗体的试剂，以及使用该抗体检测或诊断TDP-43蛋白病变病变的方法。
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公开(公告)号：US08715643B2
公开(公告)日：2014-05-06
申请号：US12936585
申请日：2009-03-06
CPC分类号： G01N33/5058 , C07K14/4711 , G01N33/5014
摘要： Disclosed is a transformed cell (a cell model) which can form a cytoplasmic inclusion body derived from TAR DNA-binding protein of 43 kDa (TDP-43) that is found in the brain of a patient suffering from a neurodegenerative disease such as FTLD and ALS. The transformed cell is characterized by having, introduced therein, a promoter capable of functioning in a host cell and a mutant TDP-43 gene.
摘要翻译： 公开了一种转化细胞（细胞模型），其可以形成来自患有神经变性疾病如FTLD的患者的脑中的43kDa（TDP-43）的TAR DNA结合蛋白的细胞质包涵体，以及 ALS。 转化细胞的特征在于在其中引入能够在宿主细胞中起作用的启动子和突变型TDP-43基因。
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公开(公告)号：US20110034447A1
公开(公告)日：2011-02-10
申请号：US12936585
申请日：2009-03-06
IPC分类号： A61K31/54 , C12N5/079 , C12Q1/68 , C07D279/18 , C07D471/04 , A61P25/28
CPC分类号： G01N33/5058 , C07K14/4711 , G01N33/5014
摘要： Disclosed is a transformed cell (a cell model) which can form a cytoplasmic inclusion body derived from TAR DNA-binding protein of 43 kDa (TDP-43) that is found in the brain of a patient suffering from a neurodegenerative disease such as FTLD and ALS. The transformed cell is characterized by having, introduced therein, a promoter capable of functioning in a host cell and a mutant TDP-43 gene.
摘要翻译： 公开了一种转化细胞（细胞模型），其可以形成来自患有神经变性疾病如FTLD的患者的脑中的43kDa（TDP-43）的TAR DNA结合蛋白的细胞质包涵体，以及 ALS。 转化细胞的特征在于在其中引入能够在宿主细胞中起作用的启动子和突变型TDP-43基因。
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公开(公告)号：US09624279B2
公开(公告)日：2017-04-18
申请号：US14348024
申请日：2012-05-18
CPC分类号： C07K14/47 , C07K14/4711 , C12P21/02 , G01N33/5058 , G01N33/6896
摘要： The purpose of the present invention is to develop a method for amplifying in vitro to a large amount of a homogenous insoluble aggregate that is equivalent to an insoluble aggregate formed in the brain of a patient. A method of producing an insoluble aggregate including TDP-43 protein and fragments thereof according to the present invention includes the steps of: (1) introducing an insoluble fraction originated from the brain of a neurodegenerative disease patient into a cell culture in which the intact TDP-43 protein can be expressed in a constitutive manner; (2) culturing the cultured cell into which the insoluble fraction has been introduced; and (3) separating an insoluble fraction from the cultured cell. Optionally, the method may additionally include a step of amplifying the insoluble aggregate of the neurodegenerative-disease-related protein in the cultured cell.
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6.发明申请METHOD FOR PRODUCING INSOLUBLE AGGREGATE OF NEURODEGENERATIVE-DISEASE-RELATED PROTEIN 有权生产与神经营养因子相关蛋白质不溶性聚集体的方法公开(公告)号：US20140248657A1
公开(公告)日：2014-09-04
申请号：US14348024
申请日：2012-05-18
CPC分类号： C07K14/47 , C07K14/4711 , C12P21/02 , G01N33/5058 , G01N33/6896
摘要： The purpose of the present invention is to develop a method for producing a large amount of an insoluble aggregate that is equivalent to an insoluble aggregate formed in the brain of a patient. A method of producing an insoluble aggregate of a neurodegenerative-disease-related protein according to the present invention comprises the steps of: (1) introducing an insoluble fraction originated from the brain of a neurodegenerative disease patient into a cultured cell in which the neurodegenerative-disease-related protein can be expressed in a constitutive manner; (2) culturing the cultured cell into which the insoluble fraction has been introduced; and (3) extracting separating an insoluble fraction from the cultured cell. Optionally, the method may additionally comprise a step of amplifying the insoluble aggregate of the neurodegenerative-disease-related protein in the cultured cell.
摘要翻译： 本发明的目的是开发用于生产大量不溶性聚集体的方法，其相当于形成在患者脑中的不溶性聚集体。 根据本发明的生产神经变性疾病相关蛋白质的不溶性聚集体的方法包括以下步骤：（1）将来自神经变性疾病患者的脑的不溶性级分引入培养的细胞中，其中神经变性 - 疾病相关蛋白可以以组成型表达; （2）培养其中引入不溶性级分的培养细胞; 和（3）从培养的细胞中提取不溶性级分。 任选地，所述方法还可以包括扩增培养细胞中神经变性疾病相关蛋白质的不溶性聚集体的步骤。
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7.发明授权
公开(公告)号：US5144258A
公开(公告)日：1992-09-01
申请号：US729601
申请日：1991-07-15
CPC分类号： H03G3/3047 , H03G3/3078
摘要： A power amplifier system suitable for a mobile radio receiver/transmitter is described. A wave form signal to be transmitted is made smooth during its rise and fall times, thereby making it possible to prevent a transmission spectrum from expanding and interfering with the adjacent channels. The power amplifier system compares an envelope signal of an inputted RF signal and that of an RF signal to be outputted, whereby the power amplifier system as a whole provides linear amplification.
摘要翻译： 描述了适用于移动无线电接收机/发射机的功率放大器系统。 要发送的波形信号在其上升和下降时间期间变得平滑，从而可以防止发射频谱扩展和干扰相邻信道。 功率放大器系统将输入的RF信号的包络信号与要输出的RF信号的包络信号进行比较，由此整个功率放大器系统提供线性放大。
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公开(公告)号：US4720829A
公开(公告)日：1988-01-19
申请号：US848112
申请日：1986-04-04
申请人： Atsushi Fukasawa , Takuro Sato , Haruhiko Akiyama , Manabu Kawabe
发明人： Atsushi Fukasawa , Takuro Sato , Haruhiko Akiyama , Manabu Kawabe
CPC分类号： H04L1/1642 , H03M13/03 , H04L1/0007 , H04L1/0009 , H04L1/002 , H04L1/0026 , H04L1/0034 , H04L1/1809 , H04L2001/125
摘要： An error control encoding method and a mobile data communication system using the method in a moving body communication system such as mobile telephone for effecting data communication through a fading channel dominated by a burst error, upon receiving data transmitted from the transmitting side on the receiving side, detects any error involved in said received data as a frame error rate involved in block data or a bit error rate in the block data and thereby changes the frame length in response to the detected error rates. The mobile data communication system employs the error control encoding method wherein a frame length employed in the transmitting part is changed in response to the extent of any involved error in the received data detected by the remote receiving part.
摘要翻译： 一种误差控制编码方法和移动数据通信系统，在移动电话机等移动体通信系统中，通过由接收侧的发送侧发送的数据，通过由突发错误支配的衰落信道进行数据通信， 检测所述接收数据中涉及的任何错误，作为块数据中涉及的帧错误率或块数据中的误码率，从而根据检测到的错误率改变帧长度。 移动数据通信系统采用错误控制编码方法，其中响应于由远程接收部分检测到的接收数据中涉及到的任何错误的程度，发送部分中使用的帧长度被改变。
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9.发明申请Ha4,a new osteoblast-and chondrocyte-specific small secreted peptide, compositions and methods of use 审中-公开Ha4，一种新的成骨细胞和软骨细胞特异性小分泌肽，组合物和使用方法公开(公告)号：US20060253914A1
公开(公告)日：2006-11-09
申请号：US10534099
申请日：2003-11-04
IPC分类号： A01K67/027 , C12Q1/68 , C07H21/04 , C12P21/06 , A61K38/18 , A61K31/59 , A61K31/445 , A61K31/66 , C07K14/475
CPC分类号： A01K67/0275 , A01K2217/075 , A01K2227/105 , A01K2267/035 , A61K38/00 , C07H21/04 , C07K14/51
摘要： A polypeptide designated HA4, expressed selectively by bone tissue, is provided. Transgenic animals that fail to express HA4 have bone formation abnormalities reflective of osteoporosis, Also provided are methods for promoting bone formation by increasing the activity or expression of HA4, methods of diagnosing or treating bone degenerative diseases, and methods of screening for drugs that alter bone formation.
摘要翻译： 提供了由骨组织选择性表达的称为HA4的多肽。 不能表达HA4的转基因动物具有反映骨质疏松症的骨形成异常。还提供了通过增加HA4的活性或表达来促进骨形成的方法，诊断或治疗骨退行性疾病的方法，以及筛选改变骨的药物的方法 形成。
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公开(公告)号：US4845740A
公开(公告)日：1989-07-04
申请号：US279786
申请日：1988-12-05
CPC分类号： G07F7/08 , G07F17/0014 , G07F7/12 , H04M17/023
摘要： A radio phone equipment for credit card is adapted to transfer part or a whole of credit card or charge card information read by a card reader as well as a dial number dialed by a key pad to a mobile telecommunication switching office by means of a modem and a transmitter/receiver, and in case of said credit card or charge card being valid, switching, on the basis of a designation on a voice channel transmitted from said mobile telecommunication switching office, or transmitting and receiving frequency to said voice channel to construct a speech channel, and furthermore detecting on-hook of a handset produced upon finishing talking to reset the equipment.
摘要翻译： 用于信用卡的无线电话设备适于将由读卡器读取的部分或全部信用卡或费用卡信息以及由键盘拨打的拨号号码通过调制解调器传送到移动电信交换局， 发送器/接收器，并且在所述信用卡或费用卡有效的情况下，基于从所述移动电信交换局发送的语音信道的指定，或者向所述语音信道发送和接收频率来构建一个 语音信道，并且还检测在完成通话时产生的手机的挂机以重置设备。
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