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1.发明申请Nucleic acid primer set for detection of drug-resistant strain of hepatitis B virus, assay kit, and method of detecting drug-resistant strain of hepatitis B virus 审中-公开用于检测乙型肝炎病毒耐药菌株的核酸引物组，测定试剂盒和检测乙型肝炎病毒耐药菌株的方法公开(公告)号：US20100248210A1
公开(公告)日：2010-09-30
申请号：US12382733
申请日：2009-03-23
申请人： Masayoshi Takahashi , Michie Hashimoto , Keiko Ito , Keiko Kizu , Shunji Mishiro , Kazuaki Takahashi , Kazunori Miyazaki , Koji Hashimoto , Nobuhiro Gemma
发明人： Masayoshi Takahashi , Michie Hashimoto , Keiko Ito , Keiko Kizu , Shunji Mishiro , Kazuaki Takahashi , Kazunori Miyazaki , Koji Hashimoto , Nobuhiro Gemma
IPC分类号： C12Q1/70
CPC分类号： C12Q1/706
摘要： The invention provides a method of detecting a drug-resistant strain of hepatitis B virus, including amplifying a hepatitis B virus nucleic acid in a sample solution by LAMP with a primer set to yield an amplification product, and hybridizing the amplification product with a probe containing a polynucleotide derived from a drug-resistant strain and/or a probe containing a polynucleotide derived from a drug-nonresistant strain, to detect a drug-resistant strain of hepatitis B virus.
摘要翻译： 本发明提供一种检测乙型肝炎病毒的耐药性菌株的方法，包括通过具有引物组的LAMP扩增样品溶液中的乙型肝炎病毒核酸以产生扩增产物，并将扩增产物与含有 衍生自耐药菌株的多核苷酸和/或含有衍生自药物不耐药菌株的多核苷酸的探针，以检测乙型肝炎病毒的耐药菌株。
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2.发明申请GENETIC MARKER SELECTION PROGRAM FOR GENETIC DIAGNOSIS, APPARATUS AND SYSTEM FOR EXECUTING THE SAME, AND GENETIC DIAGNOSIS SYSTEM 审中-公开用于遗传诊断的遗传标记选择程序，用于执行其的装置和系统以及遗传诊断系统公开(公告)号：US20070082353A1
公开(公告)日：2007-04-12
申请号：US11533134
申请日：2006-09-19
摘要： There is provided a marker selection program for selecting a marker for use in genetic diagnosis. In the program, analysis is carried out by using at least two specimen databases which respectively store data of specimens belonging different populations. By carrying out analysis without integrating all specimen data into single population, information on a minority population can be surely reflected to a gene search. Since the characteristics of each population can be reflected, high-accuracy diagnosing functions can be obtained, providing a practical diagnosing system.
摘要翻译： 提供了用于选择用于遗传诊断的标记物的标记选择程序。 在程序中，通过使用至少两个分别存储属于不同种群的标本的数据的样本数据库进行分析。 通过进行分析，不将所有样本数据整合到单个人群中，少数民族的信息可以肯定地反映到基因检索中。 由于能反映每个人群的特点，可以获得高精度诊断功能，提供实用的诊断系统。
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3.发明申请Polynucleotide probe and primer derived from hepatitis E virus recovered from japanese, chip including the same, kit including the same, and method of detecting hepatitis E virus genome using the same 审中-公开来自日本的片段的来自日本的来自戊型肝炎病毒的多核苷酸探针和引物包括相同的试剂盒，含有该试剂盒的试剂盒以及使用该试剂盒检测戊型肝炎病毒基因组的方法公开(公告)号：US20060246428A1
公开(公告)日：2006-11-02
申请号：US11455658
申请日：2006-06-20
CPC分类号： C12Q1/707 , C12Q2565/501 , C12Q2531/113
摘要： A polynucleotide probe that has a sequence of at least 8 nucleotides which can be hybridized with nucleotides from the hepatitis E virus JRA 1; a probe assay kit that includes the polynucleotide probe; and a chip on which the polynucleotide probe has been solid-phase fixed.
摘要翻译： 具有至少8个核苷酸序列的多核苷酸探针，其可与来自戊型肝炎病毒JRA 1的核苷酸杂交; 包括多核苷酸探针的探针测定试剂盒; 以及多核苷酸探针已被固相固定的芯片。
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4.发明申请Polynucleotide probe and primer derived from hepatitis E virus recovered from japanese, chip including the same, kit including the same, and method of detecting hepatitis E virus genome using the same 审中-公开来自日本的片段的来自日本的来自戊型肝炎病毒的多核苷酸探针和引物包括相同的试剂盒，含有该试剂盒的试剂盒以及使用该试剂盒检测戊型肝炎病毒基因组的方法公开(公告)号：US20060228702A1
公开(公告)日：2006-10-12
申请号：US11455703
申请日：2006-06-20
CPC分类号： C12Q1/707 , C12Q2565/501 , C12Q2531/113
摘要： A polynucleotide probe that has a sequence of at least 8 nucleotides and is used for detecting at least one hepatitis E virus selected from JSN-FH, JKN-Sap, JMY-Haw, JAK-Sai, and JRA1; a probe assay kit that includes the polynucleotide probe; and a chip on which the polynucleotide probe has been solid-phase fixed.
摘要翻译： 具有至少8个核苷酸序列并用于检测选自JSN-FH，JKN-Sap，JMY-Haw，JAK-Sai和JRA1的至少一种戊型肝炎病毒的多核苷酸探针; 包括多核苷酸探针的探针测定试剂盒; 以及多核苷酸探针已被固相固定的芯片。
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公开(公告)号：US20080166710A1
公开(公告)日：2008-07-10
申请号：US11692837
申请日：2007-03-28
IPC分类号： C12Q1/68
CPC分类号： C12Q1/701
摘要： The present invention provides methods for obtaining information regarding nucleic acid from an individual and nucleic acid associated with a disease of the individual, in particular when the disease is associated with a pathogenic microorganism present within the individual. The present invention also provide probe-immobilized substrates, such as probe-immobilized chips, for use in the methods. In particular, the present invention provides methods and probe-immobilized substrates for obtaining information regarding responsiveness to a treatment for a disease of an individual.
摘要翻译： 本发明提供了获得关于来自个体的核酸的信息和与个体的疾病相关的核酸的信息的方法，特别是当疾病与个体内存在的病原微生物相关时。 本发明还提供了用于该方法的探针固定的基底，例如探针固定的碎片。 特别地，本发明提供了用于获得关于对个体疾病的治疗的反应性的信息的方法和探针固定的基质。
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6.发明申请METHOD OF DETECTING HUMAN PAPILLOMA VIRUS BY USING NUCLEIC ACID AMPLIFICATION METHOD AND NUCLEIC ACID CHAIN-IMMOBILIZED CARRIER 有权通过使用核酸扩增方法和核酸链固定载体检测人乳头瘤病毒的方法公开(公告)号：US20090035750A1
公开(公告)日：2009-02-05
申请号：US12134420
申请日：2008-06-06
申请人： Koji Hashimoto , Keiko Ito , Naoko Nakamura , Hideki Horiuchi , Michie Hashimoto , Osamu Sato
发明人： Koji Hashimoto , Keiko Ito , Naoko Nakamura , Hideki Horiuchi , Michie Hashimoto , Osamu Sato
CPC分类号： C12Q1/708
摘要： Provided is a nucleic acid primer for LAMP amplification for use in the detection of human papilloma virus and identification of its genotype. The present invention also provides a method of detecting human papilloma virus and identifying its genotype, includes a step of amplifying the nucleic acid chains in a sample in LAMP reaction by using multiple primers including at least one primer selected from the nucleic acid primers according to the present invention and a step of detecting presence of amplified products after the amplification reaction and identifying their genotypes.
摘要翻译： 提供了用于LAMP扩增的核酸引物，用于检测人乳头瘤病毒并鉴定其基因型。 本发明还提供了一种检测人乳头状瘤病毒并鉴定其基因型的方法，包括通过使用包含至少一种引物的多个引物来扩增LAMP反应中的核酸链的步骤，该引物选自根据本发明的核酸引物 本发明和扩增反应后检测扩增产物的存在并鉴定其基因型的步骤。
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7.发明授权公开(公告)号：US07910719B2
公开(公告)日：2011-03-22
申请号：US12134420
申请日：2008-06-06
申请人： Koji Hashimoto , Keiko Ito , Naoko Nakamura , Hideki Horiuchi , Michie Hashimoto , Osamu Sato
发明人： Koji Hashimoto , Keiko Ito , Naoko Nakamura , Hideki Horiuchi , Michie Hashimoto , Osamu Sato
CPC分类号： C12Q1/708
摘要： Provided is a nucleic acid primer for LAMP amplification for use in the detection of human papilloma virus and identification of its genotype. The present invention also provides a method of detecting human papilloma virus and identifying its genotype, includes a step of amplifying the nucleic acid chains in a sample in LAMP reaction by using multiple primers including at least one primer selected from the nucleic acid primers according to the present invention and a step of detecting presence of amplified products after the amplification reaction and identifying their genotypes.
摘要翻译： 提供了用于LAMP扩增的核酸引物，用于检测人乳头瘤病毒并鉴定其基因型。 本发明还提供了一种检测人乳头状瘤病毒并鉴定其基因型的方法，包括通过使用包含至少一种引物的多个引物来扩增LAMP反应中的核酸链的步骤，该引物选自根据本发明的核酸引物 本发明和扩增反应后检测扩增产物的存在并鉴定其基因型的步骤。
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公开(公告)号：US07101670B2
公开(公告)日：2006-09-05
申请号：US10270524
申请日：2002-10-16
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： The present invention provides a polymorphic marker found in a region of the interferon receptor gene that can be used to assess the efficacy of interferon therapy. Thus, the present invention also relates to methods of assessing the efficacy of interferon therapy in an individual and means for accomplishing such a method.
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9.发明申请METHOD OF PREDICTING POTENTIAL SEVERITY OF HEPATITIS E, PROBE SETS, AND PRIMER SETS 审中-公开预防艾滋病毒E，探针组和引物组的潜在严重程度的方法公开(公告)号：US20100173283A1
公开(公告)日：2010-07-08
申请号：US12642553
申请日：2009-12-18
IPC分类号： C12Q1/70
CPC分类号： C12Q1/707 , C07K14/005 , C12N7/00 , C12N2770/28121 , C12N2770/28122
摘要： The present invention provides a method of predicting potential severity of hepatitis, includes determining that hepatitis in a subject is potentially severe when it is detected that any amino acid is mutated to an amino acid of genotype-4, the any amino acid being amino acid of an amino acid sequence in a region encoded by ORF1 of an HEV genome RNA of genotype 3, and the HEV genome RNA being contained in a specimen nucleic acid taken from the subject infected with genotype-3 HEV.
摘要翻译： 本发明提供一种预测肝炎潜在严重程度的方法，包括确定当检测到任何氨基酸被突变为基因型-4的氨基酸时，受试者中的肝炎可能是严重的，任何氨基酸是氨基酸的氨基酸 由基因型3的HEV基因组RNA由ORF1编码的区域中的氨基酸序列，以及从感染基因型3 HEV的受试者取得的标本核酸中包含的HEV基因组RNA。
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公开(公告)号：US20240093282A1
公开(公告)日：2024-03-21
申请号：US18359706
申请日：2023-07-26
申请人： Yusuke OSAKI , Yuuki Yonekawa , Michie Hashimoto , Hirotaka Unno
发明人： Yusuke OSAKI , Yuuki Yonekawa , Michie Hashimoto , Hirotaka Unno
IPC分类号： C12Q1/6851 , B01L3/00 , B01L7/00 , C12Q1/70
CPC分类号： C12Q1/6851 , B01L3/502707 , B01L3/502715 , B01L7/52 , C12Q1/701 , B01L2200/12 , B01L2200/16 , B01L2300/18 , C12Q2600/166
摘要： The present invention has an object to develop and provide a target nucleic acid detection device having a low copy number of IPC nucleic acids placed therein, and a method for producing the device, to avoid a decrease caused in the detection sensitivity to a target nucleic acid through competitive inhibition of the target nucleic acid by addition of an internal positive control (IPC) nucleic acid. Provided is a target nucleic acid detection device in which a low copy number of IPC nucleic acids that do not inhibit the amplification reaction of a target nucleic acid is preliminarily placed in a reaction well.
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