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    Synthesis of tyrosine derived polyarylates
    1.
    发明授权
    Synthesis of tyrosine derived polyarylates 有权

    公开(公告)号：US11359050B2

    公开(公告)日：2022-06-14

    申请号：US16936858

    申请日：2020-07-23

    Applicant: MEDTRONIC, INC.

    Inventor： Satish Pulapura ,  Fatima Buevich ,  Xiangji Chen ,  Suping Lyu

    IPC: C08G63/81 ,  C08G63/16 ,  C08G63/685

    Abstract: A method for preparing tyrosine derived polyarylates includes combining a desaminotyrosyl-tyrosine ethyl ester, a desaminotyrosyl-tyrosine benzylester, succinic acid and a catalyst in a flask to produce a first mixture. Methylene chloride is added to the first mixture to produce a first suspension. Diisopropylcarbodiimide (DIPC) is added to the first mixture to produce a first solution. The first solution is added to a non-solvent to produce a precipitate. The precipitate is dissolved in methylene chloride to form a polymer solution. The polymer solution is blended with a slurry to produce polymer shreds. The polymer shreds are blended with a second slurry to produce a tyrosine derived polyarylate.

    IMPLANTABLE MEDICAL DEVICE AND SYSTEM INCLUDING SAME
    2.
    发明申请
    IMPLANTABLE MEDICAL DEVICE AND SYSTEM INCLUDING SAME 有权

    公开(公告)号：US20220323778A1

    公开(公告)日：2022-10-13

    申请号：US17706850

    申请日：2022-03-29

    Applicant: Medtronic, Inc.

    Inventor： John C. Mertz ,  Kamal Deep Mothilal ,  Suping Lyu

    IPC: A61N1/375 ,  A61N1/05

    Abstract: Various embodiments of an implantable medical device and a system that includes such device are disclosed. The device includes a housing that includes a polymeric material, a sealed container disposed within the housing, and an electronic assembly disposed within the container. The device also includes a battery disposed within the container and electrically connected to the electronic assembly.

    IMPLANTABLE MEDICAL DEVICE AND METHOD OF FORMING SAME
    6.
    发明公开
    IMPLANTABLE MEDICAL DEVICE AND METHOD OF FORMING SAME 审中-公开

    公开(公告)号：US20230191137A1

    公开(公告)日：2023-06-22

    申请号：US17866734

    申请日：2022-07-18

    Applicant: Medtronic, Inc.

    Inventor： John Mertz ,  Kamal Deep Mothilal ,  Suping Lyu

    IPC: A61N1/375 ,  C08L75/04

    CPC classification number: A61N1/3752 ,  C08L75/04

    Abstract: Various embodiments of an implantable medical device and a method of forming such device are disclosed. The device includes a housing that has a first portion and a second portion connected to the first portion. The first portion includes a polymer material and the second portion includes a transparent polymer material. The housing further includes a lead bore that extends between a first end at an outer surface of the housing and a second end disposed within the housing.

    IMPLANTABLE MEDICAL LEADS HAVING HIGH FREQUENCY SHUNTS THAT INCLUDE A CONDUCTIVE INTERCONNECT
    8.
    发明申请
    IMPLANTABLE MEDICAL LEADS HAVING HIGH FREQUENCY SHUNTS THAT INCLUDE A CONDUCTIVE INTERCONNECT 审中-公开
    具有包括导电互连的高频分离器的可植入医疗引线

    公开(公告)号：US20150306382A1

    公开(公告)日：2015-10-29

    申请号：US14263241

    申请日：2014-04-28

    Applicant: Medtronic, Inc.

    Inventor： Bushan K. Purushothaman ,  Kenneth C. Gardeski ,  Suping Lyu ,  Yaling Fan ,  Peter M. Seiler

    IPC: A61N1/08 ,  A61N1/05

    CPC classification number: A61N1/08 ,  A61N1/05 ,  A61N1/086

    Abstract: Implantable medical leads include a conductive interconnect within a high frequency shunt that dissipates high frequency current. The conductive interconnect provides an elasticity that allows a drive shaft to rotate and translate during implantation of the lead while the conductive interconnect maintains physical contact with the drive shaft and with a shunt electrode before, during, and after the implantation. The conductive interconnect may provide a low friction that presents a smooth rotation and translation of the drive shaft to provide an acceptable tactile feedback during implantation. The conductive interconnect also provides a high electrical conductivity so that a substantial amount of high frequency current flows through the conductive interconnect to the shunt electrode. The conductive interconnect may include a polymer filler that partially penetrates into the interstitial spaces of the conductive interconnect to assist in maintaining the physical integrity of the conductive interconnect.

    Abstract translation: 可植入医疗引线包括高频分流器内的导电互连，消散高频电流。 导电互连提供弹性，其允许驱动轴在引线注入期间旋转和平移，而导电互连在植入之前，期间和之后与驱动轴和分流电极保持物理接触。 导电互连可以提供低摩擦，其提供驱动轴的平滑旋转和平移，以在植入期间提供可接受的触觉反馈。 导电互连还提供高导电性，使得大量的高频电流流过导电互连到分流电极。 导电互连可以包括部分地渗透到导电互连的间隙空间中以有助于维持导电互连的物理完整性的聚合物填料。

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