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1.发明授权Photoactivatable chain transfer agents and semi-telechelic photoactivatable polymers prepared therefrom 失效可光活化的链转移剂和由其制备的半遥爪可光活化聚合物
公开(公告)号：US5942555A
公开(公告)日：1999-08-24
申请号：US619303
申请日：1996-03-21
IPC分类号： C07C323/12 , C07C323/22 , C07C323/40 , C07C323/41 , C07C323/42 , C07C323/52 , C08F2/38 , C08F2/48 , C08F2/50 , C08F4/00 , C08F20/00 , C08J7/04 , G03F7/028 , C08L101/02 , C08G75/04 , C08G75/10 , C08J7/18
CPC分类号： C08J7/047 , C07C323/12 , C07C323/22 , C07C323/41 , C07C323/42 , C08F2/38 , C08J2323/12 , C08J2433/00 , C08J2439/00 , C08J2485/00 , Y10S522/904 , Y10S522/905
摘要： A photoactivatable reagent useful as a chain transfer reagent for providing a semitelechelic polymer having one or more terminal photoactivatable groups. The reagent provides one or more photoactivatable groups and one or more sulfhydryl (or other chain transfer) groups, the photoactivatable and chain transfer groups optionally being joined together by a spacer group. The reagent can be used to prepare a polymer by serving to initiate the polymerization of ethylenically unsaturated monomers. The reagent itself becomes an integral part of the resultant polymer, thereby providing the polymer with a terminal photoactivatable nature. The method provides a number of benefits, including the ability to provide homogeneous photoactivatable polymer compositions, e.g., in terms of the uniform location of the photogroup(s) on the terminal portion of each polymer molecule and the ability to build a desired nonpolar quality, and in turn improved surfactancy, into otherwise polar polymers.
摘要翻译： 可用作链转移试剂的可光活化试剂，用于提供具有一个或多个末端可光活化基团的半夺食聚合物。 试剂提供一个或多个可光活化基团和一个或多个巯基（或其它链转移基团），光可活化链和链转移基团任选地通过间隔基团连接在一起。 该试剂可用于通过用于引发烯属不饱和单体的聚合来制备聚合物。 试剂本身成为所得聚合物的组成部分，从而为聚合物提供端可光活化的性质。 该方法提供了许多益处，包括提供均匀可光活化的聚合物组合物的能力，例如，就各组分在每个聚合物分子的末端部分的均匀位置而言，以及建立期望的非极性质量的能力， 并进而改善表面活性，成为其他极性聚合物。
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公开(公告)号：US06506895B2
公开(公告)日：2003-01-14
申请号：US09028806
申请日：1998-02-24
IPC分类号： C07H2100
CPC分类号： C07H21/00 , A61L27/14 , A61L27/34 , A61L29/04 , A61L29/085 , A61L31/04 , A61L31/10 , A61L33/0011 , A61L33/0047 , C12N11/08 , C12Q1/56 , C12Q1/6834 , G01N33/543 , G01N33/68 , G01N33/6845 , G01N33/6854 , G01N2333/78 , G01N2333/8128 , G01N2333/815 , G01N2333/974
摘要： A photoactivatable nucleic acid derivative composition in which one or more photoreactive group(s) are bound to a natural or synthetic nucleic acid. The photoreactive groups can be bound to the nucleic acid before, during or after its formation, and can thereafter be activated in order to attach the nucleic acid to another molecule, e.g., to the surface of a solid support. Also described is a method of preparing such a composition, and a method of using such a composition to attach the nucleic acid to a another molecule, such as that provided by the surface of a substrate used to prepare a nucleic acid chip by photolithographic techniques.
摘要翻译： 一种可光活化的核酸衍生物组合物，其中一个或多个光反应基团与天然或合成核酸结合。 光反应性基团可以在其形成之前，期间或之后与核酸结合，然后可以活化以将核酸附着到另一个分子，例如固体支持物的表面。 还描述了制备这种组合物的方法，以及使用这种组合物将核酸附着到另一分子上的方法，例如由用于通过光刻技术制备核酸芯片的底物的表面提供的核酸。
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公开(公告)号：US20120178629A1
公开(公告)日：2012-07-12
申请号：US13334154
申请日：2011-12-22
IPC分类号： A01N25/04 , A23P1/00 , C08L29/04 , C08L39/08 , C08K5/101 , C08K5/05 , C08K5/109 , C08K5/07 , A61K47/32 , A61K8/81 , A61P17/18 , A61P31/00 , A61P9/12 , A61P31/10 , A61P25/18 , A61K39/395 , A61P3/10 , A61P37/04 , A61P37/06 , A61P31/12 , A61P25/08 , A61P37/08 , A61P9/00 , A61K38/22 , A61P33/06 , A61P25/04 , A61P23/00 , A61K31/711 , A61P7/02 , A61P7/04 , A61K38/20 , A61K38/19 , A61K38/18 , C09D11/00 , C09K3/00 , A01P13/00 , B01J35/00 , B01F5/06 , B82Y30/00
CPC分类号： B01F3/0807 , B01F5/0696 , B01J19/006 , B01J2219/00768 , B01J2219/00772 , B01J2219/30207 , B01J2219/30296 , B01J2219/30408 , B01J2219/30416 , B01J2219/312
摘要： Disclosed herein are apparatus and methods for producing emulsions, and, in particular, for maintaining laminar flow during production of emulsions containing microsuspensions.
摘要翻译： 本文公开了用于生产乳液的装置和方法，特别是用于在制备含微量悬浮液的乳液时保持层流。
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4.发明申请公开(公告)号：US20090269407A1
公开(公告)日：2009-10-29
申请号：US12387046
申请日：2009-04-27
申请人： Emily R. Rolfes , Jeff J. Ross , Joseph S. McGonigle , Gary W. Opperman , Stephen J. Chudzik , Pamela J. Reed
发明人： Emily R. Rolfes , Jeff J. Ross , Joseph S. McGonigle , Gary W. Opperman , Stephen J. Chudzik , Pamela J. Reed
IPC分类号： A61K9/10 , C07H7/02 , C08G69/48 , A61K31/7088 , A61K35/12
CPC分类号： C08B37/0006 , A61K47/61 , A61K47/6903 , A61L24/08 , A61L27/20 , A61L27/34 , A61L31/042 , A61L31/10 , C08B31/006 , C08B31/185
摘要： The present invention provides biocompatible, biodegradable matrices formed from poly-α(1→4)glucopyranose and reactive hydrazide groups. The matrices can be used for various applications in the body, including drug delivery and cell therapy.
摘要翻译： 本发明提供由poly-α（1-> 4）吡喃葡萄糖和反应性酰肼基团形成的生物相容的可生物降解的基质。 该基质可用于体内各种应用，包括药物递送和细胞治疗。
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公开(公告)号：US10258941B2
公开(公告)日：2019-04-16
申请号：US13334154
申请日：2011-12-22
摘要： Disclosed herein are apparatus and methods for producing emulsions, and, in particular, for maintaining laminar flow during production of emulsions containing microsuspensions. Disclosed herein are columns for receiving a packing material that permits fluid flow through the column. The columns have a periphery that defines an interior cavity in fluid communication with inlets and outlets of the column. Disclosed herein is a method of preparing an emulsion that includes (1) forming a first phase typically containing an organic solvent, a polymer, and one or more biologically active agents and/or chemicals; (2) forming a second phase typically containing water as the second solvent, an emulsion stabilizer and optionally a solvent; and (3) passing the first and the second phases through the column to form a “water in oil” type emulsion.
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公开(公告)号：US20090123436A1
公开(公告)日：2009-05-14
申请号：US12266955
申请日：2008-11-07
申请人： Gary W. Opperman
发明人： Gary W. Opperman
CPC分类号： C12N5/0018 , C12N2500/46
摘要： The invention relates to compositions for the cryogenic storage of biological materials and related methods. In an embodiment, the invention includes a cryopreservative composition including a chaotropic agent and a kosmotropic agent. In an embodiment, the invention includes a cryopreservative composition including urea and trimethylamine-N-oxide. In an embodiment, the invention includes a method of cryopreserving cells including contacting cells with a cryopreservative composition, the cryopreservative composition comprising a chaotropic agent and a kosmotropic agent. In an embodiment, the invention includes a method of transplanting cells into a subject, the method including administering a composition to the subject, the composition comprising an effective amount of a chaotropic agent, an effective amount of a kosmotropic agent, and cells. Other embodiments are also included herein.
摘要翻译： 本发明涉及用于生物材料的低温储存的组合物和相关方法。 在一个实施方案中，本发明包括一种包含离液剂和可溶性成分剂的冷冻保存组合物。 在一个实施方案中，本发明包括包含尿素和三甲胺-N-氧化物的冷冻保存组合物。 在一个实施方案中，本发明包括冷冻保存细胞的方法，包括使细胞与冷冻保存组合物接触，所述冷冻保存组合物包含离液剂和促肌剂。 在一个实施方案中，本发明包括将细胞移植到受试者中的方法，所述方法包括向受试者施用组合物，所述组合物包含有效量的离液剂，有效量的可溶性成分剂和细胞。 本文还包括其它实施例。
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7.发明授权公开(公告)号：US08790701B2
公开(公告)日：2014-07-29
申请号：US12387046
申请日：2009-04-27
CPC分类号： C08B37/0006 , A61K47/61 , A61K47/6903 , A61L24/08 , A61L27/20 , A61L27/34 , A61L31/042 , A61L31/10 , C08B31/006 , C08B31/185
摘要： The present invention provides biocompatible, biodegradable matrices formed from poly-α(1→4)glucopyranose and reactive hydrazide groups. The matrices can be used for various applications in the body, including drug delivery and cell therapy.
摘要翻译： 本发明提供由poly-α（1→4）吡喃葡萄糖和反应性酰肼基团形成的生物相容的可生物降解的基质。 该基质可用于体内各种应用，包括药物递送和细胞治疗。
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