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11 条记录 (耗时 0.036 秒)

    Iliac screw
    1.
    发明授权
    Iliac screw 失效
    髂螺丝

    公开(公告)号：US5643264A

    公开(公告)日：1997-07-01

    申请号：US527415

    申请日：1995-09-13

    申请人： Michael C. Sherman ,  Eddie Ray, III ,  Jean Pierre Farcy ,  Joseph Tai

    发明人： Michael C. Sherman ,  Eddie Ray, III ,  Jean Pierre Farcy ,  Joseph Tai

    IPC分类号： A61B17/70 ,  A61B17/56

    CPC分类号： A61B17/7037 ,  A61B17/7038 ,  A61B17/7055 ,  A61B17/7011 ,  A61B17/7041

    摘要： An iliac screw includes a smooth distal shank (35), a threaded proximal shank (37) and a proximal head portion (38). The smooth distal shank (35) is configured to penetrate the cancellous bone of the iliac wings, while the threaded shank (37) carries bone threads configured for engagement with the cortical or the cancellous bone. The head portion (38) is configured for engagement with an elongated fixation member, such as a spinal rod.

    摘要翻译： 髂骨螺钉包括平滑的远端柄（35），螺纹近端柄（37）和近侧头部（38）。 平滑的远端柄（35）被构造成穿透髂骨翼的松质骨，而螺纹柄（37）承载构造成与皮层或松质骨接合的骨螺纹。 头部（38）构造成与诸如脊椎杆的细长固定构件接合。

    Variable angle extension rod
    2.
    发明授权
    Variable angle extension rod 失效
    可变角度延伸杆

    公开(公告)号：US5645544A

    公开(公告)日：1997-07-08

    申请号：US527410

    申请日：1995-09-13

    申请人： Joseph Tai ,  Michael C. Sherman

    发明人： Joseph Tai ,  Michael C. Sherman

    IPC分类号： A61B17/70 ,  A61B17/56

    CPC分类号： A61B17/7037 ,  A61B17/7038 ,  A61B17/7041 ,  A61B17/7055 ,  A61B17/7013 ,  A61B17/705

    摘要： One embodiment of the invention a spinal fixation system includes an elongated spinal element (11) configured to extend adjacent the spine, and a plurality of fixation elements (15) each engagable to the spine and to the elongated spinal element (11). The embodiment further includes an extension member (28) having a head portion (30) defining a variable angle surface and an elongated portion (29) extending from the head portion, and a clamping member (31) for clamping the extension member (28) to the elongated spinal element (11). The clamping member (31) defines a mating surface configured for mating engagement with the variable angle surface of the extension member (28) to permit orientation of the elongated portion (29) of the extension member (28) at a plurality of angles relative to the elongated spinal element (11).

    摘要翻译： 本发明的一个实施例，脊柱固定系统包括构造成邻近脊柱延伸的细长脊椎元件（11）和多个可与脊柱和细长脊椎元件（11）接合的固定元件（15）。 该实施例还包括具有限定可变角度表面的头部（30）和从头部延伸的细长部分（29）的延伸构件（28）和用于夹紧延伸构件（28）的夹紧构件（31） 到细长脊椎元件（11）。 夹紧构件（31）限定配合表面，其配置成与延伸构件（28）的可变角度表面配合接合，以允许延伸构件（28）的细长部分（29）相对于 细长的脊骨元件（11）。

    Group A streptococcal polysaccharide immunogenic compositions and methods
    3.
    发明申请
    Group A streptococcal polysaccharide immunogenic compositions and methods 失效
    A组链球菌多糖免疫原性组成及方法

    公开(公告)号：US20050163808A1

    公开(公告)日：2005-07-28

    申请号：US11086214

    申请日：2005-03-21

    申请人： Milan Blake ,  John Zabriskie ,  Joseph Tai ,  Francis Michon

    发明人： Milan Blake ,  John Zabriskie ,  Joseph Tai ,  Francis Michon

    IPC分类号： A61K9/127 ,  A61K39/09 ,  A61K39/385 ,  A61P31/04 ,  A61K39/02 ,  C08B37/00

    CPC分类号： A61K39/092 ,  A61K9/1271 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/6037 ,  Y10S424/831

    摘要： This invention provides a novel immunogenic composition and vaccine, processes for producing them and methods for immunization against infections and disease caused by group A Streptococci. The compositions include group A streptococcal polysaccharide covalently linked to protein or liposomes to form immunogenic conjugates. The method of immunization for this invention comprises administering to an individual an immunogenic amount of group A polysaccharide. The group A polysaccharide may be administered as a vaccine either on its own, conjugated to proteins or conjugated to liposomes. Additionally, the group A polysaccharides may be associated with an adjuvant. This invention is particularly useful for providing both active and passive immunogenic protection for those populations most at risk of contracting group A Streptococcal infections and disease namely adults, pregnant women and in particular infants and children.

    摘要翻译： 本发明提供了一种新型的免疫原性组合物和疫苗，其制备方法以及针对由A组链球菌引起的感染和疾病的免疫方法。 组合物包括与蛋白质或脂质体共价连接以形成免疫原性缀合物的A组链球菌多糖。 本发明的免疫方法包括向个体施用免疫原性量的A组多糖。 A组多糖可以单独作为疫苗施用，与蛋白缀合或与脂质体缀合。 另外，A组多糖可以与佐剂结合。 本发明特别可用于为那些最具有承担A型链球菌感染和疾病风险的群体，即成年人，孕妇，特别是婴儿和儿童提供主动和被动免疫原性保护。

    RESORBABLE HOLLOW DEVICES FOR IMPLANTATION AND DELIVERY OF THERAPEUTIC AGENTS
    4.
    发明申请
    RESORBABLE HOLLOW DEVICES FOR IMPLANTATION AND DELIVERY OF THERAPEUTIC AGENTS 有权
    用于植入和输送治疗药物的可分离的中空装置

    公开(公告)号：US20090259177A1

    公开(公告)日：2009-10-15

    申请号：US12424140

    申请日：2009-04-15

    申请人： Susan Lynn Riley ,  Alexander R. Vaccaro ,  Joseph Tai

    发明人： Susan Lynn Riley ,  Alexander R. Vaccaro ,  Joseph Tai

    IPC分类号： A61B17/70 ,  A61M25/10

    CPC分类号： A61B17/7097 ,  A61B17/8833 ,  A61B17/8855 ,  A61B2017/00004 ,  A61B2017/8813 ,  A61B2017/883 ,  A61F2/44 ,  A61F2/4601 ,  A61F2002/30062 ,  A61F2002/30064 ,  A61M25/10 ,  A61M25/1029 ,  A61M31/002 ,  A61M2025/0057 ,  A61M2025/105

    摘要： A method of manufacturing a resorbable balloon designed to contain bone cement for vertebroplasty or kyphoplasty applications is described. The resorbable balloon can be inserted into a vertebral body following vertebral cavitation and filled with bone cement. The balloon remains in place in the vertebral body and resorbs over time. Methods and apparatus are also described for delivering therapeutic agents using collapsible, resorbable balloons. The balloons may be nested and filled with various therapeutic agents that are released over time at rates dependent upon structures and degradation rates of the balloons. Furthermore, the function of the hollow devices can encompass both encapsulation and therapeutic substance delivery roles simultaneously.

    摘要翻译： 描述了一种制造可再吸收球囊的方法，该球囊被设计用于容纳用于椎体成形术或椎体后凸成形术的骨粘固剂。 可再吸收的球囊可以在椎体空洞后插入椎体中并填充骨水泥。 气球保持在椎体内的位置，随着时间的推移再次吸收。 还描述了使用可折叠，可再吸收气囊输送治疗剂的方法和装置。 气球可以嵌套并填充随着时间的流逝释放的各种治疗剂，其取决于气囊的结构和降解速率。 此外，中空装置的功能可以同时包含包封和治疗物质递送作用。

    Methods for making and using composites, polymer scaffolds, and composite scaffolds
    5.
    发明申请
    Methods for making and using composites, polymer scaffolds, and composite scaffolds 审中-公开
    制备和使用复合材料，聚合物支架和复合支架的方法

    公开(公告)号：US20070187857A1

    公开(公告)日：2007-08-16

    申请号：US11229028

    申请日：2005-09-15

    申请人： Susan Riley ,  Joseph Tai ,  Rhiannon Dabkowski ,  Rodney Moser ,  Marc Hedrick ,  Timothy Moseley

    发明人： Susan Riley ,  Joseph Tai ,  Rhiannon Dabkowski ,  Rodney Moser ,  Marc Hedrick ,  Timothy Moseley

    IPC分类号： B29C65/00

    CPC分类号： A61L27/446 ,  A61L27/38 ,  A61L27/44 ,  A61L27/46 ,  B29C70/64 ,  B29L2031/753

    摘要： The present invention relates to methods of making and using composites and scaffolds as implantable devices useful for tissue repair, guided tissue regeneration, and tissue engineering. In particular, the present invention relates to methods of making and using compression molded resorbable thermoplastic polymer composites which can be subsequently processed with non-organic solvents to create porous, resorbable thermoplastic polymer scaffolds or composite scaffold with interconnected porosity. Furthermore, these composites or scaffolds can be coated with an organic and/or inorganic material.

    摘要翻译： 本发明涉及制备和使用复合材料和支架作为可用于组织修复，引导组织再生和组织工程的可植入装置的方法。 特别地，本发明涉及制造和使用压塑可再吸收热塑性聚合物复合材料的方法，其可以随后用非有机溶剂加工以产生具有相互连接的多孔性的多孔，可再吸收的热塑性聚合物支架或复合支架。 此外，这些复合材料或支架可以用有机和/或无机材料涂覆。

    Resorbable hollow devices for implantation and delivery of therapeutic agents
    6.
    发明申请
    Resorbable hollow devices for implantation and delivery of therapeutic agents 审中-公开
    用于植入和递送治疗剂的可再吸收中空装置

    公开(公告)号：US20060182780A1

    公开(公告)日：2006-08-17

    申请号：US11357837

    申请日：2006-02-16

    申请人： Susan Riley ,  Alexander Vaccaro ,  Joseph Tai

    发明人： Susan Riley ,  Alexander Vaccaro ,  Joseph Tai

    IPC分类号： A61M29/00 ,  A61F2/00

    CPC分类号： A61B17/7097 ,  A61B17/8833 ,  A61B17/8855 ,  A61B2017/00004 ,  A61B2017/8813 ,  A61B2017/883 ,  A61F2/44 ,  A61F2/4601 ,  A61F2002/30062 ,  A61F2002/30064 ,  A61M25/10 ,  A61M25/1029 ,  A61M31/002 ,  A61M2025/0057 ,  A61M2025/105

    摘要： A method of manufacturing a resorbable balloon designed to contain bone cement for vertebroplasty or kyphoplasty applications is described. The resorbable balloon can be inserted into a vertebral body following vertebral cavitation and filled with bone cement. The balloon remains in place in the vertebral body and resorbs over time. Methods and apparatus are also described for delivering therapeutic agents using collapsible, resorbable balloons. The balloons may be nested and filled with various therapeutic agents that are released over time at rates dependent upon structures and degradation rates of the balloons. Furthermore, the function of the hollow devices can encompass both encapsulation and therapeutic substance delivery roles simultaneously.

    摘要翻译： 描述了一种制造可再吸收球囊的方法，该球囊被设计用于容纳用于椎体成形术或椎体后凸成形术的骨粘固剂。 可再吸收的球囊可以在椎体空洞后插入椎体中并填充骨水泥。 气球保持在椎体内的位置，随着时间的推移再次吸收。 还描述了使用可折叠，可再吸收气囊输送治疗剂的方法和装置。 气球可以嵌套并填充随着时间的流逝释放的各种治疗剂，其取决于气囊的结构和降解速率。 此外，中空装置的功能可以同时包含包封和治疗物质递送作用。

    Modified immunogenic pneumolysin compositions as vaccines
    9.
    发明申请
    Modified immunogenic pneumolysin compositions as vaccines 审中-公开
    修饰的免疫原性肺炎溶蛋白组合物作为疫苗

    公开(公告)号：US20050070695A1

    公开(公告)日：2005-03-31

    申请号：US10785673

    申请日：2004-02-23

    申请人： Conceicao Minetti ,  Francis Michon ,  Jeffrey Pullen ,  Mary Polvino-Bodnar ,  Shu-Mei Liang ,  Joseph Tai

    发明人： Conceicao Minetti ,  Francis Michon ,  Jeffrey Pullen ,  Mary Polvino-Bodnar ,  Shu-Mei Liang ,  Joseph Tai

    IPC分类号： C12N15/09 ,  C07K14/195 ,  C07K14/315 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C07K14/47

    CPC分类号： C07K14/3156 ,  A61K39/092 ,  A61K2039/6037 ,  Y10S424/831 ,  Y10S530/825

    摘要： This invention relates to modified pneumolysin polypeptides that retain the immunogenic nature of pneumolysin but have reduced or undetectable hemolytic activity compared to native pneumolysin. The invention also provides a method for generating novel pneumolysin variants with these desired characteristic properties. The invention also provides immunogenic compositions useful as pharmaceutical compositions including vaccines in which non-toxic, modified pneumolysin is used to stimulate protective immunity against Streptococcus pneumoniae. The vaccines may be compositions in which the modified pneumolysin is conjugated to bacterial polysaccharides or may be carried on an attenuated viral vector. In addition, the invention also provides a method of using the non-toxic, modified pneumolysin toxoid in order to stimulate antibodies against Streptococcus pneumoniae in a treated individual which are then isolated and transferred to a second individual, thereby conferring protection against Streptococcus pneumoniae in the second individual.

    摘要翻译： 本发明涉及与天然气溶素相比，保留免疫原性的气溶菌素的修饰的气溶胶素多肽，但具有降低的或不可检测的溶血活性。 本发明还提供了一种产生具有这些所需特征性质的新型肺炎球菌变异体的方法。 本发明还提供可用作药物组合物的免疫原性组合物，包括其中无毒的改良的肺炎溶血杆菌刺激对肺炎链球菌的保护性免疫的疫苗。 疫苗可以是其中改性气溶胶与细菌多糖缀合或可以携带在减毒病毒载体上的组合物。 此外，本发明还提供了一种使用无毒的改良型肺炎杆菌素类毒素以刺激处理的个体中针对肺炎链球菌的抗体的方法，然后将其分离并转移到第二个体中，从而在肺炎链球菌中得到保护 第二个人。