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公开(公告)号:US07576215B2
公开(公告)日:2009-08-18
申请号:US11010236
申请日:2004-12-10
申请人: Michael D. Collini , Robert R. Singhaus, Jr. , Baihua Hu , James W. Jetter , Robert L. Morris , David H. Kaufman , Christopher P. Miller , John W. Ullrich , Rayomand J. Unwalla , Jay E. Wrobel , Elaine Quinet , Ponnal Nambi , Ronald C. Bernotas , Merle Elloso
发明人: Michael D. Collini , Robert R. Singhaus, Jr. , Baihua Hu , James W. Jetter , Robert L. Morris , David H. Kaufman , Christopher P. Miller , John W. Ullrich , Rayomand J. Unwalla , Jay E. Wrobel , Elaine Quinet , Ponnal Nambi , Ronald C. Bernotas , Merle Elloso
IPC分类号: C07D215/38
CPC分类号: C07D401/04 , C07D215/14 , C07D215/54 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/12
摘要: This invention provides compounds of formula I that are useful in the treatment or inhibition of LXR mediated diseases.
摘要翻译: 本发明提供可用于治疗或抑制LXR介导的疾病的式I化合物。
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公开(公告)号:US20050131014A1
公开(公告)日:2005-06-16
申请号:US11010236
申请日:2004-12-10
申请人: Michael Collini , Robert Singhaus , Baihua Hu , James Jetter , Robert Morris , David Kaufman , Christopher Miller , John Ullrich , Rayomand Unwalla , Jay Wrobel , Elaine Quinet , Ponnal Nambi , Ronald Bernotas , Merle Elloso
发明人: Michael Collini , Robert Singhaus , Baihua Hu , James Jetter , Robert Morris , David Kaufman , Christopher Miller , John Ullrich , Rayomand Unwalla , Jay Wrobel , Elaine Quinet , Ponnal Nambi , Ronald Bernotas , Merle Elloso
IPC分类号: A61K31/47 , A61K31/4709 , C07D215/14 , C07D215/54 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/12 , C07D41/02
CPC分类号: C07D401/04 , C07D215/14 , C07D215/54 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/12
摘要: This invention provides compounds of formula I that are useful in the treatment or inhibition of LXR mediated diseases.
摘要翻译: 本发明提供可用于治疗或抑制LXR介导的疾病的式I化合物。
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公开(公告)号:US07700595B2
公开(公告)日:2010-04-20
申请号:US11365750
申请日:2006-03-01
IPC分类号: C07D237/28 , C07D413/12 , A61K31/502 , A61K31/5355 , A61P9/10 , A61P3/10 , A61P25/28
CPC分类号: C07D413/12 , C07D237/28 , C07D403/12 , C07D409/12
摘要: This invention relates generally to cinnoline-based modulators of Liver X receptors (LXRs) and related methods.
摘要翻译: 本发明一般涉及基于噌啉的肝X受体调节剂(LXR)及相关方法。
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公开(公告)号:US20090069373A1
公开(公告)日:2009-03-12
申请号:US12039347
申请日:2008-02-28
申请人: Jay E. Wrobel , Baihua Hu , Michael David Collini , James Winfield Jetter , Ronald Charles Bernotas , David Harry Kaufman , Robert Ray Singhaus, JR. , John William Ullrich , Robert Lester Morris , Rayomand J. Unwalla
发明人: Jay E. Wrobel , Baihua Hu , Michael David Collini , James Winfield Jetter , Ronald Charles Bernotas , David Harry Kaufman , Robert Ray Singhaus, JR. , John William Ullrich , Robert Lester Morris , Rayomand J. Unwalla
IPC分类号: A61K31/47 , C07D215/12 , C07D401/02 , A61P9/00 , A61P25/28 , A61K31/4709 , A61P3/00 , A61P29/00 , A61P17/00
CPC分类号: C07D215/14 , C07D215/12 , C07D401/04 , C07D401/12 , C07D409/04 , C07D409/12
摘要: This invention relates generally to quinoline-based modulators of Liver X receptors (LXRs) and related methods.
摘要翻译: 本发明一般涉及基于喹啉的肝X受体调节剂(LXR)和相关方法。
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公开(公告)号:US07683091B2
公开(公告)日:2010-03-23
申请号:US11505527
申请日:2006-08-16
申请人: Baihua Hu , James W. Jetter
发明人: Baihua Hu , James W. Jetter
IPC分类号: A61K31/404 , A61K31/445 , C07D209/04 , C07D401/02
CPC分类号: C07D209/08 , C07D209/26
摘要: The present invention relates generally to substituted indoles and methods of using them.
摘要翻译: 本发明一般涉及取代的吲哚及其使用方法。
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公开(公告)号:US20080319046A1
公开(公告)日:2008-12-25
申请号:US12200164
申请日:2008-08-28
申请人: Baihua Hu
发明人: Baihua Hu
IPC分类号: A61K31/405 , C07D209/42 , A61P3/10
CPC分类号: C07D209/42 , C07D403/04
摘要: The present invention relates generally to substituted sulfonamide indoles such as substituted sulfonamide indoles, and methods of using them.
摘要翻译: 本发明一般涉及取代磺酰胺吲哚如取代磺酰胺吲哚,以及使用它们的方法。
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公开(公告)号:US07285682B2
公开(公告)日:2007-10-23
申请号:US11352887
申请日:2006-02-13
申请人: Baihua Hu
发明人: Baihua Hu
IPC分类号: C07C279/10 , A61K31/155
CPC分类号: C07C279/22 , C07C279/24
摘要: The present invention provides terphenyl guanidine compounds of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译: 本发明提供式I的三联苯胍化合物本发明还提供了用于抑制β-分泌酶(BACE)和治疗β-淀粉样沉积物和神经原纤维缠结的方法。
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公开(公告)号:US07022716B2
公开(公告)日:2006-04-04
申请号:US10330576
申请日:2002-12-27
申请人: Baihua Hu , Fuk-Wah Sum , Michael Sotirios Malamas
发明人: Baihua Hu , Fuk-Wah Sum , Michael Sotirios Malamas
IPC分类号: A61K31/4468 , C07D213/72
CPC分类号: C07D401/10 , C07D211/58 , C07D223/12 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/10 , C07D417/14
摘要: This invention provides compounds of Formula I having the structure wherein, R1, R2, R3, R4, R5, T, T1, T2, and X are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
摘要翻译: 本发明提供具有以下结构的式I化合物:其中R 1,R 2,R 3,R 4, >,R 5,T,T 1,T 2和X如上所定义,或其药学上可接受的盐,它们是 可用于治疗或抑制与胰岛素抵抗或高血糖相关的代谢紊乱(通常与肥胖或葡萄糖不耐受相关),动脉粥样硬化,胃肠道疾病,神经源性炎症,青光眼,高眼压症和尿频; 并且特别可用于治疗或抑制II型糖尿病。
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公开(公告)号:US20050096377A1
公开(公告)日:2005-05-05
申请号:US10947839
申请日:2004-09-23
申请人: Baihua Hu
发明人: Baihua Hu
IPC分类号: A61P3/10 , A61P7/02 , A61P9/10 , A61P25/28 , C07D209/42 , C07D401/12 , C07D403/04 , C07D43/02 , A61K31/405
CPC分类号: C07D209/42 , C07D403/04
摘要: The present invention relates generally to substituted sulfonamide indoles such as substituted sulfonamide indoles, and methods of using them.
摘要翻译: 本发明一般涉及取代磺酰胺吲哚如取代磺酰胺吲哚,以及使用它们的方法。
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公开(公告)号:US07605156B2
公开(公告)日:2009-10-20
申请号:US11140390
申请日:2005-05-27
申请人: John C. McKew , Steve Y. Tam , Katherine L. Lee , Lihren Chen , Paresh Thakker , Fuk-Wah Sum , Mark L. Behnke , Baihua Hu , James D. Clark , Wei Li , Valerie Clerin , Suzana Marusic , Kevin Pong
发明人: John C. McKew , Steve Y. Tam , Katherine L. Lee , Lihren Chen , Paresh Thakker , Fuk-Wah Sum , Mark L. Behnke , Baihua Hu , James D. Clark , Wei Li , Valerie Clerin , Suzana Marusic , Kevin Pong
IPC分类号: A61K31/54
CPC分类号: A61K31/505 , C07D209/14 , C07D209/16 , C07D209/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/10
摘要: This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition diseases and disorders including asthma, stroke, atherosclerosis, multiple sclerosis, Parkinson's disease, arthritic disorders, rheumatic disorders, central nervous system damage resulting from stroke, central nervous system damage resulting from ischemia, central nervous system damage resulting from trauma, inflammation caused or potentiated by prostaglandins, inflammation caused or potentiated by leukotrienes, inflammation caused or potentiated by platelet activation factor, pain caused or potentiated by prostaglandins, pain caused or potentiated by leukotrienes, and pain caused or potentiated by platelet activation factor.
摘要翻译: 本发明提供了使用通式的取代的吲哚化合物及其药学上可接受的盐形式的方法。 本发明提供了使用化合物作为各种磷脂酶,特别是磷脂酶A2酶的活性的抑制剂的方法,以及用于医学治疗,预防和抑制疾病和病症,包括哮喘,中风,动脉粥样硬化,多发性硬化,帕金森病, 关节炎疾病,风湿病,中风引起的中枢神经系统损伤,由缺血引起的中枢神经系统损伤,由创伤引起的中枢神经系统损伤,由前列腺素引起或增强的炎症,由白细胞三烯引起或增强的炎症,血小板引起或增强的炎症 活化因子,由前列腺素引起或增强的疼痛,由白三烯引起或加剧的疼痛,以及血小板激活因子引起或增强的疼痛。
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