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10 条记录 (耗时 0.063 秒)

    5-Lipoxygenase modulators
    3.
    发明申请
    5-Lipoxygenase modulators 审中-公开
    5-脂氧合酶调节剂

    公开(公告)号：US20070093524A1

    公开(公告)日：2007-04-26

    申请号：US11544073

    申请日：2006-10-06

    申请人： Ponnal Nambi ,  Liang Chen ,  Elaine Quinet ,  Jay Wrobel

    发明人： Ponnal Nambi ,  Liang Chen ,  Elaine Quinet ,  Jay Wrobel

    IPC分类号： A61K31/47

    CPC分类号： A61K31/47 ,  A61K45/06 ,  G01N2333/90241 ,  G01N2500/10 ,  A61K2300/00

    摘要： The present invention provides the use of Liver X Receptor (LXR) modulators that have been identified to downregulate 5-lipoxygenase gene expression in order to treat various diseases and disorders that involve the function of the 5-LO protein in intracellular signaling (or other cellular processes) or the function of protein products downstream of 5-LO in intracellular signaling (i.e., leukotrienes).

    摘要翻译： 本发明提供已被鉴定为下调5-脂氧合酶基因表达的肝X受体（LXR）调节剂的用途，以便治疗涉及细胞内信号传导中的5-LO蛋白功能的各种疾病和病症（或其他细胞 过程）或5-LO下游的蛋白质产物在细胞内信号传导（即白三烯）中的功能。

    Novel human LXRalpha variants
    5.
    发明申请
    Novel human LXRalpha variants 审中-公开
    新型人类LXRalpha变体

    公开(公告)号：US20070218550A1

    公开(公告)日：2007-09-20

    申请号：US11638666

    申请日：2006-12-13

    申请人： Qiang-Yuan Liu ,  Ponnal Nambi

    发明人： Qiang-Yuan Liu ,  Ponnal Nambi

    IPC分类号： C12N5/10 ,  C07H21/04 ,  C07K14/47 ,  C12N1/00 ,  C12N1/15 ,  C12N1/21 ,  C12N15/63

    CPC分类号： C07K14/70567

    摘要： This invention provides novel human LXRα variant polypeptides and nucleic acids encoding such polypeptides. This invention also provides the therapeutic, diagnostic, and research utilities as well as the production of such polynucleotides and polypeptides. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

    摘要翻译： 本发明提供了新的人LXRα变体多肽和编码这种多肽的核酸。 本发明还提供治疗，诊断和研究用途以及这些多核苷酸和多肽的产生。 要强调的是，该摘要被提供以符合要求抽象的规则，允许搜索者或其他读者快速确定技术公开内容的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。

    HAS2 splicing variant HOEFC11: a target in chronic renal failure, inflammatory diseases and myocardial ischemia
    6.
    发明授权
    HAS2 splicing variant HOEFC11: a target in chronic renal failure, inflammatory diseases and myocardial ischemia 失效
    HAS2剪接变体HOEFC11：慢性肾功能衰竭，炎性疾病和心肌缺血的靶标

    公开(公告)号：US06350446B1

    公开(公告)日：2002-02-26

    申请号：US09385174

    申请日：1999-08-30

    申请人： Yuan Zhu ,  Ponnal Nambi ,  Mark A Pullen

    发明人： Yuan Zhu ,  Ponnal Nambi ,  Mark A Pullen

    IPC分类号： A61K3843

    CPC分类号： C12N9/1051 ,  A61K38/00

    摘要： HOEFC11 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HOEFC11 polypeptides and polynucleotides in the design of protocols for the treatment of chronic renal failure, inflammatory diseases, myocardial ischemia, cancer, rheumatoid arthritis, cirrhotic liver disease, among others, and diagnostic assays for such conditions.

    摘要翻译： 公开了HOEFC11多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗慢性肾功能衰竭，炎性疾病，心肌缺血，癌症，类风湿性关节炎，肝硬化肝病等的方案中用于HOEFC11多肽和多核苷酸的方法以及用于这些病症的诊断测定法。

    Human LXRα variants
    8.
    发明授权
    Human LXRα variants 失效
    人类LXRα变体

    公开(公告)号：US07341850B2

    公开(公告)日：2008-03-11

    申请号：US10921023

    申请日：2004-08-18

    申请人： Qiang-Yuan Liu ,  Ponnal Nambi

    发明人： Qiang-Yuan Liu ,  Ponnal Nambi

    IPC分类号： C12P21/06

    CPC分类号： C07K14/70567

    摘要： This invention provides novel human LXRα variant polypeptides and nucleic acids encoding such polypeptides. This invention also provides the therapeutic, diagnostic, and research utilities as well as the production of such polynucleotides and polypeptides. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. 37 CFR 1.72(b).

    摘要翻译： 本发明提供了新的人LXRα变体多肽和编码这种多肽的核酸。 本发明还提供治疗，诊断和研究用途以及这些多核苷酸和多肽的产生。 要强调的是，该摘要被提供以符合要求抽象的规则，允许搜索者或其他读者快速确定技术公开内容的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。 37 CFR 1.72（b）。

    Novel human LXRalpha variants
    9.
    发明申请
    Novel human LXRalpha variants 失效
    新型人类LXRalpha变体

    公开(公告)号：US20050095677A1

    公开(公告)日：2005-05-05

    申请号：US10921023

    申请日：2004-08-18

    申请人： Qiang-Yuan Liu ,  Ponnal Nambi

    发明人： Qiang-Yuan Liu ,  Ponnal Nambi

    IPC分类号： C07K14/705 ,  C07H21/04 ,  C07K14/72

    CPC分类号： C07K14/70567

    摘要： This invention provides novel human LXRα variant polypeptides and nucleic acids encoding such polypeptides. This invention also provides the therapeutic, diagnostic, and research utilities as well as the production of such polynucleotides and polypeptides. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. 37 CFR 1.72(b).

    摘要翻译： 本发明提供了新的人LXRα变体多肽和编码这种多肽的核酸。 本发明还提供治疗，诊断和研究用途以及这些多核苷酸和多肽的产生。 要强调的是，该摘要被提供以符合要求抽象的规则，允许搜索者或其他读者快速确定技术公开内容的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。 37 CFR 1.72（b）。