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    Method of Detecting an Analyte
    6.
    发明申请
    Method of Detecting an Analyte 有权
    检测分析物的方法

    公开(公告)号：US20090311713A1

    公开(公告)日：2009-12-17

    申请号：US12546253

    申请日：2009-08-24

    申请人： Michael G. Pollack ,  Zhishan Hua ,  Allen E. Eckhardt ,  Prasanna Thwar ,  Vijay Srinivasan ,  Vamsee K. Pamula

    发明人： Michael G. Pollack ,  Zhishan Hua ,  Allen E. Eckhardt ,  Prasanna Thwar ,  Vijay Srinivasan ,  Vamsee K. Pamula

    IPC分类号： C12Q1/68

    CPC分类号： B01L3/502792 ,  B01L3/502753 ,  B01L3/502761 ,  B01L7/525 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/089 ,  B01L2400/0427 ,  B01L2400/043 ,  C12Q1/6848 ,  C12Q2565/629

    摘要： The invention relates to certain novel approaches to reducing or eliminating the movement of contaminants from one droplet to another on a droplet actuator via liquid filler fluid. In one application, a method of detecting an analyte is provided and includes providing in a detection window a droplet including a signal-producing substance indicative of the presence and/or quantity of an analyte and one or more magnetically responsive beads which may interfere with signal produced by the signal producing substance. The method further includes using a magnetic field for magnetically removing the magnetically responsive beads from the detection window and/or magnetically restricting the magnetically responsive beads from entering the detection window while transporting and/or retaining the droplet in the detection window. The method additionally includes detecting a signal produced by the signal-producing substance.

    摘要翻译： 本发明涉及在液滴致动器上通过液体填充液减少或消除污染物从一个液滴到另一个液滴的移动的某些新颖方法。 在一个应用中，提供检测分析物的方法，并且包括在检测窗口中提供包含指示分析物的存在和/或量的信号产生物质的液滴和一个或多个可能干扰信号的磁响应珠子 由信号产生物质产生。 该方法还包括使用磁场来从检测窗口磁性地去除磁响应珠子和/或磁力限制磁响应珠子进入检测窗口，同时在检测窗口中传送和/或保持液滴。 该方法还包括检测由信号产生物质产生的信号。

    Enhancing and/or Maintaining Oil Film Stability in a Droplet Actuator
    9.
    发明申请
    Enhancing and/or Maintaining Oil Film Stability in a Droplet Actuator 审中-公开
    在液滴致动器中增强和/或维持油膜稳定性

    公开(公告)号：US20130233425A1

    公开(公告)日：2013-09-12

    申请号：US13866105

    申请日：2013-04-19

    申请人： Vijay Srinivasan ,  Vamsee K. Pamula ,  Ramakrishna Sista ,  Prasanna Thwar

    发明人： Vijay Srinivasan ,  Vamsee K. Pamula ,  Ramakrishna Sista ,  Prasanna Thwar

    IPC分类号： F16L55/00

    CPC分类号： F16L55/00 ,  B01F13/0071 ,  B01F13/0076 ,  B01L3/502784 ,  B01L2200/143 ,  B01L2300/089 ,  B01L2300/161 ,  B01L2400/0427 ,  B01L2400/086 ,  Y10T137/206

    摘要： The present invention is directed to modified droplet actuators, fluids and methods for enhancing and/or maintaining oil film stability in a droplet actuator. In an exemplary embodiment, the invention provides a droplet actuator with one or more substrates arranged to form a droplet operations gap comprising gap-facing surfaces; droplet operations electrodes configured to conduct droplet operations in the droplet operations gap; at least one barrier included on at least one of the substrate surfaces and having dimensions selected to: permit droplet transport from atop a first droplet operations electrode to a second droplet operations electrode when the second droplet operations electrode is activated; and prevent movement of a droplet from atop a first droplet operations electrode when the first and second droplet operations electrodes are inactive.

    摘要翻译： 本发明涉及用于在液滴致动器中增强和/或维持油膜稳定性的改进的液滴致动器，流体和方法。 在示例性实施例中，本发明提供了具有一个或多个基板的液滴致动器，其被布置成形成包括间隙面的表面的液滴操作间隙; 液滴操作电极，被配置为在液滴操作间隙中进行液滴操作; 至少一个屏障包括在至少一个基板表面上，并且具有选定的尺寸：当第二液滴操作电极被激活时允许液滴从第一液滴操作电极顶部传输到第二液滴操作电极; 并且当第一和第二液滴操作电极不活动时，防止液滴从第一液滴操作电极的顶部移动。

    Droplet Actuator with Droplet Retention Structures
    10.
    发明申请
    Droplet Actuator with Droplet Retention Structures 审中-公开
    具有滴液保持结构的液滴致动器

    公开(公告)号：US20100120130A1

    公开(公告)日：2010-05-13

    申请号：US12647768

    申请日：2009-12-28

    申请人： Vijay Srinivasan ,  Vamsee K. Pamula ,  Ramakrishna Sista ,  Prasanna Thwar

    发明人： Vijay Srinivasan ,  Vamsee K. Pamula ,  Ramakrishna Sista ,  Prasanna Thwar

    IPC分类号： C12M1/00 ,  B01F13/00 ,  B01J19/08 ,  B01L3/02 ,  G01N27/26

    CPC分类号： F16L55/00 ,  B01F13/0071 ,  B01F13/0076 ,  B01L3/502784 ,  B01L2200/143 ,  B01L2300/089 ,  B01L2300/161 ,  B01L2400/0427 ,  B01L2400/086 ,  Y10T137/206

    摘要： The present invention is directed to droplet actuators with droplet retention structures, and methods related thereto. In an exemplary embodiment, the invention provides a droplet actuator with one or more substrates arranged to form a droplet operations gap comprising gap-facing surfaces; droplet operations electrodes configured to conduct droplet operations in the droplet operations gap; at least one barrier included on at least one of the substrate surfaces and having dimensions selected to: permit droplet transport from atop a first droplet operations electrode to a second droplet operations electrode when the second droplet operations electrode is activated; and prevent movement of a droplet from atop a first droplet operations electrode when the first and second droplet operations electrodes are inactive.

    摘要翻译： 本发明涉及具有液滴保持结构的液滴致动器及其相关方法。 在示例性实施例中，本发明提供了具有一个或多个基板的液滴致动器，其被布置成形成包括间隙面的表面的液滴操作间隙; 液滴操作电极，被配置为在液滴操作间隙中进行液滴操作; 至少一个屏障包括在至少一个基板表面上，并且具有选定的尺寸：当第二液滴操作电极被激活时允许液滴从第一液滴操作电极顶部传输到第二液滴操作电极; 并且当第一和第二液滴操作电极不活动时，防止液滴从第一液滴操作电极的顶部移动。