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    Method for producing a model mold core blank and a precision casting mold, and a casting method for producing a cast part having a void structure
    3.
    发明授权
    Method for producing a model mold core blank and a precision casting mold, and a casting method for producing a cast part having a void structure 有权

    公开(公告)号：US11607721B2

    公开(公告)日：2023-03-21

    申请号：US17269022

    申请日：2019-08-20

    申请人： Johannes + Michael Otto GbR

    发明人： Johannes Otto ,  Michael Otto

    IPC分类号： B22C7/02 ,  B22C9/10

    摘要： A method for producing a model mould core blank uses a ceramic blank fixed to a processing holder. During fixing, a lost core is manufactured from the ceramic blank based on a CNC manufacturing process 3D model, the processing holder being fastened in the running CNC machine. A model blank is produced by casting model material around the lost core while fixing persists. The model blank becomes part of another method for producing a model mould core, wherein an outer contour of a lost model is produced from and/or on the model blank on the basis of a second CNC manufacturing process 3D model, wherein fixing and processing holder fastening also occurs. Another method produces a precision casting mould, in which a ceramic mould is applied to the outer contour of the lost model, and a cast part having a hollow cavity structure is produced by the precision casting mould.

    Semiconductor Memory and Method for Operating a Semiconductor Memory
    4.
    发明申请
    Semiconductor Memory and Method for Operating a Semiconductor Memory 有权
    用于操作半导体存储器的半导体存储器和方法

    公开(公告)号：US20090285006A1

    公开(公告)日：2009-11-19

    申请号：US12125684

    申请日：2008-05-22

    申请人： Roland Thewes ,  Michael Otto ,  Helmut Schneider

    发明人： Roland Thewes ,  Michael Otto ,  Helmut Schneider

    IPC分类号： G11C5/06 ,  G11C7/00

    CPC分类号： G11C11/4094 ,  G11C7/08 ,  G11C11/4091 ,  G11C11/4097 ,  G11C2207/005

    摘要： A semiconductor memory has a plurality of read amplifiers to which a pair each of two complementary bit lines is connected, wherein the semiconductor memory includes at least one switching element each for each bit line, by which at least a partial section of the bit line may be electrically decoupled from the read amplifier, and wherein the semiconductor memory controls the first switching element so that the first switching element, when reading out and/or refreshing any memory cell connected to the bit line, temporarily electrically decouples at least the partial section of the bit line from the read amplifier.

    摘要翻译： 半导体存储器具有多个读取放大器，其中两个互补位线中的每一个被连接到其上，其中半导体存储器包括用于每个位线的至少一个开关元件，通过该至少一个开关元件，位线的至少部分部分可以 与读取放大器电耦合，并且其中半导体存储器控制第一开关元件，使得第一开关元件在读出和/或刷新连接到位线的任何存储单元时暂时将至少部分部分断电 来自读取放大器的位线。

    Targeting Poly-Gamma-Glutamic Acid to Treat Staphylococcus Epidermidis and Related Infections
    5.
    发明申请
    Targeting Poly-Gamma-Glutamic Acid to Treat Staphylococcus Epidermidis and Related Infections 审中-公开
    靶向多糖 - 谷氨酸治疗表皮葡萄球菌及相关感染

    公开(公告)号：US20080206276A1

    公开(公告)日：2008-08-28

    申请号：US11994984

    申请日：2006-07-10

    申请人： Michael Otto ,  Stanislava Kocianova

    发明人： Michael Otto ,  Stanislava Kocianova

    IPC分类号： A61K39/085 ,  A61P31/04

    CPC分类号： C12P21/02 ,  A61K39/085 ,  A61K2039/6037 ,  A61K2039/6056 ,  A61K2039/6081 ,  C07K16/1271 ,  C07K2317/77

    摘要： Immunogenic compositions and methods for eliciting an immune response against S. epidermidis and other related staphylococci are provided. The immunogenic compositions can include immunogenic conjugates of poly-γ-glutamic acid (such as γDLPGA) polypeptides of S. epidermidis, or related staphylococci that express a γPGA polypeptide. The γPGA conjugates elicit an effective immune response against S. epidermidis, or other staphylococci, in subjects to which the conjugates are administered. A method of treating an infection caused by a Staphylococcus organism that expresses cap genes is also disclosed. The method can include selecting a subject who is at risk of or has been diagnosed with the infection by the Staphylococcus organism which expresses γPGA from the cap genes. Further, the expression of a γPGA polypeptide by the organism can then be altered.

    摘要翻译： 提供了免疫原性组合物和引发针对表皮葡萄球菌和其他相关葡萄球菌的免疫应答的方法。 免疫原性组合物可以包括表达表皮葡萄球菌的多聚谷氨酸（例如γDLPGA）多肽或表达γPGA多肽的相关葡萄球菌的免疫原性缀合物。 γPGA偶联物在施用共轭物的受试者中引起对表皮葡萄球菌或其他葡萄球菌的有效免疫应答。 还公开了治疗由表达帽基因的葡萄球菌生物引起的感染的方法。 该方法可以包括选择患有由帽基因表达γPGA的葡萄球菌生物的风险或已被诊断患有感染的受试者。 此外，可以改变生物体的γPGA多肽的表达。

    SIMULTANEOUS QUANTIFICATION OF NUCLEIC ACIDS IN DISEASED CELLS
    7.
    发明申请
    SIMULTANEOUS QUANTIFICATION OF NUCLEIC ACIDS IN DISEASED CELLS 失效
    在细胞中同时检测核酸的量

    公开(公告)号：US20070196824A1

    公开(公告)日：2007-08-23

    申请号：US11686499

    申请日：2007-03-15

    申请人： Lieven Stuyver ,  Michael Otto

    发明人： Lieven Stuyver ,  Michael Otto

    IPC分类号： C12Q1/70 ,  C12Q1/68

    CPC分类号： C07H19/06 ,  C07H19/048 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/04 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/689 ,  C12Q1/6895 ,  C12Q1/701 ,  C12Q2600/136 ,  C12Q2600/142 ,  C12Q2600/158 ,  Y10S435/81 ,  C12Q2561/101 ,  C12Q2545/101 ,  C12Q2537/143

    摘要： Processes and methods for the simultaneous quantification of nucleic acids in diseased cells that are based on real-time PCR are provided. The real-time PCR protocol is an excellent tool for reliable quantification of in vitro drug screening and evaluation protocols to determine the efficacy of potential anti-viral agents. Quantification using these simultaneous PCR cycle threshold (Ct) detection techniques during one-step real-time RT-PCR (Applied Biosystems, CA) eliminates the variability resulting from quantification of end-point RT-PCR products. In addition, the mitochondrial toxicity assay is an added tool to assess potential side-effects for these chemotherapeutic agents.

    摘要翻译： 提供了基于实时PCR同时定量病变细胞中核酸的方法和方法。 实时PCR方案是用于可靠定量体外药物筛选和评估方案以确定潜在的抗病毒剂的功效的优良工具。 在一步实时RT-PCR（Applied Biosystems，CA）中使用这些同时PCR循环阈值（Ct）检测技术的定量消除了由终点RT-PCR产物定量产生的变异性。 此外，线粒体毒性测定是评估这些化学治疗剂的潜在副作用的一个附加工具。

    Lead substances and their use as therapeutics
    8.
    发明授权
    Lead substances and their use as therapeutics 失效
    铅物质及其作为治疗剂的用途

    公开(公告)号：US06660835B1

    公开(公告)日：2003-12-09

    申请号：US09219865

    申请日：1998-12-24

    申请人： Michael Otto ,  Roderich Suessmuth ,  Guenther Jung ,  Friedrich Goetz

    发明人： Michael Otto ,  Roderich Suessmuth ,  Guenther Jung ,  Friedrich Goetz

    IPC分类号： A61K3808

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K14/315

    摘要： The present invention relates to peptides, which are useful in treating Staphylococcus infections. More particularly, the inventive peptides interfere with the regulation of the agr system of Staphylococcus species, especially S. aureus, and thereby block the formation of different virulence factors. The inventive peptides comprise at least the amino acid sequence S V X A S Y F, whereby cyclic structures of that kind of peptides are the most potent blocking reagents.

    摘要翻译： 本发明涉及可用于治疗葡萄球菌感染的肽。 更具体地，本发明的肽干扰葡萄球菌属物种，特别是金黄色葡萄球菌的agr系统的调节，从而阻断不同毒力因子的形成。 本发明的肽至少包含氨基酸序列S V X A S Y F，其中该类肽的环状结构是最有效的封闭试剂。

    Device comprising a plurality of static random access memory cells and method of operation thereof
    9.
    发明授权
    Device comprising a plurality of static random access memory cells and method of operation thereof 有权
    一种装置，包括多个静态随机存取存储单元及其操作方法

    公开(公告)号：US08817528B2

    公开(公告)日：2014-08-26

    申请号：US13588327

    申请日：2012-08-17

    申请人： Michael Otto ,  Nigel Chan

    发明人： Michael Otto ,  Nigel Chan

    IPC分类号： G11C11/00

    CPC分类号： G11C11/413

    摘要： A method comprises writing data to one or more static random access memory (SRAM) cells. Writing data to the one or more SRAM cells comprises applying a first data signal to at least one bit line electrically connected to the one or more SRAM memory cells, electrically disconnecting at least one of a first power supply terminal and a second power supply terminal of each of the one or more SRAM cells from a power supply and applying a word line signal to a word line electrically connected to the one or more SRAM cells. Thereafter, the at least one of the first power supply terminal and the second power supply terminal of each of the one or more SRAM cells is electrically connected to the power source.

    摘要翻译： 一种方法包括将数据写入一个或多个静态随机存取存储器（SRAM）单元。 将数据写入到一个或多个SRAM单元包括将第一数据信号施加到电连接到所述一个或多个SRAM存储器单元的至少一个位线，将第一电源端子和第二电源端子中的至少一个电断开， 来自电源的一个或多个SRAM单元中的每一个，并且将字线信号施加到电连接到所述一个或多个SRAM单元的字线。 此后，一个或多个SRAM单元中的每一个的第一电源端子和第二电源端子中的至少一个电连接到电源。