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    Synthesis and use of inorganic polymer sensor for detecting nitroaromatic compounds
    1.
    发明申请
    Synthesis and use of inorganic polymer sensor for detecting nitroaromatic compounds 审中-公开
    无机聚合物传感器用于检测硝基芳族化合物的合成与应用

    公开(公告)号：US20060051872A1

    公开(公告)日：2006-03-09

    申请号：US10528967

    申请日：2003-10-06

    申请人： Michael Sailor ,  William Trogler ,  Honglae Sohm ,  Sarah Toal

    发明人： Michael Sailor ,  William Trogler ,  Honglae Sohm ,  Sarah Toal

    IPC分类号： C07F7/08 ,  C07F7/04 ,  G01N33/00

    CPC分类号： C08G79/00 ,  C07F7/0896 ,  C07F7/30 ,  C08G77/60 ,  G01N21/643 ,  G01N33/0049 ,  G01N2021/6432 ,  G01N2021/7786

    摘要： A dehydrocoupling polycondensation method for synthesizing polymetalloles including obtaining a dihydrometallole that includes silicon or germanium atoms, designating a reducing agent for preparation of dihydrometallole monomer, measuring a predetermined molar percentage of the reducing agent corresponding to a molar amount of the dihydrometallole, selecting a catalyst, and reacting the catalyst with the dihydrometallole to obtain a polymetallole. A method for detecting an analyte that may be present in ambient air or complex aqueous media including providing a polymer or copolymer containing a metalloid-metalloid backbone, exposing the polymer or copolymer to a suspected analyte or a system suspected of including the analyte, and measuring a quenching of photoluminescence of the metallole polymer or copolymer exposed to the system.

    摘要翻译： 一种用于合成多元醇的脱氢缩合缩聚方法，包括获得包含硅或锗原子的二羟基醇，指定用于制备二羟基醇单体的还原剂，测量对应于二羟基醇的摩尔量的预定摩尔百分数的还原剂，选择催化剂， 并使催化剂与二水合醇反应以获得多元醇。 用于检测可能存在于环境空气或复合水性介质中的分析物的方法，包括提供含有准金属 - 准金属主链的聚合物或共聚物，将聚合物或共聚物暴露于可疑分析物或怀疑包含分析物的体系，并测量 暴露于体系的金属聚合物或共聚物的光致发光淬灭。

    Photoluminescent polymetalloles as chemical sensors
    2.
    发明申请
    Photoluminescent polymetalloles as chemical sensors 有权
    光致发光聚合物作为化学传感器

    公开(公告)号：US20050101026A1

    公开(公告)日：2005-05-12

    申请号：US10244053

    申请日：2002-09-14

    申请人： Michael Sailor ,  William Trogler ,  Honglae Sohn ,  Rebecca Calhoun

    发明人： Michael Sailor ,  William Trogler ,  Honglae Sohn ,  Rebecca Calhoun

    IPC分类号： G01N21/64 ,  G01N31/22 ,  G01N33/22

    CPC分类号： G01N21/643 ,  G01N21/6408 ,  G01N31/22 ,  G01N33/0057 ,  G01N2021/6432 ,  Y10T436/17

    摘要： A method to develop inexpensive inorganic polymeric sensors that can provide a sensitivity and selectivity for explosive nitroaromatic compounds. Selectivity is provided by the arrays of 12 different reactive fluorescent sensors to mimic the human olfactory system. The sensors are based on photoluminescence quenching of polymers containing metalloid-metalloid backbones such as Si-Si, Si-Ge, or Ge-Ge. The sensor employs a thin film of photoluminescent copolymers, which is stable in air, water, acids, common organic solvents, and even seawater containing bioorganisms. The detection method involves measurement of the quenching of photoluminescence of the polysilole by the analyte.

    摘要翻译： 开发便宜的无机聚合物传感器的方法，可以为爆炸性硝基芳族化合物提供灵敏度和选择性。 选择性由12个不同反应荧光传感器的阵列提供，以模拟人类嗅觉系统。 这些传感器基于含有类金属 - 准金属主链如Si-Si，Si-Ge或Ge-Ge的聚合物的光致发光淬灭。 该传感器采用光致发光共聚物的薄膜，其在空气，水，酸，常见的有机溶剂，甚至包含生物有机物的海水中是稳定的。 检测方法包括通过分析物测定聚硅氧烷的光致发光的淬灭。

    Direct patterning of silicon by photoelectrochemical etching
    6.
    发明申请
    Direct patterning of silicon by photoelectrochemical etching 有权
    通过光电化学蚀刻直接图案化硅

    公开(公告)号：US20050009374A1

    公开(公告)日：2005-01-13

    申请号：US10838859

    申请日：2004-05-04

    申请人： Jun Gao ,  Michael Sailor ,  Sangeeta Bhatia ,  Christopher Flaim

    发明人： Jun Gao ,  Michael Sailor ,  Sangeeta Bhatia ,  Christopher Flaim

    IPC分类号： B81C1/00 ,  C25F3/12 ,  C25F3/14 ,  H01L21/26 ,  H01L21/3063

    CPC分类号： B81C1/00515 ,  B81C2201/0114 ,  B81C2201/0115 ,  C25F3/12 ,  C25F3/14 ,  H01L21/3063

    摘要： The invention is directed to methods for direct patterning of silicon. The invention provides the ability to fabricate complex surfaces in silicon with three dimensional features of high resolution and complex detail. The invention is suitable, for example, for use in soft lithography as embodiments of the invention can quickly create a master for use in soft lithography. In an embodiment of the invention, electrochemical etching of silicon, such as a silicon wafer, for example, is conducted while at least a portion of the silicon surface is exposed to an optical pattern. The etching creates porous silicon in the substrate, and removal of the porous silicon layer leaves a three-dimensional structure correlating to the optical pattern.

    摘要翻译： 本发明涉及直接图案化硅的方法。 本发明提供了在硅中制造具有高分辨率和复杂细节的三维特征的复杂表面的能力。 本发明适用于例如在软光刻中使用，因为本发明的实施例可以快速地创建用于软光刻的母版。 在本发明的一个实施例中，例如硅的电化学蚀刻被进行，同时硅表面的至少一部分暴露于光学图案。 蚀刻在衬底中产生多孔硅，并且去除多孔硅层留下与光学图案相关的三维结构。

    Porous microstructure multi layer spectroscopy and biosensing
    7.
    发明申请
    Porous microstructure multi layer spectroscopy and biosensing 审中-公开
    多孔微结构多层光谱和生物传感

    公开(公告)号：US20070108465A1

    公开(公告)日：2007-05-17

    申请号：US11371319

    申请日：2006-03-08

    申请人： Claudia Pacholski ,  Gordon Miskelly ,  Michael Sailor

    发明人： Claudia Pacholski ,  Gordon Miskelly ,  Michael Sailor

    IPC分类号： H01L33/00

    CPC分类号： G01N21/55 ,  G01J3/26

    摘要： A preferred embodiment biosensor is a multi-layer micro-porous thin film structure. Pores in a top layer of the micro-porous thin film structure are sized to accept a first molecule of interest. Pores in a second layer of the micro-porous thin film structure are smaller than the pores in the top layer and are sized to accept a second molecule of interest that is smaller than the first molecule of interest. The pores in the second layer are too small to accept the first molecule of interest. The pores in the top layer and the pores in the second layer are sized and arranged such that light reflected from the multi-layer micro-porous thin film structure produces multiple superimposed interference patterns that can be resolved. In preferred embodiments, the multi-layer micro-porous thin film structure is a porous silicon thin film multi-layer structure formed on a silicon substrate, such as a silicon wafer. Specific and nonspecific binding can be detected with biosensors of the invention. The position of peaks in the Fourier transform of the reflection spectrum and the shift in peak amplitudes can be used to determine the presence and quantity of targeted biological molecules of interest.

    摘要翻译： 优选实施方式生物传感器是多层微孔薄膜结构。 微孔薄膜结构的顶层中的孔被设定为接受第一分子感兴趣。 微孔薄膜结构的第二层中的孔比顶层中的孔小，并且其尺寸适于接受小于第一目的分子的第二感兴趣的分子。 第二层中的孔太小，不能接受第一分子。 顶层中的孔和第二层中的孔的尺寸和布置使得从多层微孔薄膜结构反射的光产生可以解决的多个叠加的干涉图案。 在优选的实施方案中，多层微孔薄膜结构是在诸如硅晶片的硅衬底上形成的多孔硅薄膜多层结构。 可以用本发明的生物传感器检测特异性和非特异性结合。 反射光谱的傅立叶变换中的峰位置和峰值幅度的偏移可用于确定目标生物分子的存在和数量。

    Photonic sensor particles and fabrication methods
    9.
    发明申请
    Photonic sensor particles and fabrication methods 有权
    光子传感器粒子和制造方法

    公开(公告)号：US20060255008A1

    公开(公告)日：2006-11-16

    申请号：US10567917

    申请日：2004-08-13

    申请人： Jamie Link ,  Michael Sailor

    发明人： Jamie Link ,  Michael Sailor

    IPC分类号： C23F1/00 ,  G01N30/62

    CPC分类号： B29D11/00663 ,  B82Y20/00 ,  G01N21/4788 ,  G01N21/774 ,  G02B6/1225 ,  Y10T428/249969

    摘要： The invention is related to optical particles (10), use of optical particles in sensing applications, and methods of fabricating optical particles that can target a desired analyte. The invention is also related to the self assembly of individual optical particles. An advantage of the invention is that it includes self-assembling individual photonic crystal sensors onto a target. In an embodiment of the invention, a processed sensor structure having two generally opposing surfaces is provided, wherein each of the opposing surfaces have different surface affinities, with a first optical structure formed on one of the opposing surfaces, and a second optical structure formed on the other of the opposing surfaces. The chemically and optically asymmetric opposing surfaces will spontaneously align at an organic liquid/water interface. Changes in the optical response of at least one of the opposing surfaces indicate the presence of a particular analyte for sensing applications.

    摘要翻译： 本发明涉及光学粒子（10），光学粒子在感测应用中的应用，以及制造可靶向所需分析物的光学粒子的方法。 本发明还涉及单个光学颗粒的自组装。 本发明的一个优点是它包括将单独的光子晶体传感器自组装到目标上。 在本发明的一个实施例中，提供具有两个大致相对的表面的经处理的传感器结构，其中每个相对表面具有不同的表面亲和力，其中形成在一个相对表面上的第一光学结构和形成在 另一个相对的表面。 化学和光学上不对称的相对表面将在有机液体/水界面处自发排列。 至少一个相对表面的光学响应的​​变化表示存在用于感测应用的特定分析物。

    Porous nanostructures and methods involving the same
    10.
    发明申请
    Porous nanostructures and methods involving the same 有权
    多孔纳米结构及其相关方法

    公开(公告)号：US20060105043A1

    公开(公告)日：2006-05-18

    申请号：US10546522

    申请日：2004-03-05

    申请人： Michael Sailor

    发明人： Michael Sailor

    IPC分类号： A61K9/14 ,  C12Q1/00 ,  C12Q1/70 ,  C12Q1/04

    CPC分类号： A61K47/02 ,  A61K9/0097 ,  A61K31/436 ,  A61K31/573 ,  C25F3/14 ,  G01N33/5438 ,  G01N33/552 ,  G01N2021/7773 ,  G01N2021/7776

    摘要： A method for simultaneously detecting and separating a target analyte such as a protein or other macromolecule that includes providing a porous silicon matrix on the silicon substrate, exposing the porous silicon matrix to an environment suspect of containing the target analyte, observing optical reflectivity of the porous silicon matrix; and correlating the changes in the silicon substrate to the target analyte.

    摘要翻译： 一种用于同时检测和分离诸如蛋白质或其它高分子的目标分析物的方法，其包括在硅衬底上提供多孔硅基质，将多孔硅基质暴露于怀疑含有目标分析物的环境，观察多孔硅的光学反射率 硅基体; 并将硅衬底中的变化与目标分析物相关联。