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公开(公告)号：US20060245972A1
公开(公告)日：2006-11-02
申请号：US11411159
申请日：2006-04-26
申请人： Yasuo Osone , Michihiro Saito , Hiroki Ihara , Noriyo Nishijima , Yoshihiro Nagaoka , Naruo Watanabe , Shigeyuki Sasaki , Nobuyuki Maki
发明人： Yasuo Osone , Michihiro Saito , Hiroki Ihara , Noriyo Nishijima , Yoshihiro Nagaoka , Naruo Watanabe , Shigeyuki Sasaki , Nobuyuki Maki
IPC分类号： G01N35/00
CPC分类号： B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/16 , B01L2300/021 , B01L2300/041 , B01L2300/0672 , B01L2300/0816 , B01L2400/0409 , B01L2400/0677 , B01L2400/0683 , G01N21/07 , G01N35/00069 , G01N2035/00495
摘要： A chemical analyzer has a rotatable holding disk, test cartridges disposed thereon, and a detector. The test cartridge includes a base plate having vessels and flow channels. The base plate is covered with a cover for covering the vessels and flow channels. The holding disk is rotated to generate centrifugal force, causing a fluid to be moved from one vessel at the inner peripheral side with respect to a rotation axis of the holding disk to another vessel at the outer peripheral side with respect to the rotation axis via the flow channel. In the test cartridge, at least one reagent port is formed in the base plate, and a closed vessel containing a reagent is placed in the reagent port. The closed vessel is a microcapsule, a plastic closed vessel, or a screw-in closed vessel, for example.
摘要翻译： 化学分析仪具有可旋转的保持盘，设置在其上的测试盒和检测器。 测试盒包括具有容器和流动通道的基板。 基板覆盖有用于覆盖容器和流动通道的盖。 保持盘旋转以产生离心力，使得流体相对于保持盘的旋转轴线从内周侧的一个容器移动到相对于旋转轴的外周侧的另一个容器 流通道。 在测试盒中，在底板中形成至少一个试剂口，并且将含有试剂的密闭容器放置在试剂口中。 密封容器例如是微胶囊，塑料密封容器或螺旋式密闭容器。
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公开(公告)号：US07678576B2
公开(公告)日：2010-03-16
申请号：US11319680
申请日：2005-12-29
申请人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
发明人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
CPC分类号： B01F11/0071 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/1816 , B01L2400/0409 , B01L2400/0442 , B01L2400/0475 , G01N21/0332 , G01N21/07 , G01N21/645 , G01N2021/0325 , G01N2035/00148 , G01N2035/00495 , G01N2035/00534 , Y10T436/111666
摘要： The invention provides a chemical analysis apparatus which easily agitates and warms up. A chemical analysis apparatus has a motor, a retaining disc which can be rotated by the motor, a plurality of inspection cartridges which are arranged on the retaining disc, a punching machine for punching the inspection cartridges, a warming apparatus and a detection apparatus. The inspection cartridge includes a container formed by a concave portion and a base plate having a flow path. A cover covering the container and the flow path is installed to the base plate. A liquid solution is moved to the container in an outer peripheral side with respect to a rotation axis from the container in an inner peripheral side with respect to the rotation axis via the flow path, by utilizing a centrifugal force generated on the basis of the rotation of the retaining disc. The inspection cartridge is provided with an agitating means for agitating the liquid solution within the container and a warming means for warming up the liquid solution within the container.
摘要翻译： 本发明提供一种容易搅动和加热的化学分析装置。 化学分析装置具有电动机，可由电动机旋转的保持盘，设置在保持盘上的多个检查筒，冲压检查筒的冲孔机，加温装置和检测装置。 检查筒包括由凹部形成的容器和具有流路的基板。 覆盖容器和流路的盖子安装在基板上。 通过利用基于旋转产生的离心力，液体溶液在相对于旋转轴线的旋转轴线的相对于旋转轴线的内周侧的外周侧经由流路被移动到容器 的保持盘。 检查筒设置有用于搅拌容器内的液体溶液的搅拌装置和用于预热容器内的液体溶液的加温装置。
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公开(公告)号：US20060159586A1
公开(公告)日：2006-07-20
申请号：US11319680
申请日：2005-12-29
申请人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
发明人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
IPC分类号： G01N31/22
CPC分类号： B01F11/0071 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/1816 , B01L2400/0409 , B01L2400/0442 , B01L2400/0475 , G01N21/0332 , G01N21/07 , G01N21/645 , G01N2021/0325 , G01N2035/00148 , G01N2035/00495 , G01N2035/00534 , Y10T436/111666
摘要： The invention provides a chemical analysis apparatus which easily agitates and warms up. A chemical analysis apparatus has a motor, a retaining disc which can be rotated by the motor, a plurality of inspection cartridges which are arranged on the retaining disc, a punching machine for punching the inspection cartridges, a warming apparatus and a detection apparatus. The inspection cartridge includes a container formed by a concave portion and a base plate having a flow path. A cover covering the container and the flow path is installed to the base plate. A liquid solution is moved to the container in an outer peripheral side with respect to a rotation axis from the container in an inner peripheral side with respect to the rotation axis via the flow path, by utilizing a centrifugal force generated on the basis of the rotation of the retaining disc. The inspection cartridge is provided with an agitating means for agitating the liquid solution within the container and a warming means for warming up the liquid solution within the container.
摘要翻译： 本发明提供一种容易搅动和加热的化学分析装置。 化学分析装置具有电动机，可由电动机旋转的保持盘，设置在保持盘上的多个检查筒，冲压检查筒的冲孔机，加温装置和检测装置。 检查筒包括由凹部形成的容器和具有流路的基板。 覆盖容器和流路的盖子安装在基板上。 通过利用基于旋转产生的离心力，液体溶液在相对于旋转轴线的旋转轴线的相对于旋转轴线的内周侧的外周侧经由流路被移动到容器 的保持盘。 检查筒设置有用于搅拌容器内的液体溶液的搅拌装置和用于预热容器内的液体溶液的加温装置。
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公开(公告)号：US20060153735A1
公开(公告)日：2006-07-13
申请号：US11319977
申请日：2005-12-29
CPC分类号： G01N21/07 , G01N35/025 , G01N2035/00148 , G01N2035/00495 , Y10T436/11 , Y10T436/111666 , Y10T436/25
摘要： A chemical analysis apparatus comprises a motor, a holding disk that can be rotated by the motor, a plurality of examination cartridges arranged on the holding disk, a perforator that perforates the examination cartridges, a heating device, and a detection device. The examination cartridge comprises a substrate including a vessel and a flow channel, which are defined by recesses, and a cover that covers the vessel and the flow channel. A centrifugal force generated by rotation of the holding disk is made use of to move a solution from a vessel on an inner peripheral side relative to an axis of rotation to a vessel on an outer peripheral side relative to the axis of rotation through the flow channel.
摘要翻译： 化学分析装置包括电动机，可由电动机旋转的保持盘，设置在保持盘上的多个检查盒，对检查筒进行穿孔的穿孔器，加热装置和检测装置。 检查筒包括由凹部限定的容器和流路的基板和覆盖容器和流路的盖。 通过保持盘的旋转而产生的离心力用于将溶液从相对于旋转轴线的内周侧的容器移动到通过流动通道相对于旋转轴线的外周侧上的容器 。
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公开(公告)号：US07727472B2
公开(公告)日：2010-06-01
申请号：US11319977
申请日：2005-12-29
CPC分类号： G01N21/07 , G01N35/025 , G01N2035/00148 , G01N2035/00495 , Y10T436/11 , Y10T436/111666 , Y10T436/25
摘要： A chemical analysis apparatus comprises a motor, a holding disk that can be rotated by the motor, a plurality of examination cartridges arranged on the holding disk, a perforator that perforates the examination cartridges, a heating device, and a detection device. The examination cartridge comprises a substrate including a vessel and a flow channel, which are defined by recesses, and a cover that covers the vessel and the flow channel. A centrifugal force generated by rotation of the holding disk is made use of to move a solution from a vessel on an inner peripheral side relative to an axis of rotation to a vessel on an outer peripheral side relative to the axis of rotation through the flow channel.
摘要翻译： 化学分析装置包括电动机，可由电动机旋转的保持盘，设置在保持盘上的多个检查盒，对检查筒进行穿孔的穿孔器，加热装置和检测装置。 检查筒包括由凹部限定的容器和流路的基板和覆盖容器和流路的盖。 通过保持盘的旋转而产生的离心力用于将溶液从相对于旋转轴线的内周侧的容器移动到通过流动通道相对于旋转轴线的外周侧上的容器 。
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公开(公告)号：US20070025876A1
公开(公告)日：2007-02-01
申请号：US11493751
申请日：2006-07-27
IPC分类号： G01N35/00
CPC分类号： G01N35/00029 , B01L3/502715 , B01L3/50273 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/0409 , B01L2400/0487 , G01N1/40 , G01N21/07 , G01N33/4875 , G01N2035/00148 , G01N2035/00257 , G01N2035/00504
摘要： An analysis cartridge for use in a chemical analysis device comprises a reagent cartridge having a plurality of reagent containers formed therein to be able to contain reagents, and a reaction cartridge connected to the reagent cartridge and having a reaction container formed therein. The reagent cartridge and the reaction cartridge are each made up of a base plate and a cover covering recesses formed in a surface of the base plate. Channels for interconnecting the plurality of reagent containers and the reaction container are formed in the reagent cartridge and the reaction cartridge. The channels are formed inside the base plates of the reagent cartridge and the reaction cartridge in their connected portions. The structure of the analysis cartridge for mixing and reacting a specimen and reagents can be simplified.
摘要翻译： 用于化学分析装置的分析盒包括：试剂盒，其具有形成在其中的多个试剂容器以能够容纳试剂;以及反应盒，连接到试剂盒并具有形成在其中的反应容器。 试剂盒和反应盒各自由基板和形成在基板的表面中的盖覆盖凹部构成。 用于互连多个试剂容器和反应容器的通道形成在试剂盒和反应盒中。 通道形成在试剂盒的基板和反应盒的连接部分内。 可以简化用于混合和反应样品和试剂的分析盒的结构。
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公开(公告)号：US20060159588A1
公开(公告)日：2006-07-20
申请号：US11319159
申请日：2005-12-28
申请人： Noriyo Nishijima , Yoshihiro Nagaoka , Toshiaki Yokobayashi , Michihiro Saito , Nobuyuki Maki , Satoshi Takahashi
发明人： Noriyo Nishijima , Yoshihiro Nagaoka , Toshiaki Yokobayashi , Michihiro Saito , Nobuyuki Maki , Satoshi Takahashi
IPC分类号： G01N9/30
CPC分类号： B01L3/502753 , B01L3/502723 , B01L3/502738 , B01L7/00 , B01L2200/10 , B01L2200/16 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , B01L2400/0694
摘要： A chemical analysis device has a motor, a holder disk to be rotated by the motor, a plurality of inspection cartridges, a penetrator for penetrating the inspection cartridges, a heater and a detector. The inspection cartridge has a substrate including containers formed as recesses and a flow path, and a cover is mounted on the substrate to cover the containers and flow path. By a centrifugal force generated by a rotation of the holder disk, a liquid is moved through the flow path from the container at a radially inner side with respect to a rotational axis to the container at a radially outer side with respect to the rotational axis.
摘要翻译： 化学分析装置具有电动机，由电动机旋转的保持盘，多个检查筒，穿透检查筒的穿透器，加热器和检测器。 检查盒具有包括形成为凹部和流路的容器的基板，并且在基板上安装盖以覆盖容器和流路。 通过由保持盘旋转产生的离心力，使液体相对于旋转轴在径向外侧从相对于旋转轴的径向内侧的容器移动通过容器。
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公开(公告)号：US20060073584A1
公开(公告)日：2006-04-06
申请号：US11239231
申请日：2005-09-30
申请人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Hirotoshi Ishimaru , Nobuyuki Maki , Toshiaki Yokobayashi , Michihiro Saito , Taisaku Seino
发明人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Hirotoshi Ishimaru , Nobuyuki Maki , Toshiaki Yokobayashi , Michihiro Saito , Taisaku Seino
IPC分类号： C12M1/34
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/502723 , B01L3/502753 , B01L2200/10 , B01L2200/16 , B01L2300/0654 , B01L2300/0816 , B01L2300/1822 , B01L2300/1844 , B01L2400/0406 , B01L2400/0409 , G01N2035/00356 , G01N2035/00495
摘要： A chemical analyzing apparatus accommodates therein a structure for retaining a sample and reagents. A detecting mechanism detects the sample after reaction with a reagent. After or during extraction of a biological substance from the sample in the structure, a temperature of a fluid in a space around the structure is controlled to a value which is suitable for enzyme.
摘要翻译： 化学分析装置中容纳有用于保持样品和试剂的结构。 检测机构在与试剂反应后检测样品。 在从结构中的样品中提取生物物质之后或之后，结构周围空间中的流体的温度被控制为适合于酶的值。
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公开(公告)号：US07662340B2
公开(公告)日：2010-02-16
申请号：US10500385
申请日：2001-12-28
申请人： Yoshihiro Nagaoka , Naruo Watanabe , Teruhisa Akashi , Yuji Miyahara , Kei Takenaka , Tomoki Ohashi
发明人： Yoshihiro Nagaoka , Naruo Watanabe , Teruhisa Akashi , Yuji Miyahara , Kei Takenaka , Tomoki Ohashi
IPC分类号： G01N9/30
CPC分类号： G01N35/025 , B01L3/502738 , B01L2200/0621 , B01L2300/0636 , B01L2300/0816 , B01L2400/0409 , B01L2400/0622 , B01L2400/0694 , G01N21/07 , G01N35/1079 , G01N2035/00504 , G01N2035/0449 , G01N2035/0451 , Y10T436/111666
摘要： The invention is achieved by feeding a reagent using centrifugal force, without providing a valve for controlling the flow rate of the reagent in the reagent flow path.A chemical analyzer is used which comprises a structure that is supported so as to be rotatable, said structure comprising a capturing section for capturing specific chemical substances from a specimen, specimen containers and reagent containers including washing solution containers.The washing solution containers and the other reagent containers comprise a liquid outlet port which is provided at the side opposite to the rotation center side, and the capturing section is held in the structure, closer to the outer periphery side than the specimen container and washing solution and the other reagent containers, and a flow path is provided, with a bent flow path portion which returns to the rotation center side, and which at a particular stage prevents the flow of liquid from the washing solution containers to the capturing section, and at another stage, forms the liquid flow due to the centrifugal force from the rotation of the structure.
摘要翻译： 本发明通过使用离心力供给试剂而不设置用于控制试剂流路中的试剂的流量的阀来实现。 使用化学分析器，其包括被支撑为可旋转的结构，所述结构包括用于从样品捕获特定化学物质的捕获部分，样本容器和包括洗涤溶液容器的试剂容器。 洗涤溶液容器和其他试剂容器包括设置在与旋转中心侧相反的一侧的液体出口，并且捕获部分保持在结构中，比检体容器和洗涤液更靠近外周侧 和其他试剂容器以及流路，其具有返回到旋转中心侧的弯曲流路部分，并且在特定阶段防止液体从洗涤溶液容器流向捕获部分，并且在 另一个阶段由于结构旋转的离心力而形成液体流动。
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公开(公告)号：US07384602B2
公开(公告)日：2008-06-10
申请号：US10400445
申请日：2003-03-28
CPC分类号： B01L3/502738 , B01L3/502723 , B01L3/50273 , B01L2200/0621 , B01L2200/10 , B01L2300/0803 , B01L2300/0861 , B01L2400/0409 , B01L2400/0694 , G01N35/00069 , G01N35/025 , G01N2035/00504 , G01N2035/0436 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： In a chemical analysis apparatus for extracting a specific substance, such as nucleic acid, from a sample containing a plurality of chemical substances, solutions remaining in valves are prevented so that a reagent in an earlier step does not contaminate the subsequent steps. Predetermined quantities of solutions are carried and supplied by centrifugal force without providing valves for controlling the flow of the solutions. After perforating the lids of ventilation holes 272, 273, 274 communicated with a detection container 450 and disposal containers 460 and 470 in an analysis disc 2, the analysis disc 2 is rotated to supply and carry a predetermined quantity of the sample.
摘要翻译： 在用于从含有多种化学物质的样品中提取特定物质如核酸的化学分析装置中，防止残留在阀中的溶液，使得较早步骤中的试剂不会污染随后的步骤。 通过离心力承载和提供预定量的溶液，而不提供用于控制溶液流动的阀。 在将分析盘2中的与检测容器450和处置容器460和470连通的通气孔272,273,274的盖子穿孔之后，分析盘2旋转以提供并携带预定量的样品。
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