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公开(公告)号：US20190125225A1
公开(公告)日：2019-05-02
申请号：US16178431
申请日：2018-11-01
IPC分类号： A61B5/145 , G01N27/49 , A61B5/1486 , A61B5/1495
摘要： A method of in vivo conditioning of an indwelling sensor to reduce run-in time, (stabilization time) comprising: a) applying a first potential to the sensor and measuring a first current at the first potential; b) applying a second potential to the sensor and measuring a second current at the second potential; c) determining a relationship of the first current measured to the second current measured; repeating a, b, and c until the relationship between the first current measured and the second current measured has stabilized, thereby reducing sensor run-in time.
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公开(公告)号：US20130217983A1
公开(公告)日：2013-08-22
申请号：US13731000
申请日：2012-12-29
IPC分类号： A61B5/1459 , A61B5/145
CPC分类号： A61B5/1459 , A61B5/14532 , Y10T29/49826
摘要： Embodiments provide analyte sensors, such as implantable analyte sensors, and methods of producing the same. An implantable sensor may include a base with a plurality of chambers. One or more sensor reagents may be retained within the chambers to form analysis regions. A membrane may be coupled to the chambers over the sensor reagents. The implantable sensor may be implanted into the dermis of a subject. One or more of the sensor reagents may exhibit a color change in response to the presence of a target analyte or reaction product thereof. The wavelengths of light reflected from the analysis regions may be detected and analyzed to determine a target analyte concentration. One or more portions of the sensor or components thereof may be configured to facilitate calibration of the sensor, correction of an optical signal obtained from the sensor by a reader device to accommodate variations in the surrounding tissues, and/or calculation of a representative value by a reader device.
摘要翻译： 实施例提供分析物传感器，例如可植入分析物传感器及其生产方法。 可植入传感器可以包括具有多个室的底座。 一个或多个传感器试剂可以保留在室内以形成分析区域。 膜可以通过传感器试剂连接到腔室。 植入式传感器可以植入受试者的真皮中。 一种或多种传感器试剂可以响应于目标分析物或其反应产物的存在而显示出颜色变化。 可以检测和分析从分析区域反射的光的波长以确定目标分析物浓度。 传感器或其组件的一个或多个部分可以被配置为便于传感器的校准，由读取器装置校正由传感器获得的光学信号，以适应周围组织的变化，和/或代表值的计算由 阅读器设备
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公开(公告)号：US08452359B2
公开(公告)日：2013-05-28
申请号：US11973790
申请日：2007-10-10
申请人： Mihailo V. Rebec , James E. Smous , Steven D. Brown , Hu-Wei Tan
发明人： Mihailo V. Rebec , James E. Smous , Steven D. Brown , Hu-Wei Tan
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/726 , G01N21/274 , G01N21/359 , G01N2201/067
摘要： A system for determining the concentration of an analyte in at least one body fluid in body tissue comprises an infrared light source, a body tissue interface, a detector, and a central processing unit. The body tissue interface is adapted to contact body tissue and to deliver light from the infrared light source to the contacted body tissue. The detector is adapted to receive spectral information corresponding to infrared light transmitted through the portion of body tissue being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid, the algorithm adapted to convert the received spectral information into the concentration of the analyte in at least one body fluid.
摘要翻译： 用于确定身体组织中的至少一种体液中的分析物的浓度的系统包括红外光源，身体组织界面，检测器和中央处理单元。 身体组织界面适于接触身体组织并将红外光源的光传送到被接触的身体组织。 检测器适于接收对应于通过被分析的身体组织部分透射的红外光的光谱信息，并将接收到的光谱信息转换为指示所接收的光谱信息的电信号。 中央处理单元适于将电信号与建立在体液中与分析物相关的算法进行比较，该算法适于将接收到的光谱信息转换成至少一个体液中分析物的浓度。
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公开(公告)号：US5975531A
公开(公告)日：1999-11-02
申请号：US102375
申请日：1998-06-23
CPC分类号： H04B7/18517 , H04B7/18523 , H04N7/147 , H04N7/15 , H04N7/20 , H04N2007/145 , Y10S370/916
摘要： A high speed teleconferencing apparatus and method, the apparatus including an encoding unit that encodes and compresses a first digital signal to produce a first compressed encoded signal, a multiplexer unit that receives and splits the first compressed encoded signal into at least two split compressed encoded signals, at least two converter units that receive a respective one of the at least two split first compressed encoded signals and respectively producing at least two first synchronous signals, and at least two output units that receive a respective one of at least two first synchronous signals and output at least two first adapted synchronous signals to a data link. The at least two output units can be, for example, two CCIT units that output at least two high speed first synchronous signals to a high speed data link. The at least two output units can also be two microwave transmitting units that respectively modulate a first microwave signal with the at least two first synchronous signals and combine the modulated signals to output a first combined microwave signal to the data link. The system can transmit information such as an audio/video signal of broadcast quality or file information via satellite to/from any location.
摘要翻译： 一种高速电话会议装置和方法，所述装置包括：编码单元，其对第一数字信号进行编码和压缩以产生第一压缩编码信号;多路复用器单元，其将所述第一压缩编码信号分解成至少两个分离压缩编码信号 至少两个转换器单元，其接收所述至少两个分离的第一压缩编码信号中的相应一个并分别产生至少两个第一同步信号，以及至少两个输出单元，其接收至少两个第一同步信号中的相应一个， 向数据链路输出至少两个第一适配同步信号。 至少两个输出单元可以是例如将至少两个高速第一同步信号输出到高速数据链路的两个CCIT单元。 所述至少两个输出单元也可以是两个微波发射单元，其分别利用所述至少两个第一同步信号调制第一微波信号，并组合调制信号以将第一组合微波信号输出到数据链路。 该系统可以通过卫星向/从任何位置发送诸如广播质量的音频/视频信号或文件信息的信息。
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公开(公告)号：US5594936A
公开(公告)日：1997-01-14
申请号：US85329
申请日：1993-07-02
CPC分类号： H04B7/18517 , H04B7/18523 , H04N7/147 , H04N7/15 , H04N7/165 , H04N7/20 , H04N2007/145
摘要： An information distribution system for a digital network, includes a master communications unit for establishing communications with the network in order to receive a synchronous digital signal, a distribution amplifier unit for receiving and dividing the synchronous digital signal into a plurality of synchronous signals and a plurality of communications units for establishing communications with a plurality of receiving stations. The system also includes a master controller for controlling the plurality of communications units from a central location. The invention alternatively relates to an information disseminating system for a digital network and includes a plurality of video clip storing units, each storing data related to a particular subject matter, a plurality of distribution amplifiers associated with the video clip storing units and a plurality of communications units which establish communications between the plurality of distribution amplifiers and the digital network. A menu storing unit accessible from the digital network, stores information indicating the subject matter associated with each of the plurality of video clip storing units as well as information as to how to access each of the video clip units.
摘要翻译： 一种用于数字网络的信息分发系统，包括：主通信单元，用于建立与网络的通信以便接收同步数字信号;分配放大器单元，用于接收并分频同步数字信号为多个同步信号;多个同步信号 用于建立与多个接收站的通信的通信单元。 该系统还包括用于从中心位置控制多个通信单元的主控制器。 本发明或者涉及一种用于数字网络的信息传播系统，并且包括多个视频剪辑存储单元，每个视频片段存储单元存储与特定主题相关的数据，与视频片段存储单元相关联的多个分配放大器和多个通信 在多个分配放大器和数字网络之间建立通信的单元。 可从数字网络访问的菜单存储单元，存储指示与多个视频剪辑存储单元中的每一个相关联的主题的信息以及关于如何访问每个视频剪辑单元的信息。
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公开(公告)号：US09668683B2
公开(公告)日：2017-06-06
申请号：US12087087
申请日：2006-12-21
IPC分类号： A61B5/1477 , A61B5/145 , A61B5/1468 , C12Q1/00
CPC分类号： A61B5/1477 , A61B5/14507 , A61B5/14532 , A61B5/14546 , A61B5/1468 , C12Q1/006 , Y10T29/49124
摘要： An electrochemical sensor system is adapted to assist in determining an analyte concentration of a fluid. The electrochemical sensor system comprises a substrate, conductive material and a hydrogel or liquid. The substrate having porosity therethrough. The conductive material includes at least one electrode. The at least one electrode is coupled to the substrate. The at least one electrode has a first surface and an opposing second surface. The hydrogel or liquid is adapted to assist in carrying the analyte of the fluid to the first and second surfaces of the at least one electrode.
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公开(公告)号：US08452357B2
公开(公告)日：2013-05-28
申请号：US12575802
申请日：2009-10-08
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/14532 , A61B5/14546
摘要： A non-invasive method of determining the concentration of an analyte uses Raman or fluorescence spectral information. A high-intensity band of light is applied to one side of skin tissue. The high-intensity light enters the skin tissue and generates a Raman or fluorescence signal. A Raman-generating material or fluorescence-generating material is placed in a location nearest the other side of skin tissue. The Raman-generating or fluorescence-generating material is located generally opposite of the entry of the applied high-intensity light. The Raman or fluorescence signal is collected and the analyte concentration is determined using the collected Raman signal.
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公开(公告)号：US08032197B2
公开(公告)日：2011-10-04
申请号：US11999634
申请日：2007-12-06
申请人： Mihailo V. Rebec
发明人： Mihailo V. Rebec
IPC分类号： A61B5/05
CPC分类号： A61B5/201 , A61B5/0002 , A61B5/145 , A61B5/14528 , A61B5/14546 , A61B5/686 , A61B2010/008
摘要： A method of using a diffusion-based, continuous-monitoring system to analyze for a disease or condition includes creating a diffusion channel in an area of skin. The diffusion channel is maintained for a desired duration. The level of the disease marker(s) is continuously monitored for the desired duration via a diffusion-based, continuous-monitoring device. The levels of the at least one disease marker at the area of skin are analyzed to determine if the disease or condition associated with the at least one disease marker is present.
摘要翻译： 使用基于扩散的连续监测系统来分析疾病或病症的方法包括在皮肤区域中产生扩散通道。 扩散通道保持期望的持续时间。 疾病标志物的水平通过基于扩散的连续监测装置连续监测所需的持续时间。 分析皮肤区域上的至少一种疾病标记物的水平，以确定与至少一种疾病标记物相关的疾病或病症是否存在。
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公开(公告)号：US20100210932A1
公开(公告)日：2010-08-19
申请号：US12531634
申请日：2007-12-21
申请人： Mihailo V. Rebec
发明人： Mihailo V. Rebec
IPC分类号： A61B5/145
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/14865 , A61B5/150022 , A61B5/150068 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/15087 , A61B5/150977 , A61B5/150984 , A61B5/15134 , A61B5/15136 , A61B5/155 , A61B5/157 , A61B5/681
摘要： A method of using a diffusion-based, continuous-monitoring system to analyze an analyte includes creating at least one diffusion channel in an area of skin. The diffusion channel is maintained for a desired duration. The levels of the analyte are continuously monitored for the desired duration via a diffusion-based, continuous-monitoring device. The levels of the analyte at the area of skin are analyzed to determine if a condition associated with the analyte is present.
摘要翻译： 使用基于扩散的连续监测系统来分析分析物的方法包括在皮肤区域中产生至少一个扩散通道。 扩散通道保持期望的持续时间。 分析物的水平通过基于扩散的连续监测装置连续监测所需的持续时间。 分析皮肤区域分析物的水平，以确定是否存在与分析物相关的病症。
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10.发明申请Electrochemical Sensor System Using a Substrate With at Least One Aperture and Method of Making the Same 有权使用至少一个孔径的基板的电化学传感器系统及其制造方法公开(公告)号：US20090184000A1
公开(公告)日：2009-07-23
申请号：US12087087
申请日：2006-12-21
CPC分类号： A61B5/1477 , A61B5/14507 , A61B5/14532 , A61B5/14546 , A61B5/1468 , C12Q1/006 , Y10T29/49124
摘要： An electrochemical sensor system is adapted to assist in determining an analyte concentration of a fluid. The electrochemical sensor system comprises a substrate, conductive material and a hydrogel or liquid. The substrate having porosity therethrough. The conductive material includes at least one electrode. The at least one electrode is coupled to the substrate. The at least one electrode has a first surface and an opposing second surface. The hydrogel or liquid is adapted to assist in carrying the analyte of the fluid to the first and second surfaces of the at least one electrode.
摘要翻译： 电化学传感器系统适于帮助确定流体的分析物浓度。 电化学传感器系统包括基底，导电材料和水凝胶或液体。 基底具有孔隙率。 导电材料包括至少一个电极。 所述至少一个电极耦合到所述衬底。 所述至少一个电极具有第一表面和相对的第二表面。 水凝胶或液体适于帮助将流体的分析物携带到至少一个电极的第一和第二表面。
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