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    Method and apparatus for diagnosis of tumor activity using tumor interstitial fluid pressure
    1.
    发明授权
    Method and apparatus for diagnosis of tumor activity using tumor interstitial fluid pressure 有权
    使用肿瘤间质液压力诊断肿瘤活动的方法和装置

    公开(公告)号：US08989839B2

    公开(公告)日：2015-03-24

    申请号：US13585784

    申请日：2012-08-14

    申请人： Mordechay Schlesinger ,  Long Jian Liu ,  James R. Ewing ,  Stephen L. Brown

    发明人： Mordechay Schlesinger ,  Long Jian Liu ,  James R. Ewing ,  Stephen L. Brown

    IPC分类号： A61B5/03 ,  A61B5/055 ,  A61B5/00

    CPC分类号： A61B5/03 ,  A61B5/0059

    摘要： A scanning apparatus, is used to effect multiple images of a tumor in which a contrast agent has been localized as a detectable marker over a selected time to map the change in the imaged marker. The rate of change in the imaged marker and/or contrast intensity of the dyed tissues is used to assess tumor aggressiveness and as an early predictor of response to cancer therapy. In particular, following the marking of tumor or cancerous tissues by the initial localization of an imageable contrast agent, the rate of change in the volume and/or area of the imaged marker is used to provide an indication of tumor interstitial fluid pressure (TIFP).

    摘要翻译： 扫描装置用于在所选择的时间内使造影剂已经被定位为可检测标记的肿瘤的多个图像以映射成像的标记物的变化。 使用染色组织的成像标记和/或对比度强度的变化率来评估肿瘤侵袭性，并且作为对癌症治疗反应的早期预测因子。 特别地，在通过可成像造影剂的初始定位来标记肿瘤或癌组织之后，使用成像标记物的体积和/或面积的变化率来提供肿瘤间质液压力（TIFP）的指示， 。

    METHOD AND APPARATUS FOR DIAGNOSIS OF TUMOR ACTIVITY USING TUMOR INTERSTITIAL FLUID PRESSURE
    2.
    发明申请
    METHOD AND APPARATUS FOR DIAGNOSIS OF TUMOR ACTIVITY USING TUMOR INTERSTITIAL FLUID PRESSURE 有权
    使用肿瘤间质液体压力诊断肿瘤活性的方法和装置

    公开(公告)号：US20140051981A1

    公开(公告)日：2014-02-20

    申请号：US13585784

    申请日：2012-08-14

    申请人： Mordechay Schlesinger ,  Long Jian Liu ,  James R. Ewing ,  Stephen L. Brown

    发明人： Mordechay Schlesinger ,  Long Jian Liu ,  James R. Ewing ,  Stephen L. Brown

    IPC分类号： A61B5/03

    CPC分类号： A61B5/03 ,  A61B5/0059

    摘要： A scanning apparatus, is used to effect multiple images of a tumor in which a contrast agent has been localized as a detectable marker over a selected time to map the change in the imaged marker. The rate of change in the imaged marker and/or contrast intensity of the dyed tissues is used to assess tumor aggressiveness and as an early predictor of response to cancer therapy. In particular, following the marking of tumor or cancerous tissues by the initial localization of an imageable contrast agent, the rate of change in the volume and/or area of the imaged marker is used to provide an indication of tumor interstitial fluid pressure (TIFP).

    摘要翻译： 扫描装置用于在所选择的时间内使造影剂已经被定位为可检测标记的肿瘤的多个图像以映射成像的标记物的变化。 使用染色组织的成像标记和/或对比度强度的变化率来评估肿瘤侵袭性，并且作为对癌症治疗反应的早期预测因子。 特别地，在通过可成像造影剂的初始定位来标记肿瘤或癌组织之后，使用成像标记物的体积和/或面积的变化率来提供肿瘤间质液压力（TIFP）的指示， 。

    Process for Electroless Deposition of Metals Using Highly Alkaline Plating Bath
    4.
    发明申请
    Process for Electroless Deposition of Metals Using Highly Alkaline Plating Bath 审中-公开
    使用高碱性电镀浴进行金属化学沉积的工艺

    公开(公告)号：US20130209698A1

    公开(公告)日：2013-08-15

    申请号：US13878916

    申请日：2011-10-12

    申请人： Mordechay Schlesinger ,  Robert Andrew Petro

    发明人： Mordechay Schlesinger ,  Robert Andrew Petro

    IPC分类号： C23C18/54

    CPC分类号： C23C18/54 ,  C23C18/1637 ,  C23C18/1639 ,  C23C18/1658 ,  C23C18/166 ,  C23C18/1806 ,  C23C18/1827 ,  C23C18/1855 ,  C23C18/1872 ,  C23C18/31 ,  C23C18/32 ,  C23C18/38

    摘要： A plating process using an electroless plating bath formed from two separate prepared component solutions. The component solutions mixed within 120 hours prior to plating operations, to provide a highly alkaline plating bath solution. One component solution of the two-part plating bath, is provided with a metal salt or source of plating ions, and which is initially kept in a separate solution from the second other prepared component solution. The second component solution contains formaldehyde, and preferably paraformaldehyde, used to reduce the metal salts into the metal to be deposited on a substrate. Each component solution further includes sodium hydroxide in concentrations selected so that when the two solutions are preferably mixed the final plating bath solution has a pH greater than 11.5.

    摘要翻译： 使用由两个单独制备的组分溶液形成的化学镀浴的电镀工艺。 组分溶液在电镀操作前120小时内混合，以提供高碱性电镀浴溶液。 双组分电镀液的单组分溶液具有金属盐或电镀离子源，并且最初保持在与另外另一种制备的组分溶液分离的溶液中。 第二组分溶液含有甲醛，优选多聚甲醛，用于将金属盐还原成沉积在基底上的金属。 每个组分溶液还包括浓度选择的氢氧化钠，使得当优选混合两种溶液时，最终的镀液溶液的pH值大于11.5。

    Zinc/nickel/phosphorus coatings and elecroless coating method therefor
    6.
    发明授权
    Zinc/nickel/phosphorus coatings and elecroless coating method therefor 失效
    锌/镍/磷涂层和无电极涂层方法

    公开(公告)号：US5304403A

    公开(公告)日：1994-04-19

    申请号：US941277

    申请日：1992-09-04

    申请人： Mordechay Schlesinger ,  Dexter D. Snyder

    发明人： Mordechay Schlesinger ,  Dexter D. Snyder

    IPC分类号： C23C18/48 ,  C23C26/00

    CPC分类号： C23C18/48

    摘要： In a preferred method, a zinc-rich alloy coating is applied to a substrate using an electrolysis deposition solution which contains a metal salt of zinc and a metal salt of nickel each in an amount sufficient to provide a weight ratio of zinc to nickel (Zn:Ni) of at least about 1:1; a phosphorus-containing reducing agent in an amount sufficient to cause reduction of the zinc and the nickel to ions thereof; sufficient complexing agent to maintain the nickel ions and the zinc ions in solution; and a buffer in an amount sufficient to achieve a desired pH. Preferably, the surface of the substrate is pretreated or precatalyzed before deposition by a sensitizing step using tin and an activating step using palladium.

    摘要翻译： 在优选的方法中，使用电解沉积溶液将锌富锌合金涂层施加到基底上，所述电解沉积溶液含有锌的金属盐和镍的金属盐，其量足以提供锌与镍的重量比（Zn ：Ni）为至少约1:1; 一种含磷还原剂，其量足以使锌和镍还原成离子; 足够的络合剂将镍离子和锌离子保持在溶液中; 和足以达到所需pH的量的缓冲液。 优选地，通过使用锡的敏化步骤和使用钯的活化步骤在沉积之前对基底的表面进行预处理或预分解。