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    Thermosetting adhesive sheet with electroconductive and thermoconductive properties
    2.
    发明申请
    Thermosetting adhesive sheet with electroconductive and thermoconductive properties 审中-公开
    具有导电和导热性能的热固性粘合片

    公开(公告)号：US20050233161A1

    公开(公告)日：2005-10-20

    申请号：US10508736

    申请日：2003-04-01

    申请人： Masaaki Takeda ,  Akihiko Mitsui ,  Kohichiro Kawate ,  Shigeyoshi Ishii

    发明人： Masaaki Takeda ,  Akihiko Mitsui ,  Kohichiro Kawate ,  Shigeyoshi Ishii

    IPC分类号： B32B27/00

    CPC分类号： C09J9/02 ,  C08L2666/26 ,  C09J163/00 ,  Y10T428/31855

    摘要： A thermosetting adhesive sheet with electroconductive and thermoconductive properties, which comprises a thermosetting adhesive sheet composed of a thermosetting adhesive composition comprising an ethylene-glycidyl(meth)acrylate copolymer and a carboxyl group-containing rosin, where crosslinking is formed between the ethylene of the copolymer by electron beam radiation, and having at least one through-opening region formed at a prescribed location, and further including a low melting point solder placed within said through-opening region(s) formed at the prescribed location(s).

    摘要翻译： 一种具有导电和导热特性的热固性粘合片，其包含由包含乙烯 - （甲基）丙烯酸缩水甘油酯共聚物和含羧基的松香的热固性粘合剂组合物组成的热固性粘合片，其中在共聚物的乙烯之间形成交联 通过电子束辐射，并且具有形成在规定位置的至少一个通孔区域，并且还包括放置在形成在规定位置的所述通孔区域内的低熔点焊料。

    Liquid aspirating method
    3.
    发明授权
    Liquid aspirating method 失效
    液体抽吸法

    公开(公告)号：US5488874A

    公开(公告)日：1996-02-06

    申请号：US211802

    申请日：1994-07-05

    申请人： Junichi Kawanabe ,  Masaaki Takeda ,  Hitomi Katagi ,  Yuko Kato ,  Gregory A. Bielarczyk ,  Rosie L. Magee

    发明人： Junichi Kawanabe ,  Masaaki Takeda ,  Hitomi Katagi ,  Yuko Kato ,  Gregory A. Bielarczyk ,  Rosie L. Magee

    IPC分类号： G01N1/00 ,  G01N35/10

    CPC分类号： G01N35/109 ,  G01N2035/1025 ,  G01N2035/1034

    摘要： The present invention aims to shorten an aspiration time, when aspirating a red blood cell component of a liquid sample having high viscosity. When aspirating the red blood cell component of a blood sample through a nozzle tip, a piston is pulled at its maximum to produce a maximum aspirating force, and starts aspiration. When a pressure in an aspirating system becomes equal to a predetermined value .alpha., the piston is returned to a position in which only a necessary aspiration volume of the liquid sample can be aspirated. Since the maximum aspirating force of the pump is utilized during the aspiration, the aspirating operation can be carried out more quickly.

    摘要翻译： PCT No.PCT / JP92 / 01344 Sec。 371日期：1994年7月5日 102（e）日期1994年7月5日PCT提交1992年10月15日PCT公布。 公开号WO93 / 08476 日期：1993年04月29日。本发明旨在缩短吸液时具有高粘度的液体样品的红细胞成分。 当通过喷嘴尖吸出血液样本的红细胞成分时，将活塞拉至最大值以产生最大抽吸力，并开始抽吸。 当抽吸系统中的压力变得等于预定值α时，活塞返回到只能抽吸液体样本的必要抽吸体积的位置。 由于在抽吸期间利用泵的最大抽吸力，所以可以更快地进行抽吸操作。

    Guanidinothiazole compounds, and medical compositions containing them
    4.
    发明授权
    Guanidinothiazole compounds, and medical compositions containing them 失效
    胍基噻唑化合物和含有它们的医药组合物

    公开(公告)号：US4362736A

    公开(公告)日：1982-12-07

    申请号：US127902

    申请日：1980-03-06

    申请人： Yasufumi Hirata ,  Isao Yanagisawa ,  Yoshio Ishii ,  Masaaki Takeda

    发明人： Yasufumi Hirata ,  Isao Yanagisawa ,  Yoshio Ishii ,  Masaaki Takeda

    IPC分类号： C07D277/38 ,  C07D277/46 ,  C07D277/48 ,  C07D277/20 ,  A61K31/425

    CPC分类号： C07D277/48 ,  C07D277/46

    摘要： Novel guanidinothiazole compounds of the general formula ##STR1## wherein R represents a hydrogen atom or a lower alkyl group, Y represents a sulfur atom or a methylene group, m and n each represents an integer of 1-3, A represents the group shown by ##STR2## (wherein R.sub.1 represents a hydrogen atom, a cyano group, a carbamoyl group, a ureido group, a hydroxyl group, a lower alkoxy group, a lower acyl group, an acylamino group, an arylsulfamoyl group, an aralkyl group or a carboxymethyl group, an arylsulfamoyl group, an aralkyl group or a carboxymethyl group, R.sub.2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cyano group or a lower acyl group, and R.sub.3 represents a hydrogen atom, a lower alkyl group, a hydroxyl group or a sulfamoyl group), and the pharmacologically acceptable acid addition salts thereof; these compounds are useful as gastric acid secretion inhibitors.

    摘要翻译： 新颖的通式为“IMAGE”的胍基噻唑化合物，其中R表示氢原子或低级烷基，Y表示硫原子或亚甲基，m和n各自表示1-3的整数，A表示由 （其中R 1表示氢原子，氰基，氨基甲酰基，脲基，羟基，低级烷氧基，低级酰基，酰氨基，芳基氨磺酰基，芳烷基或 羧甲基，芳基氨磺酰基，芳烷基或羧甲基，R2表示氢原子，低级烷基，低级烯基，低级炔基，氰基或低级酰基，R3表示氢 原子，低级烷基，羟基或氨磺酰基）及其药理学上可接受的酸加成盐; 这些化合物可用作胃酸分泌抑制剂。

    Fourier transform nuclear magnetic resonance spectrometer
    5.
    发明授权
    Fourier transform nuclear magnetic resonance spectrometer 失效
    傅里叶变换核磁共振光谱仪

    公开(公告)号：US4321537A

    公开(公告)日：1982-03-23

    申请号：US58430

    申请日：1979-07-18

    申请人： Hiroshi Yokokawa ,  Chutetsu Hattori ,  Masaaki Takeda

    发明人： Hiroshi Yokokawa ,  Chutetsu Hattori ,  Masaaki Takeda

    IPC分类号： G01R33/32 ,  G01R33/46 ,  G01N27/00

    CPC分类号： G01R33/46

    摘要： In a Fourier transform nuclear magnetic resonance spectrometer, as is known, a pulse modulated radio frequency is applied to a sample placed in a magnetic field, and a free induction decay signal resulting from the above application is Fourier transformed to obtain a nuclear magnetic resonance spectrum. In such a spectrometer, a material having a predetermined resonance peak, for example, tetramethylsilane is used as a reference sample, and the center frequency of the pulse modulated radio frequency is successively varied while maintaining a constant magnetic field intensity. The position of peak of tetramethylsilane in frequency spectra thus obtained is varied with the change of the center frequency. By measuring successively the signal strength of the peak, there can be obtained a frequency characteristic of a receiving system employed in the spectrometer, which is used to obtain correction coefficients of the receiving system. By multiplying a frequency spectrum of a sample to be analyzed by the correction coefficients, the frequency characteristic of the receiving system is corrected, and thus the signal strength of the frequency spectrum can be indicated with high accuracy.

    摘要翻译： 在已知的傅立叶变换核磁共振光谱仪中，将脉冲调制射频施加到放置在磁场中的样本，并且由上述应用得到的自由感应衰减信号被傅立叶变换以获得核磁共振谱 。 在这样的光谱仪中，使用具有规定的共振峰的材料，例如四甲基硅烷作为基准样品，脉冲调制射频的中心频率依次变化，同时保持恒定的磁场强度。 这样获得的频谱中四甲基硅烷的峰位置随着中心频率的变化而变化。 通过依次测量峰值的信号强度，可以获得用于获得接收系统的校正系数的光谱仪中使用的接收系统的频率特性。 通过将要分析的样本的频谱乘以校正系数，校正接收系统的频率特性，从而可以高精度地指示频谱的信号强度。

    Pyrazine derivatives
    7.
    发明授权
    Pyrazine derivatives 失效
    吡嗪衍生物

    公开(公告)号：US4041032A

    公开(公告)日：1977-08-09

    申请号：US534636

    申请日：1974-12-19

    申请人： Masuo Murakami ,  Kozo Takahashi ,  Yasuhumi Hirata ,  Mutsuo Takashima ,  Masaaki Takeda ,  Hiroyoshi Ino ,  Sumio Iwanami

    发明人： Masuo Murakami ,  Kozo Takahashi ,  Yasuhumi Hirata ,  Mutsuo Takashima ,  Masaaki Takeda ,  Hiroyoshi Ino ,  Sumio Iwanami

    IPC分类号： C07D241/24 ,  C07D241/28

    CPC分类号： C07D241/24 ,  Y10S514/872

    摘要： Pyrazine derivatives by the formula ##STR1## are disclosed. In the above formula, R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen atom, a halogen atom, a hydroxy group, a lower alkoxy group, a phenyl lower alkoxy group, a phenoxy group, a mercapto group, a lower alkylthio group, a phenyl lower alkylthio group, a phenylthio group, an amino group, a substituted amino group, a lower alkyl group, a carbamoyl group or a sulfamoyl group; R.sup.3 represents a lower alkoxy group; R.sup.4, R.sup.5, and R.sup.6, which may be the same or different, each represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, a phenyl lower alkyl group, or a phenyl group; and A represents a lower alkylene group; said R.sup.4 and A, said R.sup.5 and A, said R.sup.4 and R.sup.5, or said R.sup.5 and R.sup.6 may form a 5-membered or 6-membered nitrogen-containing heterocyclic ring which may further contain a hetero-atom together with nitrogen atom, and the pharmacologically acceptable non-toxic salts thereof. The compounds of this invention have a strong and selective antiematic activity and an effect of stimulating the gastric motility.

    摘要翻译： 披露了通过式“IMAGE”的吡嗪衍生物。 在上式中，R 1和R 2可以相同或不同，表示氢原子，卤素原子，羟基，低级烷氧基，苯基低级烷氧基，苯氧基，巯基， 低级烷硫基，苯基低级烷硫基，苯硫基，氨基，取代氨基，低级烷基，氨基甲酰基或氨磺酰基; R3表示低级烷氧基; R 4，R 5和R 6可以相同或不同，分别表示氢原子，低级烷基，环烷基，苯基低级烷基或苯基。 A表示低级亚烷基; 所述R4和A表示R5和A表示R4和R5，或所述R5和R6可以形成还可以与氮原子一起含有杂原子的5元或6元含氮杂环，并且 其药理学上可接受的无毒盐。 本发明的化合物具有强的选择性的抗活性和刺激胃动力的作用。

    Pipetting apparatus with clot detection
    8.
    发明授权
    Pipetting apparatus with clot detection 失效
    具有凝块检测的移液装置

    公开(公告)号：US5540081A

    公开(公告)日：1996-07-30

    申请号：US416833

    申请日：1995-05-15

    申请人： Masaaki Takeda ,  Hitomi Katagi ,  Yuko Kato ,  Junichi Kawanabe

    发明人： Masaaki Takeda ,  Hitomi Katagi ,  Yuko Kato ,  Junichi Kawanabe

    IPC分类号： G01N35/10 ,  G01B13/00

    CPC分类号： G01N35/1016 ,  G01N2035/1018 ,  G01N35/10

    摘要： A pipetting apparatus is provided with clot detection. The pipetting apparatus comprises a nozzle for aspirating a sample. A pressure sensor is connected with the nozzle for measuring pressure in said nozzle. A plurality of pressure difference calculating circuits are operatively connected with the pressure sensor, each for inputting an output of said pressure sensor and obtaining a pressure difference at a different pressure calculation period, respectively. A plurality of discriminating circuits each having a different discrimination threshold value determined according to each of the pressure calculation periods are provided. An alarm circuit is included for outputting a clot detection alarm signal when at least one of said discriminating circuits discriminates that the obtained pressure difference exceeds the discrimination threshold value.

    摘要翻译： PCT No.PCT / JP93 / 01227 Sec。 371日期1995年5月15日 102（e）日期1995年5月15日PCT提交1993年8月31日PCT公布。 公开号WO95 / 06878 日期：1995年3月9日。移液器具有凝块检测。 移液装置包括用于抽吸样品的喷嘴。 压力传感器与喷嘴连接，用于测量所述喷嘴中的压力。 多个压力差计算电路与压力传感器可操作地连接，每个压力传感器用于输入所述压力传感器的输出并分别在不同的压力计算周期获得压力差。 提供了各自具有根据每个压力计算周期确定的不同鉴别阈值的多个识别电路。 当所述鉴别电路中的至少一个鉴别所获得的压差超过鉴别阈值时，包括报警电路，用于输出凝块检测报警信号。

    Method for pipetting a blood sample
    9.
    发明授权
    Method for pipetting a blood sample 失效
    吸取血样的方法

    公开(公告)号：US5452619A

    公开(公告)日：1995-09-26

    申请号：US211382

    申请日：1994-07-05

    申请人： Junichi Kawanabe ,  Masaaki Takeda ,  Hitomi Katagi ,  Yuko Kato ,  Gregory A. Bielarczyk ,  Rosie L. Magee

    发明人： Junichi Kawanabe ,  Masaaki Takeda ,  Hitomi Katagi ,  Yuko Kato ,  Gregory A. Bielarczyk ,  Rosie L. Magee

    IPC分类号： G01N1/00 ,  G01N33/48 ,  G01N33/483 ,  G01N33/49 ,  G01N35/10 ,  G01N1/28

    CPC分类号： G01N35/1016 ,  G01N33/491 ,  G01N2035/1018 ,  G01N2035/1025 ,  G01N2035/103

    摘要： In pipetting a blood plasma component and a red blood cell component separated vertically in a blood sample by a centrifugation, the red blood cell component having a high viscosity is aspirated as quickly as possible. A nozzle 32 is composed of a nozzle base 35 and a disposable tip 36, and is transferred upwardly and downwardly and to the right and left by an XYZ robot 34. At first the blood plasma component in the blood sample put in a test tube 62 is pipetted by a nozzle 32, and then an inner wall of the disposable tip 36 is coated with the blood plasma component, and thereafter the red blood component is pipetted.

    摘要翻译： PCT No.PCT / JP92 / 01281 Sec。 371日期：1994年7月5日 102（e）1994年3月31日PCT提交1992年10月2日PCT公布。 出版物WO93 / 07494 日期：1993年04月15日。在移取通过离心在血液样品中垂直分离的血浆成分和红细胞成分的情况下，尽快吸出具有高粘度的红细胞成分。 喷嘴32由喷嘴基座35和一次性尖端36构成，并通过XYZ机器人34向上下方向左右移动。首先，将血液试样中的血浆成分放入试管62 由喷嘴32吸移，然后用血浆成分涂覆一次性头部36的内壁，之后吸移血液成分。

    Antisecretory heterocyclic amidine compounds
    10.
    发明授权
    Antisecretory heterocyclic amidine compounds 失效
    防雾杂环脒化合物

    公开(公告)号：US4252819A

    公开(公告)日：1981-02-24

    申请号：US934276

    申请日：1978-08-16

    申请人： Yasufumi Hirata ,  Isao Yanagisawa ,  Toshinari Tamura ,  Masaaki Takeda

    发明人： Yasufumi Hirata ,  Isao Yanagisawa ,  Toshinari Tamura ,  Masaaki Takeda

    IPC分类号： C07D233/64 ,  A61K31/40 ,  A61K31/4402 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/455 ,  A61P43/00 ,  C07D213/30 ,  C07D213/32 ,  C07D213/68 ,  C07D213/86 ,  C07D233/54 ,  C07D277/26 ,  C07D307/52 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  A61K31/34 ,  A61K31/38 ,  C07D307/54 ,  C07D333/24

    CPC分类号： C07D213/30 ,  C07D213/32 ,  C07D213/68 ,  C07D213/86 ,  C07D233/64 ,  C07D277/26 ,  C07D307/52

    摘要： Novel heterocyclic compounds shown by the formula ##STR1## wherein Het represents a 5-membered or 6-membered heterocyclic group which may have substituent(s); Z represents a sulfur atom or oxygen atom; X represents an oxygen atom or the unsubstituted or substituted imino group shown by N--R.sub.1 (wherein R.sub.1 is a hydrogen atom, a lower alkyl group, a cyano group, an unsubstituted or alkyl substituted carbamoyl group, an unsubstituted or lower alkyl substituted thiocarbamoyl group, or a lower alkanoylamino group); Y represents a hydrogen atom, a lower alkyl group which may have substituent(s), a cycloalkyl group of 3-6 carbon atoms, a lower alkenyl group, a lower alkynyl group, an aryl group which may have substituent(s), an aralkyl group which may have substituent(s), a hydroxyl group, a cyano group, a carbamoyl group, an amidino group, an alkanoyl group which may have been substituted by halogen atom(s),an alkanoylamino group, an arylcarbonylamino group, an alkylamino group, an arylamino group, an arylsulfamoyl group, a lower alkoxycarbamoyl group, or an oxamoylamino group; and m and n represent an integer of 1-3; when X is N-R.sub.1, said X and Y may combine with each other to form a 5-membered or 6-membered heterocyclic ring containing 2-3 nitrogen atoms which may have substituent(s), and the pharmaceutically acceptable acid addition salts thereof.The compounds of this invention are useful as gastric acid secretion inhibitors.

    摘要翻译： 式中，Het表示可具有取代基的5元或6元杂环基的新型杂环化合物。 Z表示硫原子或氧原子; X表示氧原子或由N-R 1表示的未取代或取代的亚氨基（其中R 1为氢原子，低级烷基，氰基，未取代或烷基取代的氨基甲酰基，未取代或低级烷基取代的硫代氨基甲酰基 ，或低级烷酰氨基）; Y表示氢原子，可具有取代基的低级烷基，3-6个碳原子的环烷基，低级烯基，低级炔基，可具有取代基的芳基， 可以具有取代基的芳烷基，羟基，氰基，氨基甲酰基，脒基，可被卤素原子取代的烷酰基，烷酰基氨基，芳基羰基氨基， 烷基氨基，芳基氨基，芳基氨磺酰基，低级烷氧基氨基甲酰基或氨甲酰基氨基; m和n表示1-3的整数; 当X为N-R 1时，所述X和Y可以彼此结合形成含有2-3个可具有取代基的氮原子的5元或6元杂环，及其药学上可接受的酸加成盐 。 本发明的化合物可用作胃酸分泌抑制剂。