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    Method of coating a medical appliance utilizing a vibrating mesh nebulizer, a system for coating a medical appliance, and a medical appliance produced by the method
    1.
    发明申请
    Method of coating a medical appliance utilizing a vibrating mesh nebulizer, a system for coating a medical appliance, and a medical appliance produced by the method 审中-公开
    利用振动筛网喷雾器涂敷医疗器具的方法，用于涂敷医疗器具的系统以及通过该方法制造的医疗器具

    公开(公告)号：US20060198941A1

    公开(公告)日：2006-09-07

    申请号：US11073198

    申请日：2005-03-04

    申请人： Niall Behan ,  David McMorrow ,  Timothy O'Connor

    发明人： Niall Behan ,  David McMorrow ,  Timothy O'Connor

    IPC分类号： A01G25/09 ,  A61L33/00 ,  B05B1/08 ,  B05B17/00

    CPC分类号： B05B17/0646 ,  A61L2420/02 ,  B05D1/02

    摘要： A method of coating a medical appliance is provided that includes contacting a coating material with a first side of a mesh nebulizer. The mesh nebulizer includes at least one aperture. The method also includes vibrating the mesh nebulizer and arranging the medical appliance in a region of a second side of the mesh nebulizer. The second side is opposite the first side. A medical appliance is provided having a coating applied by a method. A system is provided for coating a medical appliance that includes a coating source, a mesh nebulizer, an arrangement for vibrating the mesh nebulizer, and an arrangement for holding the medical appliance. A method is provided of coating a medical appliance that includes directing at least two small aperture tubes at a collision region and forcing a coating material out of the apertures of the tubes. The method also includes arranging the medical appliance in another region adjacent to the collision region.

    摘要翻译： 提供一种涂覆医疗器具的方法，其包括使涂层材料与网状喷雾器的第一侧接触。 网状雾化器包括至少一个孔。 该方法还包括使网状雾化器振动并将医疗器具布置在网状雾化器的第二侧的区域中。 第二面与第一面相对。 提供具有通过一种方法施加的涂层的医疗器具。 提供一种用于涂覆包括涂料源，网眼雾化器，用于振动网状雾化器的装置和用于保持医疗器具的装置的医疗器械的系统。 提供了一种涂覆医疗器具的方法，其包括在碰撞区域引导至少两个小孔管并迫使涂层材料离开管的孔。 该方法还包括将医疗器具布置在与碰撞区域相邻的另一区域中。

    System and method for coating a medical appliance utilizing a vibrating mesh nebulizer
    3.
    发明申请
    System and method for coating a medical appliance utilizing a vibrating mesh nebulizer 审中-公开
    使用振动筛网雾化器涂覆医疗器具的系统和方法

    公开(公告)号：US20060198942A1

    公开(公告)日：2006-09-07

    申请号：US11326744

    申请日：2006-01-05

    申请人： Timothy O'Connor ,  Niall Grenham ,  David McMorrow ,  James Shannon ,  Travis Schauer ,  Thomas Holly

    发明人： Timothy O'Connor ,  Niall Grenham ,  David McMorrow ,  James Shannon ,  Travis Schauer ,  Thomas Holly

    IPC分类号： A61L33/00

    CPC分类号： B05B17/0646 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  B05B5/08 ,  B05B7/0012 ,  B05B7/16 ,  B05B17/0676

    摘要： A method and device for coating a medical device, such as a stent, including forming coating droplets using a mesh nebulizer and transporting the coating droplets to the medical device, for example through a converging chamber. The coating droplets may be accelerated to a speed sufficient to break the coating droplets into smaller droplets upon impact with the medical device. The mesh nebulizer may have a convex inlet side and may form a converging plume of coating droplets. The mesh nebulizer may have one or more groups of pores, the pores within each group may be subject to similar amplitudes of vibration. The coating material may be heated or cooled prior to nebulizing. The chamber may include baffles configured to allow only a predetermined size range of coating particles to pass.

    摘要翻译： 一种用于涂覆诸如支架的医疗装置的方法和装置，包括使用网状雾化器形成涂层液滴并将涂布液滴输送到医疗装置，例如通过会聚室。 涂层液滴可以被加速到足以在与医疗装置碰撞时将涂层液滴分解成更小的液滴的速度。 网状雾化器可以具有凸入口侧并且可以形成会聚的涂层液滴。 网状雾化器可以具有一组或多组孔，每组中的孔可能受到类似的振幅。 涂覆材料可以在雾化之前加热或冷却。 腔室可以包括构造成仅允许涂覆颗粒的预定尺寸范围通过的挡板。

    Methods and systems for depositing coating on a medical device
    4.
    发明授权
    Methods and systems for depositing coating on a medical device 失效
    用于在医疗装置上沉积涂层的方法和系统

    公开(公告)号：US08147899B2

    公开(公告)日：2012-04-03

    申请号：US12117100

    申请日：2008-05-08

    申请人： David McMorrow ,  Timothy O'Connor

    发明人： David McMorrow ,  Timothy O'Connor

    IPC分类号： A61L33/00 ,  B05D3/00 ,  B05D1/28 ,  B05C11/00 ,  B05C1/08

    CPC分类号： B05D1/28 ,  B05D1/002 ,  B05D3/12

    摘要： The present invention is directed to methods and systems for aligning and coating a medical device during a single coating cycle. A first section of an applicator may apply a contact force to surfaces of the medical device. The contact force may align and remove surface irregularities from the medical device prior to coating the medical device with coating. The coating may be resident on a second section of the applicator.

    摘要翻译： 本发明涉及在单次涂覆循环期间对准和涂覆医疗装置的方法和系统。 施加器的第一部分可以对医疗装置的表面施加接触力。 在用涂层涂覆医疗装置之前，接触力可以对准和去除医疗装置的表面凹凸。 涂层可以驻留在施用器的第二部分上。

    Methods for making drug-eluting medical devices
    5.
    发明授权
    Methods for making drug-eluting medical devices 失效
    药物洗脱医疗器械的制备方法

    公开(公告)号：US08263171B2

    公开(公告)日：2012-09-11

    申请号：US12170889

    申请日：2008-07-10

    申请人： John T. Clarke ,  Timothy O'Connor

    发明人： John T. Clarke ,  Timothy O'Connor

    IPC分类号： A61L27/54

    CPC分类号： B05D5/00 ,  A61F2/91 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0023 ,  A61F2250/0067

    摘要： The present invention is directed to medical implants that are configured to controllably release therapeutic agent to a target site of a patient and methods of making these implants. Embodiments of the present invention may include a method comprising the steps of providing a tube having a wall with inner and outer surfaces and defining a passageway, forming an opening through the wall of the tube, applying a porous coating layer to at least one of the inner and outer surfaces of the tube, and loading a therapeutic agent solution into the passageway so that therapeutic agent passes through the opening and into the porous coating layer. The method may also include removing portions of the tube to form the implantable medical device, which may be a stent.

    摘要翻译： 本发明涉及被配置为将治疗剂可控地释放到患者的靶位点的医疗植入物和制造这些植入物的方法。 本发明的实施例可以包括一种方法，包括以下步骤：提供具有内壁和外表面的壁的管，并限定通道，形成穿过管壁的开口，将多孔涂层施加到至少一个 管的内表面和外表面，并将治疗剂溶液装载到通道中，使得治疗剂通过开口并进入多孔涂层。 该方法还可以包括去除管的部分以形成可植入的医疗装置，其可以是支架。

    METHODS FOR MAKING DRUG-ELUTING MEDICAL DEVICES
    6.
    发明申请
    METHODS FOR MAKING DRUG-ELUTING MEDICAL DEVICES 失效
    制造药物治疗设备的方法

    公开(公告)号：US20090017188A1

    公开(公告)日：2009-01-15

    申请号：US12170889

    申请日：2008-07-10

    申请人： John T. Clarke ,  Timothy O'Connor

    发明人： John T. Clarke ,  Timothy O'Connor

    IPC分类号： A61L27/54

    CPC分类号： B05D5/00 ,  A61F2/91 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0023 ,  A61F2250/0067

    摘要： The present invention is directed to medical implants that are configured to controllably release therapeutic agent to a target site of a patient and methods of making these implants. Embodiments of the present invention may include a method comprising the steps of providing a tube having a wall with inner and outer surfaces and defining a passageway, forming an opening through the wall of the tube, applying a porous coating layer to at least one of the inner and outer surfaces of the tube, and loading a therapeutic agent solution into the passageway so that therapeutic agent passes through the opening and into the porous coating layer. The method may also include removing portions of the tube to form the implantable medical device, which may be a stent.

    摘要翻译： 本发明涉及被配置为将治疗剂可控地释放到患者的靶位点的医疗植入物和制造这些植入物的方法。 本发明的实施例可以包括一种方法，包括以下步骤：提供具有内壁和外表面的壁的管，并限定通道，形成穿过管壁的开口，将多孔涂层施加到至少一个 管的内表面和外表面，并将治疗剂溶液装载到通道中，使得治疗剂通过开口并进入多孔涂层。 该方法还可以包括去除管的部分以形成可植入的医疗装置，其可以是支架。

    Coating a workpiece using a metering device and workpieces coated with this metering device
    7.
    发明申请
    Coating a workpiece using a metering device and workpieces coated with this metering device 审中-公开
    使用计量装置和涂有该计量装置的工件涂覆工件

    公开(公告)号：US20070281072A1

    公开(公告)日：2007-12-06

    申请号：US11447175

    申请日：2006-06-06

    申请人： Timothy O'Connor ,  Gabriel Sobrino ,  Liam Ward

    发明人： Timothy O'Connor ,  Gabriel Sobrino ,  Liam Ward

    IPC分类号： A61L33/00 ,  B05D3/12

    CPC分类号： B05D1/28 ,  B05C11/025 ,  B05D1/002

    摘要： The present invention is directed to methods, processes, and systems for selectively coating portions of a workpiece as well as to workpieces that have themselves been coated in accord with the invention. Under methods and processes of the invention, a target surface of a workpiece may be positioned in contact with a roller to coat a target surface of the workpiece. In some embodiments, the roller may also be positioned in contact with a metering device during portions or all of the treating and coating process. The workpiece may be an implantable medical device and the coating may include therapeutic, the workpiece may be other devices as well.

    摘要翻译： 本发明涉及用于选择性地涂覆工件的部分以及本身已经根据本发明进行了涂覆的工件的方法，工艺和系统。 在本发明的方法和方法下，工件的目标表面可以定位成与辊接触以涂覆工件的目标表面。 在一些实施例中，在处理和涂覆过程的部分或全部期间，辊也可以定位成与计量装置接触。 工件可以是可植入医疗装置，并且涂层可以包括治疗剂，工件也可以是其它装置。