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    SYSTEMS AND METHODS FOR FREEZING, STORING AND THAWING BIOPHARMACEUTICAL MATERIALS
    1.
    发明申请
    SYSTEMS AND METHODS FOR FREEZING, STORING AND THAWING BIOPHARMACEUTICAL MATERIALS 有权
    用于冷冻，储存和治疗生物材料的系统和方法

    公开(公告)号：US20070240432A1

    公开(公告)日：2007-10-18

    申请号：US11682558

    申请日：2007-03-06

    申请人： Nicolas Voute ,  Eric Lee ,  Dimitry Yakoushkin

    发明人： Nicolas Voute ,  Eric Lee ,  Dimitry Yakoushkin

    IPC分类号： F25C1/00

    CPC分类号： F25D25/005 ,  A61J1/165 ,  F25D2331/809

    摘要： A system for use in freezing, storing and thawing biopharmaceutical materials includes a flexible sterile container means for holding biopharmaceutical material therein and a holder more rigid than said container means. The container means is received in a cavity of the holder and the holder extends along a perimeter of the container means. The holder is fixedly connected to the container means. The holder includes opposing sides defining an opening and the container means extends between the opposing sides of the holder defining the opening. The container means includes a substantially smooth exterior surface extending between the opposing sides.

    摘要翻译： 用于冷冻，储存和解冻生物药物材料的系统包括用于在其中保持生物药物材料的柔性无菌容器装置和比所述容器装置更刚性的保持器。 容器装置被容纳在保持器的空腔中，并且保持器沿着容器装置的周边延伸。 保持器固定地连接到容器装置。 保持器包括限定开口的相对侧，并且容器装置在限定开口的保持器的相对侧之间延伸。 容器装置包括在相对的侧面之间延伸的基本光滑的外表面。

    Systems and methods for freezing, storing and thawing biopharmaceutical materials
    2.
    发明授权
    Systems and methods for freezing, storing and thawing biopharmaceutical materials 有权
    用于冷冻，储存和解冻生物药物材料的系统和方法

    公开(公告)号：US08863532B2

    公开(公告)日：2014-10-21

    申请号：US13213638

    申请日：2011-08-19

    申请人： Nicolas Voute ,  Eric K. Lee ,  Dimitry Yakoushkin

    发明人： Nicolas Voute ,  Eric K. Lee ,  Dimitry Yakoushkin

    IPC分类号： F25D3/08 ,  A61J1/16 ,  F25D25/00

    CPC分类号： F25D25/005 ,  A61J1/165 ,  F25D2331/809

    摘要： A system for use in freezing, storing and thawing biopharmaceutical materials includes a flexible sterile container means for holding biopharmaceutical material therein and a holder more rigid than said container means. The container means is received in a cavity of the holder and the holder extends along a perimeter of the container means. The holder is fixedly connected to the container means. The holder includes opposing sides defining an opening and the container means extends between the opposing sides of the holder defining the opening. The container means includes a substantially smooth exterior surface extending between the opposing sides.

    摘要翻译： 用于冷冻，储存和解冻生物药物材料的系统包括用于在其中保持生物药物材料的柔性无菌容器装置和比所述容器装置更刚性的保持器。 容器装置被容纳在保持器的空腔中，并且保持器沿着容器装置的周边延伸。 保持器固定地连接到容器装置。 保持器包括限定开口的相对侧，并且容器装置在限定开口的保持器的相对侧之间延伸。 容器装置包括在相对的侧面之间延伸的基本光滑的外表面。

    Systems and methods for freezing, storing and thawing biopharmaceutical materials
    3.
    发明授权
    Systems and methods for freezing, storing and thawing biopharmaceutical materials 有权
    用于冷冻，储存和解冻生物药物材料的系统和方法

    公开(公告)号：US08028532B2

    公开(公告)日：2011-10-04

    申请号：US11682558

    申请日：2007-03-06

    申请人： Nicolas Voute ,  Eric K. Lee ,  Dimitry Yakoushkin

    发明人： Nicolas Voute ,  Eric K. Lee ,  Dimitry Yakoushkin

    IPC分类号： F25C1/00

    CPC分类号： F25D25/005 ,  A61J1/165 ,  F25D2331/809

    摘要： A system for use in freezing, storing and thawing biopharmaceutical materials includes a flexible sterile container means for holding biopharmaceutical material therein and a holder more rigid than said container means. The container means is received in a cavity of the holder and the holder extends along a perimeter of the container means. The holder is fixedly connected to the container means. The holder includes opposing sides defining an opening and the container means extends between the opposing sides of the holder defining the opening. The container means includes a substantially smooth exterior surface extending between the opposing sides.

    摘要翻译： 用于冷冻，储存和解冻生物药物材料的系统包括用于在其中保持生物药物材料的柔性无菌容器装置和比所述容器装置更刚性的保持器。 容器装置被容纳在保持器的空腔中，并且保持器沿着容器装置的周边延伸。 保持器固定地连接到容器装置。 保持器包括限定开口的相对侧，并且容器装置在限定开口的保持器的相对侧之间延伸。 容器装置包括在相对的侧面之间延伸的基本光滑的外表面。

    Systems and methods for freezing, storing and thawing biopharmaceutical materials
    8.
    发明授权
    Systems and methods for freezing, storing and thawing biopharmaceutical materials 有权
    用于冷冻，储存和解冻生物药物材料的系统和方法

    公开(公告)号：US09161527B2

    公开(公告)日：2015-10-20

    申请号：US13167484

    申请日：2011-06-23

    申请人： Jonathan Cutting ,  Isabelle Gay ,  Eric K. Lee ,  Nicolas Voute

    发明人： Jonathan Cutting ,  Isabelle Gay ,  Eric K. Lee ,  Nicolas Voute

    IPC分类号： G06F17/00 ,  A01N1/02 ,  F25C1/22

    CPC分类号： F17C3/085 ,  A01N1/02 ,  A01N1/0263 ,  B01L7/00 ,  F25C1/22 ,  Y10T29/53443

    摘要： A system for using freezing, storing and thawing biopharmaceutical materials which includes a holder and a container for holding biopharmaceutical materials therein. The holder has a cavity and the container is received in the cavity. The holder includes a first portion and second portion. The container is received between the first portion and the second portion to connect the container to the holder. The holder includes an interior cradle having a bottom and edges extending from the bottom. The cradle bounds the cavity. An outer rim is connected to the cradle and separated from the cavity. The bottom includes an inner surface facing the cavity receiving the container and an outer surface. The outer surface of the bottom is recessed relative to an outer surface of the outer rim.

    摘要翻译： 一种用于使用冷冻，储存和解冻生物药物材料的系统，其包括用于在其中保持生物药物材料的保持器和容器。 保持器具有空腔并且容器容纳在空腔中。 保持器包括第一部分和第二部分。 容器容纳在第一部分和第二部分之间，以将容器连接到保持器。 保持器包括具有从底部延伸的底部和边缘的内部支架。 摇篮限定了空腔。 外缘连接到支架并与空腔分离。 底部包括面向容纳容器的空腔的内表面和外表面。 底部的外表面相对于外缘的外表面凹陷。

    POCHE A TEMOIN DE PERTE D'INTEGRITE INCORPORE, PROCEDE DE REALISATION D'UNE TELLE POCHE ET PROCEDE D'UTILISATION
    9.
    发明申请
    POCHE A TEMOIN DE PERTE D'INTEGRITE INCORPORE, PROCEDE DE REALISATION D'UNE TELLE POCHE ET PROCEDE D'UTILISATION 有权
    POCHE A TEMOIN DE PERTE D'INTEGRITE INCORPORE，PROCEDE DE REALATIONATION D'UNE TELLE POCHE ET PROCEDE D'UTILIZATION

    公开(公告)号：US20120128275A1

    公开(公告)日：2012-05-24

    申请号：US13378369

    申请日：2010-06-14

    申请人： Nicolas Voute

    发明人： Nicolas Voute

    IPC分类号： B65D33/00

    CPC分类号： B65D79/02 ,  B65B31/02 ,  B65D75/38 ,  B65D77/04 ,  B65D81/2084 ,  G01N31/22

    摘要： A pouch includes: a first closed, inner casing, made of at least one non-porous plastic material with a high-capacity gas barrier, delimiting a first space, forming a pouch stricto sensu for accommodating a biopharmaceutical product or device, a second closed, outer casing, made of at least one non-porous plastic material with a high-capacity gas barrier, delimiting a second space in which the pouch stricto sensu is located, spacer elements, at least one selected tracer gas, located in the first or second space outside of the pouch stricto sensu, with a higher partial pressure than in the second space outside of the pouch stricto sensu or in the first space, at least one colorimetric detector located, respectively, in the second space outside of the pouch stricto sensu or in the first space responsive to the concentration of the tracer gas, by switching from a first color to a second different color.

    摘要翻译： 袋包括：第一封闭的内壳，由至少一个具有高容量气体屏障的无孔塑料材料制成，限定第一空间，形成用于容纳生物药物产品或装置的密封袋，第二封闭 外壳，由具有高容量气体屏障的至少一个无孔塑料材料制成，限定其中所述密封袋位于的第二空间，间隔元件，至少一个选定的示踪气体，位于第一或 在密封袋之外的第二空间，具有比在狭缝感觉下的第二空间或第一空间中更高的分压，至少一个比色检测器分别位于密封袋外部的第二空间中 或者在第一空间中，通过从第一颜色切换到第二不同颜色来响应于示踪气体的浓度。