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公开(公告)号：US06767194B2
公开(公告)日：2004-07-27
申请号：US10041718
申请日：2002-01-08
申请人： Noo Li Jeon , Daniel T. Chiu , Christopher J. Wargo , Insung S. Choi , Hongkai Wu , Janelle R. Anderson , George M. Whitesides , Justin C. McDonald , Steven J. Metallo , Howard A. Stone
发明人： Noo Li Jeon , Daniel T. Chiu , Christopher J. Wargo , Insung S. Choi , Hongkai Wu , Janelle R. Anderson , George M. Whitesides , Justin C. McDonald , Steven J. Metallo , Howard A. Stone
IPC分类号： F04B5310
CPC分类号： B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/16 , B01L2300/0816 , B01L2300/0887 , B01L2400/0487 , B01L2400/0611 , B01L2400/0638 , B01L2400/0677 , F04B43/043 , F16K99/0001 , F16K99/0007 , F16K99/0015 , F16K99/003 , F16K99/0034 , F16K99/0048 , F16K99/0057 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , F16K2099/0086 , F16K2099/0094 , Y10T137/0497 , Y10T137/7891 , Y10T137/7895 , Y10T137/791 , Y10T137/87917
摘要： The present invention relates to microfluidic systems, including valves and pumps for microfluidic systems. The valves of the invention include check valves such as diaphragm valves and flap valves. Other valves of the invention include one-use valves. The pumps of the present invention include a reservoir and at least two check valves. The reservoir may be of variable volume. The present invention also relates to a flexible microfluidic system. The present invention additionally relates to a method of making microfluidic systems including those of the present invention. The method includes forming a microfluidic system on a master, connecting a support to the microfluidic system and removing the microfluidic system from the master. The support may remain connected to the microfluidic system or the microfluidic system may be transferred to another substrate. The present invention further relates to a method of manipulating a flow of a fluid in a microfluidic system. This method includes initiating fluid flow in a first direction and inhibiting fluid flow in a second direction and may be practiced with the valves of the present invention.
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2.发明授权Valves and pumps for microfluidic systems and method for making microfluidic systems 有权用于微流体系统的阀门和泵以及用于制造微流体系统的方法公开(公告)号：US07942160B2
公开(公告)日：2011-05-17
申请号：US10867151
申请日：2004-06-14
申请人： Noo Li Jeon , Daniel T. Chiu , Christopher J. Wargo , Insung S. Choi , Hongkai Wu , Janelle R. Anderson , George M. Whitesides , J. Cooper McDonald , Steven J. Metallo , Howard A. Stone
发明人： Noo Li Jeon , Daniel T. Chiu , Christopher J. Wargo , Insung S. Choi , Hongkai Wu , Janelle R. Anderson , George M. Whitesides , J. Cooper McDonald , Steven J. Metallo , Howard A. Stone
CPC分类号： B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/16 , B01L2300/0816 , B01L2300/0887 , B01L2400/0487 , B01L2400/0611 , B01L2400/0638 , B01L2400/0677 , F04B43/043 , F16K99/0001 , F16K99/0007 , F16K99/0015 , F16K99/003 , F16K99/0034 , F16K99/0048 , F16K99/0057 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , F16K2099/0086 , F16K2099/0094 , Y10T137/0497 , Y10T137/7891 , Y10T137/7895 , Y10T137/791 , Y10T137/87917
摘要： The present invention relates to microfluidic systems, including valves and pumps for microfluidic systems. The valves of the invention include check valves such as diaphragm valves and flap valves. Other valves of the invention include one-use valves. The pumps of the present invention include a reservoir and at least two check valves. The reservoir may be of variable volume. The present invention also relates to a flexible microfluidic system. The present invention additionally relates to a method of making microfluidic systems including those of the present invention. The method includes forming a microfluidic system on a master, connecting a support to the microfluidic system and removing the microfluidic system from the master. The support may remain connected to the microfluidic system or the microfluidic system may be transferred to another substrate. The present invention further relates to a method of manipulating a flow of a fluid in a microfluidic system. This method includes initiating fluid flow in a first direction and inhibiting fluid flow in a second direction and may be practiced with the valves of the present invention.
摘要翻译： 本发明涉及微流体系统，包括用于微流体系统的阀和泵。 本发明的阀门包括止回阀，例如隔膜阀和活门阀。 本发明的其它阀包括一次性阀。 本发明的泵包括储存器和至少两个止回阀。 储层可能是可变的体积。 本发明还涉及柔性微流体系统。 本发明还涉及制造包括本发明的微流体系统的方法。 该方法包括在母版上形成微流体系统，将支撑物连接到微流体系统并从母体移除微流体系统。 载体可以保持连接到微流体系统，或者微流体系统可以被转移到另一个基底。 本发明还涉及一种操纵微流体系统中流体流动的方法。 该方法包括启动在第一方向上的流体流动并阻止在第二方向上的流体流动，并且可以用本发明的阀来实施。
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3.发明授权Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks 有权使用包括三维排列的通道网络的微流体标记的表面图案化公开(公告)号：US07267938B2
公开(公告)日：2007-09-11
申请号：US10654587
申请日：2003-09-02
申请人： Janelle R. Anderson , Daniel T. Chiu , Noo Li Jeon , Sui Huang , Ravindra Kane , Insung S. Choi , Donald E. Ingber , George M. Whitesides
发明人： Janelle R. Anderson , Daniel T. Chiu , Noo Li Jeon , Sui Huang , Ravindra Kane , Insung S. Choi , Donald E. Ingber , George M. Whitesides
CPC分类号： C12N11/00 , B01F13/0059 , B01J2219/00382 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00725 , B01J2219/00743 , B01L3/0258 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/424 , B29C39/10 , B33Y80/00 , B81B1/00 , B81C99/009 , B82Y5/00 , B82Y30/00 , C40B40/10 , C40B60/14 , G01N33/5005 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/815
摘要： The present invention describes improved microfluidic systems and procedures for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The methods for fabrication the systems disclosed can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks can be fabricated via replica molding processes utilizing mold masters including surfaces having topological features formed by photolithography. The present invention also involves microfluidic systems and methods for fabricating complex patterns of materials, such as biological materials and cells, on surfaces utilizing the microfluidic systems. Specifically, the invention provides microfluidic surface patterning systems and methods for fabricating complex, discontinuous patterns on surfaces that can incorporate or deposit multiple materials onto the surfaces. The present invention also provides improved microfluidic stamps or applicators for microcontact surface patterning, which are able to pattern onto a surface arbitrary two-dimensional patterns, and which are able to pattern multiple substances onto a surface without the need for multiple steps of registration or stamping during patterning and without the need to selectively “ink” different regions of the stamp with different materials.
摘要翻译： 本发明描述了改进的微流体系统和用于制造改进的微流体系统的程序，其包含一个或多个水平的微流体通道。 用于制造所公开的系统的方法可以提供拓扑复杂和改进的微流体系统的方便的途径。 微流体系统可以包括其中流体流动路径的三维排列的网络，其中包括在交叉点处的交叉点处的交叉或不在其他通道上的通道，而没有物理交叉点。 微流体网络可以通过使用模具主体的复制模制工艺制造，其中包括具有通过光刻形成的拓扑特征的表面。 本发明还涉及在利用微流体系统的表面上制造诸如生物材料和细胞的复杂图案的微流体系统和方法。 具体地，本发明提供了微流体表面图案化系统和用于在表面上制造复杂的不连续图案的方法，该图案可以将多种材料结合或沉积到表面上。 本发明还提供了用于微接触表面图案化的改进的微流体标记或涂布器，其能够将图案图案化成任意的二维图案，并且能够将多种物质图案化到表面上，而不需要多个对准或冲压的步骤 在图案化期间，并且不需要使用不同材料选择性地“印刷”印模的不同区域。
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4.发明授权Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks 有权使用包括三维排列的通道网络的微流体标记的表面图案化公开(公告)号：US06686184B1
公开(公告)日：2004-02-03
申请号：US09578562
申请日：2000-05-25
申请人： Janelle R. Anderson , Daniel T. Chiu , Noo-Li Jeon , Sui Huang , Ravi Kane , Insung S. Choi , Donald E. Ingber , George M. Whitesides
发明人： Janelle R. Anderson , Daniel T. Chiu , Noo-Li Jeon , Sui Huang , Ravi Kane , Insung S. Choi , Donald E. Ingber , George M. Whitesides
IPC分类号： C12N1100
CPC分类号： C12N11/00 , B01F13/0059 , B01J2219/00382 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00725 , B01J2219/00743 , B01L3/0258 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/424 , B29C39/10 , B33Y80/00 , B81B1/00 , B81C99/009 , B82Y5/00 , B82Y30/00 , C40B40/10 , C40B60/14 , G01N33/5005 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/815
摘要： Microfluidic systems and methods are provided for fabricating complex patterns of materials, such as proteins, inorganic materials or cells, on surfaces. Complex, discontinuous patterns on surfaces can be formed incorporating or depositing multiple materials. A stamp structure has a flow path containing a series of interconnected channels. The channels include a first channel within an interior of the stamp structure, a second channel within a stamping surface of the structure defining a pattern, and a channel fluidically interconnecting the first and second channels. After contacting the stamp with a surface, a fluid is introduced into the flow path so that the fluid contacts the surface to form a pattern. In another embodiment, the stamp structure has two non-fluidically interconnected first and second flow paths defining first and second patterns of channels to produce non-continuous first and second patterns on a surface.
摘要翻译： 提供微流体系统和方法用于在表面上制造复杂的材料图案，例如蛋白质，无机材料或细胞。 可以形成结合或沉积多种材料的表面上的复杂的不连续图案。 邮票结构具有包含一系列互连通道的流路。 通道包括印模结构内部的第一通道，限定图案的结构的冲压表面内的第二通道以及流体地互连第一和第二通道的通道。 在将印模与表面接触之后，将流体引入流动路径中，使得流体接触表面以形成图案。 在另一个实施例中，印模结构具有限定第一和第二图案通道的两个非流体互连的第一和第二流动路径，以在表面上产生不连续的第一和第二图案。
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公开(公告)号：US06883559B2
公开(公告)日：2005-04-26
申请号：US10690475
申请日：2003-10-21
IPC分类号： G01N33/53 , B01D3/00 , B01F5/06 , B01F13/00 , B01F15/04 , B01J4/00 , B01J19/00 , B01J19/24 , B01L20060101 , B01L1/00 , B01L3/00 , B65B3/00 , B65B3/04 , C12M1/34 , C23G1/00 , G01F11/28 , G01N1/28 , G01N1/38 , G01N33/543 , G01N37/00
CPC分类号： B01F5/0601 , B01F5/064 , B01F13/0059 , B01F15/0404 , B01J4/001 , B01J19/0093 , B01J2219/0086 , B01J2219/00889 , B01L3/5027 , G01N1/2813 , G01N1/38
摘要： A method and apparatus for treating a fluid. A method for treating a fluid may include combining two or more separate streams into a common stream and then splitting the common stream into a new set of separate streams wherein the separate streams may possess different properties. The separate streams may be combined to produce a gradient, such as a concentration gradient or shear gradient. The apparatus of the invention may provide a network of fluidic channels that may be used to manipulate a fluid to produce, for example, a gradient or a series of solutions containing a substance at varying concentrations.
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公开(公告)号：US07314070B2
公开(公告)日：2008-01-01
申请号：US11037459
申请日：2005-01-18
IPC分类号： B65B3/00
CPC分类号： B01F5/0601 , B01F5/064 , B01F13/0059 , B01F15/0404 , B01J4/001 , B01J19/0093 , B01J2219/0086 , B01J2219/00889 , B01L3/5027 , G01N1/2813 , G01N1/38
摘要： A method and apparatus for treating a fluid. A method for treating a fluid may include combining two or more separate streams into a common stream and then splitting the common stream into a new set of separate streams wherein the separate streams may possess different properties. The separate streams may be combined to produce a gradient, such as a concentration gradient or shear gradient. The apparatus of the invention may provide a network of fluidic channels that may be used to manipulate a fluid to produce, for example, a gradient or a series of solutions containing a substance at varying concentrations.
摘要翻译： 一种用于处理流体的方法和装置。 用于处理流体的方法可以包括将两个或更多个分离的流组合成共同物流，然后将共同物流分成新的一组独立的流，其中分离的流可具有不同的性质。 可以将单独的流组合以产生梯度，例如浓度梯度或剪切梯度。 本发明的装置可以提供流体通道网络，其可以用于操纵流体以产生例如含有不同浓度物质的梯度或一系列溶液。
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公开(公告)号：US06705357B2
公开(公告)日：2004-03-16
申请号：US09954710
申请日：2001-09-18
IPC分类号： B65B300
CPC分类号： B01F5/0601 , B01F5/064 , B01F13/0059 , B01F15/0404 , B01J4/001 , B01J19/0093 , B01J2219/0086 , B01J2219/00889 , B01L3/5027 , G01N1/2813 , G01N1/38
摘要： A method and apparatus for treating a fluid. A method for treating a fluid may include combining two or more separate streams into a common stream and then splitting the common stream into a new set of separate streams wherein the separate streams may possess different properties. The separate streams may be combined to produce a gradient, such as a concentration gradient or shear gradient. The apparatus of the invention may provide a network of fluidic channels that may be used to manipulate a fluid to produce, for example, a gradient or a series of solutions containing a substance at varying concentrations.
摘要翻译： 一种用于处理流体的方法和装置。 用于处理流体的方法可以包括将两个或更多个分离的流组合成共同物流，然后将共同物流分成新的一组独立的流，其中分离的流可具有不同的性质。 可以将单独的流组合以产生梯度，例如浓度梯度或剪切梯度。 本发明的装置可以提供流体通道网络，其可以用于操纵流体以产生例如含有不同浓度物质的梯度或一系列溶液。
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公开(公告)号：US06645432B1
公开(公告)日：2003-11-11
申请号：US09578589
申请日：2000-05-25
申请人： Janelle R. Anderson , Oksana Cherniavskaya , Daniel T. Chiu , Rebecca J. Jackman , Cooper McDonald , George M. Whitesides
发明人： Janelle R. Anderson , Oksana Cherniavskaya , Daniel T. Chiu , Rebecca J. Jackman , Cooper McDonald , George M. Whitesides
IPC分类号： B01L302
CPC分类号： B01L3/0258 , B01F13/0059 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/405 , B29C33/424 , B29C39/02 , B29C39/24 , B29C66/7373 , B33Y80/00 , B81B2201/058 , B81C1/00119 , B81C2201/034 , B81C2201/036 , B82Y30/00 , Y10T137/2191 , Y10T137/2224 , Y10T436/2575
摘要： The present invention provides, in certain embodiments, improved microfluidic systems and methods for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The inventive methods can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems provided according to the invention can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks of the invention can be fabricated via replica molding processes, also provided by the invention, utilizing mold masters including surfaces having topological features formed by photolithography. The microfluidic networks of the invention are, in some cases, comprised of a single replica molded layer, and, in other cases, are comprised of two, three, or more replica molded layers that have been assembled to form the overall microfluidic network structure. The present invention also describes various novel applications for using the microfluidic network structures provided by the invention.
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公开(公告)号：US20080124663A1
公开(公告)日：2008-05-29
申请号：US11983425
申请日：2007-11-08
申请人： Janelle R. Anderson , Daniel T. Chiu , Rebecca J. Jackman , Oksana Cherniavskaya , J. Cooper McDonald , George M. Whitesides
发明人： Janelle R. Anderson , Daniel T. Chiu , Rebecca J. Jackman , Oksana Cherniavskaya , J. Cooper McDonald , George M. Whitesides
IPC分类号： G03F7/38
CPC分类号： B29C33/3857 , B01D61/18 , B01D67/003 , B01D67/0034 , B01D69/02 , B01D71/70 , B01D2323/24 , B01D2323/34 , B01D2325/028 , B01D2325/08 , B01L3/502707 , B01L2300/0874 , B01L2300/0887 , B29C33/3892 , B29C33/52 , B29C35/0888 , B29C39/021 , B29C39/34 , B29C2035/0827 , B33Y80/00 , B81B2201/058 , B81C1/00119 , B81C2201/019 , Y10T436/11 , Y10T436/2575
摘要： The present invention provides, in certain embodiments, improved microfluidic systems and methods for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The inventive methods can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems provided according to the invention can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks of the invention can be fabricated via replica molding processes, also provided by the invention, utilizing mold masters including surfaces having topological features formed by photolithography. The microfluidic networks of the invention are, in some cases, comprised of a single replica molded layer, and, in other cases, are comprised of two, three, or more replica molded layers that have been assembled to form the overall microfluidic network structure. The present invention also describes various novel applications for using the microfluidic network structures provided by the invention.
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公开(公告)号：US07323143B2
公开(公告)日：2008-01-29
申请号：US10303642
申请日：2002-11-25
申请人： Janelle R. Anderson , Daniel T. Chiu , Rebecca J. Jackman , Oksana Cherniavskaya , Justin Cooper McDonald , George M. Whitesides
发明人： Janelle R. Anderson , Daniel T. Chiu , Rebecca J. Jackman , Oksana Cherniavskaya , Justin Cooper McDonald , George M. Whitesides
CPC分类号： B29C33/3857 , B01D61/18 , B01D67/003 , B01D67/0034 , B01D69/02 , B01D71/70 , B01D2323/24 , B01D2323/34 , B01D2325/028 , B01D2325/08 , B01L3/502707 , B01L2300/0874 , B01L2300/0887 , B29C33/3892 , B29C33/52 , B29C35/0888 , B29C39/021 , B29C39/34 , B29C2035/0827 , B33Y80/00 , B81B2201/058 , B81C1/00119 , B81C2201/019 , Y10T436/11 , Y10T436/2575
摘要： The present invention provides, in certain embodiments, improved microfluidic systems and methods for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The inventive methods can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems provided according to the invention can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks of the invention can be fabricated via replica molding processes, also provided by the invention, utilizing mold masters including surfaces having topological features formed by photolithography. The microfluidic networks of the invention are, in some cases, comprised of a single replica molded layer, and, in other cases, are comprised of two, three, or more replica molded layers that have been assembled to form the overall microfluidic network structure. The present invention also describes various novel applications for using the microfluidic network structures provided by the invention.
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