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公开(公告)号：US20180154009A1
公开(公告)日：2018-06-07
申请号：US15819921
申请日：2017-11-21
发明人： Jian Yang , Robert Van Lith , Guillermo Ameer
IPC分类号： A61K47/60 , C12N5/00 , A61K9/00 , A61K47/34 , C08G63/676
CPC分类号： A61K47/60 , A61K9/0024 , A61K47/34 , C08G63/676 , C12N5/0068 , C12N2539/10
摘要： Provided herein are compositions, devices, and systems comprising thermoresponsive, biodegradable elastomeric materials, and methods of use and manufacture thereof.
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2.发明授权公开(公告)号：US09750845B2
公开(公告)日：2017-09-05
申请号：US14083071
申请日：2013-11-18
发明人： Guillermo Ameer , Antonio R. Webb
IPC分类号： A61K9/14 , A61L27/18 , A61L27/50 , A61L27/58 , A61K47/34 , A61K47/30 , A61K9/00 , A61K31/74 , A61K31/765
CPC分类号： A61L27/18 , A61K9/0024 , A61K31/74 , A61K31/765 , A61K47/30 , A61K47/34 , A61L27/50 , A61L27/58 , A61L2400/12 , C08L67/04
摘要： The present invention is directed to a novel poly(diol citrates)-based nanocomposite materials created using completely biodegradable and biocompatible polymers that may be used in tissue engineering. More specifically, the specification describes methods and compositions for making and using nanocomposites comprised of citric acid copolymers and polymers including but not limited to poly(L-lactic acid) (PLLA) and poly(lactic-co-glycolic acid) (PLGA).
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3.发明申请POLY (DIOL CO-CITRATE) HYDROXYAPATITE COMPOSITE FOR TISSUE ENGINEERING AND ORTHOPAEDIC FIXATION DEVICES 有权用于组织工程和正交固定装置的聚（二羟基 - 柠檬酸）羟基磷酸酯复合物公开(公告)号：US20140155516A1
公开(公告)日：2014-06-05
申请号：US14062442
申请日：2013-10-24
发明人： Guillermo Ameer , Hongjin Qiu , Jian Yang
CPC分类号： A61L31/127 , A61L27/12 , A61L27/18 , A61L27/425 , A61L27/427 , A61L27/46 , A61L27/58 , A61L31/026 , A61L31/06 , A61L31/121 , A61L31/123 , A61L31/148 , A61L2430/02
摘要： The present invention is directed to a novel poly(diol citrates)-based bioceramic composite materials created using completely biodegradable and a bioceramic material polymers that may be used in implantable devices. More specifically, the specification describes methods and compositions for making and using bioceramic composites comprised of citric acid copolymers and a bioceramic material.
摘要翻译： 本发明涉及一种使用完全生物降解产生的新型聚（二醇柠檬酸盐）生物陶瓷复合材料，以及可用于可植入装置的生物陶瓷材料聚合物。 更具体地说，本说明书描述了用于制造和使用由柠檬酸共聚物和生物陶瓷材料组成的生物陶瓷复合材料的方法和组合物。
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公开(公告)号：US11191842B2
公开(公告)日：2021-12-07
申请号：US15819921
申请日：2017-11-21
发明人： Jian Yang , Robert Van Lith , Guillermo Ameer
IPC分类号： A61K47/60 , C08G63/676 , A61K9/00 , A61K47/34 , C12N5/00 , C08L67/07 , C08F283/01 , A61P43/00
摘要： Provided herein are compositions, devices, and systems comprising copolymers of an N-alkyl acrylamide residue and a polyester comprising citric acid, polyethylene glycol, and glycerol 1,3-diglycerolate diacrylate, and methods of use and manufacture thereof.
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5.发明授权公开(公告)号：US08758796B2
公开(公告)日：2014-06-24
申请号：US13848339
申请日：2013-03-21
发明人： Guillermo Ameer , Jian Yang , Melina Kibbe
IPC分类号： A61F2/00
CPC分类号： A61L31/10 , A61L27/16 , A61L27/34 , A61L27/3804 , A61L27/48 , A61L27/507 , A61L27/58 , A61L33/068 , C12N5/0692 , C12N2533/40 , Y10T428/31507 , Y10T428/3154 , Y10T428/31565 , Y10T428/31663 , Y10T428/31681 , Y10T428/31736 , Y10T428/31786 , Y10T428/3179 , Y10T428/31797 , C08L27/18 , C08L67/04
摘要： The present invention is directed to a novel poly(diol citrates)-based coating for implantable devices. More specifically, the specification describes methods and compositions for making and using implantable devices coated with citric acid copolymers or citric acid copolymers impregnated with therapeutic compositions and/or cells.
摘要翻译： 本发明涉及一种用于可植入装置的新型聚（二醇柠檬酸盐）基涂层。 更具体地，本说明书描述了制备和使用涂覆有浸渍有治疗组合物和/或细胞的柠檬酸共聚物或柠檬酸共聚物的可植入装置的方法和组合物。
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6.发明授权Poly (diol-co-citrate) hydroxyapatite composite for tissue engineering and orthopaedic fixation devices 有权用于组织工程和矫形固定装置的聚（二醇 - 共 - 柠檬酸）羟基磷灰石复合材料公开(公告)号：US08992967B2
公开(公告)日：2015-03-31
申请号：US14062442
申请日：2013-10-24
发明人： Guillermo Ameer , Hongjin Qiu , Jian Yang
IPC分类号： A61F2/00 , A61L31/06 , A61L27/12 , A61L27/42 , A61L27/46 , A61L27/58 , A61L31/02 , A61L31/12 , A61L31/14
CPC分类号： A61L31/127 , A61L27/12 , A61L27/18 , A61L27/425 , A61L27/427 , A61L27/46 , A61L27/58 , A61L31/026 , A61L31/06 , A61L31/121 , A61L31/123 , A61L31/148 , A61L2430/02
摘要： The present invention is directed to a novel poly(diol citrates)-based bioceramic composite materials created using completely biodegradable and a bioceramic material polymers that may be used in implantable devices. More specifically, the specification describes methods and compositions for making and using bioceramic composites comprised of citric acid copolymers and a bioceramic material.
摘要翻译： 本发明涉及一种使用完全生物降解产生的新型聚（二醇柠檬酸盐）生物陶瓷复合材料，以及可用于可植入装置的生物陶瓷材料聚合物。 更具体地说，本说明书描述了用于制造和使用由柠檬酸共聚物和生物陶瓷材料组成的生物陶瓷复合材料的方法和组合物。
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7.发明授权Biodegradable nitric oxide generating polymers and related biomedical devices 有权可生物降解一氧化氮生成聚合物及相关生物医学装置公开(公告)号：US08772437B2
公开(公告)日：2014-07-08
申请号：US14062464
申请日：2013-10-24
发明人： Guillermo Ameer , Melina Kibbe , Haichao Zhao
IPC分类号： C08G69/44 , A61L29/08 , A61L31/16 , C09D179/02 , A61L31/06 , A61L29/16 , C08G63/685 , A61L31/10 , C08G73/02 , A61L31/14 , A61L27/34 , A61L27/54
CPC分类号： A61L31/06 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/114 , A61L2300/416 , A61L2300/42 , C08G63/6856 , C08G73/02 , C08G73/0206 , C09D179/02
摘要： Disclosed herein is a biodegradable nitric oxide-generating polymer comprising a nitric oxide-releasing N2O231 (NONOate) functional group. The polymer can be applied to various medical devices for the treatment of various diseases such as thrombosis and restenosis.
摘要翻译： 本文公开了包含一氧化氮释放N2O2（NON-Oate）官能团的可生物降解的产生一氧化氮的聚合物。 聚合物可以应用于各种医疗装置，用于治疗各种疾病如血栓形成和再狭窄。
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8.发明申请Novel Biodegradable Elastomeric Scaffold for Tissue Engineering and Light Scattering Fingerprinting Methods for Testing the Same 审中-公开用于组织工程和光散射的新型可生物降解弹性支架用于测试它们的指纹方法公开(公告)号：US20140066587A1
公开(公告)日：2014-03-06
申请号：US13971223
申请日：2013-08-20
发明人： Guillermo Ameer , Jian Yang , Ryan Hoshi
IPC分类号： C08G63/40
CPC分类号： C08G63/914 , C08G63/06 , C08G63/16 , C08G63/40 , C08G63/66 , C08G63/685
摘要： The present invention is directed to a novel biocompatible polymer that may be used in tissue engineering. More specifically, the specification describes methods and compositions for making and using citric acid copolymers.
摘要翻译： 本发明涉及可用于组织工程的新型生物相容性聚合物。 更具体地，本说明书描述了制备和使用柠檬酸共聚物的方法和组合物。
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公开(公告)号：US20210307731A1
公开(公告)日：2021-10-07
申请号：US17221200
申请日：2021-04-02
IPC分类号： A61B10/00
摘要： A medical swab includes a hollow tube shaft that has a distal end and a proximal end. A swab tip is mounted to the hollow tube shaft such that a first portion of the swab tip is positioned within the distal end of the hollow tube shaft and a second portion of the swab tip extends out from the distal end of the hollow tube shaft.
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10.发明申请POLY (DIOL CO-CITRATE) HYDROXYAPATITE COMPOSITE FOR TISSUE ENGINEERING AND ORTHOPAEDIC FIXATION DEVICES 审中-公开用于组织工程和正交固定装置的聚（二羟基 - 柠檬酸）羟基磷酸酯复合物公开(公告)号：US20150297802A1
公开(公告)日：2015-10-22
申请号：US14669173
申请日：2015-03-26
发明人： Guillermo Ameer , Hongjin Qiu , Jian Yang
IPC分类号： A61L31/12 , A61L27/58 , A61L31/14 , A61L27/18 , A61L31/06 , A61L27/42 , A61L27/12 , A61L27/46 , A61L31/02
CPC分类号： A61L31/127 , A61L27/12 , A61L27/18 , A61L27/425 , A61L27/427 , A61L27/46 , A61L27/58 , A61L31/026 , A61L31/06 , A61L31/121 , A61L31/123 , A61L31/148 , A61L2430/02
摘要： The present invention is directed to a novel poly(diol citrates)-based bioceramic composite materials created using completely biodegradable and a bioceramic material polymers that may be used in implantable devices. More specifically, the specification describes methods and compositions for making and using bioceramic composites comprised of citric acid copolymers and a bioceramic material.
摘要翻译： 本发明涉及一种使用完全生物降解产生的新型聚（二醇柠檬酸盐）生物陶瓷复合材料，以及可用于可植入装置的生物陶瓷材料聚合物。 更具体地说，本说明书描述了用于制造和使用由柠檬酸共聚物和生物陶瓷材料组成的生物陶瓷复合材料的方法和组合物。
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