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公开(公告)号：US09400236B2
公开(公告)日：2016-07-26
申请号：US14118175
申请日：2012-05-11
Applicant: Oliver Hayden
Inventor： Oliver Hayden
CPC classification number: G01N1/40 , B01L3/502761 , B01L2200/0652 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2400/043 , B01L2400/086 , B03C1/286 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N27/745
Abstract: Devices and methods for magnetophoretic analyte selection and concentration are described. Magnetically marked analytes (e.g., cells) may be separated out of a sample dynamically in flux, such that the magnetically marked analytes are present in a highly concentrated manner in a reduced sample volume. The analyte selection may be followed by an analysis.
Abstract translation: 描述了用于磁电泳分析物选择和浓缩的装置和方法。 磁性标记的分析物（例如，细胞）可以在通量中动态地从样品中分离出来，使得磁性标记的分析物以降低的样品体积以高度浓缩的方式存在。 分析物选择之后可以进行分析。
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公开(公告)号：US20140356891A1
公开(公告)日：2014-12-04
申请号：US14238943
申请日：2012-08-01
Applicant: Oliver Hayden , Michael Johannes Helou , Mathias Reisbeck , Sandro Francesco Tedde
Inventor： Oliver Hayden , Michael Johannes Helou , Mathias Reisbeck , Sandro Francesco Tedde
CPC classification number: G01N15/1031 , G01N33/54326 , G01N33/585 , G01N33/80 , G01N2015/0065 , G01N2015/1006 , G01R33/1269
Abstract: Devices and methods for magnetic flow measurement are provided. Individual analytes are detected in the through-flow, and a dynamic detection of a changing analyte state is carried out, for example with respect to the analyte size or morphology. For this purpose, the analytes to be detected, such as cells for example, are directly marked in the medium surrounding said analytes with magnetic labels and transported through the flow channel of a measuring device comprising at least two magnetic sensors. A characteristic measurement signal is generated by means of the magnetic sensors that are mutually spaced in the flow direction. The magnetic analyte diameter is calculated using the interval between the measurement deflections, and the analyte state can be evaluated using the magnetic analyte diameter.
Abstract translation: 提供磁流测量的装置和方法。 在通流中检测到各种分析物，并且例如相对于分析物的大小或形态，进行改变的分析物状态的动态检测。 为此，待检测的分析物，例如细胞，直接用磁性标记在包围所述分析物的培养基中，并通过包含至少两个磁性传感器的测量装置的流动通道传送。 通过在流动方向上相互间隔的磁性传感器产生特征测量信号。 使用测量偏转之间的间隔计算磁分析物直径，并且可以使用磁性分析物直径来评估分析物状态。
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3.发明授权Material for a photoactive layer in organic photodiodes, use therefor, and an organic photodiode 有权用于有机光电二极管中的光敏层的材料，以及有机光电二极管公开(公告)号：US08614440B2
公开(公告)日：2013-12-24
申请号：US13499243
申请日：2010-09-28
Applicant: Maria Sramek , Oliver Hayden
Inventor： Maria Sramek , Oliver Hayden
IPC: H01L51/00
CPC classification number: H01L51/4253 , C09B57/007 , Y02E10/549
Abstract: A photoactive layer in organic photodiodes includes organic photoactive dyes, including squaraines with donor-substituted aromatic substituents as the electron donor component, used as an alternative to polymer hold conductors for bulk heterojunctions typically found in the organic active layer of organic photodiodes.
Abstract translation: 有机光电二极管中的光活性层包括有机光活性染料，包括具有供体取代的芳族取代基作为电子给体组分的方酸，用作通常存在于有机光电二极管的有机活性层中的体异质结的聚合物保持导体的替代物。
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公开(公告)号：US20130330828A1
公开(公告)日：2013-12-12
申请号：US14002071
申请日：2012-02-28
Applicant: Oliver Hayden , Michael Johannes Helou , Mathias Reisbeck , Sandro Francesco Tedde
Inventor： Oliver Hayden , Michael Johannes Helou , Mathias Reisbeck , Sandro Francesco Tedde
CPC classification number: G01N15/1404 , G01N1/40 , G01N33/54333 , G01N33/569 , G01N33/585 , G01N35/0098 , H01L43/12
Abstract: A measuring device for magnetic flow cytometry has a microfluidic channel disposed along an enriching route such that a magnetically marked cell sample flowing through the microfluidic channel is aligned to magnetic guide strips, enriched by the magnetic field of a magnet at the floor of the channel, and guided past a sensor. The sensor and the magnetic guide strips are integrated on a semiconductor chip.
Abstract translation: 用于磁流式细胞术的测量装置具有沿着富集途径设置的微流体通道，使得流过微流体通道的磁标记细胞样品与通过通道底部的磁体的磁场富集的导磁条对准， 并经过传感器。 传感器和导磁条集成在半导体芯片上。
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5.发明申请公开(公告)号：US20130218048A1
公开(公告)日：2013-08-22
申请号：US13765809
申请日：2013-02-13
Applicant: Oliver Hayden , Manfred Rührig
Inventor： Oliver Hayden , Manfred Rührig
CPC classification number: G01N33/86 , A61B5/15003 , A61B5/150099 , A61B5/150221 , A61B5/150251 , A61B5/153 , A61B5/157 , G01N29/036 , G01N29/2412 , G01N2291/014 , G01N2291/0256 , G01N2291/02809 , G01R33/1269 , G01R33/18
Abstract: Sensor apparatus (1) for determining at least one biochemical function of a fluid (F) with at least one magnetoelastic capillary tube (2) through which the fluid (F) is conveyed, wherein a resonant frequency (fR) of the magnetoelastic capillary tube (2), which depends on a surface loading of the inner wall of the magnetoelastic capillary tube (2) by the fluid (F) conveyed through the tube is able to be read out in a non-contact manner for determining the biochemical function of the fluid (F).
Abstract translation: 用于通过传送流体（F）的至少一个磁弹性毛细管（2）确定流体（F）的至少一种生物化学功能的传感器装置（1），其中磁弹性毛细管的共振频率（fR） （2），其取决于通过管输送的流体（F）对磁弹性毛细管（2）的内壁的表面负载，以非接触方式读出，以确定生物化学功能 流体（F）。
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Patent Agency Ranking
6.发明申请DEVICE FOR MAGNETIC DETECTION OF INDIVIDUAL PARTICLES IN A MICROFLUID CHANNEL 失效用于在微流通道中磁性检测个体颗粒的装置公开(公告)号：US20100273184A1
公开(公告)日：2010-10-28
申请号：US12734899
申请日：2008-11-27
Applicant: Ludwig Bär , Oliver Hayden
Inventor： Ludwig Bär , Oliver Hayden
CPC classification number: G01N15/1031 , G01N15/1056 , G01N33/54366 , G01R33/1269
Abstract: A device dynamically detects particles of a fluid. The device can be miniaturized for detecting and selecting magnetized particles, particularly cells.
Abstract translation: 设备动态地检测流体的颗粒。 该装置可以小型化，用于检测和选择磁化颗粒，特别是电池。
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公开(公告)号：US09316575B2
公开(公告)日：2016-04-19
申请号：US13820866
申请日：2011-08-29
Applicant: Oliver Hayden , Michael Johannes Helou , Sandro Francesco Tedde
Inventor： Oliver Hayden , Michael Johannes Helou , Sandro Francesco Tedde
CPC classification number: G01N15/1031
Abstract: The disclosure relates to flow cytometry. A method for precise individual cell detection and cell measurement of cells in the flow is disclosed. A pair of magnetoresistive components are used to produce a characteristic measuring signal profile from which the following information can be obtained: number of measurement deviations, measurement deviation distances, measurement deviation amplitudes, measurement deviation direction and measurement deviation direction sequence. The flow speed and the cell diameter can also be determined. Also, the signal noise ratio can be determined using the measurement deviation amplitude.
Abstract translation: 本公开涉及流式细胞术。 公开了一种精确的单个细胞检测和流中的细胞的细胞测量的方法。 使用一对磁阻部件来产生特征测量信号轮廓，可从中获得以下信息：测量偏差数，测量偏差距离，测量偏差幅度，测量偏差方向和测量偏差方向序列。 也可以确定流速和细胞直径。 此外，可以使用测量偏差幅度来确定信号噪声比。
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公开(公告)号：US20130224762A1
公开(公告)日：2013-08-29
申请号：US13883497
申请日：2011-10-28
Applicant: Oliver Hayden , Michael Johannes Helou , Sandro Francesco Tedde
Inventor： Oliver Hayden , Michael Johannes Helou , Sandro Francesco Tedde
IPC: G01N27/72
CPC classification number: G01N27/72 , B03C1/02 , G01N27/745 , G01N33/54326
Abstract: Specific labeling of cells enables magnetic cell detection. The cell type to be detected is labeled, magnetic labels being bound to epitopes of a first cell-specific epitope type via antibodies of a first antibody type. Additionally, second/further magnetic labels are bound to epitopes of a second cell-specific epitope type on the cells via antibodies of a second antibody type, or the magnetic labels are bound to the antibodies of the first antibody type via antibodies of another antibody type and the antibodies of the first antibody type are bound to the epitopes of the first cell-specific epitope type on the cells.
Abstract translation: 细胞的特异性标记可以进行磁性细胞检测。 要检测的细胞类型被标记，磁性标记通过第一抗体类型的抗体与第一细胞特异性表位型的表位结合。 此外，第二/另外的磁性标记通过第二抗体类型的抗体与细胞上的第二细胞特异性表位类型的表位结合，或者磁性标记通过另一抗体类型的抗体与第一抗体类型的抗体结合 并且第一抗体类型的抗体结合到细胞上的第一细胞特异性表位型的表位。
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公开(公告)号：US20120182007A1
公开(公告)日：2012-07-19
申请号：US13499603
申请日：2010-08-17
Applicant: Ludwig Bär , Helmut Eckert , Oliver Hayden , Sandro Francesco Tedde , Michael Vieth , Roland Weiss
Inventor： Ludwig Bär , Helmut Eckert , Oliver Hayden , Sandro Francesco Tedde , Michael Vieth , Roland Weiss
IPC: G01N27/74
CPC classification number: G01N15/0656 , B01L3/502761 , B01L2300/0851 , B01L2300/0877 , B01L2300/089 , B01L2400/043 , B03C1/01 , B03C1/288 , B03C2201/18 , B03C2201/20 , B03C2201/24 , B82Y25/00 , G01N2035/00564 , G01R33/093 , G01R33/1207
Abstract: Magnetically labeled cells in a flow chamber cytometer are detected by a GMR sensor. The flow chamber includes a cell guiding device having at least one first and one second magnetic or magnetizable flow strip. The flow strips, which serve to guide the flowing cells across the sensor in a target-oriented manner, are mounted at a distance from each other such that a magnetic field BF is produced between them. The GMR sensor is arranged in the region of the magnetic field BF between the flow strips such that the magnetic field BF can be used as the operating magnetic field BGMR of the GMR sensor. In this way, the need for additional magnets for operating the GMR sensor is eliminated.
Abstract translation: 流式细胞仪中的磁性标记细胞由GMR传感器检测。 流动室包括具有至少一个第一和一个第二磁性或可磁化流动条的电池引导装置。 用于以目标取向的方式引导流动的细胞穿过传感器的流动条彼此间隔一定距离地安装，使得它们之间产生磁场BF。 GMR传感器布置在流动条之间的磁场BF的区域中，使得磁场BF可以用作GMR传感器的操作磁场BGMR。 以这种方式，消除了用于操作GMR传感器的附加磁体的需要。
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10.发明申请Monolayers of organic compounds on metal oxide surfaces or metal surfaces containing oxide and component produced therewith based on organic electronics 审中-公开在金属氧化物表面上的有机化合物的单层或含有氧化物的金属表面或基于有机电子产生的组分公开(公告)号：US20120003485A1
公开(公告)日：2012-01-05
申请号：US13138563
申请日：2010-03-03
Applicant: Dana Berlinde Habich , Marcus Halik , Oliver Hayden , Günter Schmid
Inventor： Dana Berlinde Habich , Marcus Halik , Oliver Hayden , Günter Schmid
CPC classification number: H01L51/5088 , H01L51/0021 , H01L51/5206 , Y10T428/31663
Abstract: Monolayers of organic compounds are formed on transparent conductive metal oxide surfaces these are used for example in producing organically based electronic components. By selecting the monolayer, the service life of the devices produced therewith may be improved by orders of magnitude.
Abstract translation: 有机化合物的单层形成在透明导电金属氧化物表面上，这些表面用于例如生产有机基电子元件。 通过选择单层，可以将其生产的装置的使用寿命提高数量级。
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