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公开(公告)号：US07846705B2
公开(公告)日：2010-12-07
申请号：US11778690
申请日：2007-07-17
申请人： Oliver Kensch , Wayne M. Coco , Andreas Scheidig , Ute Beister , Birgitta Leuthner , Nadine Koch , Markus Rarbach , Ulrich Kettling , Ulrich Haupts
发明人： Oliver Kensch , Wayne M. Coco , Andreas Scheidig , Ute Beister , Birgitta Leuthner , Nadine Koch , Markus Rarbach , Ulrich Kettling , Ulrich Haupts
IPC分类号： C12N9/24
CPC分类号： C11D3/38636 , A23F5/246 , A23K20/189 , A23L29/06 , C09K8/68 , C12N9/2494 , C12Y302/01078
摘要： The present invention provides an insertion, deletion and/or substitution mutein of wild-type Trichoderma reesei β-mannanase having enhanced thermostability, proteolytic stability, specific activity and/or stability at low pH, a nucleic acid molecule encoding said mannanase mutein, a composition comprising said mannanase mutein; a method for its preparation, and its use for food and feed processing, for coffee extraction and the processing of coffee waste, as a supplement to food and feed, for enzyme aided bleaching of paper pulps, as bleaching and/or desizing agent in textile industry, for oil and gas well stimulation by hydraulic fracturing, as detergent, for removal of biofilms and in delivery systems, or for the processing of renewable resources intended for the production of biological fuels.
摘要翻译： 本发明提供了具有增强的热稳定性，蛋白水解稳定性，在低pH下的比活性和/或稳定性的野生型里氏木霉 - 甘露聚糖酶的插入，缺失和/或取代突变蛋白，编码所述甘露聚糖酶突变蛋白的核酸分子， 包含所述甘露聚糖酶突变蛋白的组合物; 其制备方法及其用于食品和饲料加工的咖啡提取和咖啡废弃物的加工，作为食品和饲料的补充，用于纸浆的酶辅助漂白，作为纺织品中的漂白和/或脱浆剂 工业，通过水力压裂的油气井刺激，作为洗涤剂，用于去除生物膜和输送系统，或用于处理用于生产生物燃料的可再生资源。
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公开(公告)号：US20080064064A1
公开(公告)日：2008-03-13
申请号：US11778690
申请日：2007-07-17
申请人： Oliver Kensch , Wayne Coco , Andreas Scheidig , Ute Beister , Birgitta Leuthner , Nadine Koch , Markus Rarbach , Ulrich Kettling , Ulrich Haupts
发明人： Oliver Kensch , Wayne Coco , Andreas Scheidig , Ute Beister , Birgitta Leuthner , Nadine Koch , Markus Rarbach , Ulrich Kettling , Ulrich Haupts
IPC分类号： C12P21/04 , A23F5/24 , A23K1/14 , C07H21/04 , C09K8/60 , C11D7/42 , C12N15/00 , C12N5/06 , C12N9/48
CPC分类号： C11D3/38636 , A23F5/246 , A23K20/189 , A23L29/06 , C09K8/68 , C12N9/2494 , C12Y302/01078
摘要： The present invention provides an insertion, deletion and/or substitution mutein of wild-type Trichoderma reesei β-mannanase having enhanced thermostability, proteolytic stability, specific activity and/or stability at low pH, a nucleic acid molecule encoding said mannanase mutein, a composition comprising said mannanase mutein; a method for its preparation, and its use for food and feed processing, for coffee extraction and the processing of coffee waste, as a supplement to food and feed, for enzyme aided bleaching of paper pulps, as bleaching and/or desizing agent in textile industry, for oil and gas well stimulation by hydraulic fracturing, as detergent, for removal of biofilms and in delivery systems, or for the processing of renewable resources intended for the production of biological fuels.
摘要翻译： 本发明提供了具有增强的热稳定性，蛋白水解稳定性，比较活性和/或低pH稳定性的野生型里氏木霉β-甘露聚糖酶的插入，缺失和/或取代突变蛋白，编码所述甘露聚糖酶突变蛋白的核酸分子，组合物 包含所述甘露聚糖酶突变蛋白; 其制备方法及其用于食品和饲料加工的咖啡提取和咖啡废弃物的加工，作为食品和饲料的补充，用于纸浆的酶辅助漂白，作为纺织品中的漂白和/或脱浆剂 工业，通过水力压裂的油气井刺激，作为洗涤剂，用于去除生物膜和输送系统，或用于处理用于生产生物燃料的可再生资源。
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公开(公告)号：US20090208440A1
公开(公告)日：2009-08-20
申请号：US11969511
申请日：2008-01-04
申请人： Ulrich Haupts , Andre Koltermann , Andreas Scheidig , Christian Votsmeier , Ulrich Kettling , Oliver Kensch , Birgitta Leuthner
发明人： Ulrich Haupts , Andre Koltermann , Andreas Scheidig , Christian Votsmeier , Ulrich Kettling , Oliver Kensch , Birgitta Leuthner
CPC分类号： C12N9/6424 , A61K8/64 , A61K38/482 , A61K38/4826 , A61K38/486 , A61K38/4873 , A61K38/488 , A61Q19/00 , C12N9/50 , C12N9/6472 , C12N9/6478 , C12N9/6489 , C12N15/1034 , C12N15/62 , C12P21/06 , C12Q1/37
摘要： The present invention provides engineered enzymes generated from protein scaffolds combined with Specificity Determining Regions, the production thereof and the use of said engineered enzymes for research, nutritional care, personal care and industrial purposes.
摘要翻译： 本发明提供由与特异性确定区组合的蛋白质支架产生的工程化酶，其生产和所述工程化酶用于研究，营养保健，个人护理和工业目的的用途。
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公开(公告)号：US08399627B2
公开(公告)日：2013-03-19
申请号：US12808608
申请日：2008-12-24
申请人： Christian Votsmeier , Uwe Gritzan , Kornelia Kirchner , Michael Strerath , Kerstin Baral , Ulrich Haupts , Wayne M. Coco , Susanne Steinig , Andreas Scheidig , Klaus Pellengahr , Simone Brückner , Hanna Plittersdorf , Peter Scholz , Jan Tebbe
发明人： Christian Votsmeier , Uwe Gritzan , Kornelia Kirchner , Michael Strerath , Kerstin Baral , Ulrich Haupts , Wayne M. Coco , Susanne Steinig , Andreas Scheidig , Klaus Pellengahr , Simone Brückner , Hanna Plittersdorf , Peter Scholz , Jan Tebbe
CPC分类号： C07K16/241 , C07K2317/14 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/76 , C07K2317/90 , C07K2317/92
摘要： Provided herein are antibodies, antigen binding portions, and derivatives thereof that are capable of binding tumor necrosis factor alpha (TNFα); nucleic acids encoding the antibodies, antigen binding portions, and derivatives thereof, including complementary nucleic acids; vectors; and host cells containing the nucleic acids.
摘要翻译： 本文提供能够结合肿瘤坏死因子α（TNFα）的抗体，抗原结合部分及其衍生物; 编码抗体的核酸，抗原结合部分及其衍生物，包括互补核酸; 向量 和含有核酸的宿主细胞。
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公开(公告)号：US20130230886A1
公开(公告)日：2013-09-05
申请号：US13799650
申请日：2013-03-13
申请人： Christian Votsmeier , Uwe Gritzan , Kornelia Kirchner , Michael Strerath , Kerstin Baral , Ulrich Haupts , Wayne M. Coco , Susanne Steinig , Andreas Scheidig , Klaus Pellengahr , Simone Brückner , Hanna Plittersdorf , Peter Scholz , Jan Tebbe
发明人： Christian Votsmeier , Uwe Gritzan , Kornelia Kirchner , Michael Strerath , Kerstin Baral , Ulrich Haupts , Wayne M. Coco , Susanne Steinig , Andreas Scheidig , Klaus Pellengahr , Simone Brückner , Hanna Plittersdorf , Peter Scholz , Jan Tebbe
IPC分类号： C07K16/24
CPC分类号： C07K16/241 , C07K2317/14 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/76 , C07K2317/90 , C07K2317/92
摘要： Provided herein are antibodies, antigen binding portions, and derivatives thereof that are capable of binding tumor necrosis factor alpha (TNFα); nucleic acids encoding the antibodies, antigen binding portions, and derivatives thereof, including complementary nucleic acids; vectors; and host cells containing the nucleic acids.
摘要翻译： 本文提供能够结合肿瘤坏死因子α（TNFalpha）的抗体，抗原结合部分及其衍生物; 编码抗体的核酸，抗原结合部分及其衍生物，包括互补核酸; 向量 和含有核酸的宿主细胞。
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公开(公告)号：US07335504B2
公开(公告)日：2008-02-26
申请号：US10872197
申请日：2004-06-18
IPC分类号： C12N9/64 , G01N33/567 , C12Q1/37 , C12P21/06 , C12P21/04
CPC分类号： C12N9/6424 , A61K8/64 , A61K38/482 , A61K38/4826 , A61K38/486 , A61K38/4873 , A61K38/488 , A61Q19/00 , C12N9/50 , C12N9/6472 , C12N9/6478 , C12N9/6489 , C12N15/1034 , C12N15/62 , C12P21/06 , C12Q1/37
摘要： The present invention provides engineered enzymes generated from protein scaffolds combined with Specificity Determining Regions, the production thereof and the use of said engineered enzymes for research, nutritional care, personal care and industrial purposes.
摘要翻译： 本发明提供由与特异性确定区组合的蛋白质支架产生的工程化酶，其生产和所述工程化酶用于研究，营养保健，个人护理和工业目的的用途。
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公开(公告)号：US20050059126A1
公开(公告)日：2005-03-17
申请号：US10872197
申请日：2004-06-18
IPC分类号： A61K38/00 , A61K38/48 , C07H21/04 , C12N9/00 , C12N9/10 , C12N9/50 , C12N9/64 , C12N15/10 , C12N15/62 , C12P21/06 , C12Q1/37
CPC分类号： C12N9/6424 , A61K8/64 , A61K38/482 , A61K38/4826 , A61K38/486 , A61K38/4873 , A61K38/488 , A61Q19/00 , C12N9/50 , C12N9/6472 , C12N9/6478 , C12N9/6489 , C12N15/1034 , C12N15/62 , C12P21/06 , C12Q1/37
摘要： The present invention provides engineered enzymes generated from protein scaffolds combined with Specificity Determining Regions, the production thereof and the use of said engineered enzymes for research, nutritional care, personal care and industrial purposes.
摘要翻译： 本发明提供由与特异性确定区组合的蛋白质支架产生的工程化酶，其生产和所述工程化酶用于研究，营养保健，个人护理和工业目的的用途。
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8.发明申请Serine proteases with altered sensitivity to activity-modulating substances 审中-公开对活性调节物质敏感性高的丝氨酸蛋白酶公开(公告)号：US20060269538A1
公开(公告)日：2006-11-30
申请号：US11441635
申请日：2006-05-26
申请人： Andre Koltermann , Ulrich Kettling , Ulrich Haupts , Wayne Coco , Jan Tebbe , Christian Votsmeier , Andreas Scheidig
发明人： Andre Koltermann , Ulrich Kettling , Ulrich Haupts , Wayne Coco , Jan Tebbe , Christian Votsmeier , Andreas Scheidig
CPC分类号： C12Q1/37 , A61K38/00 , C12N9/64 , G01N2500/00
摘要： The present invention provides variants of serine proteases of the S1 class with altered sensitivity to one or more activity-modulating substances. A method for the generation of such proteases is disclosed, comprising the provision of a protease library encoding polynucleotide sequences, expression of the enzymes, screening of the library in the presence of one or several activity-modulating substances, selection of variants with altered sensitivity to one or several activity-modulating substances and isolation of those polynucleotide sequences that encode for the selected variants.
摘要翻译： 本发明提供对一种或多种活性调节物质敏感性改变的S1类丝氨酸蛋白酶的变体。 公开了产生这种蛋白酶的方法，包括提供编码多核苷酸序列的蛋白酶文库，酶的表达，在一种或几种活性调节物质存在下筛选文库，选择对 一种或几种活性调节物质以及编码所选变体的那些多核苷酸序列的分离。
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公开(公告)号：US20050002897A1
公开(公告)日：2005-01-06
申请号：US10872198
申请日：2004-06-18
CPC分类号： C12N9/6427 , A61K38/482 , A61K38/4826 , A61K38/486 , A61K38/4873 , A61K38/488 , C12P21/06 , C12Q1/37
摘要： The present invention provides method for the treatment of a disease by applying a medicament comprising a protease with a defined specificity is capable to hydrolyze specific peptide bonds within a target substrate related to such disease. The proteases with such a defined specificity can further be used for related therapeutic or diagnostic purposes.
摘要翻译： 本发明提供了通过应用包含具有确定的特异性的蛋白酶的药物能够水解与这种疾病相关的靶基质内的特异性肽键来治疗疾病的方法。 具有这种确定的特异性的蛋白酶可进一步用于相关的治疗或诊断目的。
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公开(公告)号：US20050175581A1
公开(公告)日：2005-08-11
申请号：US11021951
申请日：2004-12-22
申请人： Ulrich Haupts , Andre Koltermann , Andreas Scheidig , Christian Votsmeier , Ulrich Kettling , Wayne Coco
发明人： Ulrich Haupts , Andre Koltermann , Andreas Scheidig , Christian Votsmeier , Ulrich Kettling , Wayne Coco
CPC分类号： C12N9/6427 , A61K38/482 , A61K38/4826 , A61K38/486 , A61K38/4873 , A61K38/488 , C12P21/06 , C12Q1/37
摘要： The present invention provides method for the treatment of a disease by applying a medicament comprising a protease with a defined specificity is capable to hydrolyze specific peptide bonds within a target substrate related to such disease. The proteases with such a defined specificity can further be used for related therapeutic or diagnostic purposes.
摘要翻译： 本发明提供了通过应用包含具有确定的特异性的蛋白酶的药物能够水解与这种疾病相关的靶基质内的特异性肽键来治疗疾病的方法。 具有这种确定的特异性的蛋白酶可进一步用于相关的治疗或诊断目的。
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