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    STRUCTURED TESTING METHOD FOR DIAGNOSTIC OR THERAPY SUPPORT OF A PATIENT WITH A CHRONIC DISEASE AND DEVICES THEREOF
    2.
    发明申请
    STRUCTURED TESTING METHOD FOR DIAGNOSTIC OR THERAPY SUPPORT OF A PATIENT WITH A CHRONIC DISEASE AND DEVICES THEREOF 审中-公开
    具有慢性疾病的患者的诊断或治疗支持的结构化测试方法及其装置

    公开(公告)号：US20100212675A1

    公开(公告)日：2010-08-26

    申请号：US12643338

    申请日：2009-12-21

    申请人： P. Douglas Walling ,  Juergen Rasch-Menges ,  Stefan Weinert ,  Steven Bousamra ,  Abhishek S. Soni ,  Christoph Eisenhardt

    发明人： P. Douglas Walling ,  Juergen Rasch-Menges ,  Stefan Weinert ,  Steven Bousamra ,  Abhishek S. Soni ,  Christoph Eisenhardt

    IPC分类号： A61B5/00

    摘要： A structured testing method for diagnostic or therapy support of a patient with a chronic disease and devices thereof are disclosed which implement a structured collection procedure based on a medical use case and/or question which provides at least one or more parameters defining entry criterion, a schedule of events, adherence criterion, and exit criterion. The entry criterion establish conditions needed to be met prior to obtaining biomarker data from the patient. Each event can include one or more of a performance time, patient guidance to perform the event, a request for information from the patient a request for patient action, and a request for collection of biomarker data from the patient. The adherence criterion can be used to assess whether an event performed is acceptable to addressing the medical use case and/or question, and the exit criterion establishes conditions needed to be met prior to exiting the collection procedure.

    摘要翻译： 公开了一种用于慢性疾病患者及其装置的诊断或治疗支持的结构化测试方法，其实现基于医疗用例和/或问题的结构化收集程序，所述医疗用例和/或问题提供至少一个或多个定义入门标准的参数， 事件时间表，遵守标准和退出标准。 进入标准确定在从患者获得生物标志物数据之前需要满足的条件。 每个事件可以包括一个或多个执行时间，用于执行事件的患者指导，来自患者对病人动作的请求的请求以及从患者收集生物标志物数据的请求。 遵守标准可用于评估所执行的事件是否可以接受处理医疗用例和/或问题，退出标准确定在退出收集程序之前需要满足的条件。

    MANAGEMENT METHOD AND SYSTEM FOR IMPLEMENTATION, EXECUTION, DATA COLLECTION, AND DATA ANALYSIS OF A STRUCTURED COLLECTION PROCEDURE WHICH RUNS ON A COLLECTION DEVICE
    4.
    发明申请
    MANAGEMENT METHOD AND SYSTEM FOR IMPLEMENTATION, EXECUTION, DATA COLLECTION, AND DATA ANALYSIS OF A STRUCTURED COLLECTION PROCEDURE WHICH RUNS ON A COLLECTION DEVICE 有权
    收集装置结构化收集程序的执行，执行，数据收集和数据分析的管理方法和系统

    公开(公告)号：US20100218132A1

    公开(公告)日：2010-08-26

    申请号：US12643415

    申请日：2009-12-21

    申请人： Abhishek S. Soni ,  Stefan Weinert ,  Juergen Rasch-Menges ,  P. Douglas Walling

    发明人： Abhishek S. Soni ,  Stefan Weinert ,  Juergen Rasch-Menges ,  P. Douglas Walling

    IPC分类号： G06F9/46 ,  G06F17/30 ,  G06F15/16 ,  G06F3/048

    CPC分类号： G06F17/30289 ,  G01N33/49 ,  G01N33/66 ,  G06F19/00 ,  G06F19/3418 ,  G16H10/20 ,  G16H40/63

    摘要： Embodiments related to a system and method managing the implementation, execution, data collection, and data analysis of a structured collection procedure running on a portable, hand-held collection device are disclosed. The collection device performing the structured collection procedure has program instructions that when executed by a processor causes the processor to initiate automatically a schedule of events of the structured collection procedure upon one or more entry criterions being met at some unknown time, store in memory patient data collected in accordance to the schedule of events, end automatically the structured collection procedure upon one or more exit criterions being met at some unknown time, and mark/indicate the structured collection procedure as completed if no exception occurred during performance of an event in the schedule of events.

    摘要翻译： 公开了与在便携式手持式收集装置上运行的结构化收集过程的实现，执行，数据收集和数据分析的系统和方法相关的实施例。 执行结构化收集过程的收集装置具有当处理器执行时使处理器在某个未知时间满足一个或多个输入标准时自动启动结构化收集过程的事件调度的程序指令，存储在存储器患者数据中 根据事件进度收集，根据一些未知时间满足的一个或多个退出标准自动结束结算收集程序，并且如果在表格中的事件执行期间没有发生异常，则将结构化收集过程标记/指示为已完成 的事件。

    SYSTEMS AND METHODS FOR OPTIMIZING INSULIN DOSAGE
    5.
    发明申请
    SYSTEMS AND METHODS FOR OPTIMIZING INSULIN DOSAGE 有权
    用于优化胰岛素剂量的系统和方法

    公开(公告)号：US20110015511A1

    公开(公告)日：2011-01-20

    申请号：US12818310

    申请日：2010-06-18

    申请人： Steven Bousamra ,  Stefan Weinert ,  Juergen Rasch-Menges ,  P. Douglas Walling ,  John F. Price ,  Heino Eikmeier ,  Birgit Kraeling ,  Karl Werner ,  Ulrich Porsch

    发明人： Steven Bousamra ,  Stefan Weinert ,  Juergen Rasch-Menges ,  P. Douglas Walling ,  John F. Price ,  Heino Eikmeier ,  Birgit Kraeling ,  Karl Werner ,  Ulrich Porsch

    IPC分类号： A61B5/145 ,  G06F19/00 ,  G01N33/48 ,  G09B23/28

    CPC分类号： A61B5/0002 ,  A61B5/05 ,  A61B5/14532 ,  A61B5/14546 ,  A61M31/00 ,  A61M2230/201 ,  C12Q1/006 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3456 ,  G16H10/20 ,  G16H10/40 ,  G16H20/17 ,  G16H80/00

    摘要： Embodiments of a testing method suitable for diabetic persons to optimize their administered insulin dosage comprise collecting one or more sampling sets of biomarker data, wherein each sampling set comprises a sufficient plurality of non-adverse sampling instances and wherein each sampling instance comprises an acceptable biomarker reading at a single point in time recorded upon compliance with adherence criteria, determining a biomarker sampling parameter from each sampling set, comparing the biomarker sampling parameter to a target biomarker range, calculating an insulin adjustment parameter associated with the biomarker sampling parameter if the biomarker sampling parameter falls outside the target biomarker range, adjusting the insulin dosage by the insulin adjustment parameter if the biomarker sampling parameter falls outside the target biomarker range and if the insulin dosage does not exceed maximum dosage, and exiting the testing method if the adjusted insulin dosage is optimized. The insulin dosage is optimized when one or more biomarker sampling parameters fall within a target biomarker range.

    摘要翻译： 适于糖尿病患者优化其施用的胰岛素剂量的测试方法的实施方案包括收集一个或多个生物标志物数据的采样组，其中每个采样组包括足够多个非不良采样实例，并且其中每个采样实例包括可接受的生物标志物读数 在符合遵守标准的单个时间点上，从每个采样组确定生物标志物采样参数，将生物标志物采样参数与目标生物标志物范围进行比较，计算与生物标志物采样参数相关联的胰岛素调节参数，如果生物标志物采样参数 如果生物标志物采样参数落在目标生物标志物范围之外，并且如果胰岛素剂量不超过最大剂量，并且如果调整的胰岛素剂量是最佳的则退出测试方法，则超出目标生物标志物范围，通过胰岛素调节参数调整胰岛素剂量 zed。 当一个或多个生物标志物采样参数落入目标生物标志物范围内时，胰岛素剂量被优化。

    SYSTEM AND METHOD FOR THE ELECTROCHEMICAL MEASUREMENT OF AN ANALYTE EMPLOYING A REMOTE SENSOR
    7.
    发明申请
    SYSTEM AND METHOD FOR THE ELECTROCHEMICAL MEASUREMENT OF AN ANALYTE EMPLOYING A REMOTE SENSOR 有权
    使用远程传感器的分析仪的电化学测量系统和方法

    公开(公告)号：US20100213080A1

    公开(公告)日：2010-08-26

    申请号：US12534177

    申请日：2009-08-03

    申请人： Michael J. Celentano ,  P. Douglas Walling

    发明人： Michael J. Celentano ,  P. Douglas Walling

    IPC分类号： G01N33/50 ,  G01N33/49 ,  G01N27/26

    CPC分类号： A61B5/0002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/1495 ,  A61B2562/0295 ,  A61B2562/085 ,  G01N33/48792 ,  G06K19/0717

    摘要： A remote measurement system measures the concentrations of analytes in fluid samples. The system includes a metering device that can receive signals from a test strip or alternatively interrogate the test strip to obtain information. The test strip includes an area for receiving a fluid sample and electrochemically producing a current response that is sensed within the fluid sample. The test strip also includes an antenna and a radio frequency signal circuit for transmitting a signal indicative of the current response of a fluid sample to be analyzed. The metering device receives the signal and can convert it into a readable display in some embodiments. Remote electrochemical analysis of a fluid sample is thereby obtained.

    摘要翻译： 远程测量系统测量流体样品中分析物的浓度。 该系统包括能够从测试条接收信号或者作为询问测试条以获得信息的计量装置。 测试条包括用于接收流体样品的区域，并且电化学地产生在流体样品内感测的电流响应。 测试条还包括天线和射频信号电路，用于发送指示待分析的流体样本的当前响应的信号。 在一些实施例中，计量装置接收信号并将其转换成可读显示器。 从而获得流体样品的远程电化学分析。

    System and method for the electrochemical measurement of an analyte employing a remote sensor
    8.
    发明授权
    System and method for the electrochemical measurement of an analyte employing a remote sensor 有权
    使用远程传感器的分析物的电化学测量的系统和方法

    公开(公告)号：US08394246B2

    公开(公告)日：2013-03-12

    申请号：US12534177

    申请日：2009-08-03

    申请人： Michael J. Celentano ,  P. Douglas Walling

    发明人： Michael J. Celentano ,  P. Douglas Walling

    IPC分类号： G01N27/327 ,  G01N27/416

    CPC分类号： A61B5/0002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/1495 ,  A61B2562/0295 ,  A61B2562/085 ,  G01N33/48792 ,  G06K19/0717

    摘要： A remote measurement system measures the concentrations of analytes in fluid samples. The system includes a metering device that can receive signals from a test strip or alternatively interrogate the test strip to obtain information. The test strip includes an area for receiving a fluid sample and electrochemically producing a current response that is sensed within the fluid sample. The test strip also includes an antenna and a radio frequency signal circuit for transmitting a signal indicative of the current response of a fluid sample to be analyzed. The metering device receives the signal and can convert it into a readable display in some embodiments. Remote electrochemical analysis of a fluid sample is thereby obtained.

    摘要翻译： 远程测量系统测量流体样品中分析物的浓度。 该系统包括能够从测试条接收信号或者作为询问测试条以获得信息的计量装置。 测试条包括用于接收流体样品的区域，并且电化学地产生在流体样品内感测的电流响应。 测试条还包括天线和射频信号电路，用于发送指示待分析的流体样本的当前响应的信号。 在一些实施例中，计量装置接收信号并将其转换成可读显示器。 从而获得流体样品的远程电化学分析。

    Assay method with enzyme electrode system
    10.
    发明授权
    Assay method with enzyme electrode system 失效
    酶电极系统的测定方法

    公开(公告)号：US5508171A

    公开(公告)日：1996-04-16

    申请号：US198407

    申请日：1994-02-22

    申请人： P. Douglas Walling ,  Joseph E. Bateson ,  Lance S. Kuhn ,  M. Luann Ochs ,  Kent M. Kost ,  Martin T. Gerber ,  Klaus H. Pollmann ,  Chi-Neng A. Han

    发明人： P. Douglas Walling ,  Joseph E. Bateson ,  Lance S. Kuhn ,  M. Luann Ochs ,  Kent M. Kost ,  Martin T. Gerber ,  Klaus H. Pollmann ,  Chi-Neng A. Han

    IPC分类号： C12Q1/00 ,  C12Q1/26 ,  C12Q1/54

    CPC分类号： C12Q1/004 ,  Y10S435/817

    摘要： A new electrochemical biosensor and method of its use. The electrochemical biosensor has a pair of electrodes consisting of a working electrode and a counter electrode made of the same electrically conducting materials. The counter electrode may be the same size or smaller than the working electrode. The biosensor includes a sample receiving portion wherein a portion of the electrode surfaces is covered by a reagent that includes a redox mediator and an enzyme. A fluid that contains an analyte is added to the sample receiving portion. A reaction involving the analyte, enzyme and redox mediator occurs. After this reaction is complete, an electrical potential difference is applied between the electrodes. Diffusion limited current is measured and correlated to the concentration of analyte in the fluid.

    摘要翻译： 一种新的电化学生物传感器及其使用方法。 电化学生物传感器具有由工作电极和由相同导电材料制成的对电极组成的一对电极。 对电极的尺寸可以与工作电极相同。 生物传感器包括样品接收部分，其中一部分电极表面被包含氧化还原介体和酶的试剂覆盖。 含有分析物的流体被添加到样品接收部分。 发生涉及分析物，酶和氧化还原介体的反应。 在该反应完成之后，在电极之间施加电位差。 测量扩散限制电流并与流体中分析物的浓度相关。